In:
Technology in Cancer Research & Treatment, SAGE Publications, Vol. 13, No. 2 ( 2014-04), p. 161-168
Abstract:
MiR-145 is reported to be significantly down-regulated in ovarian cancer. This study was aimed at elucidating the roles of miR-145 in regulating the biological behavior of epithelial ovarian cancer (EOC) cells. In this report, we find out that up-regulation of miR-145 in OVCAR-3 and SKOV-3 cells inhibit cell proliferation and promote cell apoptosis. We show that miR-145 directly target the c-Myc 3′-UTR. Moreover, ectopic expression of c-Myc reduces the inhibition of cell proliferation caused by miR-145 transfection. Cell cycle assay showed that up-regulation of miR-145 reduces S phase population, and restoration of c-Myc can rescue this reduction. These findings indicate that miR-145 inhibits cell proliferation and promotes cell apoptosis by targeting c-Myc 3′-UTR. Therefore, the result indicated that miR-145 could be used as a potential therapeutic target in ovarian cancer.
Type of Medium:
Online Resource
ISSN:
1533-0346
,
1533-0338
DOI:
10.7785/tcrt.2012.500367
Language:
English
Publisher:
SAGE Publications
Publication Date:
2014
detail.hit.zdb_id:
2146365-7
detail.hit.zdb_id:
2220436-2
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