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  • SAGE Publications  (47)
  • 1
    Online Resource
    Online Resource
    Upregulated Expression of Toll-Like Receptor 7 in Peripheral Blood Basophils of Patients With Allergic Rhinitis
    SAGE Publications ; 2021
    In:  American Journal of Rhinology & Allergy Vol. 35, No. 6 ( 2021-11), p. 746-760
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 35, No. 6 ( 2021-11), p. 746-760
    Abstract: Recently, it has been reported that Toll-like receptor 7 (TLR7) agonists can improve allergic rhinitis (AR) symptoms by up-regulation of Th1 cytokine release and suppression of Th2 cell functions. However, little is known of the expression of TLR7 in basophils of AR. Objective To explore the expression of TLR7 in basophils of AR, and influence of allergens on TLR7 expression. Methods The expression levels of TLR7 in basophils of patients with AR were determined by flow cytometry, and the influence of allergens on TLR7 expression was examined by real time (q) PCR. Results The percentages of TLR7 + CCR3 + cells ( P  〈  0.001 and P = 0.011), TLR7 + CD123 + HLA-DR − cells ( P = 0 .016 and P = 0.042) and TLR7 + CCR3 + CD123 + HLA-DR − cells ( P = 0.046 and P = 0.035) in blood granulocyte and mononucleated cell populations of the patients with AR were increased, respectively compared with HC subjects. TLR7 MFI on CCR3 + cells ( P = 0.050 and P = 0.043), CD123 + HLA-DR − cells ( P  〈  0.001 and P = 0.002) and CCR3 + CD123 + HLA-DR − cells ( P  〈  0.001 and P = 0.003) were enhanced compared with HC subjects. Allergens Der p1 and OVA provoked upregulation of TLR7 expression at both protein and mRNA levels and IL-13 production in KU812 cells. House Dust Mite extract (HDME), Artemisia sieversiana wild allergen extract (ASWE), IL-31, IL-33, IL-37, and TSLP provoked elevation of IL-6 release from KU812 cells following 2 h incubation period. Conclusions The percentage of TLR7 + basophils and TLR7 expression intensity in a single basophil are both increased in the blood of patients with AR, indicating that basophils likely contribute to the pathogenesis of AR via TLR7.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.1177/1945892421993034
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2554548-6
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  • 2
    Online Resource
    Online Resource
    A pharmacogenetic study of risperidone on histamine H3 receptor gene ( HRH3 ) in Chinese Han schizophrenia patients
    SAGE Publications ; 2012
    In:  Journal of Psychopharmacology Vol. 26, No. 6 ( 2012-06), p. 813-818
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 26, No. 6 ( 2012-06), p. 813-818
    Abstract: Evidence suggests that the human histamine H3 receptor ( HRH3) may be involved in the pharmacodynamics of risperidone and influence clinical efficacy. More information on the pharmacogenetics of this receptor may therefore be useful in developing individualized therapy. However, to our knowledge, no study has been reported in this area. The aim of this investigation was to clarify whether H3 receptor polymorphism could affect risperidone efficacy. We genotyped tag single nucleotide polymorphisms (SNPs) of the HRH3 gene (rs3787429 and rs3787430) and analyzed their association with the reduction of Brief Psychiatric Rating Scale (BPRS) score in Chinese Han schizophrenia patients ( N = 129), following an eight-week period of risperidone monotherapy. The confounding effects of non-genetic factors were estimated, and then the significant one was included as the covariate for adjustment in statistical analysis. Baseline symptom score was the only significant confounding effect and thus the covariate. After adjustment, significant association of HRH3 with antipsychotic efficacy was detected (for rs3787429, p = 0.013, 0.087 after 4 weeks and 8 weeks of treatment, respectively; for rs3787430, p = 0.024, 0.010 after 4 weeks and 8 weeks of treatment, respectively) and stood up to conservative Bonferroni correction. Our results demonstrate that polymorphism of the HRH3 gene may be a potential genetic marker for predicting the therapeutic effect of risperidone, and suggest novel pharmacological links between HRH3 and risperidone. Further studies with larger samples and different ethnic populations are warranted to confirm our results.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881111405358
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2028926-1
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  • 3
    Online Resource
    Online Resource
    E-waste management in India: A mini-review
    SAGE Publications ; 2018
    In:  Waste Management & Research: The Journal for a Sustainable Circular Economy Vol. 36, No. 5 ( 2018-05), p. 408-414
    Details
    In: Waste Management & Research: The Journal for a Sustainable Circular Economy, SAGE Publications, Vol. 36, No. 5 ( 2018-05), p. 408-414
    Abstract: Environmental deterioration and health risk due to improper e-waste management has become a serious issue in India. The major portion of e-waste reaches an unorganized e-waste recycling sector and is then treated by using crude methods. This review article presents a brief highlight on e-waste management status, legislation, and technology uses in India. The present e-waste management needs to be more focused on environmentally sound management, by more active support from all the participants involved in the e-waste flow chain in India.
    Type of Medium: Online Resource
    ISSN: 0734-242X , 1096-3669
    URL: Article
    DOI: 10.1177/0734242X18767038
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1480483-9
    detail.hit.zdb_id: 46937-3
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  • 4
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    Systematic Review and Meta-analyses: Dietary Behavior Interventions in Non-dialysis Chronic Kidney Disease
    SAGE Publications ; 2020
    In:  Western Journal of Nursing Research Vol. 42, No. 11 ( 2020-11), p. 937-947
    Details
    In: Western Journal of Nursing Research, SAGE Publications, Vol. 42, No. 11 ( 2020-11), p. 937-947
    Abstract: Evidence of the effectiveness of dietary behavior interventions in patients with non-dialysis chronic kidney disease is limited. We aim to determine the benefits and barriers of dietary behavior interventions for this population. Eligible studies were obtained from databases including PubMed, Embase, the Cochrane Library, Web of Science, and CINAHL. Six studies including 432 participants were identified. Overall, dietary behavior interventions significant improved adherence to protein intake (2.64, 95% CI 1.33, 5.23, I 2 = 0) and renal function (eGFR) (2.97, 95% CI 2.59, 3.35, I 2 = 0). Moreover, dietary behavior interventions indicated a significant opportunity to promote adherence to sodium-restricted diets (SRD), blood pressure (BP), self-efficacy, and quality of life (QoL) in non-dialysis CKD patients. However, there is still need to determine dietary behavior intervention programs in large sample and amount of studies, develop reliable instruments to measure dietary adherence, and thereafter, provide more reliable results for clinical practice.
    Type of Medium: Online Resource
    ISSN: 0193-9459 , 1552-8456
    URL: Article
    DOI: 10.1177/0193945920905090
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2067773-X
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  • 5
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    Online Resource
    Fiber breakage behavior of long glass fiber-reinforced polypropylene through the convergent channel
    SAGE Publications ; 2017
    In:  Journal of Reinforced Plastics and Composites Vol. 36, No. 22 ( 2017-11), p. 1629-1638
    Details
    In: Journal of Reinforced Plastics and Composites, SAGE Publications, Vol. 36, No. 22 ( 2017-11), p. 1629-1638
    Type of Medium: Online Resource
    ISSN: 0731-6844 , 1530-7964
    URL: Article
    DOI: 10.1177/0731684417721977
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2051886-9
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  • 6
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    Online Resource
    Analysis of Circular RNA Expression Profile in HEK 293T Cells Exposed to Ionizing Radiation
    SAGE Publications ; 2019
    In:  Dose-Response Vol. 17, No. 2 ( 2019-04-01), p. 155932581983779-
    Details
    In: Dose-Response, SAGE Publications, Vol. 17, No. 2 ( 2019-04-01), p. 155932581983779-
    Abstract: Radiation therapy is one of the most common cancer treatments. It is important to understand how cells respond to ionizing radiation (IR) to improve therapeutic efficacy. Circular RNAs (circRNAs) recently have been found to regulate a variety of cellular processes. However, it is poorly defined that their expression pattern and their identity in cells following IR exposure. Here, we performed high-throughput sequencing and comprehensive analysis of circRNA expression in human embryonic kidney (HEK) 293T cells before and after irradiation. We identified totally 5592 circRNAs and discovered 1038 new circRNAs. We found 158 circRNAs with significantly differential expression after IR exposure. Among them, there were 61 upregulated and 97 downregulated circRNAs. Using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway, and circRNA-microRNA-messenger RNA network analyses, we found the differentially expressed circRNAs might be involved in the signal pathways of oxidative phosphorylation, epithelial growth factor receptor (EGFR) tyrosine kinase inhibitor resistance, and mammalian target of rapamycin (mTOR) signaling.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325819837795
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440820-7
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  • 7
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    Online Resource
    Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens
    SAGE Publications ; 2018
    In:  Molecular Pain Vol. 14 ( 2018-01), p. 174480691878125-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 14 ( 2018-01), p. 174480691878125-
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1177/1744806918781259
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2174252-2
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  • 8
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    Online Resource
    Reconsidering T component of cancer staging for T3/T4 non-small-cell lung cancer with additional nodule
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Medical Oncology Vol. 14 ( 2022-01), p. 175883592211305-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 14 ( 2022-01), p. 175883592211305-
    Abstract: Non-small-cell lung cancer (NSCLC) with additional nodule(s) located in the same lobe or ipsilateral different lobe were designated as T3 and T4, respectively, which was merely defined by anatomical location of additional nodule(s), regardless of other prognostic factors. Methods: A total of 4711 patients with T1-4, N0-2, M0 NSCLC undergoing complete resection were identified between 2009 and 2014, including 145 patients with additional nodule(s) in the same lobe (T3-Add) and 174 patients with additional tumor nodule(s) in ipsilateral different lobe (T4-Add). Overall survival (OS) was compared using multivariable Cox regression models and propensity score matching analysis (PSM). Results: T3-Add patients [T3-Add versus T3, hazard ratio (HR), 0.695; 95% confidence interval (CI), 0.528–0.915; p = 0.009] and comparable OS with T2b patients through multivariable Cox analysis, and further validated by PSM. T4-Add patients carried a wide spectrum of prognosis, and the largest diameter of single tumor was screened out as the most effective indicator for distinguishing prognosis. T4-Add (⩽3 cm) patients had better OS than T4 patients [T4-Add (⩽3 cm) versus T4, HR, 0.629; 95% CI, 0.455–0.869; p = 0.005] and comparable OS with T3 patients. And T4-Add ( 〉 3 cm) patients had comparable OS with T4 patients. Conclusion: NSCLC patients with additional nodule(s) in the same lobe and ipsilateral different lobe (maximum tumor diameter ⩽ 3 cm) should be further validated and considered restaging as T2b and T3 in the forthcoming 9th tumor, node, and metastasis staging system.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359221130502
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2503443-1
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  • 9
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    Nonpharmacological Interventions for Depressive Symptoms in End-Stage Renal Disease: A Systematic Review
    SAGE Publications ; 2020
    In:  Western Journal of Nursing Research Vol. 42, No. 6 ( 2020-06), p. 462-473
    Details
    In: Western Journal of Nursing Research, SAGE Publications, Vol. 42, No. 6 ( 2020-06), p. 462-473
    Abstract: Depressive symptoms are common in patients with end-stage renal disease, which can affect treatment and prognosis. We aimed to evaluate the effects of nonpharmacological interventions for depressive symptoms in end-stage renal disease. Eligible studies were identified using PubMed, Web of Science, the Cochrane Library, Embase, and PsycNET (up to March 2019). We identified 24 studies including 1,376 patients. We found that psychological intervention (−0.60, 95% confidence interval [CI] = [–0.87, –0.33] ), exercise (−1.13, 95% CI = [–1.56, –0.69]), and manual acupressure (−0.26, 95% CI = [–0.50, 0.03] ) were associated with a significant effect on depressive symptoms. However, few studies reported adverse events, and conclusions about safety should be drawn cautiously. While the available data show that nonpharmacological interventions are potential strategies to alleviate depressive symptoms of patients with end-stage renal disease, recommendation of the most efficacious interventions for this population will require future randomized controlled trials with large-scale, long-term intervention.
    Type of Medium: Online Resource
    ISSN: 0193-9459 , 1552-8456
    URL: Article
    DOI: 10.1177/0193945919857540
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2067773-X
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  • 10
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    Online Resource
    Entrance flow of long glass fiber reinforced polypropylene through contraction die
    SAGE Publications ; 2016
    In:  Journal of Reinforced Plastics and Composites Vol. 35, No. 2 ( 2016-01), p. 111-123
    Details
    In: Journal of Reinforced Plastics and Composites, SAGE Publications, Vol. 35, No. 2 ( 2016-01), p. 111-123
    Abstract: The entrance flow of long glass fiber reinforced polypropylene has been studied. It is demonstrated that longer glass fibers are easier to break and accumulate at the entrance. As the length of the die and shear rate increase, the fiber breakage increases for long glass fiber reinforced polypropylene. Comparison of fiber breakages of long and short glass fiber reinforced polypropylene indicates that short glass fiber mainly breaks before and at the entrance and remains almost unchanged in the die, while longer glass fibers still break after the entrance within the die. It is demonstrated that fiber accumulation increased when increasing the length of the die and shear rate. The pressure is found to oscillate at the entrance and this pressure accumulation and release should be related to the fiber interactions and fiber breakage at the entrance. It is also found that the presence of long glass fibers would lead to significantly higher viscosity which would decrease when increasing the shear rate.
    Type of Medium: Online Resource
    ISSN: 0731-6844 , 1530-7964
    URL: Article
    DOI: 10.1177/0731684415607645
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2051886-9
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