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  • 1
    Online Resource
    Online Resource
    Book Department
    SAGE Publications ; 2002
    In:  The ANNALS of the American Academy of Political and Social Science Vol. 579, No. 1 ( 2002-01-01), p. 271-297
    Details
    In: The ANNALS of the American Academy of Political and Social Science, SAGE Publications, Vol. 579, No. 1 ( 2002-01-01), p. 271-297
    Type of Medium: Online Resource
    ISSN: 0002-7162
    URL: Article
    DOI: 10.1177/0002716202579001017
    RVK:
    MN 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
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    detail.hit.zdb_id: 757146-X
    detail.hit.zdb_id: 2097792-X
    detail.hit.zdb_id: 328-1
    SSG: 7,26
    SSG: 3,4
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  • 2
    Online Resource
    Online Resource
    A randomized clinical trial of valacyclovir in multiple sclerosis
    SAGE Publications ; 2005
    In:  Multiple Sclerosis Journal Vol. 11, No. 3 ( 2005-06), p. 286-295
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 11, No. 3 ( 2005-06), p. 286-295
    Abstract: Objective: The human Herpesvirus type-6 (HHV-6) has been implicated in multiple sclerosis (MS). Valacyclovir is an antiviral agent with an excellent safety profile. A two-year, placebo-controlled, double-blind study was conducted to (1) ascertain if high-dose, prolonged treatment with valacyclovir would be safe and (2) observe if valacyclovir would delay the progression of MS clinically or by magnetic resonance imaging (MRI). Design/methods: Fifty-eight patients were stratified as to severity and randomly assigned to receive valacyclovir (3000 mg/day) or placebo for a period of two years. Patients were followed clinically over the two-year period by means of the Expanded Disability Status Scale (EDSS), the Ambulation Index (AI) and brain MRI scans. Patients underwent routine lab studies every three months. Patients continued on the medication for two years unless they had a sustained progression or repeated exacerbations. Results: No patient discontinued the study due to side effects or toxicity. In Relative Ranking of Progression, time to first attack, attack rate, and time to withdrawal there were trends (but not statistically significant) toward drug effect over placebo in the Severe clinical category. MRI evaluation showed no significant drug effect. Conclusions: Although not statistically significant, positive trends were detected for acyclovir by clinical measures, but not by MRI.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1191/1352458505ms1185oa
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2008225-3
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  • 3
    Online Resource
    Online Resource
    Variation in Platelet Transfusion Practices in Cardiac Surgery
    SAGE Publications ; 2019
    In:  Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery Vol. 14, No. 2 ( 2019-04), p. 134-143
    Details
    In: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, SAGE Publications, Vol. 14, No. 2 ( 2019-04), p. 134-143
    Abstract: Although the morbidity associated with red blood cell transfusion in cardiac surgery has been well described, the impacts of platelet transfusion are less clearly understood. Given the conflicting results of prior studies, we sought to investigate the impact of platelet transfusion on outcomes after cardiac surgery across institutions in Maryland. Methods Using a multiinstitutional statewide database created by the Maryland Cardiac Surgery Quality Initiative, we retrospectively analyzed data from 10,478 patients undergoing isolated coronary artery bypass across 10 centers. Platelet transfusion practices were compared between institutions. Multivariate logistic regression model was used to analyze the association between platelet transfusion and 30-day mortality and postoperative complications. Results Rates of platelet transfusion varied between institutions from 4.4% to 24.7% ( P 〈 0.001), a difference that remained statistically significant in propensity score–matched cohorts. Among patients on preoperative antiplatelet therapy, transfusion rates varied from 8.5% to 46.4% ( P 〈 0.001). There was no statistically significant relationship between case volume and transfusion rates ( P = 0.815). In multivariate logistic regression, platelet transfusion was associated with increased risk of 30-day mortality (OR 2.43, P = 0.008), postoperative pneumonia (OR 2.21, P = 0.004), prolonged intubation (OR 2.05, P 〈 0.001), and readmission (OR 1.43, P = 0.039). Conclusions Significant variation existed in platelet transfusion rates between institutions, even after controlling for various risk factors. This variation may be associated with increased mortality and length of stay. Further study is warranted to better understand risks associated with platelet transfusion. Standardizing practice may help reduce risk and conserve resources.
    Type of Medium: Online Resource
    ISSN: 1556-9845 , 1559-0879
    URL: Article
    DOI: 10.1177/1556984519836839
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2223439-1
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  • 4
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    The association of the human herpesvirus-6 and MS
    SAGE Publications ; 1999
    In:  Multiple Sclerosis Journal Vol. 5, No. 5 ( 1999-10), p. 355-362
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 5, No. 5 ( 1999-10), p. 355-362
    Abstract: Given the clinical and pathological nature of multiple sclerosis (MS), a viral infection has long been hypothesized as part of the etiology. In this study we investigated the possibility that the human herpesvirus-6 (HHV-6) is present in a dormant or active phase in the tissue of MS patients, specifically oligodendrocytes. Using PCR assays of MS and non-MS brain sections with primers prepared against the HHV-6 structural protein 101, the results demonstrated that 36% of MS brains were positive for the virus, while 13.5% of non-MS brains were positive. Antibody to the HHV-6 structural protein was also used in immunohistochemical experiments in brain tissue. 47% (7/15) of MS brains were positive for HHV-6, whereas 0/16 controls were positive. In addition, MS patients demonstrated high immune reactivity to this virus, even when compared to auto-immune diseases, which might cause polyclonal activation. Sera obtained from MS and control patients revealed that the IgM response to the HHV-6 virus was significantly elevated in 80% patients compared to 16% non-MS controls, P5.001. The above experiments strongly suggest that a significant number of MS brain samples contain HHV-6 antigens and genomic fragments in a dormant or active phase compared to control specimens and that MS patients mount a brisk, early IgM response.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/135245859900500509
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1999
    detail.hit.zdb_id: 2008225-3
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  • 5
    Online Resource
    Online Resource
    Examination of Gills from Salmonids with Bacterial Gill Disease using Monoclonal Antibody Probes for Flavobacterium Branchiophilum and Cytophaga Columnaris
    SAGE Publications ; 1995
    In:  Journal of Veterinary Diagnostic Investigation Vol. 7, No. 4 ( 1995-10), p. 500-505
    Details
    In: Journal of Veterinary Diagnostic Investigation, SAGE Publications, Vol. 7, No. 4 ( 1995-10), p. 500-505
    Abstract: Bacterial diseases of the gills of commercially reared salmonids in freshwater are common problems. They accounted for 18% of all diagnostic submissions to the Atlantic Veterinary College from commercial fish hatcheries. Definitive diagnosis is difficult because of the growth characteristics of the putative bacteria in culture. Research into the pathogenesis of these diseases has also been similarly limited. Monoclonal antibodies (MAbs) were developed to 2 globally significant gill bacterial pathogens, Flavobacterium branchiophilum, the causative agent of bacterial gill disease, and Cytophaga columnaris, the causative agent of columnar-is disease of salmonids. These MAbs were then used as the basis for an indirect fluorescent antibody test to assess archived cases of gill disease in our region. Flavobacterium branchiophilum was the dominant bacterium detected in the biofilm of diseased gills in our study region. Of the cases tentatively diagnosed based on histopathology as bacterial gill disease, 76.2% tested positively with the MAbs to F. branchiophilum. Also present within 18.7% of these cases were bacteria which reacted positively to the MAbs for C. columnaris. We conclude that the MAbs produced are valuable diagnostic and research probes for common bacterial diseases of the gills of salmon and trout in Atlantic Canada. This study also adds further proof that F. branchiophilum acting alone can be sufficient cause for bacterial gill disease.
    Type of Medium: Online Resource
    ISSN: 1040-6387 , 1943-4936
    URL: Article
    DOI: 10.1177/104063879500700413
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1995
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    SSG: 22
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  • 6
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    Online Resource
    Evaluation of [ 18 F]-JNJ-64326067-AAA tau PET tracer in humans
    SAGE Publications ; 2021
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 41, No. 12 ( 2021-12), p. 3302-3313
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 41, No. 12 ( 2021-12), p. 3302-3313
    Abstract: The [ 18 F]-JNJ-64326067-AAA ([ 18 F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer’s disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [ 11 C]-PIB amyloid PET scan, and a tau [ 18 F]-JNJ-067 PET scan 0-90 minutes post-injection. Only MCIs and ADs were amyloid positive. The simplified reference tissue model, Logan graphical analysis distribution volume ratio, and SUVR were evaluated for quantification. The [ 18 F]-JNJ-067 tau signal relative to the reference region continued to increase to 90 min, indicating the tracer had not reached steady state. There was no significant difference in any bilateral ROIs for MCIs or PSPs relative to HCs; AD participants showed elevated tracer relative to controls in most cortical ROIs (P  〈  0.05). Only AD participants showed elevated retention in the entorhinal cortex. There was off-target signal in the putamen, pallidum, thalamus, midbrain, superior cerebellar gray, and white matter. [ 18 F]-JNJ-067 significantly correlated (p  〈  0.05) with Mini-Mental State Exam in entorhinal cortex and temporal meta regions. There is clear binding of [ 18 F]-JNJ-067 in AD participants. Lack of binding in HCs, MCIs and PSPs suggests [ 18 F]-JNJ-067 may not bind to low levels of AD-related tau or 4 R tau.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X211031035
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2039456-1
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  • 7
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    The NCAA Cartel, Monopsonistic Restrictions, and Antitrust Policy
    SAGE Publications ; 2017
    In:  The Antitrust Bulletin Vol. 62, No. 1 ( 2017-03), p. 3-14
    Details
    In: The Antitrust Bulletin, SAGE Publications, Vol. 62, No. 1 ( 2017-03), p. 3-14
    Abstract: NCAA members behave like a buyer cartel and use the bylaws of the NCAA to maintain their collusive agreement. We model the NCAA as a collusive monopsony and demonstrate the impact on compensation and employment for student athletes, as well as the consequences for social welfare and distribution of surplus. Then we identify specific NCAA bylaws that restrain competition among cartel members, such as limits on the number of athletic scholarships awarded, recruiting, player transfers, and athletic housing. Lastly, we discuss the effects of the NCAA’s recent move to lift the restriction on contract durations for student athletes and the recent Agnew antitrust litigation which may have precipitated this change.
    Type of Medium: Online Resource
    ISSN: 0003-603X , 1930-7969
    URL: Article
    DOI: 10.1177/0003603X16688836
    RVK:
    PE 100
    RVK:
    PE 110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2065926-X
    detail.hit.zdb_id: 280116-4
    SSG: 2
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  • 8
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    Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial
    SAGE Publications ; 2020
    In:  Journal of the Intensive Care Society Vol. 21, No. 4 ( 2020-11), p. 281-282
    Details
    In: Journal of the Intensive Care Society, SAGE Publications, Vol. 21, No. 4 ( 2020-11), p. 281-282
    Abstract: Vasodilatory shock is common in critically ill patients and vasopressors are a mainstay of therapy. A meta-analysis suggested that use of a higher, as opposed to a lower, mean arterial pressure target to guide titration of vasopressor therapy, could be associated with a higher risk of death in older critically ill patients. The 65 trial is a pragmatic, multi-centre, parallel-group, open-label, randomised clinical trial of permissive hypotension (a mean arterial pressure target of 60 -65 mmHg during vasopressor therapy) versus usual care in critically ill patients aged 65 years or over with vasodilatory hypotension. The trial is conducted in 2600 patients from 65 United Kingdom adult, general critical care units. The primary outcome is all-cause mortality at 90 days. An economic evaluation is embedded. The 65 trial received favourable ethical opinion from the South Central - Oxford C Research Ethics Committee and approval from the Health Research Authority. The results will be presented at national and international conferences and published in peer-reviewed medical journals. Trial registration: ISRCTN10580502
    Type of Medium: Online Resource
    ISSN: 1751-1437
    URL: Article
    DOI: 10.1177/1751143720971433
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2701626-2
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  • 9
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    Online Resource
    Direct and Generalized Reduction of Inappropriate Behavior in a Severely Retarded Child through a Parent-Administered Behavior Modification Program
    SAGE Publications ; 1978
    In:  AAESPH Review Vol. 3, No. 2 ( 1978-06), p. 66-77
    Details
    In: AAESPH Review, SAGE Publications, Vol. 3, No. 2 ( 1978-06), p. 66-77
    Abstract: The direct and generalized effects of a parent-administered, positive reinforcement and physical restraint procedure upon the inappropriate behavior of an institutionalized, severely retarded boy were examined. The boy's mother was trained to administer the training package contingent upon three of her son's responses during a play situation conducted within the institutional setting. A hybrid of multiple baseline and reversal designs was employed to assess the effects of the procedures on the child's target behaviors. Results indicate that the procedures were effective in directly increasing the child's instruction-following behavior and decreasing his noncompliance and inappropriate play responses. Moreover, a correlated reduction in the boy's untreated aggression and clothes stripping was observed. Follow-ups conducted over a 4-month period indicate that all treatment effects were maintained over time. Possible explanations for why treatment produced a generalized decrease in responding are discussed.
    Type of Medium: Online Resource
    ISSN: 0147-4375
    URL: Article
    DOI: 10.1177/154079697800300201
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1978
    SSG: 5,3
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  • 10
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    Comparison of Neutralization and Hemagglutination-Inhibition Techniques for Measuring Mumps Antibody
    SAGE Publications ; 1967
    In:  Experimental Biology and Medicine Vol. 125, No. 4 ( 1967-08-01), p. 1068-1071
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 125, No. 4 ( 1967-08-01), p. 1068-1071
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/00379727-125-32278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1967
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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