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  • 1
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    Online Resource
    Serum ischaemia–modified albumin level is an irrelevant predictive factor for ischaemic duration in mesenteric ischaemia
    SAGE Publications ; 2014
    In:  Perfusion Vol. 29, No. 3 ( 2014-05), p. 226-230
    Details
    In: Perfusion, SAGE Publications, Vol. 29, No. 3 ( 2014-05), p. 226-230
    Abstract: Acute mesenteric ischaemia is an emergency condition that requires urgent and expeditious diagnosis and immediate surgical or medical intervention. The initial hours are critical for the recovery of the affected bowel segment. Thus, its clinic diagnostic biomarkers are important when it comes to reducing mortality and morbidity rates. Methods: Twenty-four male Sprague–Dawley rats were included in the study. The rats were divided into three equal groups. Those in Group I were sacrificed to determine the basal serum values of ischaemia-modified albumin (IMA) after a simple laparotomy. The superior mesenteric artery (SMA) was clamped in a simple laparotomy in Groups II and III; blood samples were taken at 120 minutes in Group II and 360 minutes in Group III. The serum IMA levels were identified from the blood samples and the results obtained were compared statistically. Results: The serum IMA levels were determined to be 22±6 (22) μ/L, 34±7 (34) μ/L and 36±4 (37) μ/L in Groups I, II and III, respectively. The differences between the groups were not statistically significant. Conclusion: Our results showed that the serum IMA level is not an appropriate biomarker for acute mesenteric ischaemia. Additionally, the IMA level is not an appropriate biomarker for the detection of ischaemia duration. However, future studies should be conducted to clarify the efficacy of serum IMA levels under different ischaemic conditions.
    Type of Medium: Online Resource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/0267659113505640
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2029611-3
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  • 2
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    Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue
    SAGE Publications ; 2013
    In:  Experimental Biology and Medicine Vol. 238, No. 11 ( 2013-11), p. 1242-1250
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 238, No. 11 ( 2013-11), p. 1242-1250
    Abstract: Hydrodynamic cavitation is a physical phenomenon characterized by vaporization and bubble formation in liquids under low local pressures, and their implosion following their release to a higher pressure environment. Collapse of the bubbles releases high energy and may cause damage to exposed surfaces. We recently designed a set-up to exploit the destructive nature of hydrodynamic cavitation for biomedical purposes. We have previously shown that hydrodynamic cavitation could kill leukemia cells and erode kidney stones. In this study, we analyzed the effects of cavitation on prostate cells and benign prostatic hyperplasia (BPH) tissue. We showed that hydrodynamic cavitation could kill prostate cells in a pressure- and time-dependent manner. Cavitation did not lead to programmed cell death, i.e. classical apoptosis or autophagy activation. Following the application of cavitation, we observed no prominent DNA damage and cells did not arrest in the cell cycle. Hence, we concluded that cavitation forces directly damaged the cells, leading to their pulverization. Upon application to BPH tissues from patients, cavitation could lead to a significant level of tissue destruction. Therefore similar to ultrasonic cavitation, we propose that hydrodynamic cavitation has the potential to be exploited and developed as an approach for the ablation of aberrant pathological tissues, including BPH.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370213503273
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2020856-X
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  • 3
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    Investigation of the arterial intima-media thickness in Behcet’s disease patients without vascular complaints
    SAGE Publications ; 2018
    In:  Vascular Vol. 26, No. 4 ( 2018-08), p. 356-361
    Details
    In: Vascular, SAGE Publications, Vol. 26, No. 4 ( 2018-08), p. 356-361
    Abstract: Behcet’s disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet’s disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet’s disease without vascular involvement. Methods Twenty-four patients (average age: 38.50 ± 10.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet’s disease were included in the study. Sixteen healthy subjects (average age: 39.75 ± 7.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet’s disease patients and those of the control group ( p  〉  0.05). However, there was a significant difference between the neutrophil–lymphocyte ratio ( p = 0.004), low-density lipoprotein ( p = 0.007), and triglyceride ( p = 0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil–lymphocyte ratio levels ( p = 0.012) and the disease duration ( p = 0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration ( p = 0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet’s disease. Blood neutrophil–lymphocyte ratio levels were also associated with increased intima-media thickness.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538117742827
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2143006-8
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  • 4
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    Diagnostic accuracy of mean platelet volume in thromboangiitis obliterans
    SAGE Publications ; 2014
    In:  Vascular Vol. 22, No. 1 ( 2014-02), p. 42-45
    Details
    In: Vascular, SAGE Publications, Vol. 22, No. 1 ( 2014-02), p. 42-45
    Abstract: Thromboangiitis obliterans (TAO) affects small- and medium-sized vessels of the extremities via a non-atherosclerotic inflammatory process in the elderly. Although diagnostic criteria have been determined, only a few studies have been described in the laboratory features. Diagnostic biomarkers are important for reducing disruptions caused by TAO. The diagnostic importance of mean platelet volume (MPV) was investigated in TAO patients. Forty-four patients diagnosed with TAO (study group) and 45 healthy individuals (control group) were included in the study. The age, gender and complete blood parameters obtained via peripheral venous blood samples were compared between the two groups. A receiver operating characteristic (ROC) curve was used for determining the diagnostic accuracy of the MPV variable. All the variables were statistically similar in each group except MPV and platelet counts. MPV was significantly higher and platelet count was significantly lower in the TAO group ( P 〈 0.05). In addition, diagnostic accuracy was measured by the area under the ROC curve (Figure  1 ), and MPV differs significantly ( P 〈 0.001), with a value of 0.783 (95% CI: 0.711–0.854). This study indicates that MPV is probably an important diagnostic predictor in TAO patients. Detection of blood parameters such as platelet properties is important for meticulous care of these patients. [Figure: see text]
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538112473978
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2143006-8
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  • 5
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    Online Resource
    The relationship between complete blood count parameters and Fontaine’s Stages in patients with peripheral arterial disease
    SAGE Publications ; 2014
    In:  Vascular Vol. 22, No. 6 ( 2014-12), p. 427-431
    Details
    In: Vascular, SAGE Publications, Vol. 22, No. 6 ( 2014-12), p. 427-431
    Abstract: The aim of the present study is to evaluate whether blood count parameters differ according to the stages of Fontaine’s classification and to investigate the relationship between hemogram parameters and the severity of the disease. Method Eighty-two peripheral arterial disease patients were examined prospectively. Patients were classified according to the Fontaine classification system. Fifty newly diagnosed patients were included in the study. The neutrophil-to-lymphocyte ratio, mean platelet volume, and red blood cell distribution width values were recorded. Results Mean neutrophil-to-lymphocyte ratio values were found to be 3.31 ± 1.1% in Stage I, 3.11 ± 1.3% in Stage II, and 3.48 ± 1.1% in Stage III ( p  〉  0.05). Mean platelet volume values were found to be 7.8 ± 0.6 fl (Stage I), 8.2 ± 1.0 fl (Stage II), and 9.0 ± 0.9 fl (Stage III) ( p  〈  0.05). Red blood cell distribution width values were found to be 13.6 ± 1.0% in Stage I, 14.8 ± 1.7% in Stage II, and 15.4 ± 2.3% in Stage III, being significantly different among all three stages ( p  〈  0.05). Conclusion Both red blood cell distribution width and mean platelet volume are found to be associated with the severity of atherosclerotic disease in patients with peripheral arterial disease. This finding hypothesizes that complete blood counting parameters may serve as a beneficial and cost-effective method for monitoring atherosclerotic peripheral disease.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538114522227
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2143006-8
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  • 6
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    Online Resource
    Pharmacomechanical thrombolysis with a rotator thrombolysis device in iliofemoral deep venous thrombosis
    SAGE Publications ; 2016
    In:  Vascular Vol. 24, No. 5 ( 2016-10), p. 481-486
    Details
    In: Vascular, SAGE Publications, Vol. 24, No. 5 ( 2016-10), p. 481-486
    Abstract: Deep venous thrombosis (DVT) is a life-threatening and morbid pathology. This study aimed to investigate the efficacy of an early thrombolysis procedure using a rotator thrombolysis device. Methods Sixty-seven patients with acute proximal DVT were enrolled in the study. Patients’ data were recorded retrospectively. Initially, an infrarenal retrievable vena cava filter was placed through the femoral vein. Then, a rotator thrombolysis device and a thrombolytic agent injection were applied to the occluded segments of the deep veins by puncturing the popliteal vein. Results The identified reasons were trauma (43.3%), pregnancy (20.9%), undiagnosed (11.9%), major surgical operation (10.5%), immobilization (7.5%), and malignancy (5.9%). Immediate total recanalization was conducted in all patients, and the leg diameters returned to normal ranges in the early postoperative period. Hospital mortality or severe complications were not detected. Conclusion New thrombolytic devices seem to reduce in-hospital mortality risks and may potentially decrease post-thrombotic morbidity.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538115612637
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 7
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    CoronaVac, BNT162b2 and heterologous COVID-19 vaccine outcomes in patients with ventricular assist device
    SAGE Publications ; 2023
    In:  The International Journal of Artificial Organs Vol. 46, No. 1 ( 2023-01), p. 15-21
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 46, No. 1 ( 2023-01), p. 15-21
    Abstract: A consensus has not yet been reached regarding which COVID-19 vaccine program should be applied in patients with ventricular assist device (VAD). Our aim was to assess the clinical outcome of inactivated, mRNA and heterologous vaccine program in patient with VAD. Methods: In this retrospective and cross-sectional study; adult patients who underwent VAD implantation between January 2012 and September 2021 and received any vaccine that were used in Republic of Türkiye for COVID-19, were included. The patients were divided into three groups according to the type of vaccine; “inactivated,” “mRNA” and “heterologous.” Clinical outcomes were analyzed. Results: Eighteen patients were in each group in the “inactivated,” “mRNA” and “heterologous” groups. Mean age was 51.6 ± 12 years in “inactivated” group, 42.5 ± 15.5 years in “mRNA” group and 41.1 ± 15.4 years in “heterologous” group. There was no significant difference between the groups in age, gender, body surface area, body mass index and etiology ( p  〉  0.05). After last dose of vaccines, the number of patients had COVID-19 positive test were three (16.7%), one (5.6%), and two (11.1%) in “inactivated,” “mRNA” and “heterologous” groups, respectively. Pump thrombosis was seen in two patients in “mRNA” group and one patient in “heterologous” group. No pump thrombosis was seen in “inactivated” group. COVID-19-related death or intubation was not observed. Conclusion: All vaccine that used for COVID-19 are safe and effective in patients with VAD. In countries that give priority to inactivated vaccines, mRNA vaccines may then be made as boosters.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/03913988221141719
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1474999-3
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  • 8
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    Damage to monumental masonry buildings in Hatay and Osmaniye following the 2023 Turkey earthquake sequence: The role of wall geometry, construction quality, and material properties
    SAGE Publications ; 2024
    In:  Earthquake Spectra
    Details
    In: Earthquake Spectra, SAGE Publications
    Abstract: This article reports on the findings of an investigation on 29 historic stone masonry buildings located in the cities of Hatay and Osmaniye following the 2023 Turkey earthquake sequence. The earthquake couplet on 6 February (with moment magnitudes 7.8 and 7.5) and the following events (including another earthquake which occurred on 20 February with a moment magnitude of 6.3) resulted in significant damage to the buildings. To understand why, the examined buildings were assigned an EMS-98 damage level (ranging from 1 to 5) and descriptive response categories (masonry disaggregation, local mechanism, and global response). Overall damage statistics indicated that masonry disaggregation was common and coterminous with local mechanism response. Wall geometry and construction quality indices were then investigated to explore why these were the dominant damage mechanisms. Wall geometry indices highlighted insufficient amount of walls to resist the local seismic demands, particularly in the transverse (e.g. short) direction of buildings. This deficit promoted the formation of local mechanisms. Construction quality indices suggested that stone layouts did not enable interlocking and that the walls were prone to disaggregation. To further investigate the role of material properties on the observed damage, materials were characterized using three non-destructive testing techniques: ultrasonic pulse velocity (UPV) measurements to estimate the static elastic modulus of stones, Schmidt rebound hammer (SRH) tests to estimate the compressive strength of stones, and the mortar penetrometer (MP) tests to estimate the compressive strength of mortar. The measurements indicated poor mortar quality, which may have expedited failures. Using established correlations, various other important material parameters (e.g. mortar cohesion and homogenized masonry strength) are derived. It is envisioned that the damage observations and the material measurements in this article will inform detailed modeling efforts on the behavior of historic masonry buildings during the earthquakes.
    Type of Medium: Online Resource
    ISSN: 8755-2930 , 1944-8201
    URL: Article
    DOI: 10.1177/87552930241247031
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2183411-8
    SSG: 16,13
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  • 9
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    Online Resource
    Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis
    SAGE Publications ; 2012
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 18, No. 6 ( 2012-11), p. 650-653
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 18, No. 6 ( 2012-11), p. 650-653
    Abstract: Aim: To investigate the relationship between mean platelet volume (MPV) and in-hospital deep venous thrombosis (DVT). Material and methods: 147 patients with the diagnosis of DVT and 149 control participants were included in the study. For all participants, clinical risk factors, smoking status, and other demographic data were recorded from hospital registries. The data of patients with DVT were compared with the control participants. Results: Mean MPV was significantly higher in patients with DVT than the control group (8.91 ± 1.86 vs 7.86 ± 0.9; P 〈 .001). Body mass index, smoking frequency, hematocrit, and platelet count were significantly correlated with MPV. Independent predictors of in-hospital DVT were MPV (odds ratio [OR] = 1.5; 95% confidence interval [CI] = 1.2-1.87; P ≤ .001), body mass index (OR = 1.17; 95% CI = 1.04-1.34; P = .012), and smoking (OR = 1.83; 95% CI = 1.09-3.08; P = .023). Conclusion: Mean platelet volume was significantly higher in patients with DVT, and it is an independent predictor of in-hospital DVT.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029611435838
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2230591-9
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