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  • SAGE Publications  (27)
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  • 1
    Online Resource
    Online Resource
    Anticancer Opportunity Created by Loss of Tumor Suppressor Genes
    SAGE Publications ; 2016
    In:  Technology in Cancer Research & Treatment Vol. 15, No. 6 ( 2016-12), p. 729-731
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 15, No. 6 ( 2016-12), p. 729-731
    Abstract: Deletion of oncosuppressors occurs frequently in the cancer genome. A great deal of effort has been made to therapeutically restore the lost function of oncosuppressors, with little clinically translatable success, however. Reassuringly, besides the disappointing restoration endeavors, oncosuppressor loss can be therapeutically exploited in several other ways, such as the “synthetic lethality” strategies and the “therapeutic vulnerability” created by codeletion of neighboring genes. The study by Liu et al showed that codeletion of p53 and a neighboring essential gene POLR2A rendered colon cancer cells highly sensitive to further inhibition of POLR2A both in vitro and in vivo. In recent years, several studies have reported similar phenomenon in a wide range of cancer types. In this focus article, we will introduce several kinds of anticancer opportunities created by the loss of oncosuppressors and discuss their mechanisms. Given the frequency of oncosuppressor loss in cancer, its therapeutic exploitation rather merits further investigation and may open a new window for oncotherapy.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533034615604798
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 2
    Online Resource
    Online Resource
    Effect of video-assisted education on informed consent and patient education for peripherally inserted central catheters: a randomized controlled trial
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 9 ( 2020-09), p. 030006052094791-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 9 ( 2020-09), p. 030006052094791-
    Abstract: To evaluate the effects of a video-assisted education intervention on informed consent and patient education for peripherally inserted central catheters (PICCs). Methods We conducted a randomized controlled trial comparing the effects on informed consent of video-assisted patient education and traditional face-to-face discussion in a catheter outpatient ward of a cancer centre in Guangzhou, China, in 2018. Participants were 140 patients randomly allocated (1:1 ratio) to two groups: video-assisted or traditional intervention. General information, patient retention of PICC-related information, working time spent by nurses on the procedure, and patient and nurse satisfaction with the procedure were assessed. Results The time used for informed consent was significantly shorter in the experimental group (1.02 ± 0.24 minutes) than in the control group (6.87 ± 1.10 minutes). The time used for PICC-related education was significantly shorter in the experimental group (1.03 ± 0.28 minutes) than in the control group (5.11 ± 0.57 minutes). Nurses’ degree of satisfaction with the procedure was significantly higher in the experimental group (4.10 ± 0.57) than in the control group (2.60 ± 0.70). Conclusion The use of video-assisted informed consent and patient education in this cancer centre decreased nurses’ working time and improved nurses’ satisfaction. Clinical trial registration number: ChiCTR1800015664
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520947915
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 3
    Online Resource
    Online Resource
    Curcumin ameliorates insulin signalling pathway in brain of Alzheimer’s disease transgenic mice
    SAGE Publications ; 2016
    In:  International Journal of Immunopathology and Pharmacology Vol. 29, No. 4 ( 2016-12), p. 734-741
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 29, No. 4 ( 2016-12), p. 734-741
    Abstract: Deficits in glucose, impaired insulin signalling and brain insulin resistance are common in the pathogenesis of Alzheimer’s disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce the amyloid pathology in AD. Moreover, it is a well-known fact that curcumin has anti-oxidant and anti-inflammatory properties. However, whether or not curcumin could regulate the insulin signal transduction pathway in AD remains unclear. In this study, we used APPswe/PS1dE9 double transgenic mice as the AD model to investigate the mechanisms and the effects of curcumin on AD. Immunohistochemical (IHC) staining and a western blot analysis were used to test the major proteins in the insulin signal transduction pathway. After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased. Among the curcumin groups, the medium-dose group was the most effective one. Thus, we believe that curcumin may be a potential therapeutic agent that can regulate the critical molecules in brain insulin signalling pathways. Furthermore, curcumin could be adopted as one of the AD treatments to improve a patient’s learning and memory ability.
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/0394632016659494
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2505963-4
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  • 4
    Online Resource
    Online Resource
    Evaluation of the Clinical Efficacy of Stem Cell Transplantation in the Treatment of Spinal Cord Injury: A Systematic Review and Meta-analysis
    SAGE Publications ; 2021
    In:  Cell Transplantation Vol. 30 ( 2021-01), p. 096368972110678-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 30 ( 2021-01), p. 096368972110678-
    Abstract: Stem cell transplantation has been applied to treat spinal cord injury (SCI) in clinical trials for many years. However, the clinical efficacies of stem cell transplantation in SCI have been quite diverse. The purpose of our study was to systematically investigate the efficacy of stem cell transplantation in patients with SCI. The PubMed, Web of Science, Ovid-Medline, Cochrane Library, China National Knowledge Infrastructure, VIP, Wanfang, and SinoMed databases were searched until October 27, 2020. Quantitative and qualitative data were analyzed by Review Manager 5.3 and R. Nine studies ( n = 328) were included, and the overall risk of bias was moderate. The ASIA Impairment Scale (AIS) grading improvement rate was analyzed in favor of stem cell transplantation group [odds ratio (OR) = 6.06, 95% confidence interval (CI): 3.16–11.62, P 〈 0.00001]. Urodynamic indices also showed improvement in bladder function. In subgroup analyses, the results indicated that in patients with complete (AIS A) SCI, with the application of cell numbers between n*(10 7 –10 8 ), two cell types (i.e., bone marrow–derived mesenchymal stem cells and bone marrow mononuclears), and treatment time of more than 6 months, stem cell transplantation was more beneficial for sensorimotor function ( P 〈 0.05 for all groups). The risk of fever incidence in the stem cell transplantation group was 4.22 (95% CI: 1.7–10.22, P = 0.001), and principal component analysis (PCA) suggested it was more related to transplanted cell numbers. Thus, stem cell transplantation can promote functional recovery in SCI patients. Moreover, the type and quantity of transplanted stem cells and treatment time are important factors affecting the therapeutic effect of stem cell transplantation in SCI. Further studies are needed to evaluate the effects and elucidate the mechanisms of these factors on stem cell therapy in SCI.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897211067804
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020466-8
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  • 5
    Online Resource
    Online Resource
    Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome
    SAGE Publications ; 2022
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 28 ( 2022-01), p. 107602962211089-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962211089-
    Abstract: Podoplanin (PDPN) promotes platelet aggregation and activation by interacting with C-type lectin-like receptor 2(CLEC-2) on platelets. The interaction between the upregulated PDPN and platelet CLEC-2 stimulates venous thrombosis. PDPN was identified as a risk factor for coagulation and thrombosis in inflammatory processes. Hypercoagulability is defined as the tendency to develop thrombosis according to fibrinogen and/or D dimer levels. Nephrotic syndrome is also considered to be a hypercoagulable state. The aim of this study is to investigate the association of soluble PDPN/CLEC-2 with hypercoagulability in nephrotic syndrome. Thirty-five patients with nephrotic syndrome and twenty-seven healthy volunteers were enrolled. PDPN, CLEC-2 and GPVI concentrations were tested by enzyme-linked immunosorbent assay (ELISA). Patients with nephrotic syndrome showed higher serum levels of PDPN and GPVI in comparison to healthy controls ( P  〈  .001, P = .001). PDPN levels in patients with nephrotic syndrome were significantly correlated with GPVI (r = 0.311; P = .025), hypoalbuminemia (r = −0.735; P  〈  .001), hypercholesterolemia (r = 0.665; P  〈  .001), hypertriglyceridemia (r = 0.618; P  〈  .001), fibrinogen (r = 0.606; P  〈  .001) and D-dimer (r = 0.524; P  〈  .001). Area under the curve (AUC) for the prediction of hypercoagulability in nephrotic syndrome using PDPN was 0.886 (95% CI 0.804-0.967, P  〈  .001). Cut-off value for the risk probability was 5.88 ng/ml. The sensitivity of PDPN in predicting hypercoagulability was 0.806, and the specificity was 0.846. When serum PDPN was 〉 5.88 ng/ml, the risk of hypercoagulability was significantly increased in nephrotic syndrome (OR = 22.79, 95% CI 5.92-87.69, P  〈  .001). In conclusion, soluble PDPN levels were correlated with hypercoagulability in nephrotic syndrome. PDPN has the better predictive value of hypercoagulability in nephrotic syndrome as well as was a reliable indicator of hypercoagulable state.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296221108967
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2230591-9
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  • 6
    Online Resource
    Online Resource
    Expert consensus for PVCR in severe, rigid and angular spinal deformity treatment: The Kunming consensus
    SAGE Publications ; 2017
    In:  Journal of Orthopaedic Surgery Vol. 25, No. 2 ( 2017-05), p. 230949901771393-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 25, No. 2 ( 2017-05), p. 230949901771393-
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499017713939
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2128854-9
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  • 7
    Online Resource
    Online Resource
    Spatial–degree of freedom improvement of interference alignment in multi-input, multi-output interference channels
    SAGE Publications ; 2017
    In:  International Journal of Distributed Sensor Networks Vol. 13, No. 1 ( 2017-01), p. 155014771668635-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 13, No. 1 ( 2017-01), p. 155014771668635-
    Abstract: As we know, the degree of freedom approximates the capacity of a network. To improve the achievable degree of freedom in the K-user interference network, we propose a rank minimization interference minimization algorithm. Unlike the existing methods concentrating on the promotion of degree of freedom, our rank optimization method works directly with the interference matrix rather than its projection using the receive beamformers. Moreover, we put the trace constraint of the square root of desired matrix into the rank optimization to prevent the received signal-to-interference-plus-noise ratio from reduction. The decoders are designed through a weight interference leakage minimization method. Considering that the practical obtainable signal-to-noise ratio may be limited, we improve the design of decoders in rank minimization interference minimization, and propose the rank minimization rate maximization. Rank minimization rate maximization aims to reduce the impact of interference on undesired users as much as possible while improving the desired data rate. Simulation results show that rank minimization interference minimization algorithm can provide more interference-free dimensions for desired signals than other rank minimization methods. Rank minimization rate maximization outperforms rank minimization interference minimization at low-to-moderate signal-to-noise ratios, and its performance gets closer to rank minimization interference minimization with the increase in signal-to-noise ratio. Furthermore, in an improper system, rank minimization rate maximization still performs well.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147716686351
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2192922-1
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  • 8
    Online Resource
    Online Resource
    Diagnostic Challenges of Intra-operative Frozen Consultation for Mammary Epithelioid Myofibroblastoma
    SAGE Publications ; 2022
    In:  International Journal of Surgical Pathology Vol. 30, No. 6 ( 2022-09), p. 634-641
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 30, No. 6 ( 2022-09), p. 634-641
    Abstract: Myofibroblastoma (MFB) of the breast is a rare benign neoplasm that exhibits several morphologic variants and presents diagnostic challenges for pathologists, especially in recognizing intra-operative frozen sections. In order to raise awareness of this tumor and avoid misdiagnosis, we describe a case of a 38-year-old female patient diagnosed as epithelioid MFB. This painless tumor was well-circumscribed, found in the left breast and was physically examined over a period of six months. Histologically, this tumor was predominantly composed of epithelioid cells, which arranged as single cells, small clusters or nests. Tumor stroma was collagenized with spindle cells, adipose and focal myxoid areas. This case was misinterpreted as invasive carcinoma in the frozen section. The immunohistochemical profile demonstrated positivity for Vimentin, desmin, SMA, calponin, CD34, ER, PR and AR, whereas pan-keratin, keratin 7, keratin 34βE12, keratin 5/6, EMA, p63 and S100 were negative. RB1 was abnormally negative, confirming the diagnosis of epithelioid MFB. Making a correct diagnosis is primarily dependent on awareness by the pathologist of this unusual variant of MFB and careful integration of clinicopathologic findings to avoid potential diagnostic pitfalls.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/10668969221076547
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2070102-0
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  • 9
    Online Resource
    Online Resource
    In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations
    SAGE Publications ; 2012
    In:  Antiviral Therapy Vol. 17, No. 5 ( 2012-07), p. 793-803
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 17, No. 5 ( 2012-07), p. 793-803
    Abstract: HBV infection continues to be an important worldwide cause of morbidity and mortality. Patients with chronic hepatitis B can be successfully treated using nucleoside/nucleotide analogues. However, drug-resistant HBV mutants frequently arise, leading to treatment failure and progression to liver disease. Here, we report the effects of GLS4, a non-nucleosidic inhibitor that exhibits a novel and highly specific anti-HBV activity. Methods The median inhibitory concentrations (IC 50 s) of GLS4 on HBV were measured by Southern blotting. HBV capsid and core protein levels were detected by immunoblotting. To determine the antiviral activity of GLS4 against adefovir dipivoxil (ADV)-resistant HBV mutants, HepG2 cells transiently transfected with PUC-HBV1.2 plasmids that contained one of three major ADV-resistant mutations (rtA181T, rtA181V and rtN236T) were treated with GLS4. Intracellular HBV replicative intermediates were detected by Southern blotting. The effect on the in vitro assembly of HBV capsid protein was examined using dynamic light scattering and electron microscopy. Results The IC 50 of GLS4 was 0.012 μM, which is significantly lower than that of lamivudine (0.325 μM). Immunoblot analysis of HepG2.2.15 cells and transiently transfected HepG2 cells indicated that GLS4 treatment interfered with the formation of core particles (assembly). The ADV-resistant HBV mutant strains were also sensitive to GLS4. Upon examining the in vitro assembly of HBV core protein 149 by electron microscopy, increased aberrant particles were observed after GLS4 treatment. Conclusions GLS4 is a new and unique potential anti-HBV agent that possesses a different mechanism of action than existing therapeutic drugs.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP2152
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Depression at Baseline is an Independent Risk Factor for Cognitive Decline in Patients on Peritoneal Dialysis: A Multicenter Prospective Cohort Study
    SAGE Publications ; 2019
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 39, No. 5 ( 2019-09), p. 465-471
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 39, No. 5 ( 2019-09), p. 465-471
    Abstract: Depression has been recognized as a risk factor for cognitive impairment (CI) from cross-sectional datasets. This multicenter prospective study investigated the association between depression and cognitive decline in peritoneal dialysis (PD) patients. Methods This multicenter prospective cohort study included 458 PD patients who were followed up for 2 years. The Modified Mini-Mental State Examination (3MS) was used for assessment of global cognitive function, Trail-Making Tests A and B for executive function, subtests of the Battery for the Assessment of Neuropsychological Status for immediate and delayed memory, visuospatial skill, and language ability. Depression was assessed using Zung's Self-Rating Depression Scale. Results During the 2-year follow-up, patients with moderate/severe depression at baseline showed a significant decline in global cognitive function (80.5 ± 15.2 vs 76.6 ± 15.5, p = 0.008), while patients without depression or with mild depression kept a stable global cognitive function. In the meantime, patients without depression showed significant improvements in immediate memory, visuospatial skill, and language ability. However, no significant improvement in these parameters was shown in depression groups. In multivariable linear regression analysis, depression at baseline was a significant predictor of worsening global cognitive function, whether depression was analyzed as a continuous variable (odds ratio [OR] = -0.14, 95% confidence interval [CI] -0.27, -0.01, p = 0.031) or a rank variable (OR = -1.88, 95% CI -3.30, -0.45, p = 0.010). Moreover, higher depression score or more severe depression degradation was significantly associated with decline of immediate memory, delayed memory, and language skill. Conclusion Depression was a significant risk factor for worsening of CI in PD patients.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.3747/pdi.2018.00239
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2075957-5
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