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  • SAGE Publications  (22)
  • 1
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    Online Resource
    Prednisone plus IVIg compared with prednisone or IVIg for immune thrombocytopenia in pregnancy: a national retrospective cohort study
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Hematology Vol. 13 ( 2022-01), p. 204062072210952-
    Details
    In: Therapeutic Advances in Hematology, SAGE Publications, Vol. 13 ( 2022-01), p. 204062072210952-
    Abstract: The responses of intravenous immunoglobulin (IVIg) or corticosteroids as the initial treatment on pregnancy with ITP were unsatisfactory. This study aimed to assess the safety and effectiveness of prednisone plus IVIg versus prednisone or IVIg in pregnant patients with immune thrombocytopenia (ITP). Methods: Between 1 January 2010 and 31 December 2020, 970 pregnancies diagnosed with ITP at 19 collaborative centers in China were reviewed in this observational study. A total of 513 pregnancies (52.89%) received no intervention. Concerning the remaining pregnancies, 151 (33.04%) pregnancies received an initial treatment of prednisone plus IVIg, 105 (22.98%) pregnancies received IVIg alone, and 172 (37.64%) pregnancies only received prednisone. Results: Regarding the maternal response to the initial treatment, no differences were found among the three treatment groups (41.1% for prednisone plus IVIg, 33.1% for prednisone, and 38.1% for IVIg). However, a significant difference was observed in the time to response between the prednisone plus IVIg group (4.39 ± 2.54 days) and prednisone group (7.29 ± 5.01 days; p   〈  0.001), and between the IVIg group (6.71 ± 4.85 days) and prednisone group ( p  〈  0.001). The median prednisone duration in the monotherapy group was 27 days (range, 8–195 days), whereas that in the combination group was 14 days (range, 6–85 days). No significant differences were found among these three treatment groups in neonatal outcomes, particularly concerning the neonatal platelet counts. The time to response in the combination treatment group was shorter than prednisone monotherapy. The duration of prednisone application in combination group was shorter than prednisone monotherapy. The combined therapy showed a lower predelivery platelet transfusion rate than IVIg alone. Conclusion: These findings suggest that prednisone plus IVIg may represent a potential combination therapy for pregnant patients with ITP.
    Type of Medium: Online Resource
    ISSN: 2040-6207 , 2040-6215
    URL: Article
    DOI: 10.1177/20406207221095226
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2585183-4
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  • 2
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    Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Pregnancy Outcomes
    SAGE Publications ; 2015
    In:  Asia Pacific Journal of Public Health Vol. 27, No. 6 ( 2015-09), p. 620-630
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 27, No. 6 ( 2015-09), p. 620-630
    Abstract: To investigate the single and joint effects of prepregnancy body mass index (BMI) and gestational weight gain (GWG) on pregnancy outcomes, electronic medical records of 14 196 women who delivered singleton live infant at a maternal and child health hospital in Beijing, China, in 2012 were reviewed. Logistic regression was used to assess the associations, adjusting for maternal age, height, education, parity, and offspring sex. Women of high prepregnancy BMI or excessive GWG had higher risks of gestational diabetes mellitus, hypertensive disorders in pregnancy, postpartum hemorrhage, caesarean delivery, macrosomia, and large for gestational age infant, while women of inadequate GWG had higher risks of preterm delivery, low birth weight, and small for gestational age infant. Findings suggest that antenatal care providers should help pregnant women control their GWG to normal.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539515589810
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2394975-2
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  • 3
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    Inhibitory Effects of Indigowoad Root Polysaccharides on Porcine Reproductive and Respiratory Syndrome Virus Replication In Vitro
    SAGE Publications ; 2011
    In:  Antiviral Therapy Vol. 16, No. 3 ( 2011-04), p. 357-363
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 16, No. 3 ( 2011-04), p. 357-363
    Abstract: Indigowoad root polysaccharide (IRPS) is a natural polysaccharide isolated from the traditional Chinese medicinal herb Radix Isatidis, and has many kinds of biological activities. However, the IRPS antiviral activity, especially the anti-porcine reproductive and respiratory syndrome virus (PRRSV) effect, has not been evaluated. Methods PRRSV was propagated in the MARC-145 cell line, and viral titre was determined by cytopathic effect and expressed as the 50% tissue culture infection dose (TCID 50 ) in the current study. The cell cytotoxic effect of IRPS toward MARC-145 was evaluated by MTT assay firstly, then the inhibitory effects of IRPS on PRRSV replication in vitro were investigated by determining the effect of IRPS upon a single replicative cycle of PRRSV in MARC- 145 cells. The effects of IRPS on viral RNA and protein synthesis in PRRSV-infected cells were investigated using real-time PCR and double-antibody (sandwich) ELISA. Results IRPS was able to effectively suppress the infectivity of the PRRSV in a dose-dependent manner, especially by adding IRPS during the PRRSV infection. IRPS could affect the attachment of PRRSV to MARC-145 cells, and also inhibit the viral RNA and protein synthesis. Conclusions IRPS has an antiviral effect on PRRSV replication in MARC-145 cells and might be useful in medical development for antiviral research. However, the precise mechanism of the host and viral targets of IRPS are unknown, so further studies should be conducted to investigate the precise mechanism of IRPS inhibitory effect on PRRSV infection.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP1755
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2118396-X
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  • 4
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    A Novel Norclerodane Diterpenoid from the Roots of Croton crassifolius
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 11 ( 2015-11), p. 1934578X1501001-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 11 ( 2015-11), p. 1934578X1501001-
    Abstract: A chemical investigation of Croton crassifolius afforded a novel norclerodane diterpenoid (1) with an unprecedented six-membered oxygen ring between C-1 and C-12, together with three known compounds. The structure of the new compound was elucidated based on spectroscopic (IR, 1D, and 2D NMR) and HR-ESI-MS techniques. This report describes the first example of a natural norclerodane with a 4 H-chromene ring system.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501001128
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 5
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    Design of flexure revolute joint based on double compliant curved beam
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 233, No. 13 ( 2019-07), p. 4521-4530
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 233, No. 13 ( 2019-07), p. 4521-4530
    Abstract: In view of the problems of low accuracy and large impact caused by flexure joints during the deployable process, design of an integrated flexure revolute joint for folding mechanisms is important. Using a double compliant curved beam as a flexible unit of a joint, the revolute joint is designed based on the method of compliance and stiffness ellipsoids. The geometrical constraints model of the curved beam is established to define the design range of the unit. The total error model, which is obtained by the analysis of single-parameter errors, is used to choose the size of the unit with the smallest error. The finite element models of the flexure joints are established to analyze the rotational stiffness, translational stiffness, and the maximum rotational angle of the joints. The rotational angle of one flexure revolute joint in one direction can reach 35.7°. The rotational angle of the series flexure revolute joint in one direction can achieve 51°. The experiments of single and series flexure joints are carried out to verify the correctness of the design and for the analysis of the flexure joint.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406219833085
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024890-8
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  • 6
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    A Simple and Efficient Synthesis of Novel Aryloxy-Functionalised 4,4′-bi-1,2,4-Triazoles
    SAGE Publications ; 2016
    In:  Journal of Chemical Research Vol. 40, No. 5 ( 2016-05), p. 293-295
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 40, No. 5 ( 2016-05), p. 293-295
    Abstract: A simple and efficient strategy for the synthesis of novel aryloxy-functionalised 4,4′-bi-1,2,4-triazoles was successfully explored by nucleophilic aromatic substitution of tetrachloro-4,4′-bi-1,2,4-triazole by various phenols using Cs 2 CO 3 as catalyst. The syntheses were achieved in 25–94% yields.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751916X14604745689762
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 3010810-X
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  • 7
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    Interferon-α-induced CD100 on naïve CD8 + T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction
    SAGE Publications ; 2017
    In:  Journal of International Medical Research Vol. 45, No. 1 ( 2017-02), p. 89-100
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 45, No. 1 ( 2017-02), p. 89-100
    Abstract: We investigated the effects of CD100 on naïve CD8 + T cells during hepatitis C virus (HCV) infection after interferon-α (IFN-α) therapy to clarify the mechanism underlying the effect of IFN-α in enhancing the antiviral response. Methods The CD100 molecules on subsets of CD8 + T cells were analysed with flow cytometry. The effects of CD100-overexpressing naïve CD8 + T cells were determined with ELISAs and an MTT cytotoxicity assay. The role of CD100–CD72 signal transduction was analysed with a neutralization and transwell assays. Results HCV infection reduced CD100 expression on CD8 + T cells, whereas IFN-α treatment significantly increased CD100 expression on naïve CD8 + T cells. The increased CD100 interacted with the CD72 receptor and enhanced PBMC cytokine secretion (IFN-γ and tumour necrosis factor-α) and cytotoxicity. Conclusions IFN-α-induced CD100 on naïve CD8 + T cells promotes PBMC cytokine secretion and cytotoxicity through CD100–CD72 signalling during HCV infection.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060516676136
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2082422-1
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  • 8
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    Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial
    SAGE Publications ; 2023
    In:  Journal of Cerebral Blood Flow & Metabolism
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications
    Abstract: Finding appropriate drugs to improve cerebral autoregulation (CA) in patients with acute ischemic stroke (AIS) is necessary to improve prognosis. We aimed to investigate the effect of butylphthalide on CA in patients with AIS. In this randomized controlled trial, 99 patients were 2:1 randomized to butylphthalide or placebo group. The butylphthalide group received intravenous infusion with a preconfigured butylphthalide-sodium chloride solution for 14 days and an oral butylphthalide capsule for additional 76 days. The placebo group synchronously received an intravenous infusion of 100 mL 0.9% saline and an oral butylphthalide simulation capsule. The transfer function parameter, phase difference (PD), and gain were used to quantify CA. The primary outcomes were CA levels on the affected side on day 14 and day 90. Eighty patients completed the follow-up (52 in the butylphthalide group and 28 in the placebo group). The PD of the affected side on 14 days or discharge and on 90 days was higher in the butylphthalide group than in the placebo group. The differences in safety outcomes were not significant. Therefore, butylphthalide treatment for 90 days can significantly improve CA in patients with AIS. Trial registration: ClinicalTrial.gov: NCT03413202
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X231168507
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2039456-1
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  • 9
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    Performance limitation of networked systems with controller and communication filter co-design
    SAGE Publications ; 2018
    In:  Transactions of the Institute of Measurement and Control Vol. 40, No. 4 ( 2018-02), p. 1167-1176
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 40, No. 4 ( 2018-02), p. 1167-1176
    Abstract: This paper addresses the performance limitation problem of networked systems by co-designing the controller and communication filter. The tracking performance index is measured by the energy of the error signal. Explicit expressions of the performance limitation are obtained by applying the controller and communication filter co-design, and the optimal network filter is obtained by applying the frequency domain method. It is shown that the performance limitation is closely related to the unstable poles and the non-minimum phase zeros of a given plant under the one-parameter compensator structure, whereas, under the two-parameter compensator structure, the performance limitation is unrelated to the unstable poles of a given plant. It is also demonstrated that the performance limitation can be improved and the effect of the channel noise can be eliminated by using the controller and communication filter co-design. Finally, some typical examples are presented to illustrate the theoretical results.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331216678314
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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  • 10
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    A Scientometric Analysis of Studies on Patellar Dislocation
    SAGE Publications ; 2022
    In:  Orthopaedic Journal of Sports Medicine Vol. 10, No. 11 ( 2022-11-01), p. 232596712211370-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 10, No. 11 ( 2022-11-01), p. 232596712211370-
    Abstract: Patellar dislocation is attracting considerable research interest. Purpose: To assess studies on patellar dislocation using a scientometric method to better understand the current status of research and explore future study directions. Study Design: Scoping review. Methods: The Web of Science Core Collection database was selected to retrieve publications on patellar dislocation. Articles and reviews written in English with patellar dislocation as the main topic were included. Conference abstracts, notes, letters, expert opinions, and animal studies were excluded. A total of 4632 articles were identified in our initial search. In addition, Excel 2019, CiteSpace 6.1.R1, and VOSviewer 1.6.9 were used to analyze the h-index, the most highly cited publication, publication essentials, and research themes. Results: A total of 1485 articles were included in our analysis, with 36,608 citations and an h-index of 93. Overall, 1494 institutions and 195 journals were identified from these studies. The United States (n = 531) was the most productive country. The institution and journal with the largest number of articles were the Hospital for Special Surgery (n = 59) and Knee Surgery, Sports Traumatology, Arthroscopy (n = 212), respectively. The article “Scoring of Patellofemoral Disorders” by Kujala et al in 1993 was the most highly cited reference. The most commonly found terms used were patellar dislocation, patellar instability, medial patellofemoral ligament, knee, recurrent patellar dislocation, and soft tissue restraints. Four topics were identified after clustering analysis of key terms: risk factors, medial patellofemoral ligament reconstruction, patellar dislocation in skeletally immature patients, and lateral retinacular release. Conclusion: This scientometric review of articles on patellar dislocation summarized the current status of research (countries, institutions, and authors) and identified potential research directions.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/23259671221137051
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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