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  • 1
    Online Resource
    Online Resource
    A Deep Learning-based Method to Extract Lumen and Media-Adventitia in Intravascular Ultrasound Images
    SAGE Publications ; 2022
    In:  Ultrasonic Imaging Vol. 44, No. 5-6 ( 2022-11), p. 191-203
    Details
    In: Ultrasonic Imaging, SAGE Publications, Vol. 44, No. 5-6 ( 2022-11), p. 191-203
    Abstract: Intravascular ultrasound (IVUS) imaging allows direct visualization of the coronary vessel wall and is suitable for assessing atherosclerosis and the degree of stenosis. Accurate segmentation and lumen and median-adventitia (MA) measurements from IVUS are essential for such a successful clinical evaluation. However, current automated segmentation by commercial software relies on manual corrections, which is time-consuming and user-dependent. We aim to develop a deep learning-based method using an encoder-decoder deep architecture to automatically and accurately extract both lumen and MA border. Inspired by the dual-path design of the state-of-the-art model IVUS-Net, our method named IVUS-U-Net++ achieved an extension of the U-Net++ model. More specifically, a feature pyramid network was added to the U-Net++ model, enabling the utilization of feature maps at different scales. Following the segmentation, the Pearson correlation and Bland-Altman analyses were performed to evaluate the correlations of 12 clinical parameters measured from our segmentation results and the ground truth. A dataset with 1746 IVUS images from 18 patients was used for training and testing. Our segmentation model at the patient level achieved a Jaccard measure (JM) of 0.9080 ± 0.0321 and a Hausdorff distance (HD) of 0.1484 ± 0.1584 mm for the lumen border; it achieved a JM of 0.9199 ± 0.0370 and an HD of 0.1781 ± 0.1906 mm for the MA border. The 12 clinical parameters measured from our segmentation results agreed well with those from the ground truth (all p-values are smaller than .01). Our proposed method shows great promise for its clinical use in IVUS segmentation.
    Type of Medium: Online Resource
    ISSN: 0161-7346 , 1096-0910
    URL: Article
    DOI: 10.1177/01617346221114137
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2012028-X
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  • 2
    Online Resource
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    Pioglitazone Attenuates Allergic Inflammation and Induces Production of Regulatory T Lymphocytes
    SAGE Publications ; 2010
    In:  American Journal of Rhinology & Allergy Vol. 24, No. 6 ( 2010-11), p. 454-458
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 24, No. 6 ( 2010-11), p. 454-458
    Abstract: Peroxisome proliferator–activated receptor gamma (PPAR-gamma) agonists have been shown to be involved in the regulation of allergic inflammatory responses. The molecular mechanisms by which PPAR-gamma activation inhibits the inflammatory process have not been well understood. Methods BALB/c mice received ovalbumin (OVA) sensitization followed by OVA intranasal challenge. Mice in the treatment group received intragastric administration with pioglitazone (PIO; 30 mg/kg) before each OVA challenge. Various allergic responses were then assessed. Results The frequencies of sneezing and nose-scratching and eosinophil infiltration decreased significantly in the PIO treatment group compared with the OVA group (p 〈 0.05). The PIO treatment also showed that the levels of nasal cavity lavage fluid interleukin (IL)-5 and sera OVA-specific immunoglobulin E (IgE) were markedly reduced (p 〈 0.05). PIO significantly increased the expression of Foxp3 mRNA (p 〈 0.05) and induced production of regulatory T lymphocyte (p 〈 0.01) compared with the OVA group. Conclusion Given the potent effectiveness shown by PIO, we conclude that PPAR-gamma agonists deserve investigation as potential therapies for human allergic upper airway inflammation.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.2500/ajra.2010.24.3522
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2554548-6
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  • 3
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    Online Resource
    In Vivo Evaluation of Butylene Terephthalate-ethylene Oxide-DL, Lactide Polymer as Porous Scaffolds for Tissue Engineering
    SAGE Publications ; 2009
    In:  Journal of Bioactive and Compatible Polymers Vol. 24, No. 1 ( 2009-01), p. 43-55
    Details
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 24, No. 1 ( 2009-01), p. 43-55
    Abstract: The copolymers of poly(1,4-butylene terephthalate-co-ethylene oxide-co-DL-lactide), obtained by the transesterification reactions of poly(butylenes terephthalate) with poly(ethylene glycol DL-oligo(lactic acid), were fabricated into porous scaffolds by the established solvent-casting and particulate-leaching technique with NaCl as the porogen. The morphology of the porous scaffolds were investigated by the scanning electron microscopy (SEM), and the pores within the scaffold were proven to be interconnective ranging in size from 200 to 400 μm. The human bone marrow mesenchymal stem cells (MSC) seeded on the scaffolds were confirmed to survive and proliferate within the pores of the scaffold with the observation by immunofluorescence microscope and SEM. In vivo implantation of MSC-seeded scaffolds into athymic nude mice showed significant tissue formation in the subcutaneous sites of the immunodeficient mice at 3, 4, 6, and 9 weeks. The results indicate that the scaffolds were biocompatible with MSC and the host tissue in vitro and in vivo.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    URL: Article
    DOI: 10.1177/0883911508099368
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2073790-7
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  • 4
    Online Resource
    Online Resource
    Adaptive model predictive control of a six-rotor electric vertical take-off and landing urban air mobility aircraft subject to motor failure during hovering
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 236, No. 7 ( 2022-06), p. 1396-1407
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 236, No. 7 ( 2022-06), p. 1396-1407
    Abstract: In this article, motor failure control of a six-rotor electric vertical take-off and landing (eVTOL) urban air mobility aircraft is investigated using adaptive model predictive control (MPC) based on the linear parameter-varying (LPV) model developed using the nonlinear rigid-body aircraft model. For capturing the aircraft dynamics under motor failure conditions, a family of linearized models are obtained by trimming the nonlinear aircraft model at multiple equilibrium conditions and the LPV model is obtained by linking the linear models using the failed rotor speed, where the system transition from healthy to failure is modeled by a scheduling parameter calculated based on failed rotor speed caused by available motor peak power after failure. The proposed adaptive MPC is developed to optimize the system output performance, including the rigid-body aircraft velocity and altitude, by using quadratic programming optimization with reference compensation subject to a set of time-varying constraints representing the current available propeller acceleration calculated based on the motor power. Simulation study is conducted based on the developed LPV control design and original nonlinear rigid-body model, and the simulation results demonstrate that the designed adaptive MPC controller is able to recover and maintain the aircraft at desired stable condition after motor failure.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/09544100211032434
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2032759-6
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  • 5
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    Optimal Treatments for NSCLC Patients Harboring Primary or Acquired MET Amplification
    SAGE Publications ; 2022
    In:  Technology in Cancer Research & Treatment Vol. 21 ( 2022-01), p. 153303382211284-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 21 ( 2022-01), p. 153303382211284-
    Abstract: Background: In non-small cell lung cancer (NSCLC) patients harboring MET mutations, MET-tyrosine kinase inhibitors (TKIs) have been proven to achieve a good response. However, the relative efficacy of different therapeutics in primary NSCLC patients with MET amplification and the treatment options for patients harboring acquired MET amplification after the failure of epidermal growth factor receptor (EGFR)-TKIs remain unclear. Methods: In total, 33 patients harboring primary MET amplification and 9 patients harboring acquired MET alterations identified by next-generation sequencing were enrolled. A retrospective analysis was conducted to compare the efficacy of different therapeutics. In addition, studies reporting various treatments for patients harboring MET alterations were included in the meta-analysis. Results: In our cohort of patients harboring primary MET amplification, crizotinib displayed better efficacy than immunotherapy and chemotherapy, as demonstrated both in first-line ( P = .0378) and second-line treatment regimens ( P = .0181). The disease control rates for crizotinib, immunotherapy, and chemotherapy were 81.8%, 72.7%, and 63.6%, respectively. In particular, the median progression-free survival (PFS) time after immunotherapy in patients harboring MET amplification and high programed death ligand 1 (PD-L1) expression ( 〉 50%) was only 77.5 days. The meta-analysis revealed that the median PFS times after crizotinib and immunotherapy were 4.57 and 2.94 months, respectively. In patients harboring acquired MET amplification, chemotherapy plus bevacizumab had superior efficacy (310.0 days vs 73.5 days, P = .0360) compared with MET-TKIs ± EGFR-TKIs. Conclusions: Immunotherapy showed a low response in patients harboring MET alterations, even those with concurrent high PD-L1 expression. MET-TKIs might be an optional treatment with worth-expecting efficacy. However, chemotherapy plus bevacizumab could benefit the subpopulation of patients harboring acquired MET amplification after the failure of EGFR-TKIs.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338221128414
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 6
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    Efficacy of Drug-Eluting Beads Transarterial Chemoembolization Plus Camrelizumab Compared With Conventional Transarterial Chemoembolization Plus Camrelizumab for Unresectable Hepatocellular Carcinoma
    SAGE Publications ; 2022
    In:  Cancer Control Vol. 29 ( 2022-01), p. 107327482210768-
    Details
    In: Cancer Control, SAGE Publications, Vol. 29 ( 2022-01), p. 107327482210768-
    Abstract: The purpose of this study was to compare the efficacy and safety of drug-eluting beads transarterial chemoembolization plus camrelizumab (D-TACE-C) with conventional transarterial chemoembolization plus camrelizumab (C-TACE-C) in the treatment of patients with unresectable hepatocellular carcinoma (HCC). Materials and Methods This was a retrospective study that evaluated the consecutive medical records of patients with unresectable HCC who had undergone D-TACE-C or C-TACE-C from April 2020 to August 2021. Efficacy of treatment was evaluated using tumor response, progression-free survival (PFS) and survival rates. The adverse events were recorded. Results A total of 54 patients were included in this study, including 27 patients who had received D-TACE-C treatment, and 27 patients who had received C-TACE-C treatment. The median PFS and DCR in the D-TACE-C group were significantly longer than those for the C-TACE-C group (PFS: 10 vs. 3 months, P=.017; DCR: 70.4% vs. 40.7%, P = .028). Cox regression analysis showed that D-TACE-C was the only protective factor for PFS. The 6-month and 12-month survival rates in D-TACE-C group and C-TACE-C group were 85.2% versus 79.4% (P = .646) and 65.2% versus 65.1% (P = .903), respectively. Reactive cutaneous capillary endothelial proliferation was the most common adverse event associated with the treatment. There was no significant difference in the adverse events related to TACE and camrelizumab between the two groups. No treatment-related deaths occurred in this study. Conclusions D-TACE-C is a safe and well-tolerated treatment, and may produce better PFS and tumor response in patients with unresectable HCC than C-TACE-C.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1526-2359
    URL: Article
    DOI: 10.1177/10732748221076806
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2004182-2
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  • 7
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    Serum-derived exosomes from neurofibromatosis type 1 congenital tibial pseudarthrosis impaired bone by promoting osteoclastogenesis and inhibiting osteogenesis
    SAGE Publications ; 2021
    In:  Experimental Biology and Medicine Vol. 246, No. 2 ( 2021-01), p. 130-141
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 246, No. 2 ( 2021-01), p. 130-141
    Abstract: Treatment of congenital pseudarthrosis of the tibia (CPT) still is full of challenges in pediatric orthopedist. Serum-derived exosomes (SDEs) have been proven to be participated in bone remodeling. However, the molecular changes in SDEs of CPT children and their pathologies have not been elucidated. In this study, SDEs were isolated and purified from CPT patients (CPT-SDEs) associated with neurofibromatosis type 1 (NF1) and normal children (Norm-SDEs). Then we obtained the proteomics profile of SDEs by combining liquid chromatography-tandem mass spectrometry (LC-MS/MS) and tandem mass tag label-based quantitation. In vitro, the efficacy of SDEs on osteoblastic differentiation of MC3T3-E1 cells and osteoclastogenesis ability of RAW264.7 cells were evaluated by quantitative real-time PCR (qRT-PCR) and cytochemical staining. In vivo, we used micro-CT to assess cortical bone mass and trabecular microstructures to reflect the influence of SDEs on bone remodeling after injection into the tail vein of rats. Based on proteomics analysis, 410 differentially expressed proteins, including 289 downregulated proteins and 121 upregulated proteins, were identified in the CPT-SDEs. These proteins have multiple biological functions associated with cellular metabolic processes, catalytic activity, and protein binding, which are important for cell differentiation and proliferation. In vitro, CPT-SDEs decreased the osteogenic differentiation of MC3T3-E1 cells and promoted the osteoclastogenesis of RAW264.7 cells. Injection of CPT-SDEs into the tail vein for two months resulted in bone loss in rats, as indicated by the decrease in trabecular and cortical bone mass. Our findings demonstrated the differences in proteins in SDEs between normal and CPT children with NF1. These differentially expressed proteins in CPT-SDEs contributed to deteriorating trabecular bone microstructures by inhibiting bone formation and stimulating bone resorption.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370220962737
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 8
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    Statistical Approach to Estimating Truck Traffic Speed and Its Application to Emission Inventory Modeling
    SAGE Publications ; 2011
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2233, No. 1 ( 2011-01), p. 110-119
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2233, No. 1 ( 2011-01), p. 110-119
    Abstract: Heavy-duty diesel trucks are a significant source of carbon dioxide, oxides of nitrogen, and particulate matter emissions. The construction of accurate emission inventories of these trucks requires a proper characterization of their speed because emission rates vary substantially by speed. However, data regarding truck speed have been very limited to date. This paper presents a statistical method for estimating truck traffic speed that takes advantage of the existing traffic monitoring systems. With traffic data from these systems examined, it was found that truck traffic speed can be effectively estimated on the basis of the knowledge of the overall traffic speed alone. The relationships between the two variables are shown to be very strong, with the coefficient of determination of the regression equations being .98 or higher. All regression coefficients are found to be statistically significant at the 5% alpha level. In addition, the validation results of the estimated truck traffic speed show a good estimation performance of the regression equations, where most of the average absolute errors are within the range of 2 to 4 mph. On the basis of the developed statistical relationship, regional truck activity, in terms of vehicle miles traveled versus speed distribution, on Southern California freeways was estimated and used to construct the associated running exhaust emission inventories. The resulting emission inventories show that using the heavy-duty diesel truck-specific speed distribution rather than the overall speed distribution reduces the estimates of oxides of nitrogen emissions by 4% and particulate matter emissions by 26%.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2233-13
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2403378-9
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  • 9
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    WeChat-based mobile health management for short-stature children with long-term growth hormone therapy: A nonexperimental study
    SAGE Publications ; 2023
    In:  DIGITAL HEALTH Vol. 9 ( 2023-01), p. 205520762311798-
    Details
    In: DIGITAL HEALTH, SAGE Publications, Vol. 9 ( 2023-01), p. 205520762311798-
    Abstract: To evaluate the role of a WeChat-based mobile platform in growth hormone therapy. Method Growth hormone therapy and health education information for height growth were embedded in a WeChat-based mobile platform, and the platform was evaluated through medical staff assessments, patient volunteer assessments and quantitative scoring criteria. Results In the medical staff evaluation, both clinicians and nurses had a positive attitude towards the mobile platform, believing that the design of the mobile platform was clearly visualized and easy to operate. In family volunteers’ evaluations, the summary of β-testing results showed that 90–100% of parents had a positive attitude towards the WeChat-based mobile platform. Parents of the patients and doctors and nurses assessed the mobile platform by reviewing quantitative scoring standards developed by professional researchers. All scores were 〉 16 (the average score was 18–19.3). Children treated with growth hormone therapy were included for compliance tracking for one year, and patient adherence was described in this study. Conclusion The interaction based on the WeChat platform and the health education of the public have greatly increased the interaction between doctors and patients, and improved patient satisfaction and compliance.
    Type of Medium: Online Resource
    ISSN: 2055-2076 , 2055-2076
    URL: Article
    DOI: 10.1177/20552076231179849
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2819396-9
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  • 10
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    The effect of the chuck shape on the wafer topography in back grinding of wafer with outer rim
    SAGE Publications ; 2021
    In:  Advances in Mechanical Engineering Vol. 13, No. 10 ( 2021-10), p. 168781402110504-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 13, No. 10 ( 2021-10), p. 168781402110504-
    Abstract: Back Grinding of Wafer with Outer Rim (BGWOR) is a novel method for carrier-less thinning of silicon wafers. Silicon wafers are widely used in integrated circuits (ICs). The topography of the wafer will not only directly affect the efficiency of subsequent processing of semiconductor devices, but correspondingly affect the performance and life of these devices. However, there are few studies on the shape of the ground wafer in BGWOR. In this paper, the mathematical model of the wafer topography in BGWOR was developed. With this model, the radial thickness and total thickness variation (TTV) of a wafer under different parameters, including inclination angles and radii of grinding wheel for dressing chuck, were simulated by MATLAB. Inclination angles and radii of grinding wheels for the dressing chuck had a great influence on the radial thickness and TTV of a wafer in the BGWOR. Lastly, the pilot experiments were conducted to validate the theoretical model of grinding topography and TTV of the wafer in BGWOR. To enhance the flatness of the ground wafer, it is essential to control the shape of the dressing chuck. The research results are helpful to the optimization of the dressing process of the chuck in the BGWOR.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/16878140211050488
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2501620-9
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