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  • SAGE Publications  (7)
  • 1
    Online Resource
    Online Resource
    A Conductive Hydrogel by Poly(Sodium Acrylate)/Montmorillonite Superabsorbent Composite
    SAGE Publications ; 2007
    In:  Polymers and Polymer Composites Vol. 15, No. 1 ( 2007-01), p. 29-33
    Details
    In: Polymers and Polymer Composites, SAGE Publications, Vol. 15, No. 1 ( 2007-01), p. 29-33
    Abstract: Poly(sodium acrylate)/montmorillonite superabsorbent composite was synthesised by an inverse suspension polymerisation method. A novel hydrogel electrolyte with conductivity of 100 mS·cm −1 was prepared by immersing the superabsorbent composite in 1 M KCl aqueous solution. The conductivity of the hydrogel electrolyte was investigated, and it was found that the hydrogel electrolyte exhibits liquid-like ionic conductivity. The conductivity depends mainly on the ionic intensity of the solution in which it is immersed and on the water absorbency of the superabsorbent.
    Type of Medium: Online Resource
    ISSN: 0967-3911 , 1478-2391
    URL: Article
    DOI: 10.1177/096739110701500104
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2099644-5
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  • 2
    Online Resource
    Online Resource
    Synthesis and Application of Novel Multi-arm Poly(carboxylic acid)s for Glass-ionomer Restoratives
    SAGE Publications ; 2010
    In:  Journal of Biomaterials Applications Vol. 24, No. 5 ( 2010-01), p. 419-436
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 24, No. 5 ( 2010-01), p. 419-436
    Abstract: We have developed a novel glass-ionomer cement system composed of multi-arm poly(acrylic acid-co-itaconic acid)s. These polyacids were synthesized via a chain-transfer polymerization reaction using newly synthesized multi-arm chain-transfer agents. The cements formulated with the multi-arm polyacids showed significantly lower viscosities in water as compared to those formulated with the linear polyacids. Due to the lower viscosities, the MW of the polyacids can be significantly increased for enhanced mechanical strengths, while keeping the ease of mixing and handling. The experimental cements showed significantly improved compressive strengths as compared to Fuji II after aged in water for 3 months.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328208098593
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    In Situ Curable Alpha-hydroxyacid Based Degradable Polymer Composites for Injectable Biomedical Applications
    SAGE Publications ; 2008
    In:  Journal of Composite Materials Vol. 42, No. 14 ( 2008-07), p. 1385-1400
    Details
    In: Journal of Composite Materials, SAGE Publications, Vol. 42, No. 14 ( 2008-07), p. 1385-1400
    Abstract: In Situ polymerizable liquid degradable oligomeric polyesters based upon alpha-hydroxyacids were synthesized and characterized. Injectable and in situ curable composites formulated with these oligomeric polyesters and bioabsorble beta-tricalcium phosphate, were prepared at room temperature using the redox-initiation system. The results show that increasing glycolic acid/l-lactic acid molar ratio increased the initial compressive and diametral tensile strengths and curing time but decreased the degree of conversion. Increasing molecular weight of oligomeric polyesters decreased the initial strengths, exotherm and conversion but increased the curing time. Increasing the number of initiator arm decreased the initial strengths and curing time but increased the exotherm and conversion. During the course of degradation, all the materials showed a burst degradation behavior within 24 h, followed by an increase in strength. The degradation rate is found to be dependant upon the molar ratio, molecular weight of oligomeric polyester, number of initiator arm and type of comonomer.
    Type of Medium: Online Resource
    ISSN: 0021-9983 , 1530-793X
    URL: Article
    DOI: 10.1177/0021998308092215
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 160490-9
    detail.hit.zdb_id: 2081924-9
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  • 4
    Online Resource
    Online Resource
    Application of High-Throughput Sequencing in the Diagnosis of Inherited Thrombocytopenia
    SAGE Publications ; 2018
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 24, No. 9_suppl ( 2018-12), p. 94S-103S
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 24, No. 9_suppl ( 2018-12), p. 94S-103S
    Abstract: Inherited thrombocytopenia is a group of hereditary diseases with a reduction in platelet count as the main clinical manifestation. Clinically, there is an urgent need for a convenient and rapid diagnosis method. We introduced a high-throughput, next-generation sequencing (NGS) platform into the routine diagnosis of patients with unexplained thrombocytopenia and analyzed the gene sequencing results to evaluate the value of NGS technology in the screening and diagnosis of inherited thrombocytopenia. From a cohort of 112 patients with thrombocytopenia, we screened 43 patients with hereditary features. For the blood samples of these 43 patients, a gene sequencing platform for hemorrhagic and thrombotic diseases comprising 89 genes was used to perform gene detection using NGS technology. When we combined the screening results with clinical features and other findings, 15 (34.9%) of 43patients were diagnosed with inherited thrombocytopenia. In addition, 19 pathogenic variants, including 8 previously unreported variants, were identified in these patients. Through the use of this detection platform, we expect to establish a more effective diagnostic approach to such disorders.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029618790696
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2230591-9
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  • 5
    Online Resource
    Online Resource
    Numerical investigation of clocking effect on unsteady fluid flow in vicinity of tongue for centrifugal pump with vaned diffuser
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, SAGE Publications
    Abstract: In order to investigate the clocking effect on unsteady flow distortion in the vicinity of the tongue and hydraulic loss in the volute, experiments and numerical simulations were conducted with four different relative angular positions between the vane and tongue. Numerical results were validated against experimental data, which included measurements of pressure pulsation at the tongue and downstream of the tongue. The radial and circumferential velocities near the tongue at the diffuser-volute clearance were depicted by expanding the rotating surface, and comparisons were made under different diffuser positions to reveal the flow distortion affected by the clocking effect. Shear stress rates and total pressure distributions at the volute exit pipe were also depicted to study the flow loss in the volute affected by the flow pattern from the tongue. The findings show that the pressure fluctuation at the tongue and downstream of the tongue is significantly affected by the diffuser mounting position. The amplitude and intensity of pressure pulsation under θ d1 are clearly smaller than those at other diffuser positions. As the vane trailing edge approaches the tongue, the pressure gradient becomes very large, leading to the formation of a vortex at the tongue that promotes crowding effects and reverse flow occurring in the exit pipe. This, in turn, leads to deflection of the main flow in the volute, high velocity gradients, and subsequently large shear stress rates and hydraulic losses. When the diffuser is installed at θ d4 , the flow distortion and flow loss are improved.
    Type of Medium: Online Resource
    ISSN: 0957-6509 , 2041-2967
    URL: Article
    DOI: 10.1177/09576509231204026
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024892-1
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  • 6
    Online Resource
    Online Resource
    SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury
    SAGE Publications ; 2023
    In:  Innate Immunity Vol. 29, No. 1-2 ( 2023-01), p. 25-34
    Details
    In: Innate Immunity, SAGE Publications, Vol. 29, No. 1-2 ( 2023-01), p. 25-34
    Abstract: M1/M2 macrophage polarization plays a pivotal role in the development of acute lung injury (ALI). The hypoxia-inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis, which functions upstream of macrophage polarization, has been implicated in this process. The function of HIF-1α is known to be tightly regulated by SUMOylation. Upregulation of SUMO-specific peptidase 3 (SENP3), a deSUMOylation enzyme, is induced by reactive oxygen species (ROS), which are abundantly produced during ALI. To explore the links between SENP3, macrophage polarization, and lung injury, we used mice with Senp3 conditional knockout in myeloid cells. In the lipopolysaccharide (LPS)-induced ALI model, we found that in vitro and in vivo SENP3 deficiency markedly inhibited M1 polarization and production of pro-inflammatory cytokines and alleviated lung injury. Further, we demonstrated that SENP3 deficiency suppressed the LPS-induced inflammatory response through PKM2 in a HIF-1α-dependent manner. Moreover, mice injected with LPS after PKM2 inhibitor (shikonin) treatment displayed inhibition of M1 macrophage polarization and reduced lung injury. In summary, this work revealed that SENP3 promotes M1 macrophage polarization and production of proinflammatory cytokines via the HIF-1α/PKM2 axis, contributing to lung injury; thus, SENP3 may represent a potential therapeutic target for ALI treatment.
    Type of Medium: Online Resource
    ISSN: 1753-4259 , 1753-4267
    URL: Article
    DOI: 10.1177/17534259231166212
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2381250-3
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  • 7
    Online Resource
    Online Resource
    Synthesis, structure, properties and a theoretical study of [ZnCl 2 (4,4'-bipy)] n
    SAGE Publications ; 2009
    In:  Journal of Chemical Research Vol. 2009, No. 1 ( 2009-01), p. 38-40
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2009, No. 1 ( 2009-01), p. 38-40
    Abstract: The compound [ZnCl 2 (4,4'-bipy)] n , has been synthesised via hydrothermal reaction and structurally characterised. It crystallises in the space group Cc of the monoclinic system: a = 15.883(5), b = 25.656(5), c = 14.642(6) Å, β = 110.321(4)°, V = 5595(3) Å 3 , C 10 H 8 Cl 2 N 2 Zn, M r = 292.45 g mol −1 , D c = 1.736 g cm −3 , S = 1.003, μ(Mo Kα) = 2.636 mm −1 , F(000) = 2920, R = 0.0471 and wR = 0.0946. The complex has a one-dimensional zigzag chain-like structure. Photoluminescent investigation reveals that it displays a strong emission in the purple region and molecular orbital (MO) calculation indicates that the emission originates from the ligand-to-ligand charge-transfer (LLCT) transition.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/030823409X393718
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 3010810-X
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