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  • 1
    Online Resource
    Online Resource
    Role of Amputation in Improving Mobility, Pain Outcomes, and Emotional and Psychological Well-Being in Children With Metastatic Osteosarcoma
    SAGE Publications ; 2019
    In:  American Journal of Hospice and Palliative Medicine® Vol. 36, No. 2 ( 2019-02), p. 105-110
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 36, No. 2 ( 2019-02), p. 105-110
    Abstract: Few studies have analyzed the benefit of limb amputations in children with metastatic osteosarcoma and limited life span. Objective: We studied outcomes of limb amputations in children with metastatic osteosarcoma. Design: We performed a retrospective review of patients who underwent limb amputations (January 1995-June 2015) and died within 1 year of surgery. Setting/Participants: We studied 12 patients with osteosarcoma at a single institution. Measurements: Data on mobility, pain, and emotional and psychological well-being were retrieved from medical records from 1 month before surgery to 6 months after surgery. Results: Of the 12 patients (7 females and 5 males; median age at surgery 13 years [range, 7-20 years]) meeting study criteria, 3 patients and 9 patients had primary osteosarcoma in upper and lower limbs, respectively. Mobility improved postamputation in 8 bedridden/wheelchair-bound patients. Postamputation, emotional, and psychological well-being improved for 9 patients, 3 patients had persistent psychological and/or emotional symptoms, and no patient experienced signs of regret. Daily mean pain scores were significantly lower at 1 week (median 3 [range, 0-6] ; P = .03) and 3 months (median 0 [range, 0-8]; P = .02) postsurgery than at 1 week presurgery (median 5.5 [range, 0-10] ). Morphine consumption (mg/kg/d) showed a trend toward higher values at 1 week (median 0.2 [range, 0-7.6]; P = .6) and 3 months (median 0.2 [range, 0-0.5] ; P = .3) postsurgery than at 1 week presurgery (median 0.1 [range, 0-0.5]). Conclusions: Patients undergoing limb amputations had reduced pain and improved mobility and emotional and psychological well-being. Amputations are likely to benefit children with limited life expectancy.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/1049909118791119
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2236674-X
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  • 2
    Online Resource
    Online Resource
    Bisphosphonate Use in Pediatric Oncology for Pain Management
    SAGE Publications ; 2019
    In:  American Journal of Hospice and Palliative Medicine® Vol. 36, No. 2 ( 2019-02), p. 138-142
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 36, No. 2 ( 2019-02), p. 138-142
    Abstract: The use of bisphosphonates for pain control in children with cancer is not extensively studied. We retrospectively evaluated 35 children with cancer treated with intravenous bisphosphonates for pain management at a single institution from 1998 through 2015. We analyzed pain scores and opioid and adjuvant medication consumption before bisphosphonate administration, daily for 2 weeks, and at 3 and 4 weeks after administration. We also determined the time interval between diagnosis and first administration of bisphosphonates and duration of life after bisphosphonate administration. Mean pain scores were 2.45 (±2.96) and 0.75 (±1.69) before and 14 days after bisphosphonate administration, respectively ( P = .25), and morphine equivalent doses of opioids were 5.52 (±13.35) and 5.27 (±9.77), respectively ( P = .07). Opioid consumption was significantly decreased at days 4 to 8, days 11 to 12, and week 3 after first bisphosphonate administration. The median duration of life after first bisphosphonate administration was 80 days, indicating its use late in the course of treatment. Bisphosphonates did not significantly improve pain outcomes at 2 weeks, but opioid consumption was reduced at several time points during the first 3 weeks. The use of bisphosphonates earlier in the course of pediatric oncological disease should be evaluated in prospective investigations.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/1049909118793114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2236674-X
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  • 3
    Online Resource
    Online Resource
    An EGFR and AKT Signaling Pathway was Identified with Mediation Model in Osteosarcomas Clinical Study
    SAGE Publications ; 2007
    In:  Biomarker Insights Vol. 2 ( 2007-01), p. 117727190700200-
    Details
    In: Biomarker Insights, SAGE Publications, Vol. 2 ( 2007-01), p. 117727190700200-
    Abstract: Identification of correlation pattern and signal pathway among biomarkers in patients has become increasingly interesting for its potential values in diagnosis, treatment and prognosis. EGFR and p-AKT signaling in osteosarcoma (OS) patients were analyzed for its relationship with cancer cell proliferation maker, Ki-67, using causal procedures and statistical tests. A total of 69 patients were collected who present to Vanderbilt University Medical Center with newly diagnosed, previously untreated osteosarcomas during the clinical study period 1994 through 2003. Tissue microarrays were constructed for EGFR, p-AKT and Ki-67. The mediation model was constructed with structural equation model (SEM) for the causal analysis of the three biomarkers in osteosarcoma patients. The results suggested a mediating effect of p-AKT for the causal relationship between EGFR and Ki-67. The study also found significant associations between EGFR and Ki-67 (p = 0.002), EGFR and p-AKT (p = 0.027), and p-AKT and Ki-67 controlling EGFR (p = 0.004). After the impact of EGFR on Ki-67 was accounted for by p-AKT, the relation between EGFR and Ki-67 was no longer significant (p = 0.381). The mediating effect was confirmed with Sobel test (p 〈 0.001) and Goodman (I) test (p 〈 0.001). The study indicated that a mediation model could be an approach to exploring the correlation pattern of EGFR and AKT signal pathway for cancer cell proliferation in OS patients in clinical study.
    Type of Medium: Online Resource
    ISSN: 1177-2719 , 1177-2719
    URL: Article
    DOI: 10.1177/117727190700200035
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2256754-9
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  • 4
    Online Resource
    Online Resource
    Fortification of Salt with Iodine
    SAGE Publications ; 1998
    In:  Food and Nutrition Bulletin Vol. 19, No. 2 ( 1998-01), p. 172-175
    Details
    In: Food and Nutrition Bulletin, SAGE Publications, Vol. 19, No. 2 ( 1998-01), p. 172-175
    Abstract: Iodized salt is the best means of providing iodine to deficient populations, and it has been used successfully and safely for 70 years around the world. In China about 450 million people live in iodine-deficient areas. The prevalence of endemic goitre in 7- to 14-year-old children was estimated to be 20% (7 million cases). The Chinese government has undertaken to eliminate iodine-deficiency disorders by the year 2000, and the manufacture and use of iodized salt throughout China has been compulsory since early 1995. Currently, potassium iodate is used. National regulations require the iodine content of iodized salt to be no less than 30 mg/kg in the salt-processing plant, no less than 25 mg/kg in the market, and no less than 20 mg/kg in the household. According to sporadic sample checking, however, the iodine content of salt in the market and the household is far from satisfactory. The loss of iodine during cooking is as high as 50% to 70%. The major problems in the fortification of salt with iodine in China are the use of uniodized salt in remote areas, an unsatisfactory system for monitoring the quality of iodized salt, the lack of knowledge and skill among marketing staffs, the loss of iodine during storage and cooking, and the lack of nationwide systematic studies to monitor the effectiveness of iodized salt in the control of endemic goitre.
    Type of Medium: Online Resource
    ISSN: 0379-5721 , 1564-8265
    URL: Article
    DOI: 10.1177/156482659801900214
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 2075729-3
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  • 5
    Online Resource
    Online Resource
    Tears of the Popliteomeniscal Fascicles of the Lateral Meniscus: An Arthroscopic Classification
    SAGE Publications ; 2021
    In:  CARTILAGE Vol. 13, No. 1_suppl ( 2021-12), p. 256S-261S
    Details
    In: CARTILAGE, SAGE Publications, Vol. 13, No. 1_suppl ( 2021-12), p. 256S-261S
    Abstract: To bring forward an arthroscopic classification of the popliteomeniscal fascicles of the lateral meniscus (PFLM) tears. Design Six fresh frozen knee joint samples of adult males were chosen, and the lateral meniscus at the popliteal hiatus region were measured to analyze their anatomic relationship. Patients who had received magnetic resonance imaging scan at knee joint before the surgery and diagnosed as PFLM tears by arthroscopy from April 2014 to October 2017 were selected. Data regarding the integrity of PFLM were prospectively recorded in a data registry. Tear morphology and treatment received were subsequently extracted by 2 independent reviewers from operative notes and arthroscopic surgical photos. Results The average length and thickness of the popliteal hiatus of the lateral meniscus were 2.09 ± 0.21 cm and 0.43 ± 0.08 cm, respectively. The average length of anterosuperior popliteomeniscal fascicle (APF) was 0.87 ± 0.18 cm, and the posterosuperior popliteomeniscal fascicle (PPF) was 0.72 ± 0.15 cm. A total of 36 PFLM tears in 36 patients were divided as type I (APF tear; n = 5, 13.9%), type II (PPF tear; n = 20, 55.6%), and type III (both APF and PPF tears; n = 11, 30.6%). All patients were treated with arthroscopic all-inside repair using a suture hook for the PFLM tears and follow-up for 21.1 months. All patients have done well with significantly improved Lysholm and International Knee Documentation Committee scores at the last follow-up relative to preoperative scores ( P 〈 0.01). Conclusion This study suggests to possibly classify the PFLM tears for clinical practice.
    Type of Medium: Online Resource
    ISSN: 1947-6035 , 1947-6043
    URL: Article
    DOI: 10.1177/1947603520980156
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2515870-3
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