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  • SAGE Publications  (9)
  • 1
    Online Resource
    Online Resource
    Effect of pyrolysis temperatures and times on the adsorption of cadmium onto orange peel derived biochar
    SAGE Publications ; 2016
    In:  Waste Management & Research: The Journal for a Sustainable Circular Economy Vol. 34, No. 2 ( 2016-02), p. 129-138
    Details
    In: Waste Management & Research: The Journal for a Sustainable Circular Economy, SAGE Publications, Vol. 34, No. 2 ( 2016-02), p. 129-138
    Abstract: The mechanism and capacity of adsorption of cadmium (Cd) on orange peel (OP)-derived biochar at various pyrolysis temperatures (400, 500, 600, 700 and 800°C) and heating times (2 and 6 h) were investigated. Biochar was characterized using proximate analysis, point of zero charge (PZC) analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction. Equilibrium and kinetic experiments of Cd adsorption on biochar were performed. The results indicated that the pH value at PZC of biochar approached 9.5. Equilibrium can be reached rapidly (within 1 min) in kinetic experiments and a removal rate of 80.6–96.9% can be generated. The results fitted the pseudo-second-order model closely. The adsorption capacity was estimated using the Langmuir model. The adsorption capacity of Cd on biochar was independent of the pyrolysis temperature and heating time ( p 〉 0.01). The maximum adsorption capacity of Cd was 114.69 (mg g −1 ). The adsorption of Cd on biochar was regarded as chemisorption. The primary adsorption mechanisms were regarded as Cπ–cation interactions and surface precipitation. Cadmium can react with calcite to form the precipitation of (Ca,Cd)CO 3 on the surface of biochar. The OP-derived biochar can be considered a favourable alternative and a new green adsorbent for removing Cd 2+ ions from an aqueous solution.
    Type of Medium: Online Resource
    ISSN: 0734-242X , 1096-3669
    URL: Article
    DOI: 10.1177/0734242X15615698
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1480483-9
    detail.hit.zdb_id: 46937-3
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  • 2
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    Online Resource
    Enhanced Excitability of Small Dorsal Root Ganglion Neurons in Rats with Bone Cancer Pain
    SAGE Publications ; 2012
    In:  Molecular Pain Vol. 8 ( 2012-01-01), p. 1744-8069-8-24-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 8 ( 2012-01-01), p. 1744-8069-8-24-
    Abstract: Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. The aim of this study was to determine whether enhanced excitability of primary sensory neurons contributed to peripheral sensitization and tumor-induced hyperalgesia during cancer condition. In this study, using techniques of whole-cell patch-clamp recording associated with immunofluorescent staining, single-cell reverse-transcriptase PCR and behavioral test, we investigated whether the intrinsic membrane properties and the excitability of small-sized dorsal root ganglion (DRG) neurons altered in a rat model of bone cancer pain, and whether suppression of DRG neurons activity inhibited the bone cancer-induced pain. Results: Our present study showed that implantation of MRMT-1 tumor cells into the tibial canal in rats produced significant mechanical and thermal hyperalgesia in the ipsilateral hind paw. Moreover, implantation of tumor cells provoked spontaneous discharges and tonic excitatory discharges evoked by a depolarizing current pulse in small-sized DRG neurons. In line with these findings, alterations in intrinsic membrane properties that reflect the enhanced neuronal excitability were observed in small DRG neurons in bone cancer rats, of which including: 1) depolarized resting membrane potential (RMP); 2) decreased input resistance (R in ); 3) a marked reduction in current threshold (CT) and voltage threshold (TP) of action potential (AP); 4) a dramatic decrease in amplitude, overshot, and duration of evoked action potentials as well as in amplitude and duration of afterhyperpolarization (AHP); and 5) a significant increase in the firing frequency of evoked action potentials. Here, the decreased AP threshold and increased firing frequency of evoked action potentials implicate the occurrence of hyperexcitability in small-sized DRG neurons in bone cancer rats. In addiotion, immunofluorescent staining and single-cell reverse-transcriptase PCR revealed that in isolated small DRG neurons, most neurons were IB4-positive, or expressed TRPV1 or CGRP, indicating that most recorded small DRG neurons were nociceptive neurons. Finally, using in vivo behavioral test, we found that blockade of DRG neurons activity by TTX inhibited the tumor-evoked mechanical allodynia and thermal hyperalgesia in bone cancer rats, implicating that the enhanced excitability of primary sensory neurons underlied the development of bone cancer pain. Conclusions: Our present results suggest that implantation of tumor cells into the tibial canal in rats induces an enhanced excitability of small-sized DRG neurons that is probably as results of alterations in intrinsic electrogenic properties of these neurons. Therefore, alterations in intrinsic membrane properties associated with the hyperexcitability of primary sensory neurons likely contribute to the peripheral sensitization and tumor-induced hyperalgesia under cancer condition.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1186/1744-8069-8-24
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2174252-2
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  • 3
    Online Resource
    Online Resource
    Neural Stem Cell Transplantation Is Associated with Inhibition of Apoptosis, Bcl-xL Upregulation, and Recovery of Neurological Function in a Rat Model of Traumatic Brain Injury
    SAGE Publications ; 2017
    In:  Cell Transplantation Vol. 26, No. 7 ( 2017-07), p. 1262-1275
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 26, No. 7 ( 2017-07), p. 1262-1275
    Abstract: Traumatic brain injury (TBI) is a common disease that usually causes severe neurological damage, and current treatment is far from satisfactory. The neuroprotective effects of neural stem cell (NSC) transplantation in the injured nervous system have largely been known, but the underlying mechanisms remain unclear, and their limited sources impede their clinical application. Here, we established a rat model of TBI by dropping a weight onto the cortical motor area of the brain and explored the effect of engrafted NSCs (passage 3, derived from the hippocampus of embryonic 12- to 14-d green fluorescent protein transgenic mice) on TBI rats. Moreover, RT-PCR and Western blotting were employed to investigate the possible mechanism associated with NSC grafts. We found rats with TBI exhibited a severe motor and equilibrium dysfunction, while NSC transplantation could partly improve the motor function and significantly reduce cell apoptosis and increase B-cell lymphoma–extra large (Bcl-xL) expression at 7 d postoperation. However, other genes including Bax, B-cell lymphoma 2, Fas ligand, and caspase3 did not exhibit significant differences in expression. Moreover, to test whether Bcl-xL could be used as a therapeutic target, herpes simplex virus (HSV) 1 carrying Bcl-xL recombinant was constructed and injected into the pericontusional cortices. Bcl-xL overexpression not only resulted in a significant improvement in neurological function but also inhibits cell apoptosis, as compared with the TBI rats, and exhibits the same effects as the administration of NSC. The present study therefore indicated that NSC transplantation could promote the recovery of TBI rats in a manner similar to that of Bcl-xL overexpression. Therefore, Bcl-xL overexpression, to some extent, could be considered as a useful strategy to replace NSC grafting in the treatment of TBI in future clinical practices.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689717715168
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2020466-8
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  • 4
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    Online Resource
    Robust Control of a High-precision Positioning Stage Using an Integrated H∞ and QFT Controller
    SAGE Publications ; 2011
    In:  Journal of Intelligent Material Systems and Structures Vol. 22, No. 5 ( 2011-03), p. 421-433
    Details
    In: Journal of Intelligent Material Systems and Structures, SAGE Publications, Vol. 22, No. 5 ( 2011-03), p. 421-433
    Abstract: A new three-axis high precision stage is developed in this article, which consists of an X-Y moving platform and a rotational stage on the top of the platform. Piezoelectric actuators embedded in the flexure hinge are utilized to drive the stage and the displacements are measured by laser displacement sensors. To facilitate the design of the device, dynamic models are developed using the Lagrangian approach. The natural frequency of the system is analyzed and compared with the finite element model. Due to the installation and fabrication errors, it is found that the dynamics of the X-Y moving platform is coupled. To achieve better performance, the H ∞ controller for the MIMO system is developed first to eliminate the coupling effects. Variable payloads are considered in the design process to achieve system robustness. Then, the H ∞ controller is then reshaped using the QFT. The noise and control efforts are reduced significantly after applying the QFT technique. The results demonstrate that the coupling between the X-Y axes can be reduced with the integrated H ∞ and QFT controller. Moreover, the settling time and positioning accuracy for a 10-µm step input are less than 0.1 s and 0.3 µm, respectively.
    Type of Medium: Online Resource
    ISSN: 1045-389X , 1530-8138
    URL: Article
    DOI: 10.1177/1045389X10390251
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2088313-4
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  • 5
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    Prevalence and extent of right-to-left shunt on contrast-enhanced transcranial Doppler in Chinese patients with migraine in a multicentre case-control study
    SAGE Publications ; 2018
    In:  Cephalalgia Vol. 38, No. 4 ( 2018-04), p. 690-696
    Details
    In: Cephalalgia, SAGE Publications, Vol. 38, No. 4 ( 2018-04), p. 690-696
    Abstract: The association between RLS and migraine is still debated. The aim of this study is to investigate the prevalence and grade of RLS in Chinese patients with migraine and to evaluate the relationship between RLS and migraine. Methods A multi-center case-control study of contrast-enhanced transcranial Doppler was conducted in 931 consecutive patients with migraine (240 of 931 had migraine with aura and 691 of 931 were in the migraine without aura group) and 282 were healthy adults. Clinical trial no. NCT02425696. Results The prevalence of RLS was 63.8% and 39.9% in the migraine with aura group (MA+) and migraine without aura group (MA−), respectively, significantly higher than that of the healthy group (29.4%, p  〈  0.001; p  〈  0.001). The positive rate of large RLS in the MA+ group and MA− group was 32.1% and 16.5%, respectively, significantly higher than healthy group (6.4%, p  〈  0.001; p  〈  0.001). There was no difference among groups in terms of positive rate of permanent RLS ( p = 0.704). Conclusion This multi-centre case-control study suggested that there is an association between RLS and migraine with and without aura, especially when the shunt is large.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/0333102417708203
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2019999-5
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  • 6
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    Online Resource
    MicroRNA-34a Targets Bcl-2 and Sensitizes Human Hepatocellular Carcinoma Cells to Sorafenib Treatment
    SAGE Publications ; 2014
    In:  Technology in Cancer Research & Treatment Vol. 13, No. 1 ( 2014-02), p. 77-86
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 13, No. 1 ( 2014-02), p. 77-86
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.7785/tcrt.2012.500364
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 7
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    Automated Macular Fluid Volume As a Treatment Indicator for Diabetic Macular Edema
    SAGE Publications ; 2023
    In:  Journal of VitreoRetinal Diseases Vol. 7, No. 3 ( 2023-05), p. 226-231
    Details
    In: Journal of VitreoRetinal Diseases, SAGE Publications, Vol. 7, No. 3 ( 2023-05), p. 226-231
    Abstract: Introduction: To assess the diagnostic accuracy of automatically quantified macular fluid volume (MFV) for treatment-required diabetic macular edema (DME). Methods: This retrospective cross-sectional study included eyes with DME. The commercial software on optical coherence tomography (OCT) produced the central subfield thickness (CST), and a custom deep-learning algorithm automatically segmented the fluid cysts and quantified the MFV from the volumetric scans of an OCT angiography system. Retina specialists treated patients per standard of care based on clinical and OCT findings without access to the MFV. The main outcome measures were the area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity of the CST, MFV, and visual acuity (VA) for treatment indication. Results: Of 139 eyes, 39 (28%) were treated for DME during the study period and 101 (72%) were previously treated. The algorithm detected fluid in all eyes; however, only 54 eyes (39%) met the DRCR.net criteria for center-involved ME. The AUROC of MFV predicting a treatment decision of 0.81 was greater than that of CST (0.67) ( P = .0048). Untreated eyes that met the optimal threshold for treatment-required DME based on MFV ( 〉 0.031 mm 3 ) had better VA than treated eyes ( P = .0053). A multivariate logistic regression model showed that MFV ( P = .0008) and VA ( P = .0061) were significantly associated with a treatment decision, but CST was not. Conclusions: MFV had a higher correlation with the need for treatment for DME than CST and may be especially useful for ongoing management of DME.
    Type of Medium: Online Resource
    ISSN: 2474-1264 , 2474-1272
    URL: Article
    DOI: 10.1177/24741264231164846
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2898183-2
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  • 8
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    Attention-deficit/hyperactivity disorder and ischemic stroke: A Mendelian randomization study
    SAGE Publications ; 2023
    In:  International Journal of Stroke Vol. 18, No. 3 ( 2023-03), p. 346-353
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 18, No. 3 ( 2023-03), p. 346-353
    Abstract: Observational studies have found an association between attention-deficit/hyperactivity disorder (ADHD) and ischemic stroke. Aims: The purpose of this study was to investigate whether genetic liability to ADHD has a causal effect on ischemic stroke and its subtypes. Methods: In this two-sample Mendelian randomization (MR) study, genetic variants (nine single-nucleotide polymorphisms; P  〈  5 × 10 -8 ) using as instrumental variables for the analysis was obtained from a genome-wide association study of ADHD with 19,099 cases and 34,194 controls. The outcome datasets for stroke and its subtypes were obtained from the MEGASTROKE consortium, with 40,585 cases and 406,111 controls. MR inverse variance-weighted method was conducted to investigate the effect of genetic liability to ADHD on ischemic stroke and its subtypes. Sensitivity analyses (median-based methods, MR-Egger, MR-robust adjusted profile scores, MR-pleiotropy residual sum and outlier) were also utilized to assess horizontal pleiotropy and remove outliers. Multivariable MR (MVMR) analyses were conducted to explore potential mediators. Results: Genetically determined ADHD (per 1 SD) was significantly associated with a higher risk of any ischemic stroke (AIS) (odds ratio (OR) = 1.15, 95% confidence interval (CI) = 1.05–1.25, P = 0.002) and large-artery atherosclerotic stroke (LAS) (OR = 1.40, 95% CI = 1.10–1.76, P = 0.005). The significant association was also found in sensitivity analyses and MVMR analyses. Conclusions: Genetic liability to ADHD was significantly associated with an increased risk of AIS, especially LAS. The association between ADHD and LAS was independent of age of smoking initiation but mediated by coronary artery disease.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930221108272
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2211666-7
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  • 9
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    Repeated Whole-Body Exposure to Low-Dose Radiation Combined With Topical Application of Basic Fibroblast Growth Factor and Zinc Accelerates Wound Healing in Diabetic Rats
    SAGE Publications ; 2018
    In:  Dose-Response Vol. 16, No. 3 ( 2018-07-01), p. 155932581878984-
    Details
    In: Dose-Response, SAGE Publications, Vol. 16, No. 3 ( 2018-07-01), p. 155932581878984-
    Abstract: We reported the acceleration of skin wound healing in diabetic rats by repeated exposure to low-dose radiation (LDR). Here, we explored whether the wound healing could be further improved when LDR was combined with a topical application of basic fibroblast growth factor (bFGF) or zinc. Wounds were established on the backs of type 1 diabetic rats induced by a single injection of streptozotocin. Rats were treated daily with normal saline (Diabetes), LDR, bFGF, zinc, or combined 3 treatments for 5 consecutive days with a 2-day break between each consecutive 5-day treatment. Changes in wound size, histopathology, and microvessel density were assessed on days 5, 10, and 15, respectively, once treatment is started. All treatment regimens significantly accelerated skin wound healing, tissue remodeling, and new vessel formation compared to diabetes group. However, the combined LDR plus bFGF and zinc provided a better beneficial effect on wound healing than either one of these treatments alone. Further, we found that the effects of LDR and bFGF were similar, whereas zinc alone induced a weaker response. Our results suggest that whole-body LDR plus the topical application of bFGF and zinc can further accelerate wound healing in diabetic rats.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325818789845
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2440820-7
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