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  • SAGE Publications  (27)
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  • 1
    Online Resource
    Online Resource
    High levels of NK Cells in graft are associated with reduced febrile neutropenia after haploidentical peripheral blood stem cell transplantation
    SAGE Publications ; 2023
    In:  Journal of International Medical Research Vol. 51, No. 7 ( 2023-07)
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 51, No. 7 ( 2023-07)
    Abstract: To investigate the impact of natural killer (NK) cells in the graft on the outcome following haploidentical peripheral blood stem cell transplantation (haplo-PBSCT). Methods We retrospectively collected data from patients who had undergone haplo-PBSCT at our centre from January 2019 to November 2021. The percentage of NK cells in stem cell grafts was detected by flow cytometry. Based on the median (range) count of NK cells (1.8 [0.4–6.0] × 10 8 /kg), patients were separated into high and low NK cell count groups. Results Data from 96 patients were analysed. Patients were evenly distributed (48 in each group) into high and low NK cell count groups. There was no significant difference in neutrophil and platelet recovery between the two groups. However, the rates of febrile neutropenia, bacterial infection, and invasive fungal disease (IFD) were significantly reduced in the high compared with the low NK cell count group. There was no significant difference in rates of cytomegalovirus (CMV) and Epstein–Barr virus (EBV) infections between groups. There was no significant difference between groups in grades II and above acute graft versus host disease (GVHD), progression-free survival (PFS), or overall survival (OS). Conclusion A high number of NK cells in the graft may reduce febrile neutropenia, IFD and bacterial infection following haplo-PBSCT but it has no significant effect on aGVHD, PFS, or OS.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605231187932
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Comparative study of microvascular structural changes in the gestational diabetic placenta
    SAGE Publications ; 2023
    In:  Diabetes and Vascular Disease Research Vol. 20, No. 3 ( 2023-05), p. 147916412311736-
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 20, No. 3 ( 2023-05), p. 147916412311736-
    Abstract: Microvascular morphology and pathological changes in gestational diabetes mellitus (GDM) placentas and normal placentas were observed via vascular casting technology, electron microscopy, and pathological detection technology. Vascular structure and histological morphology changes in GDM placentas were examined to generate basic experimental data for the diagnosis and prognostic determination of GDM. Methods This case–control study involving 60 placentas, 30 from healthy controls and 30 from patients with GDM. Differences in size, weight, volume, umbilical cord diameter, and gestational age were assessed. Histological changes in the placentas in the two groups were analyzed and compared. A placental vessel casting model was constructed using a self-setting dental powder technique, to compare the two groups. The placental cast microvessels of the two groups were compared using scanning electron microscopy. Results There were no significant differences in maternal age or gestational age between the GDM group and the control group ( p 〉 .05). The size, weight, volume, and thickness of the placentas in the GDM group were significantly greater than those in the control group, as was umbilical cord diameter ( p 〈 .05). Immature villus, fibrinoid necrosis, calcification, and vascular thrombosis were significantly greater in the placental mass in the GDM group ( p 〈 .05). The terminal branches of the microvessels in diabetic placenta casts were sparse, with significantly fewer ends and lower villous volume ( p 〈 .05). Conclusion Gestational diabetes can cause gross and histological changes in the placenta, particularly placental microvascular changes.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/14791641231173627
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2250797-8
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  • 3
    Online Resource
    Online Resource
    Clinical Efficacy and Safety of Omalizumab in the Treatment of Allergic Rhinitis: A Systematic Review and Meta-analysis of Randomized Clinical Trials
    SAGE Publications ; 2020
    In:  American Journal of Rhinology & Allergy Vol. 34, No. 2 ( 2020-03), p. 196-208
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 34, No. 2 ( 2020-03), p. 196-208
    Abstract: Patients with moderate to severe allergic rhinitis (AR) who are treated according to the current rhinitis management guidelines may be inadequately controlled. These patients are at risk of serious comorbidities, such as asthma and chronic sinusitis. These symptoms, sneezing and an itchy, runny, stuffy nose, may have a negative impact on patients’ daily functioning. Omalizumab is being developed as a new choice for the treatment of AR. We therefore undertook a meta-analysis to assess the efficacy and safety of omalizumab in the treatment of AR. Methods We systematically searched PubMed, Cochrane Library, and MEDLINE databases for randomized controlled studies on the treatment of AR with omalizumab. Our evaluation outcomes were symptom scores, medication efficacy, combined symptom and medication scores, and adverse events. We descriptively summarized and quantitatively synthesized original data to evaluate the efficacy and safety of omalizumab in the treatment of AR by using Stata12.0 software for meta-analyses. Results The results of our meta-analysis showed that there were statistically significant differences between the omalizumab group and the control group in the following aspects: daily nasal symptom score (standardized mean difference [SMD] = –0.443, 95% confidence interval [CI] : –0.538 to –0.347, P  〈  .001); daily ocular symptom score (SMD = –0.385, 95% CI: –0.5 to –0.269, P  〈  .001); daily nasal medication symptom scores (SMD = –0.421, 95% CI: –0.591 to –0.251, P  〈  .001); proportion of days of emergency drug use (risk ratio [RR] = 0.488, 95% CI: 0.307 to 0.788, P  〈  .005); rhinoconjunctivitis-specific quality of life questionnaire (SMD = –0.286, 95% CI: –0.418 to –0.154, P  〈  .001); and overall evaluation (RR = 1.435, 95% CI: 1.303–1.582, P  〈  .001). There was no statistically significant difference in safety indicator: adverse events (RR = 1.026, 95% CI: 0.916–1.150, P = .655). Conclusion Omalizumab is effective and relatively safe in patients with AR; omalizumab used in conjunction with special immunotherapy has shown promising results, especially in reducing adverse events.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.1177/1945892419884774
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2554548-6
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  • 4
    Online Resource
    Online Resource
    Effective solidification/stabilisation of mercury-contaminated wastes using zeolites and chemically bonded phosphate ceramics
    SAGE Publications ; 2015
    In:  Waste Management & Research: The Journal for a Sustainable Circular Economy Vol. 33, No. 2 ( 2015-02), p. 183-190
    Details
    In: Waste Management & Research: The Journal for a Sustainable Circular Economy, SAGE Publications, Vol. 33, No. 2 ( 2015-02), p. 183-190
    Abstract: In this study, two kinds of zeolites materials (natural zeolite and thiol-functionalised zeolite) were added to the chemically bonded phosphate ceramic processes to treat mercury-contaminated wastes. Strong promotion effects of zeolites (natural zeolite and thiol-functionalised zeolite) on the stability of mercury in the wastes were obtained and these technologies showed promising advantages toward the traditional Portland cement process, i.e. using Portland cement as a solidification agent and natural or thiol-functionalised zeolite as a stabilisation agent. Not only is a high stabilisation efficiency (lowered the Toxicity Characteristic Leaching Procedure Hg by above 10%) obtained, but also a lower dosage of solidification (for thiol-functionalised zeolite as stabilisation agent, 0.5 g g −1 and 0.7 g g −1 for chemically bonded phosphate ceramic and Portland cement, respectively) and stabilisation agents (for natural zeolite as stabilisation agent, 0.35 g g −1 and 0.4 g g −1 for chemically bonded phosphate ceramic and Portland cement, respectively) were used compared with the Portland cement process. Treated by thiol-functionalised zeolite and chemically bonded phosphate ceramic under optimum parameters, the waste containing 1500 mg Hg kg −1 passed the Toxicity Characteristic Leaching Procedure test. Moreover, stabilisation/solidification technology using natural zeolite and chemically bonded phosphate ceramic also passed the Toxicity Characteristic Leaching Procedure test (the mercury waste containing 625 mg Hg kg −1 ). Moreover, the presence of chloride and phosphate did not have a negative effect on the chemically bonded phosphate ceramic/thiol-functionalised zeolite treatment process; thus, showing potential for future application in treatment of ‘difficult-to-manage’ mercury-contaminated wastes or landfill disposal with high phosphate and chloride content.
    Type of Medium: Online Resource
    ISSN: 0734-242X , 1096-3669
    URL: Article
    DOI: 10.1177/0734242X14563376
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 1480483-9
    detail.hit.zdb_id: 46937-3
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  • 5
    Online Resource
    Online Resource
    Computational study of the influence of in-cylinder flow on spark ignition–controlled auto-ignition hybrid combustion in a gasoline engine
    SAGE Publications ; 2015
    In:  International Journal of Engine Research Vol. 16, No. 6 ( 2015-09), p. 795-809
    Details
    In: International Journal of Engine Research, SAGE Publications, Vol. 16, No. 6 ( 2015-09), p. 795-809
    Abstract: In this research, computational fluid dynamics simulations were performed to investigate the effect of in-cylinder flow motion on the in-cylinder conditions and spark ignition–controlled auto-ignition hybrid combustion. It is proved in this study that asymmetric intake valve events could be used to generate the swirl-dominated flow motion. However, the macroscopic flows, such as the swirl and tumble, show very weak correlations with zone-to-zone conditions and hybrid combustion process. The detailed investigation on the in-cylinder zone-to-zone conditions indicates that the in-cylinder turbulent kinetic energy level and the mean flow velocity (Vm) around the spark plug would directly affect the early flame propagation process, which in turn affect the subsequent auto-ignition process through changing the heat transfer between central burned gas and end-gas. In addition, the increased temperature inhomogeneity of the spherical zones caused by the in-cylinder flow motion would prolong the auto-ignition combustion. The structures of the flame front and auto-ignition sites also demonstrate the significant impact of in-cylinder motion on the combustion process. It is found that the combustion mode transition is very sensitive to the in-cylinder turbulent kinetic energy, Vm, and temperature and its inhomogeneity, indicating that these flow and thermal conditions could be used to optimize the hybrid combustion mode operation. It also proves the fluctuations of the in-cylinder flow, and thermal conditions could be the reasons leading to significant cycle-to-cycle variations in spark ignition–controlled auto-ignition hybrid combustion.
    Type of Medium: Online Resource
    ISSN: 1468-0874 , 2041-3149
    URL: Article
    DOI: 10.1177/1468087414554627
    RVK:
    ZG 1100
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2030603-9
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  • 6
    Online Resource
    Online Resource
    The effects of natural gas composition on conventional dual-fuel and reactivity-controlled compression ignition combustion in a heavy-duty diesel engine
    SAGE Publications ; 2022
    In:  International Journal of Engine Research Vol. 23, No. 3 ( 2022-03), p. 397-415
    Details
    In: International Journal of Engine Research, SAGE Publications, Vol. 23, No. 3 ( 2022-03), p. 397-415
    Abstract: The use of natural gas (NG) in dual-fuel heavy-duty engines has the potential to reduce pollutant and greenhouse gas (GHG) emissions from the transport sector when compared to the conventional diesel engines. However, NG composition and methane slip are of interest because both can adversely affect the benefits of NG as an alternative fuel, especially when considering GHG emissions. Therefore, this study experimentally investigated the effects of NG fuel properties on the performance and emissions of both conventional dual-fuel and reactivity-controlled compression ignition (RCCI) engine operations. Three different gas mixtures were selected to simulate typical NG compositions available in the world market, with methane numbers (MN) of 80.9, 87.6 and 94.1. These fuels were tested in a single-cylinder compression ignition engine operating at 0.6, 1.2 and 1.8 MPa net indicated mean effective pressure (IMEP). A high-pressure common rail system allowed for the use of various diesel injection strategies while a variable valve actuation system enabled the effective compression ratio to be adjusted via late intake valve closing (LIVC). The RCCI combustion was found to be more sensitive to changes in MN than the conventional NG-diesel dual-fuel operation. The gas mixture with the lowest MN reduced both total unburned hydrocarbons emissions and methane slip at the expense of higher nitrogen oxides (NOx) emissions. The effects of MN on the net indicated efficiency were more significant at 0.6 MPa IMEP, yielding differences of up to 4.9% between the RCCI operations with the lowest and highest MN fuels. Overall, this work revealed that the combination of the RCCI combustion and LIVC can achieve up to 80% lower methane slip and NOx emissions and relatively higher net indicated efficiency than the conventional dual-fuel regime, independent of the NG composition.
    Type of Medium: Online Resource
    ISSN: 1468-0874 , 2041-3149
    URL: Article
    DOI: 10.1177/1468087420984044
    RVK:
    ZG 1100
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2030603-9
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  • 7
    Online Resource
    Online Resource
    The comparison between traditional spark ignition and micro flame ignition in gasoline high dilution combustion
    SAGE Publications ; 2021
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 235, No. 8 ( 2021-07), p. 2242-2252
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 235, No. 8 ( 2021-07), p. 2242-2252
    Abstract: Gasoline spark ignition (SI) – Controlled auto-ignition (CAI) hybrid combustion had previously been shown to expanding the operational range of high-efficiency low-temperature combustion and reducing fuel consumption. However, the spark ignition became ineffective when the mixture became highly diluted and the large cyclic variation and even misfire would occur. To achieve high-efficiency combustion in extended engine operational range and overcome the limitation of SI-CAI hybrid combustion, Micro Flame Ignition (MFI) was proposed and researched as a mean to providing multiple auto-ignition sites to initiate the combustion process of the diluted mixture. In this research, both engine experiments and Computational Fluid Dynamics (CFD) simulations were carried out to study the MFI combustion and SI-CAI hybrid combustion in a single-cylinder optical engine. Compared to the SI-CAI hybrid combustion, the flame propagation in MFI hybrid combustion was initiated by a large number of reaction fronts produced by the DME auto-ignition at multiple sites. MFI was found to deliver substantially more heat and ignition energy to the premixed mixture than the single spark ignition, enabling much faster initial heat release. However, the flame front expansion speed of MFI hybrid combustion dropped significantly to a similar value to that of the SI-CAI case because of the slower flame speed of diluted gasoline mixture. The MFI combustion exhibited three phases of autoignition stage, flame propagation stage and fast heat release stage. It is characterized by a higher peak heat release rate and shorter duration of the main combustion than those of the SI-CAI combustion. Besides, the use of spark ignition in the MFI operation promoted the autoignition of DME, leading to a shorter combustion duration and faster combustion than the MFI combustion without spark ignition. As a result, the spark assisted MFI strategy could be used to control the combustion phasing and optimize the MFI combustion process.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/0954407020983164
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2032754-7
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  • 8
    Online Resource
    Online Resource
    Control and optimization of spark ignition–controlled auto-ignition hybrid combustion based on stratified flame ignition
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 233, No. 12 ( 2019-10), p. 3057-3073
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 233, No. 12 ( 2019-10), p. 3057-3073
    Abstract: Spark ignition–controlled auto-ignition hybrid combustion, also known as spark assisted compression ignition, is of considerable interest in gasoline engines because of its potential to enlarge the operating range of gasoline diluted combustion. However, it was found that the spark ignition–controlled auto-ignition hybrid combustion process was often characterized with large cycle-to-cycle variations. In this research, a new approach by combining the traditional second-order derivative method and Wiebe function fitting method was proposed to identify different heat release stages of spark ignition–controlled auto-ignition hybrid combustion. The heat release characteristics of the spark ignition–controlled auto-ignition hybrid combustion based on stratified flame ignition strategy and its control methods were investigated in detail. The effect of control parameters, including spark timing, direct injection ratio and dilution strategy, on improving the thermal efficiency and decreasing the variation of heat release trace in spark ignition–controlled auto-ignition hybrid combustion based on stratified flame ignition strategy was analysed. The advance of flame propagation ending point and the increase in the average heat release rate in flame propagation stage benefitted the fuel economy and reduced the variations of heat release in spark ignition–controlled auto-ignition hybrid combustion. Although the increase in direct injection ratio contributed to the stability of heat release in the spark ignition–controlled auto-ignition hybrid combustion based on the stratified flame ignition strategy, the thermal efficiency of spark ignition–controlled auto-ignition hybrid combustion cannot be effectively optimized due to the decrease in combustion efficiency. The application of exhaust gas recirculation and air dilution could decrease the variations of heat release process and increase the thermal efficiency of spark ignition–controlled auto-ignition hybrid combustion based on stratified flame ignition strategy.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/0954407018817626
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032754-7
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  • 9
    Online Resource
    Online Resource
    Characterizing street hierarchies through network analysis and large-scale taxi traffic flow: a case study of Wuhan, China
    SAGE Publications ; 2016
    In:  Environment and Planning B: Planning and Design Vol. 43, No. 2 ( 2016-03), p. 276-296
    Details
    In: Environment and Planning B: Planning and Design, SAGE Publications, Vol. 43, No. 2 ( 2016-03), p. 276-296
    Abstract: Hierarchy is an important property of a street network, which suggests that only a small number of streets are prominent. A previous empirical study of a European city has identified four levels of scale in a street network, namely the top 1%, top 20%, bottom 80%, and bottom 20%. This paper investigates such street hierarchies in a large Asian city, Wuhan, with a complicated network of streets. Based on network analysis, we find that street hierarchies in this case study are slightly different so that the fourth scale is adjusted from the initial 20 to 25%. The detected street hierarchies are further compared to the intensity of large-scale traffic flows at different time scales. We find that distributions of both daily and hourly traffic conform well to the street hierarchies. More specifically, the 20% of top streets accommodate about 98% of traffic flow, and the 1% of top streets account for more than 60% of traffic flow. Moreover, this finding indicates that the current street network of Wuhan needs to be improved because the top 20% of streets are rather overburdened leading to traffic congestion. Our study not only provides new quantitative evidence as to the emergence of street hierarchies but also highlights the possible traffic congestion.
    Type of Medium: Online Resource
    ISSN: 0265-8135 , 1472-3417
    URL: Article
    DOI: 10.1177/0265813515614456
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2039719-7
    detail.hit.zdb_id: 199345-8
    detail.hit.zdb_id: 2879402-3
    SSG: 3,4
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  • 10
    Online Resource
    Online Resource
    Endovascular Aortic Repair With Castor Single-Branched Stent-Graft in Treatment of Acute Type B Aortic Syndrome and Aberrant Right Subclavian Artery
    SAGE Publications ; 2021
    In:  Vascular and Endovascular Surgery Vol. 55, No. 6 ( 2021-08), p. 551-559
    Details
    In: Vascular and Endovascular Surgery, SAGE Publications, Vol. 55, No. 6 ( 2021-08), p. 551-559
    Abstract: In this retrospective study, we presented the results of Castor single-branched stent-graft in a small series of patients with acute type B aortic syndrome and aberrant right subclavian artery (ARSA). Methods: Between January 2019 and November 2019, 5 patients were diagnosed with acute type B aortic syndrome and ARSA (4 patients with intramural hematoma and ARSA, 1 patient with type B aortic dissection and ARSA). All the patients underwent thoracic endovascular aortic repair (TEVAR) using Castor single-branched stent-graft. In-hospital and 3-month outcomes were collected. Results: The mean operative time was 116 ± 20.43 minutes (range 90-145). All the TEVAR procedures were successfully performed without conversion to open surgery (100% success rate). All the ARSAs of the 5 patients were revascularized in situ by Castor single-branched stent-grafts. No deaths and complications were observed in the 3-month follow-up. The maximal diameters of diseased aortas in the 4 patients with IMH decreased 3 months after TEVAR. The false lumen in the graft-covered segment was completely thrombosed in the patient with type B aortic dissection. Conclusions: Castor single-branched stent-graft may be a good choice in treatment of acute type B aortic syndrome and aberrant right subclavian artery.
    Type of Medium: Online Resource
    ISSN: 1538-5744 , 1938-9116
    URL: Article
    DOI: 10.1177/15385744211005664
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2095223-5
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