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  • 1
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    Online Resource
    Tai Chi for improving cardiopulmonary function and quality of life in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
    SAGE Publications ; 2016
    In:  Clinical Rehabilitation Vol. 30, No. 8 ( 2016-08), p. 750-764
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 30, No. 8 ( 2016-08), p. 750-764
    Abstract: To examine the effect of Tai Chi on cardiopulmonary function and quality of life in chronic obstructive pulmonary disease. Data sources: Cochrane Library, PUBMED, EMBASE, China Biology Medicine disc, China National Knowledge Infrastructure, and Wanfang database. Methods: Articles on randomized controlled trials comparing Tai Chi with other treatments or no treatment were identified. A random-effects model was used to calculate the pooled mean difference (MD) with 95% confidence interval (CI). Results: Fifteen articles involving 1354 participants were included. Compared with the control group, Tai Chi was more effective in improving exercise capacity on 6-minute walking distance (short term: MD = 16.02, 95% CI 2.86 to 29.17; mid term: MD = 30.90, 95% CI 6.88 to 54.93; long term: MD = 24.63, 95% CI 2.30 to 46.95), as well as pulmonary functions on forced expiratory volume in the first second (mid term: MD = 0.10; 95% CI 0.01 to 0.19), and forced vital capacity (mid term: MD = 0.20; 95% CI 0.04 to 0.36). Concerning quality of life, we found Tai Chi was better than the control group for the Chronic Respiratory Disease Questionnaire dyspnoea score (short term: MD = 0.90; 95% CI 0.51 to 1.29), fatigue score (short term: MD = 0.75; 95% CI 0.42 to 1.09), and total score (short term: MD = 1.92; 95% CI 0.54 to 3.31). Conclusions: Tai Chi may improve exercise capacity in the short, mid, and long terms. However, no significant long term differences in pulmonary function and quality of life were observed for patients with chronic obstructive pulmonary disease.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215515604903
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2028323-4
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  • 2
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    Dynamic constitutive relation of 5083P-O aluminium alloy and its influence on energy-absorbing structure
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 10 ( 2018-10), p. 168781401880733-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 10 ( 2018-10), p. 168781401880733-
    Abstract: Dynamic and quasi-static tensile tests of 5083P-O aluminium alloy were carried out using RPL100 electronic creep/fatigue testing machine and the split Hopkinson tension bar, respectively. The dynamic constitutive relation of the material at high strain rates was studied, and the constitutive model in accordance with Cowper–Symonds form was established. At the same time, a method to describe the constitutive relation of material using the strain rate interpolation method which is included in LS-DYNA software was proposed. The advantages and accuracy of this method were verified by comparing the results of the finite element simulation with the fitting results of the Cowper-Symonds model. The influence of material strain rate effect on squeezing force, energy absorption and deformation mode of the squeezing energy-absorbing structure based on the constitutive models of 5083P-O were studied by means of finite element simulation. The results show that when the strain rate of the structure deformation is low, the material strain rate strengthening effect has little influence on the structure. However, with the increase of the strain rate, the strengthening effect of the material will improve the squeezing force and the energy absorption of the structure, and will also influence the deformation mode, that is, the decrease of the deformation with high strain rates while the increase of the deformation with low strain rates.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814018807334
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2501620-9
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  • 3
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    NaH-Promoted Transformation of Arylthioureas to Aryl-Isothioureas by S-Allylation and S-Benzylation Reactions
    SAGE Publications ; 2017
    In:  Journal of Chemical Research Vol. 41, No. 3 ( 2017-03), p. 165-167
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 41, No. 3 ( 2017-03), p. 165-167
    Abstract: A series of 16 substituted aryl-isothioureas were prepared in excellent yields (80–97%) by reacting substituted arylthioureas with allyl bromide or substituted benzyl bromides in the presence of NaH in DMSO at room temperature. The substituent variations on the benzyl reactants had a larger effect on the yields than substituent variations on the allyl reactants. The method provides a facile and convenient preparation of some potentially biologically active compounds.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751917X14878812592733
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 3010810-X
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  • 4
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    Comparative Proteomic Analysis of the Effect of the Four-Herb Chinese Medicine ANBP on Promoting Mouse Skin Wound Healing
    SAGE Publications ; 2017
    In:  The International Journal of Lower Extremity Wounds Vol. 16, No. 3 ( 2017-09), p. 154-162
    Details
    In: The International Journal of Lower Extremity Wounds, SAGE Publications, Vol. 16, No. 3 ( 2017-09), p. 154-162
    Abstract: Traditional Chinese medicine has great potential to improve wound healing. ANBP, the mixture of 4 Chinese herbs— Agrimoniapilosa, Nelumbonucifera, Boswelliacarteri, and Pollen typhae—is effective in trauma treatment while its mechanism is still elusive. In this study, quantitative proteomics and bioinformatics analyses were performed to decipher the possible roles of ANBP in accelerated wound healing of mouse skin. Among all 3171 identified proteins, 90, 71, 80, and 140 proteins were found to be differently expressed in 6 hours, 3 days, 7 days, and 14 days ANBP-treated tissues compared with corresponding control tissues, respectively. The result showed that different biological processes and pathways were activated at different healing stages. At the early healing stage, ANBP treatment mainly affected several biological processes, including immune and defense response, vascular system restoration, hemostasis and coagulation regulation, lipid metabolism and signal transduction, while muscle tissue, hair, epidermis, extracellular matrix and tissue remodeling related activities were the major events in ANBP promoted later wound healing. This is the first quantitative proteome study of ANBP-treated wound tissues, which provide a new perspective for the mechanism of ANBP accelerated wound healing and is of guiding significance for clinical application of ANBP in trauma disorders cure.
    Type of Medium: Online Resource
    ISSN: 1534-7346 , 1552-6941
    URL: Article
    DOI: 10.1177/1534734617720623
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2135166-1
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  • 5
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    Path following control for a stratospheric airship with actuator saturation
    SAGE Publications ; 2017
    In:  Transactions of the Institute of Measurement and Control Vol. 39, No. 7 ( 2017-07), p. 987-999
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 39, No. 7 ( 2017-07), p. 987-999
    Abstract: This paper proposes two different path following control schemes for a stratospheric airship with actuator saturation. Each of the control schemes consists of a guidance loop and an attitude control loop. In both schemes, guidance laws are designed according to the line-of-sight guidance-based path following principle. In the first control scheme, a robust H∞ controller without constraints is designed based on the planar model of a stratospheric airship to stabilize path-following errors. The input constraints are then addressed by using a regional [Formula: see text]-based model recovery anti-windup compensator, which prevents the unconstrained controller from misbehaving in the constrained closed loop with anti-windup augmentation and ensures the systematic stability. In the second control scheme, model predictive control is applied to guarantee the path-following of the closed-loop system and explicitly address the magnitude an d rate of rudders of the stratospheric airship. Theoretical results are illustrated by numerical simulations where both closed-loop systems are capable of following their desired paths and the constraints on control inputs are satisfied.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331215625770
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2025882-3
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  • 6
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    Base-promoted synthesis of N -arylbenzamides by N -benzoylation of dimethylphenylthioureas
    SAGE Publications ; 2017
    In:  Journal of Chemical Research Vol. 41, No. 8 ( 2017-08), p. 484-486
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 41, No. 8 ( 2017-08), p. 484-486
    Abstract: An efficient synthesis of 10 N-arylbenzamides was achieved by N-benzoylation of N,N-dimethyl-( N′-phenyl)thioureas with 4-substituted benzoyl chlorides in dimethylacetamide in the presence of K 2 CO 3 . The features of this method include good yields, short reaction times and broad substrate scope. This work showed that arylthiourea derivatives can be alternative and useful starting materials for the preparation of N-arylbenzamides.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751917X15016635672213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 3010810-X
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  • 7
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    Overall Disability Response Score: An integrated endpoint to assess disability improvement and worsening over time in patients with multiple sclerosis
    SAGE Publications ; 2022
    In:  Multiple Sclerosis Journal Vol. 28, No. 14 ( 2022-12), p. 2263-2273
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 28, No. 14 ( 2022-12), p. 2263-2273
    Abstract: Overall Disability Response Score (ODRS) is a composite endpoint including Expanded Disability Status Scale, Timed 25-foot Walk, and 9-Hole Peg Test, designed to quantify both disability improvement and worsening in multiple sclerosis (MS). Objective: To assess the sensitivity and clinical meaningfulness of ODRS using natalizumab Phase 3 data sets (AFFIRM in relapsing-remitting MS and ASCEND in secondary progressive MS). Methods: Differences in ODRS over 96 weeks, ODRS at Week 96, and slope of ODRS change per year between natalizumab and placebo groups were analyzed. Correlation between ODRS and changes in patient-reported outcomes was also analyzed. Results: The difference (95% confidence interval (CI)) in the ODRS over 96 weeks between natalizumab and placebo groups was 0.34 (0.21–0.46) in AFFIRM ( p  〈  0.001), and 0.18 (0.03–0.34) in ASCEND ( p = 0.021). Significant differences between treatment arms were also observed in ODRS at Week 96 and in the slope of change per year in both studies. There was a significant linear correlation between ODRS at Week 96 and the change from baseline in both the physical and mental components of the 36-item Short Form Survey (SF-36) in both studies. Conclusion: This analysis supports ODRS as a sensitive and potentially clinically meaningful disability outcome measure in MS.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/13524585221114997
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2008225-3
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  • 8
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    Impact Analysis of Extra Traffic Induced by Project Construction during Planned Special Events
    SAGE Publications ; 2019
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2673, No. 7 ( 2019-07), p. 402-412
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2673, No. 7 ( 2019-07), p. 402-412
    Abstract: The questions of how serious the extra traffic impact induced by project construction is on urban road networks and whether the construction should continue during planned special events represent a critical problem. In this paper, a framework of methodologies and workflow is presented in analyzing the project construction induced traffic impact during special events. We first analyze the characteristics of the traffic flow attracted by special events and project construction induced traffic flow. We then show how to evaluate the project construction induced traffic impact during special events and propose some quantitative analysis methods, which are different in nature from the traditional approach of traffic impact analysis. Some management and improvement strategies are subsequently proposed to mitigate the negative impact of project construction. A case study of a vertical construction during Expo 2010 in Shanghai is discussed as an application of the proposed framework. The results show that the traffic impact of this vertical construction during Expo is moderate. Through our subsequent monitoring of this vertical construction practice during Expo 2010, it can be concluded that the analysis method is reliable, the negative traffic impact of vertical construction to Expo is insignificant, and the suggested operation and management strategies are effective.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/0361198119840346
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2403378-9
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  • 9
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    Inhibition of EZH2 expression is associated with the proliferation, apoptosis, and migration of SW620 colorectal cancer cells in vitro
    SAGE Publications ; 2015
    In:  Experimental Biology and Medicine Vol. 240, No. 4 ( 2015-04), p. 458-466
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 240, No. 4 ( 2015-04), p. 458-466
    Abstract: Epigenetic changes have been recently recognized as important in human cancers. Enhancer of zeste homologue 2 gene (EZH2) has been shown the overexpression in various human cancers, consistent with a straightforward role of EZH2 as an oncogene, but its function in carcinogenesis is partly contradictory. The role of EZH2 in development of human colorectal cancer (CRC) has not yet been clarified. In the present study, we observed up-regulation of EZH2 expression in tumor tissues from CRC patients. The expression of EZH2 in CRC cell lines is consistent with the trend in cancer tissues using reverse transcription polymerase chain reaction (RT-PCR). We showed that TNM stage and lymph node metastasis in CRC patients are significantly correlated with EZH2 expression levels. EZH2 level of transcription and protein is inhibited by small interfering RNA (siRNA). More importantly, EZH2-siRNA inhibits the proliferation and migration of SW620 cells while promoting their apoptosis, and inducing G0/G1 cell cycle arrest of SW620 cells. Collectively, our results suggest that upregulated EZH2 expression may contribute to the progression of the patients with CRC. A comprehensive study of epigenetic mechanisms and the relevance of EZH2 in CRC is important for fully understanding this disease and as a basis for developing new treatment options in patients with CRC.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370214542215
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 10
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    Evaluation of apparent diffusion coefficient mappings in amnestic mild cognitive impairment using an image analysis software brain search
    SAGE Publications ; 2011
    In:  Acta Radiologica Vol. 52, No. 10 ( 2011-12), p. 1147-1154
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 52, No. 10 ( 2011-12), p. 1147-1154
    Abstract: The apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can quantify alterations in water diffusivity resulting from microscopic structural changes from amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). Purpose To investigate the ADC value for aMCI and AD using Brain Search (BS) software based on anatomical volumes of interest (AVOI). Material and Methods In total, 174 aged people were screened, and 25 patients with AD, 26 patients with aMCI, and 18 normal controls (NCs) were recruited. DWI was performed at 1.5 T with a fluid-attenuated inversion recovery (FLAIR), and the independent ADC mapping was generated after imaging acquisition. Ninety regional parcellations were adopted in a Brain Search (BS) based on the automated anatomic labeling atlas. The gray scale intensities (water diffusivity) from the collected ADC mappings were analyzed with BS. The mean value of each anatomical brain region was compared among aMCI, AD, and NC. The statistically significant ( P 〈 0.05) group differences are displayed in color. Results During the pathological process of AD, the changes of water diffusivity appeared first in the left hippocampus, then gradually progressed to the bilateral sides and eventually displayed right lateralization. The ADC values from aMCI were obviously elevated compared to the values from the NC group in the left limbic cortex. Between the AD and NC groups, the significantly different brain areas included the bilateral hippocampus, the Cingulum_Mid, the ParaHippocampal_R, and the Temporal and Frontal lobes. There was a negative correlation between the ADC values and the scores from MMSE, MoCA, the Digit test, Raven's IQ, and WAIS IQ. Additionally, the ADC values were positively correlated with the scores from CDR, ADL, and ADAS-Cog. Conclusion The water diffusivity for aMCI and AD displays asymmetric anatomical lateralization. The water diffusivity alterations can be analyzed and visualized with our newly designed analytic imaging software, BS, which can be used as a good reference for examining and diagnosing aMCI and AD patients.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1258/ar.2011.100430
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2024579-8
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