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  • SAGE Publications  (68)
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  • 1
    Online Resource
    Online Resource
    Breakdown of the Gut Barrier in Patients with Multiple Organ Dysfunction Syndrome is Attenuated by Continuous Blood Purification: Effects on Tight Junction Structural Proteins
    SAGE Publications ; 2010
    In:  The International Journal of Artificial Organs Vol. 33, No. 1 ( 2010-01), p. 5-14
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 33, No. 1 ( 2010-01), p. 5-14
    Abstract: Breakdown of the gut barrier increases intestinal permeability and allows movement of intraluminal contents across the mucosa, which can lead to distant organ injury and multiple organ dysfunction syndrome (MODS). Intestinal permeability is associated with alterations in cellular tight junctions involving the structural proteins occludin and zonula occludens-1 (ZO-1). The aim of this study was to investigate the effect of continuous blood purification (CBP) on gut barrier function in patients with MODS. Method Serum diamine oxidase (DAO) and endotoxin, epithelial monolayer permeability, and transepithelial electrical resistance (TER) were used as markers for the assessment of gut barrier function in 22 patients with MODS who underwent continuous venovenous hemofiltration (CVVH) for 24 hours. Blood samples were taken from patients at 0, 6, 12, and 24 hours during CVVH therapy. Serum DAO and endotoxin were determined by spectrophotography. Permeability and TER were assessed using Caco-2 cell monolayers. Occludin and ZO-1 protein levels were analyzed by immunoblotting and immunofluorescence staining. And inducible nitric oxide synthase (iNOS) mRNA levels and nitric oxide (NO) production were determined by real-time PCR and spectrophotography, respectively. Result Gut barrier dysfunction was evident in patients with MODS compared with normal controls. Serum DAO, endotoxin levels, and epithelial permeability were elevated, while TER was decreased in patients with MODS, and this change was more pronounced in nonsurvivors. Breakdown and reorganization of occludin and ZO-1 away from tight junctions was found in all MODS patients. After CBP treatment, APACHE II and MODS scores improved significantly. Serum DAO and endotoxin levels and epithelial permeability also diminished, while TER increased in all patients; CBP significantly attenuated breakdown and reorganization of tight junction proteins, and also attenuated the inflammation-induced increase in iNOS mRNA expression and NO production. Conclusion Breakdown of gut barrier function is present in patients with MODS and may be correlated with poor outcomes in the disease. CBP can not only improve the general conditions, as measured by the APACHE II score, but also improve gut barrier dysfunction by attenuating the breakdown and reorganization of occludin and ZO-1. This beneficial effect of CBP on gut barrier dysfunction is associated with down-regulation of iNOS.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139881003300102
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 1474999-3
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  • 2
    Online Resource
    Online Resource
    Disease-related stressors of caregiving burden among different types of family caregivers of persons with schizophrenia in rural China
    SAGE Publications ; 2019
    In:  International Journal of Social Psychiatry Vol. 65, No. 7-8 ( 2019-11), p. 603-614
    Details
    In: International Journal of Social Psychiatry, SAGE Publications, Vol. 65, No. 7-8 ( 2019-11), p. 603-614
    Abstract: Little is known about the impacts of schizophrenia on different types of caregiving burden. Aim: This study aims to examine how the severity of schizophrenia, social functioning and aggressive behavior are associated with caregiving burden across different kinship types. Method: The analytic sample included 300 dyads of persons with schizophrenia and their family caregivers in Xinjin, Chengdu, China. The 10th edition of the International Classification of Diseases (ICD-10) was utilized to identify the patients, whose symptom severity, social functioning and aggressive behavior were measured. Caregiving burden was estimated using the Burden Scale for Family Caregivers–short (BSFC-s). Results: A higher level of burden was significantly associated with female caregivers, larger family size, lower income, worse symptoms, poorer functional status and more aggressive behaviors. Parent caregivers showed greater burden if the patients had better functioning of social interest and concern or more aggression toward property. Mother caregivers showed greater burden than fathers. Spouses tended to perceive greater burden if the patients had better marital functioning, poorer occupational functioning or more aggressive behaviors toward property. Patients attacking others or a father with schizophrenia was related to a higher burden of child caregivers. A heavier burden of other relatives was correlated with patients’ more verbal aggression and self-harm. Conclusion: This study shows the distinct impacts of disease-related factors on the caregiving burden across different kinship types. Our findings have implications for health-care professionals and practitioners in terms of developing more targeted family-based or individualized intervention to ameliorate burden according to kinship types and deal with behavioral and functional problems in schizophrenia.
    Type of Medium: Online Resource
    ISSN: 0020-7640 , 1741-2854
    URL: Article
    DOI: 10.1177/0020764019866224
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2066492-8
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  • 3
    Online Resource
    Online Resource
    Carbon deposition mechanism of molten salt cleaning and optimization of multicomponent molten salt formula for remanufacturing
    SAGE Publications ; 2021
    In:  Science Progress Vol. 104, No. 3 ( 2021-07), p. 003685042110310-
    Details
    In: Science Progress, SAGE Publications, Vol. 104, No. 3 ( 2021-07), p. 003685042110310-
    Abstract: In remanufacturing engineering, cleaning is the key factor for subsequent blank inspection and parts repair. Molten salt has the characteristics of low viscosity, good fluidity, and strong chemical stability. Salt bath cleaning can be comprehensively applied to remove various organic pollutants. Molten salt has the function of self-cleaning. The dirt in the cleaning pool can be decomposed and reused. Moreover, the waste molten salt is massive, and the waste residue is easy to treat. The formation and adsorption mechanism of carbon deposition was explored, and the formation mechanism of carbon deposition was verified by experiments. Then, the existing formula was improved by mixing experiment and compared with the current cleaning method; the cleaning effect was excellent. A new molten salt formula is proposed on the basis of the research on solar thermal storage medium. The composition percentage and the optimal process parameters of the new molten salt formula were determined on the basis of the experimental design of mixture. The cleaning effect of the new formula is good.
    Type of Medium: Online Resource
    ISSN: 0036-8504 , 2047-7163
    URL: Article
    DOI: 10.1177/00368504211031078
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2483680-1
    detail.hit.zdb_id: 2199376-2
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    Cardiomyocyte differentiation induced in cardiac progenitor cells by cardiac fibroblast-conditioned medium
    SAGE Publications ; 2014
    In:  Experimental Biology and Medicine Vol. 239, No. 5 ( 2014-05), p. 628-637
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 239, No. 5 ( 2014-05), p. 628-637
    Abstract: Our previous study showed that after being treated with 5-azacytidine, Nkx2.5 + human cardiac progenitor cells (CPCs) derived from embryonic heart tubes could differentiate into cardiomyocytes. Although 5-azacytidine is a classical agent that induces myogenic differentiation in various types of cells, the drug is toxic and unspecific for myogenic differentiation. To investigate the possibility of inducing CPCs to differentiate into cardiomyocytes by a specific and non-toxic method, CPCs of passage 15 and mesenchymal stem cells (MSCs) were treated with cardiac ventricular fibroblast-conditioned medium (CVF-conditioned medium). Following this treatment, the Nkx2.5 + CPCs underwent cardiomyogenic differentiation. Phase-contrast microscopy showed that the morphology of the treated CPCs gradually changed. Ultrastructural observation confirmed that the cells contained typical sarcomeres. The expression of cardiomyocyte-associated genes, such as alpha-cardiac actin, cardiac troponin T, and beta-myosin heavy chain (MHC), was increased in the CPCs that had undergone cardiomyogenic differentiation compared with untreated cells. In contrast, the MSCs did not exhibit changes in morphology or molecular expression after being treated with CVF-conditioned medium. The results indicated that Nkx2.5 + CPCs treated with CVF-conditioned medium were capable of differentiating into a cardiac phenotype, whereas treated MSCs did not appear to undergo cardiomyogenic differentiation. Subsequently, following the addition of Dkk1 and the blocking of Wnt signaling pathway, CVF-conditioned medium-induced morphological changes and expression of cardiomyocyte-associated genes of Nkx2.5 + CPCs were inhibited, which indicates that CVF-conditioned medium-induced cardiomyogenic differentiation of Nkx2.5 + CPCs is associated with Wnt signaling pathway. In addition, we also found that the activation of Wnt signaling pathway was accompanied by higher expression of GATA-4 and the blocking of the pathway inhibited the expression of GATA-4 in CVF-conditioned medium-incubated Nkx2.5 + CPCs. This finding suggests that Wnt signaling pathway may alter GATA-4 expression and activate the cardiogenic program in the regulation of differentiation. In conclusion, Nkx2.5 + CPCs have enormous potential for cardiomyogenic differentiation and the CVF-conditioned medium specifically induces CPCs to differentiate into a cardiac phenotype. Wnt signaling pathway is involved in CVF-conditioned medium-induced cardiomyogenic differentiation of Nkx2.5 + CPCs.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370214525323
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Protection of Mammalian Cells from Severe Acute Respiratory Syndrome Coronavirus Infection by Equine Neutralizing Antibody
    SAGE Publications ; 2005
    In:  Antiviral Therapy Vol. 10, No. 5 ( 2005-07), p. 681-690
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 10, No. 5 ( 2005-07), p. 681-690
    Abstract: The aetiological agent for severe acute respiratory syndrome (SARS) has been determined to be a new type of coronavirus (SARS-CoV) that infects a wide range of mammalian hosts. Up to now, there have been no specific drugs to protect against SARS-CoV infection, thus developing effective strategies against this newly emerged viral infection warrants urgent efforts. Adoptive immune therapy with pathogen-specific heterologous immunoglobulin has been successfully used to control the dissemination of many viral infections. To investigate whether a neutralizing antibody against SARS-CoV raised in an artiodactylous host can have a protective role on primate cells, we prepared serum IgGs and their pepsin-digested F(ab’) 2 fragments from horses inoculated with purified SARS-CoV (BJ-01 strain). The protective effect of the F(ab’) 2 fragments against SARS-CoV infection was determined in cultured Vero E6 cells by cytopathic effect (CPE), MTT and plaque-forming assays and in a Balb/c mouse model by CPE and quantitative RT-PCR. The results showed the neutralization titres of F(ab’) 2 from three horses all reached at least 1:1600, and 50 μg of the F(ab’) 2 fragments could completely neutralize 1x10 4 TCID 50 SARS-CoV in vivo. Additionally, we observed that F(ab’) 2 against BJ-01 strain could also protect cells from infection by the variant GZ-01 strain in vitro and in vivo. Our work has provided experimental support for testing the protective equine immunoglobulin in future large primate or human trials.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350501000504
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Preparation and properties of reduced graphene oxide-carbon nanotubes aerogel/cotton flexible composite fabric with electromagnetic shielding function
    SAGE Publications ; 2022
    In:  Journal of Industrial Textiles Vol. 51, No. 4_suppl ( 2022-06), p. 7119S-7134S
    Details
    In: Journal of Industrial Textiles, SAGE Publications, Vol. 51, No. 4_suppl ( 2022-06), p. 7119S-7134S
    Abstract: The electromagnetic pollution has become a serious problem with the rapid development of electromagnetic industry. The present work prepared an electromagnetic interference (EMI) functional composite fabric. Reduced graphene oxide (rGO)-carbon nanotubes (CNTs) aerogel with three-dimensional (3-D) architecture were coated to the cotton fabric with the assistance of waterborne polyurethane (WPU). The structure of graphene aerogel was affected by the amount of CNTs. Small amount of CNTs is helpful to minish the pore size of aerogel and thus improve the EMI value. However, it has been shown that excess CNTs will destroy the 3-D architecture of graphene aerogel. Result shows that the EMI shielding effectiveness exceeded 35 dB when the weight ratio of rGO and CNTs was 7:3, and EMI value of the corresponding composite fabric samples reached 34 dB. Consequently, excellent EMI results were obtained by the unique 3-D rGO-CNTs aerogel in the case of a small nano-carbon material amount. The present work will be expected to make contributions to the practical application of rGO-CNTs aerogel.
    Type of Medium: Online Resource
    ISSN: 1528-0837 , 1530-8057
    URL: Article
    DOI: 10.1177/15280837211060879
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2095351-3
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  • 7
    Online Resource
    Online Resource
    Knowledge, contact and stigma of mental illness: Comparing three stakeholder groups in Hong Kong
    SAGE Publications ; 2022
    In:  International Journal of Social Psychiatry Vol. 68, No. 2 ( 2022-03), p. 365-375
    Details
    In: International Journal of Social Psychiatry, SAGE Publications, Vol. 68, No. 2 ( 2022-03), p. 365-375
    Abstract: It remains unknown what the impacts of multiple dimensions of contact (e.g. level, quantity and quality) are on the stigma of mental illness. Aims: To explore the relationship between the multiple dimensions of contact and stigma of mental illness among family members (FM), mental health workers (MHW) and community residents (CR) in Hong Kong. Methods: The stigma, contact and knowledge were measured in FM, MHW and CR in Hong Kong. Multiple regression analyses were used. Results: MHW ( n = 141) had higher knowledge, more contact and lower stigma of mental illness than CR ( n = 95) or FM ( n = 62). Knowledge and contact quality were significantly associated with lower stigma of mental illness in the three groups. However, contact level and contact quantity were not significantly associated with most stigma components. The contact level was positively associated with stigma of mental illness among FM and CR. Conclusions: The results of this study highlight the differences in knowledge, contact and stigma of mental illness among different stakeholder groups. This study suggests that positive contact (e.g. equal, supportive, voluntary and pleasant contact) reduces stigma of mental illness, while negative contact (e.g. unfriendly, unsupportive, unpleasant contact) may increase stigma. The Enhancing Contact Model (ECM) should be tested in future anti-stigma interventions.
    Type of Medium: Online Resource
    ISSN: 0020-7640 , 1741-2854
    URL: Article
    DOI: 10.1177/0020764021997479
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2066492-8
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  • 8
    Online Resource
    Online Resource
    Prediction of overall survival after radical gastrectomy using nomograms created by tumor markers
    SAGE Publications ; 2023
    In:  Journal of Investigative Medicine
    Details
    In: Journal of Investigative Medicine, SAGE Publications
    Abstract: Prediction of prognosis after radical resection of gastric cancer has not been well established. Therefore, we aimed to establish a prognostic model based on a new score system of patients with gastric cancer. A total of 1235 patients who underwent curative gastrectomy at our hospital from October 2015 to April 2017 were included in this study. Univariate and multivariate analyses were used to screen for prognostic risk factors. Construction of the nomogram was based on Cox proportional hazard regression models. The construction of the new score models was analyzed by the receiver operating characteristic curve (ROC curve), calibration curve, and decision curve. Multivariate analysis showed that tumor size, T, N, carcinoembryonic antigen, CA125, and CA19-9 were independent prognostic factors. The new score model had a greater AUC (The area under the ROC curve) than other systems, and the C-index of the nomogram was highly reliable for evaluating the survival of patients with gastric cancer. Based on the tumor markers and other clinical indicators, we developed a precise model to predict the prognosis of patients with gastric cancer after radical surgery. This score system can be helpful to both surgeons and patients.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1177/10815589231179927
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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  • 9
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    Online Resource
    Comparing the Effects of Twice-Daily Exenatide and Insulin on Renal Function in Patients with Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Controlled Trial
    SAGE Publications ; 2022
    In:  Journal of Investigative Medicine Vol. 70, No. 7 ( 2022-10), p. 1529-1535
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 70, No. 7 ( 2022-10), p. 1529-1535
    Abstract: This is a secondary analysis of a randomized controlled trial (RCT) on the effects of the glucagon-like peptide-1 receptor agonists exenatide and insulin aspartate 30 injection on carotid intima-media thickness. Here, we report the renal outcomes of the intervention in patients with type 2 diabetes mellitus (T2DM). Data from the RCT study was used to evaluate the effect of exenatide or insulin given for 52 weeks on estimated glomerular filtration rate (eGFR) in patients with T2DM. The primary end point was the change in the eGFR from baseline between the exenatide and insulin groups in normal versus overweight patients and patients with obesity. The secondary end point was the correlation between change in eGFR and oxidative stress, glycemic control, and dyslipidemia. There was a significant difference in eGFR between the insulin and exenatide groups at 52 weeks (p=0.0135). Within the insulin group, the eGFR remained below baseline at 52 weeks in all patients, and there was an increase in body weight in the normal group compared with the overweight patients and patients with obesity. The opposite was observed in the exenatide group. A decrease in body weight was prominent in the exenatide group at 52 weeks (p 〈 0.05), the eGFR was below baseline in overweight patients and patients with obesity and significantly above baseline in the normal group (p 〈 0.05). The eGFR was positively correlated to 8-oxo-7,8-dihydroguanosine in the insulin group (p 〈 0.05) but not the exenatide group. It can be concluded that compared with insulin, exenatide may improve renal function in overweight patients and patients with obesity more than in normal-weight patients with T2DM, but a further RCT is needed to confirm this effect.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-2021-002237
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 10
    Online Resource
    Online Resource
    Prevalence and types of coronary to pulmonary artery fistula in a Chinese population at dual-source CT coronary angiography
    SAGE Publications ; 2014
    In:  Acta Radiologica Vol. 55, No. 9 ( 2014-11), p. 1031-1039
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 55, No. 9 ( 2014-11), p. 1031-1039
    Abstract: Coronary to pulmonary artery fistula (CPAF) is rare; reports on the prevalence and types of CPAF in a large cohort of patients are scarce. Purpose To analyze the prevalence and types of CPAF on computed tomography coronary angiography (CTCA) in a large Chinese population. Material and Methods CTCA data of 58,533 patients from five Chinese tertiary referral medical centers were retrospectively studied. The prevalence, origin, aneurysmal sac, fistula tracts, and extracardiac communication of CPAF were recorded. CTCA findings were compared with conventional coronary angiography when possible. Results Ninety-nine patients had CPAF (prevalence of 0.17%). Of the 99 CPAF cases, fistulas were found to originate from either both coronary arteries in 52 patients or from one coronary artery (33 cases from the left and 14 cases from the right coronary artery). Ten CPAF patients were complicated with the communication of extracardiac arteries. Fifteen (15.2%) CPAF patients had aneurysmal sac formation. Thirty (30.3%) patients had a single fistula tract, while 69 (69.7%) patients had multiple fistula tracts. CTCA findings in 16 patients were similar to those at DSA. Conclusion Based on this large cohort, the prevalence of CPAF in the Chinese population is about 0.17%, with origin from either the left or right coronary artery or from both. CTCA can clearly visualize the types, abnormal vascular tracts, and aneurysmal sac formation of CPAF.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185113512299
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2024579-8
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