GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    A quick and accurate method for the estimation of covariate effects based on empirical Bayes estimates in mixed-effects modeling: Correction of bias due to shrinkage
    SAGE Publications ; 2019
    In:  Statistical Methods in Medical Research Vol. 28, No. 12 ( 2019-12), p. 3568-3578
    Details
    In: Statistical Methods in Medical Research, SAGE Publications, Vol. 28, No. 12 ( 2019-12), p. 3568-3578
    Abstract: Nonlinear mixed-effects modeling is a popular approach to describe the temporal trajectory of repeated measurements of clinical endpoints collected over time in clinical trials, to distinguish the within-subject and the between-subject variabilities, and to investigate clinically important risk factors (covariates) that may partly explain the between-subject variability. Due to the complex computing algorithms involved in nonlinear mixed-effects modeling, estimation of covariate effects is often time-consuming and error-prone owing to local convergence. We develop a fast and accurate estimation method based on empirical Bayes estimates from the base mixed-effects model without covariates, and simple regressions outside of the nonlinear mixed-effect modeling framework. Application of the method is illustrated using a pharmacokinetic dataset from an anticoagulation drug for the prevention of major cardiovascular events in patients with acute coronary syndrome. Both the application and extensive simulations demonstrated that the performance of this high-throughput method is comparable to the commonly used maximum likelihood estimation in nonlinear mixed-effects modeling.
    Type of Medium: Online Resource
    ISSN: 0962-2802 , 1477-0334
    URL: Article
    DOI: 10.1177/0962280218812595
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2001539-2
    detail.hit.zdb_id: 1136948-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    From Strength-Based Parenting to Subjective Well-Being of College Students: A Chain Mediating Role of Personal Growth Initiative and Strengths Use
    SAGE Publications ; 2023
    In:  Psychological Reports
    Details
    In: Psychological Reports, SAGE Publications
    Abstract: Previous research demonstrated a positive relationship between strength-based parenting (SBP) and subjective well-being (SWB). However, the underlying mechanisms still need further research. Based on the social cognitive theory and developmental assets framework, we investigated the influence of SBP on college students’ SWB through the mediating role of personal growth initiative (PGI) and strengths use. A total of 621 Chinese college students were recruited. Participants completed self-report scales about the SBP, PGI, strengths use and SWB. The results showed that SBP had a positive impact on college students’ SWB. On the one hand, PGI and strengths use mediated the above relationship respectively. On the other hand, SBP influenced SWB through the chain mediating effect of PGI and strengths use. The findings indicate that exploring the relationship between SBP and SWB has positive implications for family education and youth development.
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.1177/00332941231181656
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
    SAGE Publications ; 2018
    In:  Cell Transplantation Vol. 27, No. 2 ( 2018-02), p. 310-324
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 27, No. 2 ( 2018-02), p. 310-324
    Abstract: Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”. The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689717746999
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2020466-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Efficient algorithms for survival data with multiple outcomes using the frailty model
    SAGE Publications ; 2023
    In:  Statistical Methods in Medical Research Vol. 32, No. 1 ( 2023-01), p. 118-132
    Details
    In: Statistical Methods in Medical Research, SAGE Publications, Vol. 32, No. 1 ( 2023-01), p. 118-132
    Abstract: Survival data with multiple outcomes are frequently encountered in biomedical investigations. An illustrative example comes from Alzheimer’s Disease Neuroimaging Initiative study where the cognitively normal subjects may clinically progress to mild cognitive impairment and/or Alzheimer’s disease dementia. Transition time from normal cognition to mild cognitive impairment and that from mild cognitive impairment to Alzheimer’s disease are expected to be correlated within subjects and the dependence is often accommodated by the frailty (random effects). Estimation in the frailty model unavoidably involves multiple integrations which may be intractable and hence leads to severe computational challenges, especially in the presence of high-dimensional covariates. In this paper, we propose efficient minorization–maximization algorithms in the frailty model for survival data with multiple outcomes. The alternating direction method of multipliers is further incorporated for simultaneous variable selection and homogeneity pursuit via regularization and fusion. Extensive simulation studies are conducted to assess the performance of the proposed algorithms. An application to the Alzheimer’s Disease Neuroimaging Initiative data is also provided to illustrate their practical utilities.
    Type of Medium: Online Resource
    ISSN: 0962-2802 , 1477-0334
    URL: Article
    DOI: 10.1177/09622802221133554
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2001539-2
    detail.hit.zdb_id: 1136948-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    armDNA: A functional beta model for detecting age-related genomewide DNA methylation marks
    SAGE Publications ; 2018
    In:  Statistical Methods in Medical Research Vol. 27, No. 9 ( 2018-09), p. 2627-2640
    Details
    In: Statistical Methods in Medical Research, SAGE Publications, Vol. 27, No. 9 ( 2018-09), p. 2627-2640
    Abstract: DNA methylation has been shown to play an important role in many complex diseases. The rapid development of high-throughput DNA methylation scan technologies provides great opportunities for genomewide DNA methylation-disease association studies. As methylation is a dynamic process involving time, it is quite plausible that age contributes to its variation to a large extent. Therefore, in analyzing genomewide DNA methylation data, it is important to identify age-related DNA methylation marks and delineate their functional relationship. This helps us to better understand the underlying biological mechanism and facilitate early diagnosis and prognosis analysis of complex diseases. We develop a functional beta model for analyzing DNA methylation data and detecting age-related DNA methylation marks on the whole genome by naturally taking sampling scheme into account and accommodating flexible age-methylation dynamics. We focus on DNA methylation data obtained through the widely used bisulfite conversion technique and propose to use a beta model to relate the DNA methylation level to the age. Adjusting for certain confounders, the functional age effect is left completely unspecified, offering great flexibility and allowing extra data dynamics. An efficient algorithm is developed for estimating unknown parameters, and the Wald test is used to detect age-related DNA methylation marks. Simulation studies and several real data applications were provided to demonstrate the performance of the proposed method.
    Type of Medium: Online Resource
    ISSN: 0962-2802 , 1477-0334
    URL: Article
    DOI: 10.1177/0962280216683571
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2001539-2
    detail.hit.zdb_id: 1136948-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    The efficacy and safety of fluticasone propionate/formoterol compared with fluticasone propionate/salmeterol in treating pediatric asthma: a systematic review and meta-analysis
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 3 ( 2020-03), p. 030006051988944-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 3 ( 2020-03), p. 030006051988944-
    Abstract: To evaluate the efficacy and safety of fluticasone propionate/formoterol (FP/FORM) versus fluticasone propionate/salmeterol (FP/SAL) in treating pediatric asthma during a 12-week treatment cycle. Methods Randomized controlled trials of FP/FORM compared with FP/SAL in treating pediatric asthma were searched systematically using Medline, Embase, and the Cochrane Controlled Trials Register. Results Two articles including 546 patients were evaluated. The FP/SAL group showed obvious improvements in pre-dose forced expiratory volume in 1 s (FEV 1 ) from day 0 to 84, asthma symptom scores, and sleep disturbance scores compared with the FP/FORM group; however, the FP/FORM group had improved peak expiratory flow rate (PEFR). In terms of 2-hour post-dose FEV 1 from day 0 to 84, 2-hour forced expiratory flow at 25%, 50%, and 75%, and 2-hour forced vital capacity, we observed no significant differences between the two groups. For safety, including patients with at least one adverse event, bronchitis, cough, or pharyngitis, both groups had similar incidences, differing only in incidence of nasopharyngitis. Conclusion Compared with FP/FORM, FP/SAL showed a clear improvement in pre-dose FEV 1 , asthma symptom scores, and sleep disturbance scores. However, FP/FORM resulted in improved PEFR with a lower incidence of nasopharyngitis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060519889442
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Extracting fiber length distributions from dual-beard fibrographs with the Levenberg–Marquardt algorithm
    SAGE Publications ; 2020
    In:  Textile Research Journal Vol. 90, No. 1 ( 2020-01), p. 37-48
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 90, No. 1 ( 2020-01), p. 37-48
    Abstract: Fiber length is a critical cotton fiber property that impacts yarn strength, yarn evenness, and ultimately fabric strength and appearance. In this paper, a new fiber fibrograph method was presented for accurate measurements of fiber length distributions (FLDs). The method, called the dual-beard fibrograph (DBF), was based on the transmission image of a combed sample with two tapered fiber ends/beards, and the approximation of the fibrograph with a series of triangular base functions. A desktop scanner was used to generate the transmission image of a dual-beard sample, and essential image-processing algorithms were utilized to mitigate image differences originating from variations in the scanning condition (e.g., brightness, resolution) and the sample condition (e.g., weight, orientation). The fibrograph approximation was implemented by minimizing a cost function that contains the sum of squared errors between the DBF and the ensemble of the weighted triangular base functions, and the regularization term that stabilizes the optimization with the Levenberg–Marquardt algorithm. The minimization eventually determined the optimal weights of the triangular base functions, which defined the FLDs of the scanned image. Important length measurements currently used in the industry can be easily calculated from the FLD. It was found that the DBF could correctly detect fiber lengths cut from 5 to 10 mm, respectively, and it could measure the short fiber content change after a known number of short fibers was added to an existing sample. When compared with an existing fiber testing instrument, the DBF was able to output more reasonable cotton length distributions.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/0040517519858762
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2209596-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Reference values of glomerular filtration rate for healthy adults in southern China: a cross-sectional survey
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Chronic Disease Vol. 12 ( 2021-01), p. 204062232110352-
    Details
    In: Therapeutic Advances in Chronic Disease, SAGE Publications, Vol. 12 ( 2021-01), p. 204062232110352-
    Abstract: Currently the global data on the glomerular filtration rate of healthy adults are insufficient, with relatively little data for other races and countries. Especially in China, there are no such figures. Methods: In this cross-sectional study, we included healthy Han adults in southern China. Participants completed a lifestyle and medical history questionnaire and had their blood pressure measured, and blood and urine samples collected. Serum creatinine was measured and used to estimated glomerular filtration rate (eGFR) by the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulae. The normal range of eGFR is described, and the influence of gender and age on eGFR is analyzed by the statistical method. Results: We provided the largest sample size of eGFR research in China at present. The mean age of the 20,930 healthy individuals was 40.9 ± 12.3 years, 58.8% were women. The eGFR MDRD for women and men were 111.3 ± 17.4 mL/min per 1.73 m 2 and 103.3 ± 15.9 mL/min per 1.73 m 2 , respectively. The eGFR CKD-EPI for women and men were 110.3 ± 12.1 mL/min per 1.73 m 2 and 103.8 ± 13.3 mL/min per 1.73 m 2 , respectively. The eGFR MDRD of women and men in all age groups decreased continuously by 7.3 ml/min/1.73 m 2 /decade and 4.4 ml/min/1.73 m 2 /decade, respectively. The eGFR CKD-EPI of women and men in all age groups decreased continuously by 8.4 ml/min/1.73 m 2 /decade and 6.9 ml/min/1.73 m 2 /decade. Conclusions: The eGFR of women is higher than men and with the increasing age, the eGFR of women declines faster than men.
    Type of Medium: Online Resource
    ISSN: 2040-6223 , 2040-6231
    URL: Article
    DOI: 10.1177/20406223211035287
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2554816-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Transplantation of Pro-Oligodendroblasts, Preconditioned by LPS-Stimulated Microglia, Promotes Recovery after Acute Contusive Spinal Cord Injury
    SAGE Publications ; 2016
    In:  Cell Transplantation Vol. 25, No. 12 ( 2016-12), p. 2111-2128
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 25, No. 12 ( 2016-12), p. 2111-2128
    Abstract: Spinal cord injury (SCI) is a significant clinical challenge, and to date no effective treatment is available. Oligodendrocyte progenitor cell (OPC) transplantation has been a promising strategy for SCI repair. However, the poor posttransplantation survival and deficiency in differentiation into myelinating oligodendrocytes (OLs) are two major challenges that limit the use of OPCs as donor cells. Here we report the generation of an OL lineage population [i.e., pro-oligodendroblasts (proOLs)] that is relatively more mature than OPCs for transplantation after SCI. We found that proOLs responded to lipopolysaccharide (LPS)-stimulated microglia conditioned medium (L + M) by preserving toll-like receptor 4 (TLR4) expression, improving cell viability, and enhancing the expression of a myelinating OL marker myelin basic protein (MBP), compared to other OL lineage cells exposed to either LPS-stimulated (L + M) or nonstimulated microglia conditioned medium (L - M). When L + M-stimulated proOLs were intrathecally delivered through a lumbar puncture after a T10 thoracic contusive SCI, they promoted behavioral recovery, as assessed by the Basso–Beattie–Bresnahan (BBB) locomotor rating scale, stride length, and slips on the grid tests. Histologically, transplantation of L + M proOLs caused a considerable increase in intralesional axon numbers and myelination, and less accumulation of invading macrophages when compared with the vehicle control or OPC transplantation. Thus, transplantation of proOLs, preconditioned by L + M, may offer a better therapeutic potential for SCI than OPCs since the former may have initiated the differentiation process toward OLs prior to transplantation.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368916X692636
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2020466-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Fiber-Content Measurement of Wool–Cashmere Blends Using Near-Infrared Spectroscopy
    SAGE Publications ; 2017
    In:  Applied Spectroscopy Vol. 71, No. 10 ( 2017-10), p. 2367-2376
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 71, No. 10 ( 2017-10), p. 2367-2376
    Abstract: Cashmere and wool are two protein fibers with analogous geometrical attributes, but distinct physical properties. Due to its scarcity and unique features, cashmere is a much more expensive fiber than wool. In the textile production, cashmere is often intentionally blended with fine wool in order to reduce the material cost. To identify the fiber contents of a wool–cashmere blend is important to quality control and product classification. The goal of this study is to develop a reliable method for estimating fiber contents in wool–cashmere blends based on near-infrared (NIR) spectroscopy. In this study, we prepared two sets of cashmere–wool blends by using either whole fibers or fiber snippets in 11 different blend ratios of the two fibers and collected the NIR spectra of all the 22 samples. Of the 11 samples in each set, six were used as a subset for calibration and five as a subset for validation. By referencing the NIR band assignment to chemical bonds in protein, we identified six characteristic wavelength bands where the NIR absorbance powers of the two fibers were significantly different. We then performed the chemometric analysis with two multilinear regression (MLR) equations to predict the cashmere content (CC) in a blended sample. The experiment with these samples demonstrated that the predicted CCs from the MLR models were consistent with the CCs given in the preparations of the two sample sets (whole fiber or snippet), and the errors of the predicted CCs could be limited to 0.5% if the testing was performed over at least 25 locations. The MLR models seem to be reliable and accurate enough for estimating the cashmere content in a wool–cashmere blend and have potential to be used for tackling the cashmere adulteration problem.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1177/0003702817713480
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1474251-2
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...