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  • SAGE Publications  (5)
  • 1
    Online Resource
    Online Resource
    External validation of ABCD series scores for predicting early stroke events following transient ischemic attack in a large nationwide registry
    SAGE Publications ; 2022
    In:  European Stroke Journal Vol. 7, No. 4 ( 2022-12), p. 439-446
    Details
    In: European Stroke Journal, SAGE Publications, Vol. 7, No. 4 ( 2022-12), p. 439-446
    Abstract: In the context of modern guideline-based strategies, new validations of prognostic scores for predicting early stroke risk are needed. We aimed to compare the validity of the ABCD series scores and assess the incremental values of risk components for predicting in-hospital stroke events in patients with transient ischemic attack (TIA). Patients and methods: We abstracted data from the Chinese Stroke Center Alliance (CSCA), a nationwide registry with 68,433 TIA patients admitted within 7 days of symptom onset from 1476 hospitals. TIA was defined by time-based criteria according to the World Health Organization (WHO). The discrimination of ABCD, ABCD2, ABCD2-I, and ABCD3 scores for predicting in-hospital stroke events was assessed by the area under the receiver-operating characteristics curves (AUC). The incremental predictive values of added risk predictor were determined by net reclassification improvement (NRI) and integrated discrimination improvement (IDI). Results: A total of 29,286 TIA patients were included, of whom 1466 (5.0%) had in-hospital stroke events. Compared with ABCD2-I score (AUC 0.79, 95% confidence interval [CI] 0.77–0.80), ABCD (AUC 0.58, 95% CI 0.57–0.60), ABCD2 (AUC 0.58, 95% CI 0.56–0.59), and ABCD3 (AUC 0.58, 95% CI 0.56–0.60) had lower predictive utility. An incremental value was observed when adding infarction on DWI (IDI = 0.0597, NRI = 1.1036) into ABCD2 score to be ABCD2-I. Conclusion: The traditional scales utilizing medical history (ABCD, ABCD2, and ABCD3 scores) show fair ability for predicting in-hospital stroke events after TIA, but the ABCD2-I score, which adds infarction on DWI, improves the predictive ability.
    Type of Medium: Online Resource
    ISSN: 2396-9873 , 2396-9881
    URL: Article
    DOI: 10.1177/23969873221113145
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2851287-X
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    Online Resource
  • 2
    Online Resource
    Online Resource
    The Practice and Innovation of General Education at University of Maryland: A Case Study
    SAGE Publications ; 2013
    In:  International Journal of Chinese Education Vol. 2, No. 1 ( 2013-01), p. 9-30
    Details
    In: International Journal of Chinese Education, SAGE Publications, Vol. 2, No. 1 ( 2013-01), p. 9-30
    Abstract: Universities in the U. S. have adopted new curriculum to meet changes in the world. But how bold is the change, and how expanded is the reform vary by institutions. In this article, we look at the new curriculum for general education at the University of Maryland as a case study. We will first conduct a review of literature, which provides readers with an overview of the evolvement of general education and how it leads to the current types of reforms. We then present the reform at the University of Maryland, highlighting some key changes such as the addition of the I-Series courses, to illustrate the depth and breadth in reform in general education, and finally we reflect on the innovation and challenges of the reform.
    Type of Medium: Online Resource
    ISSN: 2212-5868 , 2212-5868
    URL: Article
    DOI: 10.1163/22125868-12340011
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2700727-3
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  • 3
    Online Resource
    Online Resource
    Hard return: the development and transformation process of social participation in stroke survivors; a qualitative study and initial theory
    SAGE Publications ; 2020
    In:  Clinical Rehabilitation Vol. 34, No. 6 ( 2020-06), p. 824-836
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 34, No. 6 ( 2020-06), p. 824-836
    Abstract: Given the characteristic of high disability rates, the successful return of stroke patients to society is increasingly becoming a serious challenge. This study aimed developing a theory to reveal the development and transformation process of social participation among stroke survivors as a foundation for creating strategies to improve their social participation. Design: A constructivist grounded theory approach using data from in-depth semi-structure interviews. Setting: The settings were various, including the stroke follow-up clinic, rehabilitation institutions, subjects’ homes, park, work unit, and rest home in Shanghai, China. Subjects: In all, 36 stroke survivors who have passed through the acute phase and returned home participated in this study to share their experiences of social participation and processes of changes from September 2017 to January 2019. Results: A substantive theory on the development and transformation process of social participation among stroke survivors was generated, which included four process ingredients: “in-orbit,” “off-orbit,” “returning orbit,” and “in-orbit again.” The core concept “hard return” revealed not only the tough development process but also the unsatisfactory change results. Both participation abilities and participation willingness had an important impact on social participation and also played a significant role in driving its development. Conclusion: This study has identified the development process of social participation in stroke survivors and “hard-return” suggests not only the tough process but also unsatisfactory results. Interventions targeted process ingredients seem to be potentially promising to improve stroke survivors’ social function outcomes.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215520917191
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2028323-4
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  • 4
    Online Resource
    Online Resource
    Video-Assisted Modified Left Sympathectomy for Long-QT Syndrome
    SAGE Publications ; 2000
    In:  Asian Cardiovascular and Thoracic Annals Vol. 8, No. 1 ( 2000-03), p. 52-53
    Details
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 8, No. 1 ( 2000-03), p. 52-53
    Abstract: A 22-year-old female suffering from idiopathic long-QT syndrome complicated by frequent syncope, torsade-de-pointes-type ventricular tachycardia, and asthma, was successfully treated by video-assisted extensive left second and third thoracic sympathetic ganglionectomy, instead of left stellate and first thoracic ganglio-nectomy, to avoid postoperative Horner's syndrome. The QT interval was significantly shortened from 0.6 to 0.43 seconds four days after the surgery. It remained at 0.43 seconds during a 3-month follow-up with no recurrence of tachycardia or syncope.
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    URL: Article
    DOI: 10.1177/021849230000800114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2044527-1
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  • 5
    Online Resource
    Online Resource
    Protective effect of additional cathelicidin antimicrobial peptide PR-39 on prosthetic-joint infections
    SAGE Publications ; 2023
    In:  Journal of Orthopaedic Surgery Vol. 31, No. 2 ( 2023-05), p. 102255362311752-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 31, No. 2 ( 2023-05), p. 102255362311752-
    Abstract: Prosthetic-joint infection (PJI) is one of the severest complications after arthroplasty. However, antibiotics are not effective in the bacteria in biofilm outside the prosthetic-joint. Antimicrobial peptides have an efficient antimicrobial activity in staphylococcus aureus compared with conventional antibiotics. Methods Bone marrow stem cells (BMSCs) were isolated, cultured and transfected with cathelicidins antimicrobial peptides proline-arginine-rich 39 amino acid peptide (PR-39) lentivirus. The expression of PR-39 gene in BMSCs was detected by RT-PCR, and the antibacterial activity of PR-39 was measured by agar diffusion method. The transfection efficiency was detected by fluorescence microscopy. The infection model of artificial knee joint in rabbits were established. Kirschner wire was used as the knee joint implant to implant the distal femur through the femoral intercondylar fossa of rabbits. 24 rabbits were randomly divided into 2 groups for the above operations: group A was inoculated 0.5 mL into the joint cavity immediately after the incision was sutured 1 × 10 7 Staphylococcus aureus of colony forming unit (CFU), group B was inoculated with Staphylococcus aureus and PR-39. After operation, the wound conditions and histological changes were observed by X-ray and optical microscope respectively, CRP and erythrocyte sedimentation rate were measured by test assay. Results The transfection efficiency of lentivirus vectortransfected BMSCs was 74.09%. The supernatant of lentivirus vector had obvious inhibitory effect on Staphylococcus aureus, and the antibacterial rate was 98.43%. 100% infection observed in group A while few infection observed in group B; serum CRP and ESR at a high level in group A while decreased in group B after operation. There were no significant difference in CRP and ESR between the pLV/PR-39 group and pLV/EGFP group at day 1 and 3 respectively after surgery. However, CRP and ESR in the pLV/PR-39 groupwere significantly lower than the pLV/EGFP group at day 7 and 14 respectively after operation. Conclusions Rabbits planted BMSCs expressing PR-39 were significantly increased resistance to Staphylococcus aureus in PJI than control group thus showing great potential for preventing implant-associated infection. It will provide a potential new therapeutic agent for implant-associated infection.
    Type of Medium: Online Resource
    ISSN: 1022-5536 , 2309-4990
    URL: Article
    DOI: 10.1177/10225536231175237
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2128854-9
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