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  • 1
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    Online Resource
    Tyrosol Ameliorates Liver Inflammatory Response in a Mouse Model of Nonalcoholic Fatty Liver Disease (NFALD) by Regulating JAK1/STAT3
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 7 ( 2022-07), p. 1934578X2211110-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 7 ( 2022-07), p. 1934578X2211110-
    Abstract: Nonalcoholic fatty liver disease (NAFLD) is becoming one of the major health issues globally. NAFLD is usually associated with obesity and other metabolic syndromes, and there is no specific cure to address this issue so far. Featured by lipid accumulation in hepatocytes, and later progressing to fibrosis, inflammatory responses are involved in the various levels of the pathological changes. In the present study, we added a natural compound, tyrosol, which in our previous study had demonstrated anti-inflammatory properties, to a high-fat diet-induced NAFLD mouse model and investigated whether tyrosol could mitigate the liver damage by attenuating the inflammation response. The treatment with tyrosol significantly improved the liver function and decreased the fasting glucose level in NAFLD mice. Morphologically, our results showed that tyrosol could reduce the fat deposition and lipid droplets accumulation in liver tissue. The key regulating factors, JAK1 and STAT3, were increased in NAFLD mice, but tyrosol treatment could effectively prevent the upregulation. The expression levels of pro-inflammatory cytokine genes in liver tissue of the NAFLD mice were upregulated, which could be effectively prevented by the treatment with tyrosol. Overall, in the high-fat diet-induced NAFLD mouse model, tyrosol could improve the liver function and, more importantly, ameliorate the inflammatory response triggered by the high-fat diet. Although our data here are consistent with the previous report that tyrosol could exert beneficial effects on the NAFLD animal model, we also provide solid evidence that tyrosol is able to conquer the inflammatory response in liver, which is related to the high-fat-diet feeding. Tyrosol could be a promising candidate for the treatment of NAFLD in the future.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221111033
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2430442-6
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  • 2
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    PRMT5 Promotes EMT Through Regulating Akt Activity in Human Lung Cancer
    SAGE Publications ; 2021
    In:  Cell Transplantation Vol. 30 ( 2021-01-01), p. 096368972110017-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 30 ( 2021-01-01), p. 096368972110017-
    Abstract: The type II protein arginine methyltransferase 5 (PRMT5) has been engaged in various human cancer development and progression types. Nevertheless, few studies uncover the biological functions of PRMT5 in the epithelial-mesenchymal transition (EMT) of human lung cancer cells, and the associated molecular mechanisms and signaling cascades are entirely unknown. Here, we show that PRMT5 is the ectopic expression in human lung cancer tissues and cell lines. Further study reveals that silencing PRMT5 by lentivirus-mediated shRNA or blocking of PRMT5 by specific inhibitor GSK591 attenuates the expression levels of EMT-related markers in vivo, using the xenograft mouse model. Moreover, our results show that down-regulation of PRMT5 impairs EGFR/Akt signaling cascades in human lung cancer cells, whereas re-expression of PRMT5 recovers those changes, suggesting that PRMT5 regulates EMT probably through EGFR/Akt signaling axis. Altogether, our results demonstrate that PRMT5 serves as a critical oncogenic regulator and promotes EMT in human lung cancer cells. More importantly, our findings also suggest that PRMT5 may be a potential therapeutic candidate for the treatment of human lung cancer.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897211001772
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020466-8
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  • 3
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    The effects of 8DSS peptide on remineralization in a rat model of enamel caries evaluated by two nondestructive techniques
    SAGE Publications ; 2019
    In:  Journal of Applied Biomaterials & Functional Materials Vol. 17, No. 1 ( 2019-01), p. 228080001982779-
    Details
    In: Journal of Applied Biomaterials & Functional Materials, SAGE Publications, Vol. 17, No. 1 ( 2019-01), p. 228080001982779-
    Abstract: Nowadays, dental caries is one of the most common oral health problems, affecting most individuals. It has been found that, by remineralizing enamel at an early stage in the formation of enamel caries, teeth can be effectively protected from dental caries. In this work, a peptide with eight repetitive sequences of aspartate-serine-serine (8DSS) is applied as the bio-mineralizer in an in-vivo rat enamel caries model. Nondestructive quantitative light-induced fluorescence-digital (QLF-D) imaging and micro-computed tomography (micro-CT) are used to evaluate the remineralization of enamel carious lesions by measuring the total fluorescence radiance loss of the molar area (Δ Q Total ), acquired using QLF-D imaging, and the mineral density and residual molar enamel volume, acquired using micro-CT. Correlations are explored between Δ Q Total and mineral density (strong correlation, r = 0.8000, p 〈 0.001) and Δ Q Total and residual molar enamel volume (moderate correlation, r = 0.6375, p 〈 0.001). Our results demonstrate that 8DSS is a promising in-vivo remineralization agent that exhibits comparable effects to NaF ( p 〈 0.05), which has been verified using the classical Keyes method. Moreover, the nondestructive QLF-D and micro-CT methods can be combined to quantify the remineralization of enamel carious lesions three-dimensionally in vivo, making them broadly applicable in quantifying hard tissues.
    Type of Medium: Online Resource
    ISSN: 2280-8000 , 2280-8000
    URL: Article
    DOI: 10.1177/2280800019827798
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2673624-X
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  • 4
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    Combined Effect of Dynapenia and Abdominal Obesity on the Prevalence of Peripheral Artery Disease in Older Adults Over 75 Years Old in China
    SAGE Publications ; 2023
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 29 ( 2023-01), p. 107602962311695-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 29 ( 2023-01), p. 107602962311695-
    Abstract: The objective is to examine the separate and joint effects of dynapenia and abdominal obesity on the prevalence of peripheral artery disease (PAD) in older adults of different ages (60-74 and over 75 years old). This study comprised 1293 community-dwelling Chinese participants recruited from Shanghai, China, who were aged at least 60 years (753 women; mean age: 72.0 ± 5.9 years). Dynapenia was defined as low-grip strength ( 〈 28.0 kg for males and 〈 18.0 kg for females) but normal skeletal muscle index (≥7.0 kg/m 2 for males and ≥5.7 kg/m 2 for females). Abdominal obesity was determined according to waist circumference (≥90 cm for males and ≥85 cm for females), and PAD was diagnosed by an ankle-brachial index  ≤ 0.9. Binary logistic regression models were performed to determine associations between dynapenia, abdominal obesity, and the combination of dynapenia and abdominal obesity and PAD. According to dynapenia and abdominal obesity status stratified by age (60-74 or over 75), the patients were divided into 4 groups: normal, dynapenia alone, abdominal obesity alone, and co-occurring groups. A logistic regression showed that the co-occurring groups (odds ratio = 4.63, 95% confidence interval = 1.41-15.21) had a higher prevalence of PAD than the normal group after adjusting for the covariates in older adults over 75 years of age. The combination of dynapenia and abdominal obesity increase the prevalence of PAD in older adults over 75 years. The present findings have important implications for the early identification of older adults with PAD and appropriate interventions should be implemented.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296231169503
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2230591-9
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  • 5
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    Facile flame-retardant finishing for cotton in supercritical CO 2
    SAGE Publications ; 2022
    In:  Textile Research Journal Vol. 92, No. 13-14 ( 2022-07), p. 2306-2316
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 92, No. 13-14 ( 2022-07), p. 2306-2316
    Abstract: Traditional water-based flame-retardant finishing causes serious pollution due to the use of a large number of chemicals, and color change is easily generated since the flame-retardant finishing takes place after the cotton dyeing. An eco-friendly flame-retardant finishing of dyed cotton was explored using 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), 2,2′-oxybis-(5,5-dimethyl-1,3,2,-dioxaphosphorinane-2,2′-disulfide) (5060), SiO 2 , DOPO/SiO 2 (1:1), 5060/SiO 2 (1:1) and DOPO/5060 (1:1) in supercritical CO 2 . The effects of finishing time and pressure as well as temperature on the flame-retarding properties of the cotton were discussed. As expected, samples with the higher weight gain rates exhibit a lower after-flame time as well as after-glow time. In different flame-retardant systems, cotton fabric finished with DOPO presents the lowest after-flame time of 20.6 s and after-glow time of 0 s at 130°C, 22 MPa and 120 min due to its biphenyl ring and O=P-O bond. Moreover, tiny fluctuations of L*, a*, b* and K/ S values occurred from 32.10 to 34.24, 5.78 to 6.05, –37.89 to –37.64 and 10.59 to 10.81 when the cotton samples were treated with DOPO, 5060, SiO 2 , DOPO/SiO 2 (1:1), 5060/SiO 2 (1:1) and DOPO/5060 (1:1), proving that no significant negative role in the color property of the samples occurs after supercritical CO 2 finishing.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/00405175221074068
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2209596-2
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  • 6
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    Efficacy and Safety of Sublingual Immunotherapy in Children Aged 3–13 Years with Allergic Rhinitis
    SAGE Publications ; 2014
    In:  American Journal of Rhinology & Allergy Vol. 28, No. 2 ( 2014-03), p. 131-139
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 28, No. 2 ( 2014-03), p. 131-139
    Abstract: Sublingual immunotherapy (SLIT) is recommended for allergic diseases. However, clinical studies containing evidence-based data of this treatment in young children, which is rarely reported in the literature, are needed. This study was designed to assess the efficacy and safety of SLIT in children, including very young children. Methods Two hundred sixty-four children aged 3–13 years old (133 children, 3–5 years old) with Dermatophagoides farinae–induced allergic rhinitis with or without asthma treated by standard pharmacotherapy had randomly received either SLIT (SLIT group) or no SLIT (control group) for 12 months. Symptoms, medications, visual analog scale (VAS) and presence of adverse events (AEs) were assessed at monthly visits. Skin-prick test and Dermatophagoides farinae–specific IgE and IgG4 were measured before and after treatment. Results Both treatments were effective in the global clinical scores during the first seven visits when compared with baseline (all, p 〈 0.01), and SLIT showed lower symptoms scores and VAS scores throughout this period (all, p 〈 0.01). These improvements continued until the later visits only in the SLIT group. Also, the asthma medication consumption was decreased by SLIT treatment only at the end of study (p 〈 0.01). The specific IgG4 was significantly increased after SLIT treatment when compared with the control group, but no significant change of specific IgE was observed in either groups. In the SLIT group, there was no significant difference between children less than or more than 5 year old in terms clinical efficacy, onset of action, immunologic parameters, and safety. No severe systemic AEs were reported. Conclusion SLIT is effective and well-tolerated in children with allergic rhinitis 3–13 years old.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.2500/ajra.2014.28.4006
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2554548-6
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  • 7
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    A new robust control strategy for axial flux permanent magnet motor applied on legged lunar robots
    SAGE Publications ; 2023
    In:  Journal of Vibration and Control Vol. 29, No. 3-4 ( 2023-02), p. 953-967
    Details
    In: Journal of Vibration and Control, SAGE Publications, Vol. 29, No. 3-4 ( 2023-02), p. 953-967
    Abstract: Legged robots have the advantage of strong terrain adaptability in lunar exploration. A new robust controller is designed for axial flux permanent magnet motors applied on the legged lunar robots to diminish the disturbance from uncertainty and external circumstance. The theoretical verification is carried out through Lyapunov stability theory. The numerical simulation and real-time experiment are carried out to access the stability and dynamic property of the systems adopting the proposed controller. The results are compared with the traditional control strategies to demonstrate the advantages of the proposed controller. The new robust controller contributes to the dynamic stability of legged lunar robots and is also appropriate for the similar mechanical systems.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    URL: Article
    DOI: 10.1177/10775463211056465
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2070247-4
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  • 8
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    Adaptive inverse control of time waveform replication for electrohydraulic shaking table
    SAGE Publications ; 2011
    In:  Journal of Vibration and Control Vol. 17, No. 11 ( 2011-10), p. 1611-1633
    Details
    In: Journal of Vibration and Control, SAGE Publications, Vol. 17, No. 11 ( 2011-10), p. 1611-1633
    Abstract: A combined control strategy with an adaptive inverse control (AIC) and an inverse frequency response function (IFRF) equalization technique is proposed for the electrohydraulic shaking table (EST) system. The control purpose is to improve the accuracy of time waveform replication. In contrast to the iterative compensation through repetitive excitations control approach of industrial EST controllers, the proposed control strategy utilizes an IFRF of the EST system for extending the EST system frequency bandwidth and obtaining asymptotic reference tracking, and employs a variable tap-length filtered-x least-mean-squares algorithm to adaptively tune the time-domain drive signal and further improve the position and acceleration tracking performance of the EST system. Thus, the proposed combined control strategy is designed to combine the merits of IFRF and AIC. The procedures of the proposed control strategy are programmed in MATLAB/Simulink, and then compiled to a real-time PC with Microsoft Visual Studio.NET for implementation. The simulated and experimental results show that this control strategy achieves satisfactory position and acceleration waveform replication accuracy.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    URL: Article
    DOI: 10.1177/1077546310380431
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2070247-4
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  • 9
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    Myeloperoxidase (MPO) and Interleukin-17 (IL-17) Plasma Levels are Increased in Patients with Acute Coronary Syndromes
    SAGE Publications ; 2009
    In:  Journal of International Medical Research Vol. 37, No. 3 ( 2009-05), p. 862-866
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 37, No. 3 ( 2009-05), p. 862-866
    Abstract: There are several reports of myeloperoxidase (MPO) playing an important role in acute coronary syndromes (ACS). Interleukin-17 (IL-17) is a pro-inflammatory cytokine produced by activated CD4 T cells that has a chemotactic and activating effect on neutrophils. It has also been shown that IL-17 recruits neutrophils via the release of C-X-C chemokines. The roles of MPO and IL-17 in ACS, however, have not been established. This study measured plasma MPO and IL-17 levels in 10 patients with ACS, 11 age- and sex-matched patients with stable angina and 12 healthy control subjects. Plasma MPO and IL-17 levels were significantly elevated in ACS patients compared with the patients with stable angina and the healthy control subjects. In addition, plasma MPO levels correlated with plasma IL-17 levels in all study participants. It is concluded that MPO and IL-17 are powerful indicators of acute coronary inflammation, however the data set was very small, so larger prospective studies are required.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323000903700331
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2082422-1
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  • 10
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    Prognostic value of dynamic plasma endostatin for the prediction of mortality in acute kidney injury: A prospective cohort study
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 7 ( 2020-07), p. 030006052094085-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 7 ( 2020-07), p. 030006052094085-
    Abstract: The aim of the current study was to evaluate the value of plasma endostatin for predicting 30-day mortality of patients with acute kidney injury (AKI). Methods Patients who underwent non-cardiac major surgery and developed AKI in the first 48 hours after admission to the intensive care unit were consecutively included. Concentrations of plasma neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys C), and endostatin were measured at three time points: 0, 24, and 48 hours after the AKI diagnosis. Clinical patient characteristics were recorded after AKI was diagnosed. Results A total of 256 new-onset AKI patients were enrolled. Of these, 48 (18.7%) patients died within 30 days. The difference in plasma endostatin values between 0 and 24 hours (ΔEndostatin-24h) yielded the best area under the curve (AUC) of 0.747 for predicting 30-day mortality in AKI patients; NGAL and Cys C achieved AUC of 0.672 and 0.647, respectively. The predictive AUC increased to 0.833 when ΔEndostatin-24h was combined with sequential organ failure assessment score and AKI classification. Conclusion Dynamic plasma endostatin is useful for predicting 30-day mortality in AKI patients. The predictive power of dynamic plasma endostatin can be significantly improved when it is combined with clinical patient data.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520940856
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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