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  • 1
    Online Resource
    Online Resource
    Partial stabilization of underactuated post-capture combination with inaccurate measurement information and unknown disturbances
    SAGE Publications ; 2018
    In:  Transactions of the Institute of Measurement and Control Vol. 40, No. 13 ( 2018-09), p. 3625-3639
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 40, No. 13 ( 2018-09), p. 3625-3639
    Abstract: This paper aims to address the attitude stabilization issue of post-capture combination with underactuated actuators, measurement inaccuracy and unknown external disturbances during on-orbit servicing. A precise and practical form of underactuated attitude dynamics is proposed for the asymmetric combination with two control torques. With the adopted partial stabilization strategy, a sliding mode controller is first proposed to achieve partial stabilization of the combination against the effect of unknown external disturbances. Through the additional consideration of the measurement inaccuracy in the inertia tensor and the mass centroid, an underactuated adaptive sliding mode controller with compensation laws is proposed in presence of uncertainties and disturbances. Numerical simulations validate the effectiveness of proposed partial attitude stabilization controllers.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331217728570
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2025882-3
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  • 2
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    Traffic travel pattern recognition based on sparse Global Positioning System trajectory data
    SAGE Publications ; 2020
    In:  International Journal of Distributed Sensor Networks Vol. 16, No. 10 ( 2020-10), p. 155014772096846-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 16, No. 10 ( 2020-10), p. 155014772096846-
    Abstract: This article mainly uses sparse Global Positioning System trajectory data to identify traffic travel pattern. In this article, the data are preprocessed and the eigenvalues are calculated. Then, the Global Positioning System track points are identified and extracted by walking and non-walking segments. Finally, the three machine learning models of support-vector machine, decision tree, and convolutional neural network are used for comparison experiments. The innovation of this article is to propose a walking and non-walking identification method based on density-based spatial clustering of applications with noise clustering. The method takes into account the continuous state between the geographical distributions, and it has better noise immunity against the influence of external factors. In this process, this article directly achieves better conversion point recognition results through the Global Positioning System track point information, which lays a good foundation for the accuracy of travel pattern recognition. The experimental results of this article show that compared with threshold-based and multi-layer perceptron–based methods, the recognition method based on density-based spatial clustering of applications with noise clustering has the highest accuracy, reaching 82.20%. Then, support-vector machine, decision tree, and convolutional neural network are used for traffic travel pattern recognition. The F1-score of support-vector machine is the highest, reaching 0.84, and the F1-scores of decision tree and convolutional neural network are 0.78 and 0.80, respectively. Finally, the support-vector machine was used for the recognition test to achieve an accuracy of 76.83%.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147720968469
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2192922-1
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  • 3
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    Orthopaedic Injuries in Equestrian Sports : A Current Concepts Review
    SAGE Publications ; 2015
    In:  Orthopaedic Journal of Sports Medicine Vol. 3, No. 9 ( 2015-09-01), p. 232596711560392-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 3, No. 9 ( 2015-09-01), p. 232596711560392-
    Abstract: Despite the common nature of orthopaedic injuries in equestrian sports, there is no published review to specifically characterize orthopaedic injuries in equestrian athletes. Purpose: To characterize orthopaedic injury patterns in equine sports–related injuries and their treatment. Study Design: Systematic review; Level of evidence, 4. Methods: This review was performed through a PubMed, EMBASE, and Scopus query (from 1978 to June 2014) in the English literature using search terms “(equine-related OR equestrian-related OR horse-related OR equestrian OR equestrians) AND (injury OR injuries).” Only full-text studies reporting on orthopaedic injury patterns pertinent to equestrian sports in the United States (US) and the United Kingdom (UK) were included. Orthopaedic injuries were defined as those resulting in a fracture or dislocation. In all, 182 studies were excluded, leaving a total of 27 studies for evaluation. The studies included were analyzed for demographic and epidemiological data for orthopaedic injuries, including fractures and dislocations. Cranial and facial injuries were excluded from analysis. Results: The majority of those injured in the US were female (64.5%). The leading cause of injury in the US was falling from a horse. The use of protective equipment seemed to vary widely, with helmet use ranging from less than 6% up to 66.7%. In the UK, fractures were found to account for 17.4% of reported injures, compared with 33.6% of injuries in the US. The majority of fractures in US riders occurred in the upper extremities (50.7%). Conclusion: This review helps characterize the epidemiology of equestrian injuries based on currently available data.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/2325967115603924
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2706251-X
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  • 4
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    Antimetastatic Effects of Celastrus orbiculatus on Human Gastric Adenocarcinoma by Inhibiting Epithelial–Mesenchymal Transition and NF-κB/Snail Signaling Pathway
    SAGE Publications ; 2015
    In:  Integrative Cancer Therapies Vol. 14, No. 3 ( 2015-05), p. 271-281
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 14, No. 3 ( 2015-05), p. 271-281
    Abstract: Aim of the Study. Celastrus orbiculatus has been used as a folk medicine in China for the treatment of many diseases. In the laboratory, the ethyl acetate extract of Celastrus orbiculatus (COE) displays a wide range of anticancer functions. However, the inhibition of the metastasis mechanism of COE in gastric cancer cells has not been investigated so far. The present study was undertaken to determine if the antimetastatic effects of COE were involved in inhibition of the epithelial–mesenchymal transition (EMT) of human gastric adenocarcinoma SGC-7901 cells. Methods. The adhesion, invasion, and migration of SGC-7901 cells were determined by COE treatment in vitro, using Matrigel-coated plate, transwell membrane chamber, and wound healing models, respectively. In vivo, the growth-inhibiting and antimetastatic effects of COE on the nude mice model of gastric cancer were tested and the mechanisms were explored. The expression of EMT markers and nuclear factor κB (NF-κB)/Snail signaling pathway were evaluated by using western blotting and immunohistochemistry. Results. Treatment with COE dose-dependently inhibited the proliferation, adhesion, invasion, and migration of SGC-7901 cells in vitro, which was realized by enhancing the expression of E-cadherin and reducing N-cadherin and vimentin expression. Moreover, COE suppressed the activation of NF-κB/Snail signaling pathway induced by tumor necrosis factor-α. In addition, COE effectively suppressed tumor growth and metastasis in the nude mice model due to reduced expression of N-cadherin, vimentin, NF-κB p65, and Snail and increased expression of E-cadherin in the tumor tissues. Conclusion. Our findings provided new evidence that COE is an effective inhibitor of metastatic potential of SGC-7901 cells through suppression of EMT and NF-κB/Snail signal pathway. Based on these findings, COE may be considered a novel anticancer agent for the treatment of metastasis in gastric cancer.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735415572880
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2101248-9
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  • 5
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    Factors Causing Delay of Access to Tuberculosis Diagnosis Among New, Active Tuberculosis Patients : A Prospective Cohort Study
    SAGE Publications ; 2014
    In:  Asia Pacific Journal of Public Health Vol. 26, No. 1 ( 2014-01), p. 33-41
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 26, No. 1 ( 2014-01), p. 33-41
    Abstract: Few studies have examined, in a prospective cohort study, factors causing delay of access to tuberculosis (TB) diagnosis among new, active TB patients. A prospective cohort study (2009-2011) was carried out among 408 889 Chinese. Data on known/potential influencing factors were obtained from baseline questionnaires. We used stepwise logistic regression models to analyze the association between several known/potential influencing factors and diagnosis delay, assessed the current situation, and explored determinants of diagnosis delay. During follow-up and final visits, 202 new, active TB patients were found. Median patient delay was 5.4 (quartile 2.7-26) weeks, health system delay was 0 (quartile 0-1.6) weeks, and diagnosis delay was 9.9 (quartile 3.1-28.1) weeks. The influencing factors on patient delay were age and duration of symptoms. Smoking and sputum smear status were influencing factors for health system delay, and duration of symptoms was one of the factors for diagnosis delay. These findings provide information on the current situation of diagnosis delay and evidence for specific strategy development for TB control in China.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539513502523
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2394975-2
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  • 6
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    Dual-mode frequency splitting elimination of ring periodic structures via feature shifting
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 230, No. 18 ( 2016-11), p. 3347-3357
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 230, No. 18 ( 2016-11), p. 3347-3357
    Abstract: Ring periodic structures are widely spread in engineering applications, where natural frequencies can split due to the deviation from axisymmetry. This work aims at the elimination of the dual-mode natural frequency splitting by using feature shifting. A concept of equivalent feature is introduced based on the grouping idea and an analytical model with discrete features is established. The relationships between the group number, feature number, shifting angle and excited circumferential wavenumber are identified as closed-form expressions. The splitting for structures with unshifted standard features depends on the feature number and wavenumber regardless of the grouping patterns. The equivalence between various groupings is verified. Simple rules governing the dual-mode splitting are elaborated, where one splitting is removed by a combination of equivalent feature number and wavenumber, and the other is eliminated by feature shifting. The rules allow immediate estimation and elimination of the dual-mode splitting where the modified structures still hold symmetry. The results can find application in vibratory structures where the frequency splitting is the key concern. The main results are verified by the Finite Element method.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406215606744
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2024890-8
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  • 7
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    Attitude stabilization and test validation of underactuated post-capture combination with multiple disturbances
    SAGE Publications ; 2019
    In:  Transactions of the Institute of Measurement and Control Vol. 41, No. 9 ( 2019-06), p. 2596-2611
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 41, No. 9 ( 2019-06), p. 2596-2611
    Abstract: This paper aims to address attitude stabilization control of an underactuated post-capture combination and achieve test validation based on the magnetism–buoyancy hybrid micro-gravity experiment system (MBHMES). Using a precise reduced model, a cascade control law is proposed to solve the issue theoretically. First, an advanced quaternion-based kinematic control law is proposed to stabilize the attitude of the non-symmetric post-capture combination. This control law can overcome the singularity brought about by the small initial attitude under the consideration of uncontrolled angular velocity. Then, considering the existence of multiple disturbances introduced by the fluid flow and electromagnetic force, an effective adaptive dynamic controller is proposed to meet the attitude requirement and reduce the negative effect of the multiple disturbances. For test demonstrations, a scenario of a base body capturing the target with robotics, to achieve attitude stabilization expectation, is described. Simulation results demonstrate the performance of the cascade control laws and test data show the effectiveness of the proposed method.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331218805146
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2025882-3
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  • 8
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    Reactive Oxygen Species Secreted by Leukocytes in Semen Induce Self-Expression of Interleukin-6 and Affect Sperm Quality
    SAGE Publications ; 2020
    In:  American Journal of Men's Health Vol. 14, No. 5 ( 2020-09), p. 155798832097005-
    Details
    In: American Journal of Men's Health, SAGE Publications, Vol. 14, No. 5 ( 2020-09), p. 155798832097005-
    Abstract: Reproductive tract inflammation is considered an important cause of male infertility. Increased leukocytes in semen can produce many reactive oxygen species (ROS), which affect sperm function. The aim of this study is to identify the main source of ROS in seminal plasma and to assess the effect of ROS on leukocytes. Semen samples ( n = 20) with leukocyte concentration 〉 1 × 10 6 were collected from a male infertility clinic. This study mainly compares the sperm function parameters of the normal group and the semen white blood cell group 〉 1 × 10 6 . The results identified that ROS in semen was closely related to sperm function parameters, and CD45 + leucocytes were the main source of ROS. Compared with the control group, the concentration of IL-2, IL-4, IL-6, IFN-γ, and TNF-α was higher in the experimental group. Leukocytes in semen may regulate the secretion of ROS through the mammalian target of rapamycin (mTOR) pathway. A considerable amount of ROS can upregulate the expression of IL-6 in leukocytes via the nuclear factor kappa-B (NF-kB) pathway.
    Type of Medium: Online Resource
    ISSN: 1557-9883 , 1557-9891
    URL: Article
    DOI: 10.1177/1557988320970053
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2275106-3
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  • 9
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    Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Met Mouse Model of Autism
    SAGE Publications ; 2019
    In:  Molecular Imaging Vol. 18 ( 2019-01-01), p. 153601211882103-
    Details
    In: Molecular Imaging, SAGE Publications, Vol. 18 ( 2019-01-01), p. 153601211882103-
    Abstract: MET, the gene encoding the tyrosine kinase receptor for hepatocyte growth factor, is a susceptibility gene for autism spectrum disorder (ASD). Genetically altered mice with a kinase-inactive Met offer a potential model for understanding neural circuit organization changes in autism. Here, we focus on the somatosensory thalamocortical circuitry because distinct somatosensory sensitivity phenotypes accompany ASD, and this system plays a major role in sensorimotor and social behaviors in mice. We employed resting-state functional magnetic resonance imaging and in vivo high-resolution proton MR spectroscopy to examine neuronal connectivity and neurotransmission of wild-type, heterozygous Met–Emx1, and fully inactive homozygous Met–Emx1 mice. Met–Emx1 brains showed impaired maturation of large-scale somatosensory network connectivity when compared with wild-type controls. Significant sex × genotype interaction in both network features and glutamate/gamma-aminobutyric acid (GABA) balance was observed. Female Met–Emx1 brains showed significant connectivity and glutamate/GABA balance changes in the somatosensory thalamocortical system when compared with wild-type brains. The glutamate/GABA ratio in the thalamus was correlated with the connectivity between the somatosensory cortex and the thalamus in heterozygous Met–Emx1 female brains. The findings support the hypothesis that aberrant functioning of the somatosensory thalamocortical system is at the core of the conspicuous somatosensory behavioral phenotypes observed in Met–Emx1 mice.
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1536-0121
    URL: Article
    DOI: 10.1177/1536012118821034
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2069848-3
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  • 10
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    Urolithin A alleviates neuropathic pain and activates mitophagy
    SAGE Publications ; 2023
    In:  Molecular Pain Vol. 19 ( 2023-12)
    Details
    In: Molecular Pain, SAGE Publications, Vol. 19 ( 2023-12)
    Abstract: Neuropathic pain (NP) occurs frequently in the general population and has a negative impact on the quality of life. There is no effective therapy available yet owing to the complex pathophysiology of NP. In our previous study, we found that urolithin A (UA), a naturally occurring microflora-derived metabolite, could relieve NP in mice by inhibiting the activation of microglia and release of inflammation factors. Here in this study, we sought to investigate whether mitophagy would be activated when UA alleviated NP in mice. We showed that the autophagy flow was blocked in the spinal dorsal horn of the chronic constriction injury (CCI) mice when the most obvious pain behavior occurs. Intraperitoneal injection of UA markedly activated the mitophagy mediated by PTEN-induced kinase 1/Parkin, promoted mitobiogenesis in both neurons and microglia, and alleviated NP in the CCI mice. In summary, our data suggest that UA alleviates NP in mice and meanwhile induces mitophagy activation, which highlights a therapeutic potential of UA in the treatment of NP.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1177/17448069231190815
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2174252-2
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