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  • SAGE Publications  (15)
  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2012
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture Vol. 226, No. 8 ( 2012-08), p. 1287-1297
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications, Vol. 226, No. 8 ( 2012-08), p. 1287-1297
    Abstract: Finite element simulation of metal machining requires accurate constitutive models to characterize the material stress–strain response in plastic deformation processes. An optimization methodology using genetic algorithms was developed to determine the Johnson–Cook material model for Ti–6Al–4V alloy. The optimization of the parameters resulted in lower errors between the calculated flow stress and the experimental values obtained through the split Hopkinson pressure bar tests at different temperatures (ranging from 25 °C to 900 °C) and strain rates (2000 and 2500s −1 ). Optimized Johnson–Cook constitutive parameters were used to calculate the flow stress under various conditions. The calculated results showed excellent agreement with the experimental values, with errors lower than 4%. In addition, Ti–6Al–4V alloy orthogonal cutting experiments were carried out to validate the finite element simulation results. The experimental chip morphology was compared with the simulation results obtained by the optimized Johnson–Cook model (M2) and the original Johnson–Cook model (M1). The simulated results (including chip morphology and cutting force) were affected by the flow stress model. Comparison of the experimental and simulated results revealed that the optimized Johnson–Cook model can provide relatively good prediction results for the titanium alloy machining process, especially for chip morphology prediction.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2032745-6
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Advances in Mechanical Engineering Vol. 11, No. 5 ( 2019-05), p. 168781401984932-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 11, No. 5 ( 2019-05), p. 168781401984932-
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2501620-9
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Ear, Nose & Throat Journal Vol. 102, No. 6 ( 2023-06), p. 362-368
    In: Ear, Nose & Throat Journal, SAGE Publications, Vol. 102, No. 6 ( 2023-06), p. 362-368
    Abstract: Extirpation of multiple head and neck paragangliomas carries challenge due to close anatomic relationships with critical neurovascular bundles. Objectives: This study aims to assess whether the application of 3-D models can assist with surgical planning and treatment of these paragangliomas, decrease surgically related morbidity and mortality. Methods: Fourteen patients undergoing surgical resection of multiple head and neck paragangliomas were enrolled in this study. A preoperative 3-D model was created based on radiologic data, and relevant critical anatomic relationships were preoperatively assessed and intraoperatively validated. Results: All 14 patients presented with multiple head and neck paragangliomas, including bilateral carotid body tumors (CBT, n = 9), concurrent CBT with glomus jugulare tumors (GJT, n = 4), and multiple vagal paragangliomas (n = 1). Ten patients underwent genomic analysis and all harbored succinate dehydrogenase complex subunit D (SDHD) mutations. Under guidance of the 3-D model, the internal carotid artery (ICA) was circumferentially encased by tumor on 5 of the operated sides, in 4 (80%) of which the tumor was successfully dissected out from the ICA, whereas ICA reconstruction was required on one side (20%). Following removal of CBT, anterior rerouting of the facial nerve was avoided in 3 (75%) of 4 patients during the extirpation of GJT with assistance of a 3-D model. Two patients developed permanent postoperative vocal cord paralysis. There was no vessel rupture or mortality in this study cohort. Conclusion: The 3-D model is beneficial for establishment of a preoperative strategy, as well as planning and guiding the intraoperative procedure for resection of multiple head and neck paragangliomas.
    Type of Medium: Online Resource
    ISSN: 0145-5613 , 1942-7522
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2067528-8
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Indoor and Built Environment Vol. 32, No. 2 ( 2023-02), p. 305-322
    In: Indoor and Built Environment, SAGE Publications, Vol. 32, No. 2 ( 2023-02), p. 305-322
    Abstract: Environmental chambers are a kind of equipment to simulate various conventional and extreme environments, which are usually applied to create various environmental conditions and conduct various studies related to environmental parameters. Through our review of literature of the past 30 years, environmental chambers have been mainly used in the following four aspects: pollutants’ emission characterization, human thermal comfort research, products and materials development and transformation and the reaction and behaviour of other living bodies such as animals and plants. In this paper, the current application of environmental chambers is summarized based on the research objectives, conditions and technical means. The purpose of this paper is to provide a review of the use of environmental chambers for research and analyze the current application of environmental chambers for the future application of environmental chambers and explore the direction of its future transformation and application.
    Type of Medium: Online Resource
    ISSN: 1420-326X , 1423-0070
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1482713-X
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  • 5
    In: Cell Transplantation, SAGE Publications, Vol. 25, No. 7 ( 2016-07), p. 1343-1357
    Abstract: Neuronal progenitor cells (NPCs) derived from human embryonic stem cells (hESCs) are an excellent cell source for transplantation therapy due to their availability and ethical acceptability. However, the traditional method of expansion and differentiation of hESCs into NPCs in monolayer cultures requires a long time, and the cell yield is low. A microcarrier (MC) platform can improve the expansion of hESCs and increase the yield of NPCs. In this study, for the first time, we transplanted microcarrier-expanded hESC-derived NPCs into the striatum of adult NOD-SCID IL2Rgc null mice, either as single cells or as cell aggregates. The recipient mice were perfused, and the in vivo survival, differentiation, and targeted innervation of the transplanted cells were assessed by immunostaining. We found that both the transplanted single NPCs and aggregate NPCs were able to survive 1 month posttransplantation, as revealed by human-specific neural cell adhesion molecule (NCAM) and human nuclear antigen staining. Compared to the single cells, the transplanted cell aggregates showed better survival over a 3-month period. In addition, both the transplanted single NPCs and the aggregate NPCs were able to differentiate into DCX-positive immature neurons and Tuj1-positive neurons in vivo by 1 month posttransplantation. However, only the transplantation of aggregate NPCs was shown to result in mature neurons at 3 months posttransplantation. Furthermore, we found that the cell aggregates were able to send long axons to innervate their targets. Our study provides preclinical evidence that the use of MCs to expand and differentiate hESC-derived NPCs and transplantation of these cells as aggregates produce longer survival in vivo.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2020466-8
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  • 6
    In: Interventional Neuroradiology, SAGE Publications
    Abstract: We present an updated ultrafast dynamic computed tomography myelography technique that can be used for the localization of spontaneous spinal cerebrospinal fluid leaks in the setting of spontaneous intracranial hypotension. This has over twice the temporal resolution of previously described techniques at the same radiation dose output.
    Type of Medium: Online Resource
    ISSN: 1591-0199 , 2385-2011
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2571161-1
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  International Journal of Distributed Sensor Networks Vol. 14, No. 11 ( 2018-11), p. 155014771880648-
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 14, No. 11 ( 2018-11), p. 155014771880648-
    Abstract: Failure prediction for hard disk drives is a typical and effective approach to improve the reliability of storage systems. In a large-scale data center environment, the various brands and models of drives serve diverse applications with different input/output workload patterns, and non-ignorable differences exist in each type of drive failures, which make this mechanism much challenging. Although many efforts are devoted to this mechanism, the accuracy still needs to be improved. In this article, we propose a failure prediction method for hard disk drives based on a part-voting random forest, which differentiates prediction of failures in a coarse-grained manner. We conduct groups of validation experiments on two real-world datasets, which contain the SMART data of 64,193 drives. The experimental results show that our proposed method can achieve a better prediction accuracy than state-of-the-art methods.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2192922-1
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  International Journal of Distributed Sensor Networks Vol. 14, No. 10 ( 2018-10), p. 155014771879758-
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 14, No. 10 ( 2018-10), p. 155014771879758-
    Abstract: In recent years, semantic sensor networks are proposed, which apply ontologies to provide query capabilities and data access and allow users to express their needs at a conceptual level. In such sensor networks, a large amount of web ontologies are separately created by sensors to represent their own knowledge. These ontologies are distributed in different sensors and provide knowledge for semantic queries. It has become a very pressing issue to locate the desired ontologies for a given semantic query. To address this issue, we propose an approach based on structured peer-to-peer protocol to publish shareable ontologies on different sensors and automatically discover the ontologies useful for a given SPARQL query. Therefore, if a SPARQL query is given, our approach can locate ontologies desired and further send the query to them to find out solutions for the query. In addition, if solutions can be found out from a web ontology published, our approach makes sure to discover the ontology and get the solutions from it for the query. We conduct three experiments to evaluate the approach, the results of which demonstrate that our approach is effective and efficient.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2192922-1
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  • 9
    In: Acta Radiologica, SAGE Publications, Vol. 61, No. 9 ( 2020-09), p. 1186-1195
    Abstract: Low tube potential-high tube current computed tomography (CT) imaging allows reduction in iodine-based contrast dose and may extend the benefit of routine contrast-enhanced CT exams to patients at risk of nephrotoxicity. Purpose To determine the ability of an iodine contrast reduction algorithm to maintain diagnostic image quality for contrast-enhanced abdominal CT. Material and Methods CT exams with iodine contrast reduction were prescribed for patients at risk for renal dysfunction. The iodine contrast reduction algorithm combines weight-based contrast volume reduction with patient width-based low tube potential selection and bolus-tracking. Control exams with routine iodine dose were selected based on weight, width, and scan protocol. Three radiologists evaluated image quality and diagnostic confidence using a 4-point scale ( 〈 2 acceptable). Another radiologist assessed contrast reduction indications and measured portal vein and liver contrast-to-noise ratios. Results Forty-six contrast reduction algorithm and control exams were compared (mean creatinine 1.6 vs. 1.2 mg/dL, P ≤  0.0001). Thirty-nine contrast reduction patients had an eGFR 〈 60 mL/min/1.73m 2 and 15 had single or transplanted kidney. Mean iodine contrast dose was lower in the contrast reduction group (20.9 vs. 39.4 g/mL, P  〈  0.0001). Diagnostic confidence was rated as acceptable in 95% (131/138) of contrast reduction and 100% of control exams (1.18–1.28 vs. 1.02–1.13, respectively; P  〉  0.06). Liver attenuation and contrast-to-noise ratio (CNR) were similar ( P =  0.08), but portal vein attenuation and CNR were lower with contrast-reduction (mean 176 vs. 198 HU, P =  0.02; 13 vs. 16, P =  0.0002). Conclusion This size-based contrast reduction algorithm using low kV and bolus tracking reduced iodine contrast dose by 50%, while achieving acceptable image quality in 95% of exams.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2024579-8
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  • 10
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 35, No. 1 ( 2020-07), p. 49-58
    Abstract: Here, we describe a novel microfilter device to capture circulating tumor cells in an efficient and low-cost manner. Then, we validated the safety and clinical utility of the novel microfilter device. We next performed mutation analysis from circulating tumor cells collected from lung cancer patients using this new device. Our results indicate that this microfilter system can be used to investigate the genome landscape of circulating tumor cells collected from lung cancer patients. Further, our results highlight a proof-of-concept demonstration indicating that circulating tumor cell can be used for mutation profiling during tumor evolution, therapy prediction, and monitoring, with immediate clinical applicability.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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