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  • SAGE Publications  (4)
  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2014
    In:  Journal of International Medical Research Vol. 42, No. 2 ( 2014-04), p. 494-502
    In: Journal of International Medical Research, SAGE Publications, Vol. 42, No. 2 ( 2014-04), p. 494-502
    Abstract: To investigate tear-film break-up time and spatial distribution via noninvasive Keratograph 4 in patients with cataracts and dry eye syndrome (DES). Methods Noninvasive first break-up time (NIKf-BUT) and average break-up time (NIKav-BUT) were evaluated via Keratograph 4 in patients with age-related cataracts and DES. The location and size of tear break regions were recorded and the distribution of first break-up areas was summarized. Patients also underwent conventional break-up time assessments (TBUT test and Schirmer’s test). Results A total of 43 left and 43 right eyes were examined. There was no significant difference between TBUT and NIKav-BUT. NIKf-BUT was significantly shorter than TBUT. Both NIKf-BUT and NIKav-BUT correlated positively with TBUT. In both the left and right eye, the most common first break-up areas were the peripheral domain of the inferior precorneal surface and the central domain of the superior portion. Conclusions The Keratograph 4 appears to provide an effective noninvasive method for assessing tear film, enabling effective preoperative evaluation of tear film break-up regularity, informing the location of the incision and reducing the probability of postoperative DES.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 184023-X
    detail.hit.zdb_id: 2082422-1
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  • 2
    In: Energy Exploration & Exploitation, SAGE Publications, Vol. 38, No. 5 ( 2020-09), p. 1428-1453
    Abstract: Coalbed methane wells in the Shizhuangnan Block exhibit significant productivity differences. The reasons were determined based on the impact analysis of geological factors and drainage strategies on production capacity at 82 wells. Grey relational analysis was further utilized to quantitatively analyze the correlation degree of geological parameters to production characteristics. It is found that the main reason for wells with high water production is the ingress of external water, i.e. connecting adjacent aquifer by natural faults or artificial fractures. And aquifer characteristics, especially thickness of aquifer has the greatest influence on the water production, followed by pore connectivity, porosity, and shale content. For the wells that have not been affected by external water, the gas productivity differences are mainly affected by reservoir conditions and drainage strategies. Finally, an analytical process was proposed to provide theoretical support for rational production of coalbed methane wells.
    Type of Medium: Online Resource
    ISSN: 0144-5987 , 2048-4054
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2026571-2
    detail.hit.zdb_id: 782623-0
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  European Journal of Ophthalmology Vol. 25, No. 5 ( 2015-09), p. 416-421
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 25, No. 5 ( 2015-09), p. 416-421
    Abstract: We investigated the clinical staging and management of cataracts to decrease the incidence of complications of phacoemulsification and improve the postoperative visual function of patients with exfoliation syndrome (XFS) with cataract. Methods Cataracts with XFS were divided into early, middle, and late stages using the Emery-Little lens opacities classification system. Phacoemulsification and intraocular lens (IOL) implantation were performed in all eyes. The incidences of intraoperative and early postoperative complications of phacoemulsification were compared, and differences in the outcomes of phacoemulsification were evaluated. Results There were 23, 31, and 34 eyes with early-, middle- and late-stage XFS, respectively. The mean ultrasound time, cumulative dissipated energy, and incidence of moderate to severe corneal edema and wound burn in the late-stage group were significantly higher than in the early- and middle-stage groups (p 〈 0.05). The incidence of zonular dehiscence, capsular rupture, vitreous loss, and iritis were not significant among the 3 groups (p 〉 0.05). Intraocular pressure rise in the early postoperative period and the level of optic atrophy in the late-stage group were significantly higher than in the other 2 groups (p 〈 0.05). The gain in visual acuity in the early- and middle-stage groups after surgery was better than in the late-stage group of XFS, and the difference was statistically significant (p 〈 0.05). Conclusions The clinical staging of cataract with XFS contributed to the choice of operation time and its management. Phacoemulsification and IOL implantation in early- and middle-stage XFS induced fewer complications and led to better recovery of visual function after surgery.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 1475018-1
    detail.hit.zdb_id: 1089461-5
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2024
    In:  European Journal of Ophthalmology
    In: European Journal of Ophthalmology, SAGE Publications
    Abstract: Relative anterior microphthalmos (RAM) is a rare congenital defect associated with severe vision impairment that is primarily caused by genetic alterations. The purpose of this study was to identify the causative genetic variants in two Chinese families with RAM with an autosomal recessive inheritance pattern. Methods DNA samples were obtained from two probands and their family members. Targeted next-generation sequencing (NGS) was used to screen 425 genes associated with inherited eye diseases to identify possible disease-causing variants in the two patients. Sanger sequencing was subsequently used to validate the results in both families. Results The targeted NGS panel identified potentially causative novel variants of the latent transforming growth factor beta binding protein 2 ( LTBP2) gene in the two RAM families: a missense variant (c.2771C  〉  T; p.Ala924Val) and an intronic variant (c.4582 + 9A  〉  G) in Family A and a different missense variant (c.5239C  〉  A; p.Arg1747Ser) and a synonymous variant (c.951G  〉  A; p.Pro317Pro) in Family B. These four novel variants all cosegregated with the disease phenotype. Conclusion To our knowledge, this is the first study to report novel LTBP2 gene variants related to RAM. Considering the importance of LTBP2 in ocular development, we provide initial insights into the potential pathogenic mechanisms of LTBP2 in RAM.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 1475018-1
    detail.hit.zdb_id: 1089461-5
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