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  • SAGE Publications  (38)
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  • SAGE Publications  (38)
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  • 1
    Online Resource
    Online Resource
    RETRACTED: Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis
    SAGE Publications ; 2017
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 37, No. 3 ( 2017-03), p. 967-979
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 37, No. 3 ( 2017-03), p. 967-979
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X16648712
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2039456-1
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  • 2
    Online Resource
    Online Resource
    Kinematics analysis and performance testing of 6-RR- RP -RR parallel platform with offset RR-hinges based on Denavit-Hartenberg parameter method
    SAGE Publications ; 2021
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 235, No. 18 ( 2021-09), p. 3519-3533
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 235, No. 18 ( 2021-09), p. 3519-3533
    Abstract: A six degrees-of-freedom parallel platform in a 6-RR-RP-RR configuration with high accuracy, high stiffness and a large working stroke is studied for application to the sub-mirror adjustment system of a large-aperture telescope. To meet the performance requirements, the parallel platform adopts a self-centering and well-designed offset universal hinge. The two hinge axes of the offset hinge do not intersect but have a specific offset in space, which makes the kinematics more complex than that with a common universal hinge. Therefore, to solve this complex kinematics problem, this paper innovatively introduces the Denavit–Hartenberg (D-H) parameter method that is used for series mechanisms. The method has a simple modeling process, strong applicability and continuity, providing a new tool for the analysis and application of the parallel mechanisms. A kinematics model of the parallel platform can be constructed and solved using a numerical iteration method. The accuracy of the numerical kinematics solution is verified using a co-simulation method. This paper analyses the passive derivative motion and the leg length error is compensated. Finally, test studies of the motion resolution, the repetitive positioning accuracy, the motion stroke, the static stiffness of the legs, and the static stiffness and dynamic stiffness of the entire machine were also carried out to verify the platform’s performance.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406220978437
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2024890-8
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  • 3
    Online Resource
    Online Resource
    Kinematics analysis and testing of novel 6- P -RR-R-RR parallel platform with offset RR-joints
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 233, No. 10 ( 2019-05), p. 3512-3530
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 233, No. 10 ( 2019-05), p. 3512-3530
    Abstract: This paper presents a novel six-degree-of-freedom (6-DOF) parallel platform that is used as the third mirror adjustment system of a large space telescope. In order to meet the design requirements of high precision, a large load–size ratio, and high stiffness in both the transverse and the vertical directions, the parallel platform is designed to be a 6-P-RR-R-RR structure via use of offset RR-joints. The inverse kinematics problem of the designed platform with offset RR-joints is much more complicated than that of a parallel platform with common universal joints owing to the presence of joint-dependent variables in the former problem. In this study, inverse kinematics of the designed parallel platform is mathematically modeled and the Newton–Raphson numerical iterative computation is performed. The accuracy and effectiveness of the proposed mathematical approach are verified by numerical co-simulations using MATLAB and ADAMS. The initial position of the platform is determined by a precision measuring arm. A test system is constructed, and then inverse kinematics solution, resolutions and adjusting steps accuracies of the platform are tested using grating length gauges. Motion strokes of the parallel mechanism are measured using laser tracker.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406218817001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 4
    Online Resource
    Online Resource
    Design and analysis of a triangular bi-axial flexure hinge
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications
    Abstract: To achieve the requirement of flexure hinges for specific optical precision equipment, a new triangular bi-axial flexure hinge is proposed. The analysis model for the flexibility of the triangular bi-axial flexure hinges is derived. After that, the linear and nonlinear finite element methods are used to verify the analysis model. Then, the physical dimensions of the hinge are optimized using the multi-island genetic algorithm in conjunction with the finite element method, and the rotational stiffness and center drift are diminished. Static analysis and modal analysis of the hinge are conducted. A test system was built to gage the flexure hinge’s rotational stiffness. The results demonstrated that there was good agreement between the analytically calculated value, simulated calculated value, and experimental value. To summarize, the analysis model met the design requirements of the triangular bi-axial flexible hinge, and the multi-island genetic algorithm effectively optimized the physical dimensions of the hinge and enhanced its performance. The design process provides new ideas for the design of other forms of hinges.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/09544062231154836
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Bioelectric effect of a chitosan bioelectret membrane on bone regeneration in rabbit cranial defects
    SAGE Publications ; 2012
    In:  Journal of Bioactive and Compatible Polymers Vol. 27, No. 2 ( 2012-03), p. 122-132
    Details
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 27, No. 2 ( 2012-03), p. 122-132
    Abstract: In this study, the effects of a chitosan bioelectret membrane on bone regeneration in a rabbit cranial defect model were examined. The bioelectret was fabricated by film casting and polarized by grid-controlled corona charging (−1 kV). In vitro, the equivalence surface charge density of the bioelectret gradually reduced under both wet and dry conditions. In vivo, two rectangular transosseous defects of 8 mm × 10 mm were created symmetrically on each rabbit cranial bone. The defects were treated with the bioelectret membrane, with unpolarized membrane, and no membrane, respectively. The rabbits were killed at 4, 8, and 12 weeks postoperatively, and specimens were examined by micro-computed tomography and histological analysis. The bioelectret membrane recipients had a significantly higher volume of newly formed bone and greater rate of material degradation than the unpolarized membrane. Furthermore, the bioelectret membrane induced new bone formation not only around the host bone but also in the center of the defects. The chitosan bioelectret membrane application has an apparent potential in guided bone regeneration applications.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    URL: Article
    DOI: 10.1177/0883911512436773
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2073790-7
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  • 6
    Online Resource
    Online Resource
    Superparamagnetic Perfluorooctylbromide Nanoparticles as a Multimodal Contrast Agent for Us, Mr, and Ct Imaging
    SAGE Publications ; 2013
    In:  Acta Radiologica Vol. 54, No. 3 ( 2013-04), p. 278-283
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 54, No. 3 ( 2013-04), p. 278-283
    Abstract: Multimodal contrast agents usually containing two or more signal components can be used for several imaging modalities. Thus, complimentary information can be obtained by using just one kind of contrast agents. Purpose To investigate the potential of superparamagnetic perfluorooctylbromide nanoparticles (M-PFOBNP) as a multimodal contrast agent for ultrasonography (US)/magnetic resonance (MR)/computed tomography (CT) multimodality imaging. Material and Methods The composite agent M-PFOBNP was developed by introducing superparamagnetic Fe3O4 nanoparticles into perfluorooctylbromide nanoparticles (PFOBNP). Several analytical tools were employed to characterize the agent. The potential of M-PFOBNP for US/MR/CT multimodality imaging were assessed in vivo. The cellular uptake and cytotoxicity of the agent were studied in vitro. Results M-PFOBNP with well-defined spherical morphology and homogeneous size of 200-250 nm was obtained. Fe3O4 nanoparticles were successfully integrated into PFOBNP and preserved their superparamagnetic characteristics after encapsulation. The in vivo studies showed that M-PFOBNP produced higher echogenicity than PFOBNP and possessed strong magnetic susceptibility and radiopacity for multimodality imaging. Macrophages incubated with different concentrations of M-PFOBNP resulted in a dose-dependent cellular uptake, which did not affect the viability of the cells. Conclusion M-PFOBNP may potentially serve as a multimodal contrast agent for enhanced US, MR, and CT imaging.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1258/ar.2012.120130
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2024579-8
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  • 7
    Online Resource
    Online Resource
    Enhanced recovery after surgery (ERAS) pathway optimizes outcomes and costs for minimally invasive radical prostatectomy
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 6 ( 2020-06), p. 030006052092007-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 6 ( 2020-06), p. 030006052092007-
    Abstract: To evaluate the impact of an enhanced recovery after surgery (ERAS) pathway on patients undergoing minimally invasive radical prostatectomy at a single institute. Methods In this retrospective study, 301 patients who underwent laparoscopic or robot-assisted laparoscopic radical prostatectomy from May 2014 to September 2018 were consecutively recruited. Before April 2017, the patients were treated with conventional care; all patients were treated with the ERAS pathway thereafter. The primary outcome was the postoperative length of hospital stay (LOS). The secondary outcomes were hospitalization costs and postoperative complications. Results In total, 138 patients were treated with the ERAS pathway, and the remaining patients underwent conventional care. The postoperative LOS was significantly shorter in the ERAS group than in the conventional group (median, 6 vs. 8 days). The hospitalization costs were also significantly lower in the ERAS group ($4086 vs. $5530). Ten (6.1%) patients in the ERAS group and 17 (12.3%) patients in the conventional group developed postoperative complications. The multivariable analysis showed that ERAS care was a significant independent predictive factor for a shortened LOS and reduced hospitalization costs. Conclusions The ERAS pathway was associated with a shortened LOS and reduced hospitalization costs for patients undergoing minimally invasive radical prostatectomy.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520920072
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 8
    Online Resource
    Online Resource
    Comparison Between Single- and Double-Bundle Anterior Cruciate Ligament Reconstruction With 6- to 8-Stranded Hamstring Autograft : A Prospective, Randomized Clinical Trial
    SAGE Publications ; 2016
    In:  The American Journal of Sports Medicine Vol. 44, No. 9 ( 2016-09), p. 2314-2322
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 44, No. 9 ( 2016-09), p. 2314-2322
    Abstract: Whether double-bundle (DB) anterior cruciate ligament (ACL) reconstruction with 6- to 8-stranded hamstring autograft (HG) is better than single-bundle (SB) ACL reconstruction remains debatable, as long-term follow-up data are lacking. Purpose: To prospectively investigate and compare the long-term results of DB and SB ACL reconstruction with a 6- to 8-stranded HG. Study Design: Randomized controlled clinical trial; Level of evidence: 1. Methods: A total of 80 patients with chronic ACL rupture were randomized to SB or DB ACL reconstruction with a 6- to 8-stranded HG. In the SB group, both the semitendinosus tendon (ST) and the gracilis tendon (GT) were prepared in 3 or 4 strands, with a total of 6 to 8 strands. In the DB group, the ST was prepared in 3 or 4 strands used for the anteromedial bundle, and the GT was prepared in the same manner for the posterolateral bundle. Each graft was fixed with an EndoButton, a bioabsorbable interference screw, and a staple. Outcome assessment was performed by a blinded independent observer using International Knee Documentation Committee (IKDC), Tegner, and Lysholm scores, as well as range of motion (ROM), Lachman test, pivot-shift test, KT-2000 arthrometer side-to-side difference, and return-to-sport data. Results: A total of 68 patients (DB group, 34; SB group, 34) were observed for a mean of 80 months (range, 74-86 months). There were 2 traumatic instability failures and two 5° extension restrictions in the DB group, while no failures or 5° extension restrictions were observed in the SB group. The mean Lysholm, Tegner, and IKDC scores improved significantly in both groups compared with preoperation scores ( P 〈 .05). No patient had a positive Lachman test result. No significant differences were found between groups in functional scores, incidence of pivot shift, ROM, Lachman test, KT-2000 arthrometer anterior laxity, or time and level of return to sport. Conclusion: Both SB and DB ACL reconstruction with 6- to 8-stranded HG showed satisfactory results in subjective scores and anteroposterior and rotational stability over a nearly 7-year follow-up; neither technique was superior.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546516650876
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 9
    Online Resource
    Online Resource
    Donor Cell Fate in Particulated Juvenile Allograft Cartilage for the Repair of Articular Cartilage Defects
    SAGE Publications ; 2020
    In:  The American Journal of Sports Medicine Vol. 48, No. 13 ( 2020-11), p. 3224-3232
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 48, No. 13 ( 2020-11), p. 3224-3232
    Abstract: Particulated juvenile allograft cartilage (PJAC) has demonstrated good clinical efficacy in repairing articular cartilage defects, but the related repair mechanism after transplant and the biological characteristics of the transplanted cells are still unclear. Purpose: To study the efficacy of PJAC in repairing full-thickness cartilage defects and the specific fate of donor cells to provide experimental evidence for its clinical application. Study Design: Controlled laboratory study. Methods: Twenty female Guizhou minipigs were randomly divided into an experimental group and a control group. An 8-mm cylindrical full-thickness cartilage defect was created in the femoral trochlea of 1 knee in all minipigs. The experimental group received transplant of PJAC from 5 male juvenile Guizhou minipigs (PJAC group; n = 10) and the control group received autologous cartilage chips (ACC group; n = 10). Follow-up assessments were conducted at 1 month and 3 months to track the transplanted cells by the male-specific sex-determining region Y-linked (SRY) gene; tissue sections were hybridized in situ, and O’Driscoll histological scoring was performed according to hematoxylin and eosin staining, safranin O and fast green staining, and toluidine blue O staining, as well as immunohistochemical evaluation of aggrecan and Sry-type HMG-box 9 (SOX9). Results: All 20 Guizhou minipigs were followed; no infection or incision healing disorder occurred after the operation. By SRY in situ hybridization, the SRY signal of the transplanted cells was positive in the repaired tissue of the defect, and the SRY positive signal could still be detected in repaired tissue at 3 months postoperatively. The average number of positive cells was 68.6 ± 11.91 at 1 month and 32.6 ± 3.03 at 3 months (confocal microscope: ×400), and the difference was statistically significant. The O’Driscoll histological scores were 14 ± 0.71 in the ACC group and 9.8 ± 0.84 in the PJAC group at 1 month, and 18 ± 1.20 in the ACC group and 17.4 ± 1.14 in the PJAC group at 3 months. The scores were statistically significant between the ACC group and PJAC group at 1 month. The positive rates of SOX9 in the PJAC and ACC groups at 1 month were 67.6% ± 3.78% and 63.4% ± 5.30%, respectively, and the difference was not statistically significant ( P 〉 .05). The positive rates of SOX9 in the PJAC and ACC groups at 3 months were 68.8% ± 2.69% and 17.1% ± 1.26%, respectively, and the difference was statistically significant ( P 〈 .05). The positive rates of aggrecan in the PJAC and ACC groups at 1 month were 40.5% ± 2.78% and 42.4% ± 0.54% respectively, and the difference was not statistically significant ( P 〉 .05). The positive rates of aggrecan in the PJAC and ACC groups at 3 months were 40.8% ± 1.50% and 30.1% ± 2.44%, respectively, and the difference was not statistically significant ( P 〉 .05). Conclusion: An animal model was established with Guizhou minipigs, and the cartilage defect was repaired with PJAC from male minipigs. The SRY gene positive signal could be detected from the repaired tissue by in situ hybridization, indicating that the transplanted cells survived at least 3 months. The key genes of cartilage formation, SOX9 and aggrecan, were expressed at 1 month and 3 months, and SOX9 expression was stronger in the PJAC group than the ACC group at 3 months. Clinical Relevance: This study suggests that it is feasible to study the biological characteristics of transplanted cells in the cartilage region by the sex-determining gene.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546520958700
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 10
    Online Resource
    Online Resource
    Deep medullary veins are associated with widespread brain structural abnormalities
    SAGE Publications ; 2022
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 42, No. 6 ( 2022-06), p. 997-1006
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 42, No. 6 ( 2022-06), p. 997-1006
    Abstract: Our aim is to investigate the association of cerebral deep medullary veins (DMVs) with white matter microstructural integrity and regional brain atrophy in MRI. In a community-based cohort of 979 participants (mean age 55.4 years), DMVs were identified on susceptibility-weighted imaging. Brain structural measurements including gray matter and hippocampus volumes, as well as diffusion tensor metrics, were evaluated. The mean (SD)number of DMVs was 19.0 (1.7). A fewer number of DMVs was related to lower fractional anisotropy and higher mean diffusivity in multiple voxels on the white matter skeleton (threshold-free cluster enhancement corrected p  〈  0.05, adjusted for age and sex). Also, fewer DMVs were significantly related to a lower gray matter fraction and a hippocampal fraction (0.10 and 0.11 per DMV, respectively; SE, 0.03 for both; p  〈  0.001 for both). A significant correlation between DMVs’ reduction and cortical atrophy was observed in the bilateral occipital lobes, temporal lobes, hippocampus, and frontal lobes (p  〈  0.001, adjusted for age, sex, and total intracranial volume). Our results provided evidence that cerebral small venules disease play a role in brain parenchymal lesions and neurodegenerative processes.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X211065210
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2039456-1
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