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  • SAGE Publications  (39)
  • 1
    Online Resource
    Online Resource
    Weakly supervised multitask learning models to identify symptom onset time of unclear-onset intracerebral hemorrhage
    SAGE Publications ; 2022
    In:  International Journal of Stroke Vol. 17, No. 7 ( 2022-08), p. 785-792
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 17, No. 7 ( 2022-08), p. 785-792
    Abstract: Approximately one-third of spontaneous intracerebral hemorrhage patients did not know the onset time and were excluded from studies about time-dependent treatments for hyperacute spontaneous intracerebral hemorrhage. Aims To help clinicians explore the benefit of time-dependent treatments for unclear-onset patients, we presented artificial intelligence models to identify onset time using non-contrast computed tomography (NCCT) based on weakly supervised multitask learning (WS-MTL) structure. Methods The patients with reliable symptom onset time (strong label) or repeat CT (weak label) were included and split into training set and test set (internal and external). The WS-MTL structure utilized strong and weak labels simultaneously to improve performance. The models included three binary classification models for classifying whether NCCT acquired within 6, 8 or 12 h for different treatments measured by area under curve, and a regression model for determining the exact onset time measured by mean absolute error. The generalizability of models was also explored in comprehensive analysis. Results A total of 4004 patients with 10,780 NCCT scans were included. The performance of WS-MTL classification model showed high accuracy, and that of regression model was satisfactory in ≤6 h subgroup. In comprehensive analysis, the WS-MTL showed better performance for larger hematomas and thinner scans. And the performance improved effectively as training amounts increasing and could be improved steadily through retraining. Conclusions The WS-MTL models showed good performance and generalizability. Considering the large number of unclear-onset spontaneous intracerebral hemorrhage patients, it may be worth to integrate the WS-MTL model into clinical practice to identify the onset time.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930211051531
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2211666-7
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  • 2
    Online Resource
    Online Resource
    Two Patterns of Alanine Aminotransferase Increase to Predict Long-Term Viral Response in Chronic Hepatitis B Patients: Virus- or Host-Induced?
    SAGE Publications ; 2011
    In:  Antiviral Therapy Vol. 16, No. 3 ( 2011-04), p. 299-307
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 16, No. 3 ( 2011-04), p. 299-307
    Abstract: Serum alanine aminotransferase (ALT) increase is a well-known phenomenon during interferon treatment for chronic hepatitis B. However, little is known about these increases during nucleoside/ nucleotide treatment and the effects on long-term clinical outcomes. Methods A total of 170 treatment-naive hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients were treated with a nucleoside/nucleotide analogue for at least 2 years and followed up for 1 more year post-treatment. Clinical characteristics were detected and analysed at baseline and at every 3-month interval. Results Two patterns of ALT increase, virus- and host-induced, were detected. Virus-induced increases were characterized by a rapid increase in serum ALT and HBV DNA typically after 2 years of treatment, and were more common than host-induced ALT increases (15.9% versus 6.5%; P 〈 0.05) with a median ALT increase of 5.7fold the upper limit of normal (ULN). Host-induced ALT increases were characterized by moderately increased ALT (median 2.5-fold ULN) with a slow decrease in HBV DNA that occurred mainly in the first year of treatment (63.6%). Most importantly, host-induced increases were associated with favourable long-term treatment outcomes in HBV DNA undetectable rate (82% versus 0%), HBeAg seroconversion (82% versus 7%) and histological improvement. Moreover, interferon-γ-expressing T-helper cells were increased in patients with host-induced ALT increases. Conclusions Two patterns of ALT increases may occur during nucleoside/nucleotide analogue treatment. Host induced ALT increases, accompanied by decreased HBV DNA, lead to better long-term clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP1758
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Investigation of Residents’ Health Literacy Status and Its Risk Factors in Jiangsu Province of China
    SAGE Publications ; 2015
    In:  Asia Pacific Journal of Public Health Vol. 27, No. 2 ( 2015-03), p. NP2764-NP2772
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 27, No. 2 ( 2015-03), p. NP2764-NP2772
    Abstract: Health literacy has become an important public health concern. Multistage cluster random sampling was used to select 12 450 individuals. Using the 2009 Chinese Health Literacy questionnaire, participants were divided into groups with poor or not poor health literacy status. The knowledge rates for 6 areas of health literacy were determined with the following results: science concept of health (60.0%), literacy for preventing acute infectious disease (66.8%), literacy for preventing noncommunicable chronic disease (51.9%), safety and first aid (66.8%), obtaining and making use of basic medical care (55.3%), and comprehensive health literacy (52.5%). Multiple logistic regression showed that living in a rural area, fewer individuals in a household, younger age, low education, agricultural or rural migrant occupation workers, and low family income were associated with a poor health literacy status. Our results support the use of health education and promotion interventions to improve health literacy in this high-risk population in China.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539513487012
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2394975-2
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  • 4
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    Online Resource
    The fire retardant properties and pyrolysis mechanism of polysulfonamide (PSA) fibers
    SAGE Publications ; 2018
    In:  Textile Research Journal Vol. 88, No. 11 ( 2018-06), p. 1299-1307
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 88, No. 11 ( 2018-06), p. 1299-1307
    Abstract: In the present work, the fire retardant properties and pyrolysis mechanism of polysulfonamide (PSA) fibers were investigated by cone calorimetry, scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR), and pyrolysis-gas chromatography-mass spectrometry. The fire retardant behaviors were reflected by the cone calorimeter data under heat fluxes of 35, 50, and 75 kW/m 2 . This demonstrated that, when exposed to higher heat flux, PSA fibers were ignited easier and burned more completely, indicated by lower time to ignition and higher peak heat release rate. It was further confirmed from the morphology of the residual chars that the original fiber shape can be kept at lower heat flux, but it changed into coherent carbonaceous chars with holes at higher heat flux. In comparison of the FTIR spectra of raw fibers with residual chars, it was noticed that upon heating, the amide linkage was more liable to be broken than that of sulfone groups. Additionally, with elevated heat flux, most of the absorption bands vanished and transformed into the typical feature of carbonaceous material. The pyrolysis products showed that some volatile products with small molecular weight, such as benzene, benzonitrile, and aniline, can be created at high temperature, which can be easily ignited. With this research, the fire retardant properties of PSA fibers are revealed and the corresponding pyrolysis mechanism is proposed, which can guide its application in practice.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/0040517517698990
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2209596-2
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  • 5
    Online Resource
    Online Resource
    Research on Vehicle Automatically Tracking Mechanism in VANET
    SAGE Publications ; 2013
    In:  International Journal of Distributed Sensor Networks Vol. 9, No. 8 ( 2013-08-01), p. 592129-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 9, No. 8 ( 2013-08-01), p. 592129-
    Abstract: The intelligent vehicle is a complex system equipped with advanced technologies such as the artificial intelligence, automatic control, and computer, communication. It is a combination of multiple academic subjects and the latest technologies representing the developing tendency of future automobile technology and attracts more and more attention. In this paper, we made some useful explorations in the fields of intelligent vehicle control technology and obstacle avoidance, and a deep research is carried out about the distance of vehicle, vehicle tracking, vehicle lane changing and intersections obstacle avoidance and communication protocols, and some innovative ideas are proposed during the research. By using VANET, some predictable status of tracing and tracking of intelligent vehicle technology was researched, and the communication protocols between two vehicles, the safe spacing algorithm, the method of computing the actual distance at corners and straights, and the trajectory of lane change were designed. In addition, a series of vehicle tracing and tracking technologies, such as without knowing the road conditions, homeostatic mechanism, keeping a safe spacing to the target vehicle, and adjusting its own speed to track the target vehicle smoothly to the destination by comparing the actual distance and safe spacing between vehicles, were discussed here.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1155/2013/592129
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2192922-1
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  • 6
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    Online Resource
    High levels of NK Cells in graft are associated with reduced febrile neutropenia after haploidentical peripheral blood stem cell transplantation
    SAGE Publications ; 2023
    In:  Journal of International Medical Research Vol. 51, No. 7 ( 2023-07)
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 51, No. 7 ( 2023-07)
    Abstract: To investigate the impact of natural killer (NK) cells in the graft on the outcome following haploidentical peripheral blood stem cell transplantation (haplo-PBSCT). Methods We retrospectively collected data from patients who had undergone haplo-PBSCT at our centre from January 2019 to November 2021. The percentage of NK cells in stem cell grafts was detected by flow cytometry. Based on the median (range) count of NK cells (1.8 [0.4–6.0] × 10 8 /kg), patients were separated into high and low NK cell count groups. Results Data from 96 patients were analysed. Patients were evenly distributed (48 in each group) into high and low NK cell count groups. There was no significant difference in neutrophil and platelet recovery between the two groups. However, the rates of febrile neutropenia, bacterial infection, and invasive fungal disease (IFD) were significantly reduced in the high compared with the low NK cell count group. There was no significant difference in rates of cytomegalovirus (CMV) and Epstein–Barr virus (EBV) infections between groups. There was no significant difference between groups in grades II and above acute graft versus host disease (GVHD), progression-free survival (PFS), or overall survival (OS). Conclusion A high number of NK cells in the graft may reduce febrile neutropenia, IFD and bacterial infection following haplo-PBSCT but it has no significant effect on aGVHD, PFS, or OS.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605231187932
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2082422-1
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  • 7
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    Online Resource
    Clinical Evaluation of the Pre-Analytical Capabilities of Hemostasis Instrument
    SAGE Publications ; 2022
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 28 ( 2022-01), p. 107602962211184-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962211184-
    Abstract: Objective: Evaluate the technical performance of the pre-analytical hemolysis-icterus-lipemia (HIL) check module on the ACL-TOP-750. Methods: 8433 routine coagulation samples were evaluated for HIL, the presence of clotting and low sample volume by both visual inspection and the pre-analytical HIL check module on the ACL-TOP-750. Results: 7726 samples were in agreement with both methods and 707 were not consistent. 356 samples with low volume were identified by visual inspection and 920 by the instrument (2.7 mL threshold). Visual inspection identified 56 lipemic samples while 13 of those with moderate or high lipemia were identified by the instrument. Visual inspection identified 47 hemolyzed samples while 7 with moderate or high hemolysis were identified by the instrument. Both visual inspection and the instrument identified 36 icteric samples. For triglyceride concentration and bilirubin concentration, there was good correlation between the ACL-TOP-750 and the DXC800 biochemistry analyzer. Among 30 samples with varying amounts of clotting, 27 were discovered by visual inspection and 3 were discovered by the instrument. Conclusion: The pre-analytical check module on the ACL-TOP-750 improved the detection rate of samples below the target 2.7 mL volume, and the accuracy in detection of HIL. However, the automated method could not replace visual assessment of clotting in samples.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296221118483
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2230591-9
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  • 8
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    Online Resource
    Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice
    SAGE Publications ; 2017
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 37, No. 9 ( 2017-09), p. 3110-3123
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 37, No. 9 ( 2017-09), p. 3110-3123
    Abstract: Iron overload plays a key role in the secondary brain damage that develops after intracerebral hemorrhage (ICH). The significant increase in iron deposition is associated with the generation of reactive oxygen species (ROS), which leads to oxidative brain damage. In this study, we examined the protective effects of VK-28, a brain-permeable iron chelator, against hemoglobin toxicity in an ex vivo organotypic hippocampal slice culture (OHSC) model and in middle-aged mice subjected to an in vivo, collagenase-induced ICH model. We found that the effects of VK-28 were similar to those of deferoxamine (DFX), a well-studied iron chelator. Both decreased cell death and ROS production in OHSCs and in vivo, decreased iron-deposition and microglial activation around hematoma in vivo, and improved neurologic function. Moreover, compared with DFX, VK-28 polarized microglia to an M2-like phenotype, reduced brain water content, deceased white matter injury, improved neurobehavioral performance, and reduced overall death rate after ICH. The protection of VK-28 was confirmed in a blood-injection ICH model and in aged-male and young female mice. Our findings indicate that VK-28 is protective against iron toxicity after ICH and that, at the dosage tested, it has better efficacy and less toxicity than DFX does.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X17709186
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2039456-1
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  • 9
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    Online Resource
    Synthesis, characterization and swelling behaviors of guar gum- g -poly(sodium acrylate- co -styrene)/vermiculite superabsorbent composites
    SAGE Publications ; 2011
    In:  Journal of Composite Materials Vol. 45, No. 21 ( 2011-10), p. 2189-2198
    Details
    In: Journal of Composite Materials, SAGE Publications, Vol. 45, No. 21 ( 2011-10), p. 2189-2198
    Abstract: A series of novel superabsorbent composites guar gum- g-poly(sodium acrylate- co-styrene)/vermiculite (GG- g-poly(NaA- co-St)/VMT) were prepared by the simultaneous graft copolymerization of guar gum (GG), partially neutralized acrylic acid (NaA), styrene (St) and vermiculite (VMT) using ammonium persulfate (APS) as the initiator and N,N′-methylene- bis-acrylamide (MBA) as the crosslinker. Fourier transform–infrared (FT-IR) and ultraviolet-visible (UV-vis) spectroscopy revealed that NaA and St had been grafted onto GG main-chain, and VMT participated in polymerization reaction. The simultaneous incorporation of St and VMT improved the surface pore structure, and VMT led to a better dispersion in the polymer matrix as shown by field emission scanning electron microscope (FESEM). Swelling results indicated that the inclusion of proper amount of St and VMT in the superabsorbents induced enhanced swelling capability, rate, and salt-resistant performance. Moreover, the composites showed good pH-stability in the solution of various pHs, and exhibited smart swelling–shrinking on–off swelling characteristic in physiological solution, which can be used as promising candidate for its applications in various fields.
    Type of Medium: Online Resource
    ISSN: 0021-9983 , 1530-793X
    URL: Article
    DOI: 10.1177/0021998311401071
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 160490-9
    detail.hit.zdb_id: 2081924-9
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  • 10
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    Traffic fatalities prediction using support vector machine with hybrid particle swarm optimization
    SAGE Publications ; 2018
    In:  Journal of Algorithms & Computational Technology Vol. 12, No. 1 ( 2018-03), p. 20-29
    Details
    In: Journal of Algorithms & Computational Technology, SAGE Publications, Vol. 12, No. 1 ( 2018-03), p. 20-29
    Type of Medium: Online Resource
    ISSN: 1748-3018 , 1748-3026
    URL: Article
    DOI: 10.1177/1748301817729953
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2478205-1
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