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  • SAGE Publications  (11)
  • 1
    Online Resource
    Online Resource
    Chinese guideline on the application of anti-seizure medications in the perioperative period of supratentorial craniocerebral surgery
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Neurological Disorders Vol. 15 ( 2022-01), p. 175628642211143-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 15 ( 2022-01), p. 175628642211143-
    Abstract: Seizures are a common symptom of craniocerebral diseases, and epilepsy is one of the comorbidities of craniocerebral diseases. However, how to rationally use anti-seizure medications (ASMs) in the perioperative period of craniocerebral surgery to control or avoid seizures and reduce their associated harm is a problem. The China Association Against Epilepsy (CAAE) united with the Trauma Group of the Chinese Neurosurgery Society, Glioma Professional Committee of the Chinese Anti-Cancer Association, Neuro-Oncology Branch of the Chinese Neuroscience Society, and Neurotraumatic Group of Chinese Trauma Society, and selected experts for consultancy regarding outcomes from evidence-based medicine in domestic and foreign literature. These experts referred to the existing research evidence, drug characteristics, Chinese FDA-approved indications, and expert experience, and finished the current guideline on the application of ASMs during the perioperative period of craniocerebral surgery, aiming to guide relevant clinical practice. This guideline consists of six sections: application scope of guideline, concepts of craniocerebral surgery-related seizures and epilepsy, postoperative application of ASMs in patients without seizures before surgery, application of ASMs in patients with seizures associated with lesions before surgery, emergency treatment of postoperative seizures, and 16 recommendations.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/17562864221114357
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2442245-9
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  • 2
    Online Resource
    Online Resource
    In vivo evaluation of posterior eye elasticity using shaker-based optical coherence elastography
    SAGE Publications ; 2020
    In:  Experimental Biology and Medicine Vol. 245, No. 4 ( 2020-02), p. 282-288
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 245, No. 4 ( 2020-02), p. 282-288
    Abstract: Age-related macular degeneration (AMD) is a progressive retinal disease and becomes the leading cause of blindness. It is well established that early detection is the key to preservation of functional vision. However, it is very difficult to diagnose AMD in very early stages, before structural changes are evident. Consequently, investigating the biomechanical properties of the retina maybe essential for understanding its physiological function. In this study, we present a shear wave-based quantitative method for estimating the elasticity of the posterior eye using shaker-based optical coherence elastography. This technique has been developed and validated on both a homogeneous phantom and a healthy rabbit in vivo. The shear wave speed from the ganglion side to the photoreceptor side of the rabbit eye is 4.1 m/s, 4.9 m/s, and 6.7 m/s, respectively. In addition, the most stiff sclera region has an average shear wave speed of 9.1 m/s. The results demonstrate the feasibility of using this technique to quantify biomechanical properties of the posterior eye and its potential translation to the clinical study. Impact statement Herein, we propose a potentially clinical applicable shaker-based optical coherence elastography (OCE) technique to characterize the biomechanical properties of the posterior eye, including different layers of the retina. Compared with either acoustic radiation force OCE or air-puff OCE, the newly developed method can induce sufficient shear wave propagation at the posterior eye with high resolution and large field of view.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370219897617
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    The effect of lanthanum trimethacrylate on the mechanical properties and flame retardancy of dynamically vulcanized PP/EPDM thermoplastic vulcanizates
    SAGE Publications ; 2018
    In:  Journal of Elastomers & Plastics Vol. 50, No. 4 ( 2018-06), p. 339-353
    Details
    In: Journal of Elastomers & Plastics, SAGE Publications, Vol. 50, No. 4 ( 2018-06), p. 339-353
    Abstract: A new kind of polypropylene/ethylene–propylene–diene monomer (PP/EPDM) thermoplastic elastomer (TPE) with good mechanical properties and flame retardancy was prepared via in situ peroxide-induced dynamic vulcanization using lanthanum trimethacrylate (LaTMA) as a reinforcing agent. The morphology, structure, and mechanical properties and reinforcement mechanism of PP/EPDM/LaTMA TPE were investigated by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, rubber process analyzer, cross-link density test, and so on. The flame retardancy was investigated by limiting oxygen index (LOI) test. The results showed that when the amount of lanthanum oxide was 4.96 phr and methyl methacrylate was 7.85 phr, the compatibility between EPDM and PP was greatly improved. Besides, the tensile strength, tear strength, elongation at break, and hardness (shore A) of PP/EPDM/LaTMA TPE were increased from 6.2 MPa, 41.7 kN m −1 , 148%, and 81 up to 11.1 MPa, 77.3 kN m −1 , 365%, and 89, respectively. And the LOI of PP/EPDM/LaTMA TPE was increased to 19.0%. The SEM images, the higher G′, and the ionic cross-link suggested that a strong filler–filler network was formed by the polymerization and the grafted of LaTMA in the PP and EPDM phase which enhanced the compatibility between PP and EPDM. The DSC and FTIR results further proved that during the processing.
    Type of Medium: Online Resource
    ISSN: 0095-2443 , 1530-8006
    URL: Article
    DOI: 10.1177/0095244317729553
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2098535-6
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  • 4
    Online Resource
    Online Resource
    Collagen Triple Helix Repeat Containing 1 Promotes Melanoma Cell Adhesion and Survival
    SAGE Publications ; 2011
    In:  Journal of Cutaneous Medicine and Surgery Vol. 15, No. 2 ( 2011-03), p. 103-110
    Details
    In: Journal of Cutaneous Medicine and Surgery, SAGE Publications, Vol. 15, No. 2 ( 2011-03), p. 103-110
    Abstract: The extracellular protein collagen triple helix repeat containing 1 (CTHRC1) is aberrantly upregulated in melanoma and most human solid cancers. However, its role in cancer remains unknown. Objective: In this study, we investigated the functional impact of CTHRC1 on melanoma cells in vitro. Methods: Stable clones of cultured melanoma cells expressing different amounts of CTHRC1 protein were generated and evaluated to characterize their growth, survival, and attachment ability as well as their sensitivity to chemotherapy. Results: In cultured MMAN and MMRU melanoma cells, increased expression of CTHRC1 protein resulted in morphologic cell changes, enhanced cell adhesion to culture surfaces, increased cell proliferation, and decreased apoptosis. Furthermore, decreased CTHRC1 expression through antisense inhibition enhanced temozolomide sensitivity. Conclusion: CTHRC1 expression influences cellular processes, including cell adhesion and survival. Additionally, CTHRC1 inhibition may represent a potential method for decreasing melanoma resistance to conventional chemotherapy.
    Type of Medium: Online Resource
    ISSN: 1203-4754 , 1615-7109
    URL: Article
    DOI: 10.2310/7750.2011.10014
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2038674-6
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  • 5
    Online Resource
    Online Resource
    Are online mental health interventions for youth effective? A systematic review
    SAGE Publications ; 2021
    In:  Journal of Telemedicine and Telecare Vol. 27, No. 10 ( 2021-12), p. 638-666
    Details
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 27, No. 10 ( 2021-12), p. 638-666
    Abstract: This systematic review aims to examine the effectiveness of online mental health interventions for youth. Methods We searched seven electronic databases (PubMed, PsycINFO, Medline, Embase, CINAHL, Web of Science and SCOPUS) for the past 10 years to identify randomized controlled trials which have evaluated the use of telehealth interventions for young people with mental health problems. The included studies were assessed for quality and risk of bias. Results Forty-five randomized controlled trials ( n = 13,291 participants) were eligible for this review. Most studies (35 trials) evaluated the use of web-based self-help platforms to deliver cognitive behavioural therapy (14 trials), mindfulness (four trials), acceptance commitment therapy (five trials) and positive psychology (two trials). Mobile/computer applications were used to deliver cognitive behavioural therapy (four trials) and coping strategies training (two trials). Web-based synchronous chat (one trial) was used to assist communication between counsellors and participants. Three studies used artificial intelligence-based conversational agents to deliver cognitive behavioural therapy (two trials) and problem-solving-strategy training (one trial). Eighty-two percent ( n = 37) identified the participants as student population (i.e. university students, high school students). Sixty-four percent ( n = 29) of the telehealth interventions were found to be effective in managing depression, anxiety, stress, insomnia and improving quality of life when compared with control conditions. Conclusions Online mental health interventions were found to be effective in managing diverse mental health conditions among youth. Online self-help platforms were the most frequently used modality and artificial intelligence-based chatbots are merging as potential solutions. Future research is warranted to investigate the solutions to improve the retention rate and satisfaction of telehealth interventions among this population.
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    URL: Article
    DOI: 10.1177/1357633X211047285
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2007700-2
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  • 6
    Online Resource
    Online Resource
    Effects of Leukocyte Depletion on Cardiopulmonary Protection and Inflammation after Valve Surgery
    SAGE Publications ; 2010
    In:  The International Journal of Artificial Organs Vol. 33, No. 11 ( 2010-01), p. 812-818
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 33, No. 11 ( 2010-01), p. 812-818
    Abstract: To evaluate the effects of leukocyte-depleting filtration on myocardial and pulmonary protection and the inflammatory response in patients undergoing valve surgery. Methods Fifty-two patients who underwent mitral valve or mitral and aortic valve replacement were randomized into two groups with or without a leukocyte-depleting filter during surgery. The filter was used from 10 minutes before the release of the aortic cross-clamp to the end of cardiopulmonary bypass. Results Total leukocyte and neutrophil counts showed a short-term reduction in patients undergoing leukocyte filtration, but there was no significant difference between the two groups during the study. Serum levels of cardiac troponin I were lower than that of the control group (p=0.030). Leukocyte depletion resulted in a significantly higher oxygenation index (p=0.002) and a lower respiratory index (p=0.003) compared with the control group. Serum levels of interleukin-8 were significantly elevated in patients undergoing leukocyte filtration compared with patients without leukocyte filtration (p=0.001). There were no statistically significant differences between the two groups with regards to the concentration of interleukin-6 and TNFα, or the duration of intensive care and hospital stay. Conclusions Leukocyte depletion is associated with improved myocardial and lung protection but does not appear to attenuate the inflammatory response in valve surgery.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139881003301106
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 1474999-3
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  • 7
    Online Resource
    Online Resource
    Upregulation of MiR-212 Inhibits Migration and Tumorigenicity and Inactivates Wnt/β-Catenin Signaling in Human Hepatocellular Carcinoma
    SAGE Publications ; 2018
    In:  Technology in Cancer Research & Treatment Vol. 17 ( 2018-01), p. 153303461876522-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 17 ( 2018-01), p. 153303461876522-
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533034618765221
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 8
    Online Resource
    Online Resource
    Clinical Application of the Residual Thyroid Cartilage for Laryngeal Function Reconstruction in the Partial Laryngectomy—A Single Center Experience
    SAGE Publications ; 2023
    In:  Ear, Nose & Throat Journal
    Details
    In: Ear, Nose & Throat Journal, SAGE Publications
    Abstract: To investigate the outcomes of using the residual thyroid cartilage for laryngeal function reconstruction in early glottic laryngeal carcinoma. Methods From March 2017 to June 2022, 21 patients with glottic carcinoma who underwent laryngeal function reconstruction were analyzed retrospectively. The operation was performed under general anesthesia. Reconstruction of ipsilateral hemilarynx defect by downward movement of ipsilateral residual thyroid cartilage plate. During the follow-up period, the laryngeal function and tumor recurrence were evaluated. Results otally 20 male patients and 1 female patient were enrolled in this study. Of the 20 initial primary tumors, there were 6 patients with T1N0M0 stage, 12 ones with T2N0M0 stage, 1 with T1N1M0 stage, 1 with T3N0M0 stage, and 1 with T2N1M0 stage. The patient with recurrent tumor was T3N1M0 stage. The follow-up time ranged from 9 to 63 months. All patients were healed by first intention after surgery. All patients without laryngeal stenosis were removed from tracheotomy tube. So far, all patients have good laryngeal function. One patient relapsed at the last follow-up. Conclusion It is safe to repair hemilarynx defect with residual thyroid cartilage plate on the affected side, and it is an important choice for laryngeal function reconstruction after vertical partial laryngectomy.
    Type of Medium: Online Resource
    ISSN: 0145-5613 , 1942-7522
    URL: Article
    DOI: 10.1177/01455613231168479
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2067528-8
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  • 9
    Online Resource
    Online Resource
    Potential Role of Neurogenic Inflammatory Factors in the Pathogenesis of Vitiligo
    SAGE Publications ; 2012
    In:  Journal of Cutaneous Medicine and Surgery Vol. 16, No. 4 ( 2012-07), p. 230-244
    Details
    In: Journal of Cutaneous Medicine and Surgery, SAGE Publications, Vol. 16, No. 4 ( 2012-07), p. 230-244
    Abstract: Vitiligo is a highly complex multifactorial condition of the skin that has an unclear mechanism of pathogenesis. Objective: This review summarizes the role of various neurogenic inflammatory factors significantly upregulated in vitiligo. Methods: A literature review was conducted of all pertinent data regarding neuropeptides that are altered in vitiligo and their possible role in the destruction of melanocytes. Results: The close associations between the skin, immune system, and nervous system, along with specific changes demonstrated in vitiligo patients, support a pathogenic mechanism of vitiligo that involves neuroimmunologic factors, the release of which can be governed by mental stress. Conclusion: Neuropeptides and nerve growth factors are critical regulators of emotional response and may precipitate the onset and development of vitiligo in certain predisposed individuals. More studies are required to investigate whether a direct link exists between genetics, mental stress, and neurogenic factors in vitiligo.
    Type of Medium: Online Resource
    ISSN: 1203-4754 , 1615-7109
    URL: Article
    DOI: 10.1177/120347541201600404
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2038674-6
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  • 10
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    Online Resource
    Research on the impact and friction and wear properties of acrylonitrile–butadiene–rubber composites filled with SiC and graphite
    SAGE Publications ; 2014
    In:  Journal of Thermoplastic Composite Materials Vol. 27, No. 8 ( 2014-08), p. 1013-1021
    Details
    In: Journal of Thermoplastic Composite Materials, SAGE Publications, Vol. 27, No. 8 ( 2014-08), p. 1013-1021
    Abstract: To improve the friction and wear behavior of hydrogenated nitrile butadiene rubber (HNBR) composites, graphite and silane-treated Silicon carbon (SiC) were incorporated. The tribological properties of the resulting composites were investigated systematically on a model ball-on-block test rig. The friction and wear mechanisms of the composites were studied through analyzing the worn surfaces by a scanning electron microscopy. Experimental results showed that the friction and wear behavior of the filled composites were improved greatest when graphite and silane-treated SiC were added together, indicating that there was a synergistic effect between them.
    Type of Medium: Online Resource
    ISSN: 0892-7057 , 1530-7980
    URL: Article
    DOI: 10.1177/0892705712461643
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2098671-3
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