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  • SAGE Publications  (5)
  • 1
    Online Resource
    Online Resource
    Surrogate endpoints for overall survival in anti-programmed death-1 and anti-programmed death ligand 1 trials of advanced melanoma
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592092958-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592092958-
    Abstract: We assessed the surrogacy of objective response rate (ORR), disease control rate (DCR) and progression-free survival (PFS) for overall survival (OS) in anti-PD-1/PD-L1 trials of metastatic melanoma through a meta-analysis of randomized controlled trials (RCTs). Methods: PubMed and EMBASE were searched for phase II/III RCTs till June 2019 investigating anti-PD-1/PD-L1 agents. Treatment effect (hazard ratio or odds ratio) on potential surrogates (ORR/DCR/PFS) and OS were collected. At trial level, we assessed the correlation between treatment effect on potential surrogates and OS, weighted by sample size, fixed and random effect models, and calculated the surrogate threshold effect (STE). Sensitivity analyses and leave-one-out cross-validation approach were performed to evaluate the robustness of our findings. Results: We included 8 RCTs (4110 patients; 11 comparisons). We did not identify strong correlations between ORR [coefficient of determination ( R 2 ): 0.09–0.25], DCR (0.41–0.57) and OS. However, we noted a strong correlation between PFS and OS, with R 2 of 0.82 in sample size, 0.75 in fixed effect and 0.72 in random effect model weighting, the robustness of which was further verified by leave-one-out cross-validation approach. Sensitivity analyses with restriction to trials with less than 50% crossover, phase III trials, large trials and first-line trials strengthened the correlation (0.78–0.94). The STE for PFS was 0.78. Conclusions: PFS may be the appropriate surrogate for OS in anti-PD-1/PD-L1 trials of metastatic melanoma. A future anti-PD-1/PD-L1 trial would need less than 0.78 for PFS of the upper limit of confidence interval to predict an OS benefit.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920929583
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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    Online Resource
  • 2
    Online Resource
    Online Resource
    An investigation of the structure-borne sound transmission in a T-joint equipped with a dynamic vibration absorber based on fluid–structure interaction dynamics
    SAGE Publications ; 2018
    In:  Journal of Vibration and Control Vol. 24, No. 22 ( 2018-11), p. 5449-5460
    Details
    In: Journal of Vibration and Control, SAGE Publications, Vol. 24, No. 22 ( 2018-11), p. 5449-5460
    Abstract: A novel analytical method is presented in this paper for evaluating the propagation characteristics of structure-borne sound in a T-joint, the web plate of which is in contact with heavy fluid. Firstly, based on the dynamics of fluid–structure interaction, a mathematical model that considers the effect of fluid is established for the T-joint, which is equipped with a dynamic vibration absorber. The waves in the T-joint structure are described by the dynamical equation of thin plates, while the motion of fluid is described by the Helmholtz equation in the ideal acoustic medium. For the convenience of mathematics, the semi-infinite fluid domain is extended virtually into the infinite space. The Fourier transform method is utilized to obtain analytical solutions with high precision. Several examples are given to analyse the characteristics of the coupled transmission of bending and longitudinal waves in the T-joint. Comparisons are made with the results for the no-fluid case. The effects of the mass and frequency parameters of the dynamic vibration absorber on the inhibition of longitudinal wave transmission are also investigated. It is found that the existence of the heavy fluid has a significant influence on the propagation of bending waves in the T-joint. The dynamic absorber can inhibit the longitudinal waves in the web plate of the T-joint, while it has no effect on the bending waves.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    URL: Article
    DOI: 10.1177/1077546318754998
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2070247-4
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  • 3
    Online Resource
    Online Resource
    Acupoint Thread Embedding Combined With Wenshen Bugu Decoction for the Treatment of Aromatase Inhibitor-Associated Musculoskeletal Symptom Among Postmenopausal Breast Cancer Patients: Study Protocol of a Randomized Controlled Trial
    SAGE Publications ; 2023
    In:  Integrative Cancer Therapies Vol. 22 ( 2023-01)
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 22 ( 2023-01)
    Abstract: Aromatase inhibitors (AIs) are recommended as the preferred therapy for postmenopausal women with hormone receptor-positive (HR+) breast cancer. As a result, aromatase inhibitor-associated musculoskeletal symptom (AIMSS) have become a major problem leading to therapy discontinuation and decreased quality of life in patients receiving adjuvant AIs treatment. Multiple therapies have been attempted, but have yielded limited clinical results. This study will be performed to determine whether acupoint thread embedding (ATE) combined with Wenshen Bugu Decoction can effectively treat AIMSS, so as to improve the AIs medication compliance of postmenopausal breast cancer patients. Methods: This study will utilize a randomized, 2 parallel groups controlled trial design. A total of 128 eligible postmenopausal breast cancer women with AIMSS will be randomized to receive a 12-week treatment with Wenshen Bugu Decoction alone (control group) or in combination with ATE (treatment group) in a 1:1 ratio. The primary outcome will be the 12 week Brief Pain Inventory Worst Pain (BPI-WP) score. The secondary outcome measures will include response rate, Brief Pain Inventory-Short Form (BFI-SF), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Functional Assessment of Cancer Therapy-Endocrine Symptom (FACT-ES), Functional Assessment of Cancer Therapy-Breast (FACT-B), bone marrow density (BMD), blood markers of bone metabolite, Morisky medication adherence scale-8 (MMAS-8), credibility and expectancy, and survival outcomes. Discussion: This trial may provide clinical evidence that ATE combined with Wenshen Bugu Decoction can be beneficial for treating AIMSS among postmenopausal breast cancer survivors. Our findings will be helpful to enhance the quality of life and reduce the occurrence of AIs withdrawal.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/15347354231188679
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2101248-9
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  • 4
    Online Resource
    Online Resource
    Computational fluid dynamics (CFD) analysis in a ruptured vertebral artery dissecting aneurysm implanted by Pipeline when recurrent after LVIS-assisted coiling treatment: Case report and review of the literatures
    SAGE Publications ; 2023
    In:  Interventional Neuroradiology Vol. 29, No. 4 ( 2023-08), p. 442-449
    Details
    In: Interventional Neuroradiology, SAGE Publications, Vol. 29, No. 4 ( 2023-08), p. 442-449
    Abstract: Hemodynamics plays an important role in the natural history of the process of rupture and recurrence of intracranial aneurysms. This study aimed to investigate the role of hemodynamics for recurrence in a vertebral artery dissecting aneurysm (VADA). Methods A patient with a ruptured VADA firstly treated by low-profile visualized intraluminal support (LVIS)-assisted coiling, and was implanted with a Pipeline Embolization Device (PED) after aneurysm recurrence. Finite element analysis and computational fluid dynamics simulations were conducted in 6 serial imaging procedures, and the calculated hemodynamics was correlated with aneurysm recurrence. Results Wall shear stress (WSS) was not effectively suppressed, resulting in aneurysm recurrence with initial entry tear to occur above the protuberance after 7 months of LVIS stent-assisted coiling. With the implantation of PED, WSS, inflow stream and velocity at the aneurysm neck significantly decreased. During the 3-month follow-up after PED deployment, there was significant shrinkage of the sac and the blood flow in the sac was reduced considerably. The 27-month follow-up after PED deployment indicated the aneurysm was stable. Conclusions The present case study suggests that insufficient suppression of high WSS and high inflow velocity at the neck of the parent artery, especially near the posterior inferior cerebellar artery, might be associated with aneurysm recurrence.
    Type of Medium: Online Resource
    ISSN: 1591-0199 , 2385-2011
    URL: Article
    DOI: 10.1177/15910199221097766
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2571161-1
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  • 5
    Online Resource
    Online Resource
    Synthesis of Combretastatin A-4 and Erianin
    SAGE Publications ; 2008
    In:  Journal of Chemical Research Vol. 2008, No. 6 ( 2008-06), p. 354-356
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2008, No. 6 ( 2008-06), p. 354-356
    Abstract: A concise route to two anti-tubulin natural products combretastatin A-4 and erianin has been developed. Combretastatin A-4 was obtained by a Perkin reaction between 3-bromo-4-methoxyphenyl acetic acid and 3,4,5-trimethoxybenzaldehyde, hydroxyl transformation, decarboxylation with a high level of cis-selectivity ( cis/trans = 95/5), and erianin was obtained by subsequent hydrogenation. The overall yields of combretastatin A-4 and erianin were 37.5 and 30.8%, respectively.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/030823408X324751
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 3010810-X
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