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  • SAGE Publications  (11)
  • 1
    Online Resource
    Online Resource
    Effects of Center-Based Delivery of Tai Chi and Qi Gong Group Classes on Self-Reported Symptoms in Cancer Patients and Caregivers
    SAGE Publications ; 2020
    In:  Integrative Cancer Therapies Vol. 19 ( 2020-01), p. 153473542094160-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 19 ( 2020-01), p. 153473542094160-
    Abstract: Background: There is increasing interest in complementary approaches such as Tai Chi (TC) and Qi Gong (QG) in oncology settings. We explored the effects of TC/QG delivered in group classes at a comprehensive cancer center. Methods: Patients and caregivers who participated in TC or QG completed assessments before and after an in-person group class. Assessments included questions about expectancy/satisfaction and common cancer symptoms (Edmonton Symptom Assessment Scale [ESAS]). ESAS distress subscales analyzed included global (GDS), physical (PHS), and psychosocial (PSS). Results: Three hundred four participants (184 patients, 120 caregivers) were included in the analysis. At baseline, caregivers had a greater expectancy for change in energy level as a result of class participation compared with patients (22.9% vs 9.9%). No significant difference was observed between baseline patient and caregiver PSS. Clinically significant improvement in well-being was observed among patients in TC classes (1.0) and caregivers in QG classes (1.2). For fatigue, patients (1.4) and caregivers (1.0) participating in QG experienced clinically significant improvement. Both TC and QG classes were associated with clinically significant improvements (ESAS GDS decrease ≥3) in global distress for patients (TC = 4.52, SD= 7.6; QG = 6.05, SD = 7.9) and caregivers (TC = 3.73, SD = 6.3; QG = 4.02, SD = 7.8). Eighty-nine percent of participants responded that their expectations were met. Conclusions: Patients and caregivers participating in TC or QG group classes were satisfied overall and experienced significant improvement in global distress. Additional research is warranted to explore the integration of TC and QG in the delivery of supportive cancer care.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735420941605
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2101248-9
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  • 2
    Online Resource
    Online Resource
    Randomized Feasibility Study of Meditative Practices in Hospitalized Cancer Patients
    SAGE Publications ; 2020
    In:  Integrative Cancer Therapies Vol. 19 ( 2020-01), p. 153473542090990-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 19 ( 2020-01), p. 153473542090990-
    Abstract: Introduction: There is limited research regarding the benefits of mind-body practices such as meditation in hospitalized patients with an active diagnosis of any cancer type. Methods: We conducted a prospective, randomized, clinical trial (NCT03445572) comparing 2 meditative practices—Isha Kriya (IK) and meditative slow breathing (MSB)—versus wait-list controls in hospitalized cancer patients. Our aim was to determine the feasibility of meditation practice in cancer inpatients. Feasibility was defined as recruitment of more than 50% of the eligible patients approached and at least 60% of the patients having meditated at least 4 days by day 7. Acceptability was assessed on day 7 as a positive response on at least 2 questions on the modified Global Symptom Evaluation (GSE) scale. Results: Forty patients (39% of the eligible patients approached) consented to participate in the study and were randomly assigned to the MSB (n = 13), IK (n = 14), or wait-list (n = 13) groups. Of the 27 patients assigned to receive MSB and IK meditations, day 7 data were available for 18 patients. Fifteen of the 18 patients meditated at least once in the first 7 days, and most (12/15) responded positively on the GSE. Conclusion: Both IK and MSB meditations were acceptable among the hospitalized cancer patients. Feasibility for enrollment and practice was likely not achieved due to limited uninterrupted time for daily meditation, high levels of morbidity in some participants, and limited research staff support. Shorter term outcomes should be explored in future meditation studies involving hospitalized cancer patients.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735420909903
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2101248-9
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  • 3
    Online Resource
    Online Resource
    Mechanical and failure characteristics of rock-like material with multiple crossed joint sets under uniaxial compression
    SAGE Publications ; 2017
    In:  Advances in Mechanical Engineering Vol. 9, No. 7 ( 2017-07), p. 168781401770871-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 9, No. 7 ( 2017-07), p. 168781401770871-
    Abstract: The strength and deformation of rock masses transected by persistent joints are controlled by the fracture network. In this work, bonded particle model modeled by particle flow code in three dimensions was used to study the effect of geometry parameters on the strength and behavior of jointed rock masses under uniaxial compression. The effect of the number of crossed joint sets, joint orientation, and joint spacing on the uniaxial compressive strength was investigated, and this article presents the results of the numerical simulations. Rigorous validation process had done before the numerical experiments. Four types of blocks (Series A, B, C, and D) with different numbers of joint sets were considered in this article. Then, a sensitivity study is undertaken to investigate the effects of joint set numbers and joint geometry configuration on the failure mode, unconfined compressive strength, and Young’s modulus of jointed rock mass. The interaction among the crossed joint sets was found to have marked effects on the mechanical properties and failure modes. A study about the effects of joint spacing on the failure modes, unconfined compressive strength, and Young’s modulus was also conducted. Joint spacing was found to have no significant effect on the failure modes of jointed rock masses in a certain range. It is also shown that the range and variance of unconfined compressive strength are affected principally by joint set numbers and decreased slightly with the decrease in joint spacing. The effect of crossed joint sets on the stress field was carried out. Stress concentration was found to be the reason for relatively lower strength of blocks with crossed joint sets compared to the block with the same weakest single joint set. The result in this article is of great help to reveal the mechanism of damage and fracture of jointed rocks under uniaxial compression.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814017708710
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2501620-9
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  • 4
    Online Resource
    Online Resource
    Hypoxia-Inducible Factor-1α Accumulation in the Brain after Experimental Intracerebral Hemorrhage
    SAGE Publications ; 2002
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 22, No. 6 ( 2002-06), p. 689-696
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 22, No. 6 ( 2002-06), p. 689-696
    Abstract: Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of HIF-1α and HIF-1β protein subunits, has been implicated in cellular protection and cell death in cerebral ischemia. The extent to which HIF-1 plays a role in brain pathology during intracerebral hemorrhage (ICH) is unknown. This study determined whether HIF-1α is upregulated at different time points in a rat model of ICH and the role of thrombin and red blood cell lysis in upregulation. Recently, thrombin has been implicated as a nonhypoxic regulator of HIF-1α in cultured smooth-muscle cells. Male Sprague-Dawley rats received intracerebral infusions of saline, autologous whole blood, blood plus hirudin, thrombin, thrombin plus hirudin, or lysed erythrocytes. Rats were killed at different time points for Western blot analysis, immunohistochemistry, immunofluorescent double staining, and reverse transcription polymerase chain reaction measurements of HIF-1α. HIF-1α protein levels increased without changing HIF-1α messenger RNA levels after intracerebral infusions of blood, thrombin, and lysed erythrocytes. HIF-1α positive cells, which proved to be neurons, were found in the brain after ICH. Hirudin, a specific thrombin inhibitor, reduced HIF-1α upregulation in response to both thrombin and blood. This study demonstrates that perihematomal HIF-1α protein is upregulated after ICH. This phenomenon is an early response of brain parenchyma to the clot. Thrombin and erythrocyte lysate are involved in HIF-1α upregulation through reducing HIF-1α degradation.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1097/00004647-200206000-00007
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2039456-1
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  • 5
    Online Resource
    Online Resource
    Thrombin-Receptor Activation and Thrombin-Induced Brain Tolerance
    SAGE Publications ; 2002
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 22, No. 4 ( 2002-04), p. 404-410
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 22, No. 4 ( 2002-04), p. 404-410
    Abstract: The authors previously found that pretreatment with a low dose of thrombin attenuates the brain edema induced by a large dose of thrombin or an intracerebral hemorrhage, and reduces infarct volume after focal cerebral ischemia (i.e., thrombin preconditioning). This study investigated whether thrombin preconditioning is caused by activation of the thrombin receptor, also called protease-activated receptor. In the in vivo studies, thrombin-induced brain tolerance was eliminated by RPPGF (Arg-Pro-Pro-Gly-Phe), a thrombin-receptor antagonist. Pretreatment with a thrombin-receptor agonist reduced the amount of edema induced by a large dose of thrombin infused into the ipsilateral basal ganglia 7 days later (81.3 ± 0.7% vs. 82.6 ± 0.8% in the control, P 〈 0.05). In the in vitro study, low doses of thrombin (1 or 2 U/mL) did not induce cell death. However, doses greater than 5 U/mL resulted in dose-dependent lactate dehydrogenase release ( P 〈 0.01). Thrombin and thrombin receptor-activating peptide preconditioning reduced lactate dehydrogenase release induced by a high dose of thrombin (10 and 20 U/mL), whereas RPPGF blocked the effect of thrombin preconditioning in vitro. Western blots indicated that p44/42 mitogen-activated protein kinases were activated after thrombin preconditioning. Finally, inhibition of p44/42 mitogen-activated protein kinases activation by PD98059 abolished the thrombin-preconditioning effect. Results indicate that thrombin-induced brain tolerance is in part achieved through activation of the thrombin receptor. Activation of the thrombin receptor in the brain may be neuroprotective. The protective effect of thrombin preconditioning is achieved through the p44/42 mitogen-activated protein kinase signal-transduction pathway.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1097/00004647-200204000-00004
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
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  • 6
    Online Resource
    Online Resource
    Research on crack initiation mechanism and fracture criterion of rock-type materials under compression–shear stress
    SAGE Publications ; 2017
    In:  Advances in Mechanical Engineering Vol. 9, No. 10 ( 2017-10), p. 168781401772008-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 9, No. 10 ( 2017-10), p. 168781401772008-
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814017720087
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2501620-9
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  • 7
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    Online Resource
    Case Study on Influence of Step Blast-Excavation on Support Systems of Existing Service Tunnel with Small Interval
    SAGE Publications ; 2013
    In:  Advances in Mechanical Engineering Vol. 5 ( 2013-01), p. 257457-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 5 ( 2013-01), p. 257457-
    Abstract: During the construction of newly built tunnel (NBT) adjacent to the existing service tunnel (EST), stability of the EST with small interval is affected by vibration waves which are caused by blasting load. The support structures of the EST will be cracked and damaged, while the unreasonable blast-excavation methods are adopted. Presently, the studies on behavior of support structure in the EST under blasting load are not totally clear, especially for the bolts system. Besides, the responses of support structure on blasting load are lacking comprehensive research. In this paper, New Zuofang tunnel is taken as a study case to study the influence of step blast-excavation in NBT on support structures of the EST through field experiment and numerical simulation. Some data, such as blasting vibration velocity (BVV) and frequency of support structures, are obtained through field measurement. Based on these data, the formula of BVVs is obtained. Research on stability of tunnel support structures affected by step blast-excavation is conducted using numerical simulation method. The dynamic-plastic constitutive model is adopted in the software ABAQUS to assess safety of support structures. The range and degree of damage for the support structures are obtained. In addition, change laws of axial force and stress with time for the bolts are analyzed.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1155/2013/257457
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
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  • 8
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    Online Resource
    Lubrication and stability enhancement by attaching superconducting magnetic force on non-contacting mechanical seals for reusable rocket turbopump
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 236, No. 5 ( 2022-05), p. 892-907
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 236, No. 5 ( 2022-05), p. 892-907
    Abstract: The purpose of this paper is to investigate the lubrication performance and stability improvement of rocket turbopump mechanical seals by attaching superconducting magnetic force. A comprehensive multiphysics numerical model is presented including microscale clearance flow, magnetic field, as well as three degrees of freedom dynamic motion. The Maxwell equation and modified Reynolds equation considering mass-conserving boundary conditions and turbulence flow were solved simultaneously at each time step to obtain the transient response of sealing parameters. Results indicate that the mechanical seal attaching superconducting magnetic force could dramatically improve carrying capacity and lubrication characteristics under heavy loading conditions, and it also has an appreciable effect on dynamic stability. It is worth exploring the application of superconducting magnetic force in reusable rockets and cryogenic equipment combined with its unique advantages.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/13506501211039782
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2032767-5
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  • 9
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    Online Resource
    Plasminogen Activator Inhibitor-1 Induction after Experimental Intracerebral Hemorrhage
    SAGE Publications ; 2002
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 22, No. 1 ( 2002-01), p. 55-61
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 22, No. 1 ( 2002-01), p. 55-61
    Abstract: Serine proteases, such as thrombin and tissue-type plasminogen activator, play an important role in brain injury after intracerebral hemorrhage and other neurologic disorders. Plasminogen activator inhibitor-1 is one of the serine protease inhibitors, or serpins. The balance between serine proteases and serpins may affect the outcome of intracerebral hemorrhage. The purpose of this study was to determine whether plasminogen activator inhibitor-1 and tissue-type plasminogen activator are upregulated after intracerebral hemorrhage and the role that thrombin plays in that induction. Plasminogen activator inhibitor-1 protein levels were upregulated after intracerebral hemorrhage. Brain plasminogen activator inhibitor-1 content also increased after thrombin infusion in a dose-dependent manner. Hirudin, a specific thrombin inhibitor, blocked the upregulation of plasminogen activator inhibitor-1 after intracerebral hemorrhage. Time courses showed that plasminogen activator inhibitor-1 levels around the hematoma peaked at the first day. Plasminogen activator inhibitor-1–positive cells were detected in the perihematomal area and the ipsilateral basal ganglia after thrombin infusion, but not in the contralateral hemisphere. Plasminogen activator inhibitor-1 messenger RNA levels were increased at 24 hours after intracerebral hemorrhage and after thrombin infusion. However, tissue-type plasminogen activator protein levels were the same in the control, whole-blood, and thrombin-infusion groups. In conclusion, intracerebral hemorrhage and thrombin infusion stimulate plasminogen activator inhibitor-1 but not tissue-type plasminogen activator production in the brain. The upregulation of plasminogen activator inhibitor-1 may be neuroprotective by limiting thrombin or other serine protease-induced toxicity.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1097/00004647-200201000-00007
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2039456-1
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  • 10
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    The influence and chronological uncertainties of the 8.2 ka cooling event on continental climate records in China
    SAGE Publications ; 2007
    In:  The Holocene Vol. 17, No. 7 ( 2007-11), p. 1041-1050
    Details
    In: The Holocene, SAGE Publications, Vol. 17, No. 7 ( 2007-11), p. 1041-1050
    Abstract: A compilation of early-Holocene terrestrial records from lacustrine sediments, ice cores, peat bog, palaeosols, stalagmites and flood sediments from China indicates that the early-Holocene climate was unstable and characterized by at least one centennial-scale (500—200 years) cooling event between 9.0 and 7.6 ka BP. The cold period recorded in different settings has been previously linked to the 8.2 ka event suggested by δ 18 O ice from Greenland ice cores, but the differences in time duration and regional climate conditions have been attributed to monsoon systems, inadequate age control and sampling resolution, and complex topography in China. However, our compilation indicates that it is premature to attribute the cold periods recorded at different locations in China simply to the 8.2 ka event, let alone to attribute the cause of those anomalies to a freshening of the North Atlantic Ocean circulation. Whether there was one synchronous event or not in China, where the climate is mainly affected by the monsoons and the westerlies, is open to discussion, because most of the records lack sufficient dating control to define clearly the nature of the cooling event. If a cooling event did occur, more evidence is required in multiple dimensions to characterize the time duration, magnitude and cause of the event, so much work remains to be done.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683607082439
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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