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  • 1
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    Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19
    SAGE Publications ; 2022
    In:  Journal of Intensive Care Medicine Vol. 37, No. 4 ( 2022-04), p. 500-509
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications, Vol. 37, No. 4 ( 2022-04), p. 500-509
    Abstract: To determine whether surge conditions were associated with increased mortality. Design Multicenter cohort study. Setting U.S. ICUs participating in STOP-COVID. Patients Consecutive adults with COVID-19 admitted to participating ICUs between March 4 and July 1, 2020. Interventions None Measurements and Main Results The main outcome was 28-day in-hospital mortality. To assess the association between admission to an ICU during a surge period and mortality, we used two different strategies: (1) an inverse probability weighted difference-in-differences model limited to appropriately matched surge and non-surge patients and (2) a meta-regression of 50 multivariable difference-in-differences models (each based on sets of randomly matched surge- and non-surge hospitals). In the first analysis, we considered a single surge period for the cohort (March 23 – May 6). In the second, each surge hospital had its own surge period (which was compared to the same time periods in matched non-surge hospitals). Our cohort consisted of 4342 ICU patients (average age 60.8 [sd 14.8], 63.5% men) in 53 U.S. hospitals. Of these, 13 hospitals encountered surge conditions. In analysis 1, the increase in mortality seen during surge was not statistically significant (odds ratio [95% CI] : 1.30 [0.47-3.58], p = .6). In analysis 2, surge was associated with an increased odds of death (odds ratio 1.39 [95% CI, 1.34-1.43] , p  〈  .001). Conclusions Admission to an ICU with COVID-19 in a hospital that is experiencing surge conditions may be associated with an increased odds of death. Given the high incidence of COVID-19, such increases would translate into substantial excess mortality.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/08850666211067509
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 2
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    The Current Status of Spinal Posttraumatic Deformity: A Systematic Review
    SAGE Publications ; 2021
    In:  Global Spine Journal Vol. 11, No. 8 ( 2021-10), p. 1266-1280
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 11, No. 8 ( 2021-10), p. 1266-1280
    Abstract: Systematic Review. Objective: To systematically analyze the definitions and descriptions in literature of “Spinal Posttraumatic Deformity” (SPTD) in order to support the development of a uniform and comprehensive definition of clinically relevant SPTD. Methods: A literature search in 11 international databases was performed using “deformity” AND “posttraumatic” and its synonyms. When an original definition or a description of SPTD (Patient factors, Radiological outcomes, Patient Reported Outcome Measurements and Surgical indication) was present the article was included. The retrieved articles were assessed for methodological quality and the presented data was extracted. Results: 46 articles met the inclusion criteria. “Symptomatic SPTD” was mentioned multiple times as an entity, however any description of “symptomatic SPTD” was not found. Pain was mentioned as a key factor in SPTD. Other patient related parameters were (progression of) neurological deficit, bone quality, age, comorbidities and functional disability. Various ways were used to determine the amount of deformity on radiographs. The amount of deformity ranged from not deviant for normal to 〉 30°. Sagittal balance and spinopelvic parameters such as the Pelvic Incidence, Pelvic Tilt and Sacral Slope were taken into account and were used as surgical indicators and preoperative planning. The Visual Analog Scale for pain and the Oswestry Disability Index were used mostly to evaluate surgical intervention. Conclusion: A clear-cut definition or consensus is not available in the literature about clinically relevant SPTD. Our research acts as the basis for international efforts for the development of a definition of SPTD.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/2192568220969153
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 3
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    Sound absorption of open celled aluminium foam fabricated by investment casting method
    SAGE Publications ; 2011
    In:  Materials Science and Technology Vol. 27, No. 4 ( 2011-04), p. 800-804
    Details
    In: Materials Science and Technology, SAGE Publications, Vol. 27, No. 4 ( 2011-04), p. 800-804
    Abstract: The sound absorption behaviour of an open celled aluminium foam fabricated by investment casting method was examined and correlated with the pore size, sample thickness and backing air gap depth in the present study. The foam shows low sound absorption coefficients at relatively low frequencies or with relatively thin sample thickness due to its 90% or higher open porosity. As frequency or sample thickness increases, the sound absorption is significantly enhanced. Furthermore, if the sample is backed with an air gap, the approximate periodical resonant absorption peaks emerge from the background and shift towards low frequencies with increasing the gap depth. It is also found that the present aluminium foam has even better absorption performance than polyurethane foam, with almost the same pore parameters as the former. The observation on the pore surface and further experiments demonstrate that the difference is attributed to rougher pore surface of the aluminium foam that makes the sound wave loss increase through enhanced friction between the air and the surface.
    Type of Medium: Online Resource
    ISSN: 0267-0836 , 1743-2847
    URL: Article
    DOI: 10.1179/026708309X12506934374047
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
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    detail.hit.zdb_id: 2037367-3
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  • 4
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    Interspecies Organogenesis for Human Transplantation
    SAGE Publications ; 2019
    In:  Cell Transplantation Vol. 28, No. 9-10 ( 2019-09), p. 1091-1105
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 28, No. 9-10 ( 2019-09), p. 1091-1105
    Abstract: Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of the current barriers limiting the success of blastocyst complementation.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689719845351
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 5
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    Effects of elements W and C on microstructure and wear property of γ-TiAl surface alloying layer
    SAGE Publications ; 2015
    In:  Surface Engineering Vol. 31, No. 12 ( 2015-12), p. 942-948
    Details
    In: Surface Engineering, SAGE Publications, Vol. 31, No. 12 ( 2015-12), p. 942-948
    Abstract: To solve the poor tribological property of the γ-TiAl alloy, the duplex treatment of plasma carburisation on plasma alloying γ-TiAl with tungsten was conducted by double glow plasma surface alloying technique. The results indicated the alloying layer consisted of TiC and W 2 C phase, metallurgically adhered to the substrate. In terms of the H/E and H 3 /E 2 ratios, the duplex treated specimen was nearly three times larger than the untreated specimen. The wear property of the specimens was tested on a pin-on-disk tribometer by rubbing against Si 3 N 4 ceramic ball. The wear rate of the duplex-treated specimens is 1·056×10 −4 mm 3 N −1 m −1 , which is only 25·9% of that of the untreated specimens. The relationship between alloying layer mechanical property and wear resistance indicates that the carbide phase formed within the alloying layer contributes to the improvement of the wear performance.
    Type of Medium: Online Resource
    ISSN: 0267-0844 , 1743-2944
    URL: Article
    DOI: 10.1179/1743294414Y.0000000386
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
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  • 6
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    Factors associated with acceptability of circumcision among male drug users in western China: a cross-sectional study
    SAGE Publications ; 2013
    In:  International Journal of STD & AIDS Vol. 24, No. 7 ( 2013-07), p. 541-547
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 24, No. 7 ( 2013-07), p. 541-547
    Abstract: This study is aimed to investigate whether male circumcision (MC) is feasible among IDUs in China. 1304 drug users who attended methadone maintenance therapy clinics in Guangxi, Chongqing and Xinjiang were selected for participation by using convenience sampling, and completed a self-administered questionnaire. The factors associated with the acceptability of MC were examined via multiple logistic regression models. 45.2% (589/1304) of the participants reported an acceptance of MC. Many of the participants who were initially not willing to accept MC (715/1304) had changed their mind when they were informed that MC would reduce the risk of HIV and STDs (43.4%; 310/715), that MC is associated with few surgery-related complications (23.1%; 165/715), that the surgical procedure could be arranged free of charge (20.1%, 144/715). In the multivariate analysis, higher acceptability of MC was associated with knowledge of the hazards of phimosis (OR=2.22), the presence of phimosis (OR=14.87), and knowledge that MC can prevent AIDS and STDs (OR=1.49); while lower acceptability was associated with residing in Chongqing province (OR=0.41) and an educational level of junior (OR=0.64) and senior high (OR=0.63) school. The MC policy targeting IDUs in China should take into account these factors associated with MC acceptability.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1177/0956462412473893
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2009782-7
    detail.hit.zdb_id: 1018089-8
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  • 7
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    Influence of zirconium alloying layer on properties of TC11 alloy
    SAGE Publications ; 2014
    In:  Surface Engineering Vol. 30, No. 11 ( 2014-11), p. 822-827
    Details
    In: Surface Engineering, SAGE Publications, Vol. 30, No. 11 ( 2014-11), p. 822-827
    Abstract: Zirconium (Zr) alloying layer was formed in the TC11 surface by using the double glow plasma surface alloying technique. The microstructure, surface hardness and oxidation resistance of the alloying layer were investigated by X-ray diffraction, scanning electron microscope and energy dispersive X-ray spectrometry, respectively. The results showed that the alloying layer consisted of a compact and homogeneous Ti–Zr mutual diffusion layer, and the surface alloying elements all displayed gradient distributions. The zirconium alloying layer enhanced the surface hardness by solution strengthening. The improvement of TC11 oxidation resistance was due to the formation of compact and uniform oxide scales, which was consisted of ZrO 2 as the major phase and TiO 2 as the minor phase.
    Type of Medium: Online Resource
    ISSN: 0267-0844 , 1743-2944
    URL: Article
    DOI: 10.1179/1743294414Y.0000000263
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
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  • 8
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    Reproducibility and Comparison of DCE-MRI and DCE-CT Perfusion Parameters in a Rat Tumor Model
    SAGE Publications ; 2012
    In:  Technology in Cancer Research & Treatment Vol. 11, No. 3 ( 2012-06), p. 279-288
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 11, No. 3 ( 2012-06), p. 279-288
    Abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and computed tomography (DCE-CT) provide independent measures of biomarkers related to tumor perfusion. We compared the reproducibilities and absolute values of DCE-MRI and DCE-CT biomarkers in the same tumors in an animal model, to investigate the physiologic validity of both approaches. DCE-MRI and DCE-CT were each performed sequentially on three consecutive days in each of twelve rats bearing C6 glioma xenografts. DCE-MRI yielded endothelial transfer constant ( K trans ), extracellular, extravascular space volume fraction ( v e ), and contrast agent reflux rate constant ( k ep ); and DCE-CT, blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface area product (PS) using Tofts and deconvolution physiological models, with 6.6 and 0.4 seconds temporal resolutions, respectively. Variability in DCE-CT and DCE-MRI were evaluated by variance components analysis. Intra-rat coefficients of variation for DCE-CT parameters BF, BV, MTT and PS were 25%, 22%, 18% and 23%; and for DCE-MRI parameters K trans , k ep and v e were 23%, 16% and 20%, respectively. Mean (±SD) BF, BV, MTT and PS were: 44.6 (±13.7) ml min −1 100 g −1 , 5.7 (±1.5) ml 100 g −1 , 10.8 (±2.3) seconds, and 14.6 (±4.7) ml min −1 100 g −1 , respectively. Mean (±SD) K trans , k ep and v e were: 0.21 (±0.05) min −1 , 0.68 (±0.14) min −1 , and 0.29 (±0.06), respectively. Permeability estimates from DCE-MRI ( K trans ) were 44% higher than from DCE-CT (PS), despite application of appropriate corrections. DCE-MRI and DCE-CT biomarkers of tumor perfusion have similar reproducibilities suggesting that they may have comparable utility, but their derived parameter values are not equivalent.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.7785/tcrt.2012.500296
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
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  • 9
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    Microfluidic-Based 18 F-Labeling of Biomolecules for Immuno–Positron Emission Tomography
    SAGE Publications ; 2011
    In:  Molecular Imaging Vol. 10, No. 3 ( 2011-05), p. 7290.2010.00043-
    Details
    In: Molecular Imaging, SAGE Publications, Vol. 10, No. 3 ( 2011-05), p. 7290.2010.00043-
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1536-0121
    URL: Article
    DOI: 10.2310/7290.2010.00043
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2069848-3
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  • 10
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    Oxidation behaviour of plasma surface alloying on Ti6Al4V alloy
    SAGE Publications ; 2018
    In:  Surface Engineering Vol. 34, No. 1 ( 2018-01), p. 14-21
    Details
    In: Surface Engineering, SAGE Publications, Vol. 34, No. 1 ( 2018-01), p. 14-21
    Abstract: Ti–CrNi alloy coatings with 20, 40, 60 and 80 at-%Ni were prepared on Ti6Al4V alloy surface by double glow plasma surface alloying technique. The cyclic oxidation behaviour of the coatings was investigated at 750, 850 and 950°C. The results show that each coating has a complete structure of settled layer, mutual diffusion layer and sputtering affected zone. When the Ni content was 40 at-%, the Ti–CrNi alloy coating showed the best cyclic oxidation resistance. The oxide scale with ‘Cr 2 O 3 film+NiO film’ structure showed the best resistance to peeling.
    Type of Medium: Online Resource
    ISSN: 0267-0844 , 1743-2944
    URL: Article
    DOI: 10.1179/1743294415Y.0000000095
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 51142-0
    detail.hit.zdb_id: 2053755-4
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