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  • SAGE Publications  (28)
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  • 1
    Online Resource
    Online Resource
    Association Between Parity and the Age at Menopause and Menopausal Syndrome in Northwest China
    SAGE Publications ; 2021
    In:  Asia Pacific Journal of Public Health Vol. 33, No. 1 ( 2021-01), p. 60-66
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 33, No. 1 ( 2021-01), p. 60-66
    Abstract: This study evaluated the relationships between parity and the age at menopause and menopausal syndrome among Chinese women in Gansu. A total of 7236 women aged 40 to 55 years met study eligibility criteria. The modified Kupperman Menopausal Index scale was used to assess the severity of menopausal syndrome. Cox regression was applied to estimate hazard ratio and 95% confidence interval, and logistic regression was performed to calculate odds ratio and confidence interval. The mean age at menopause was 47.91 ± 3.31 years. There is no relationship between parity and age at menopause. Women with nulliparity or multiparity seemed to have higher risks of moderate and severe menopausal syndrome. The potential beneficial effects of one or two births on menopausal syndrome were also observed by applying the multivariable logistic regression analysis, particularly in urogenital symptoms. Women with nulliparity and multiparity appeared to be at the higher risks of menopause syndrome.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539520960987
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2394975-2
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  • 2
    Online Resource
    Online Resource
    A pharmacogenetic study of risperidone on histamine H3 receptor gene ( HRH3 ) in Chinese Han schizophrenia patients
    SAGE Publications ; 2012
    In:  Journal of Psychopharmacology Vol. 26, No. 6 ( 2012-06), p. 813-818
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 26, No. 6 ( 2012-06), p. 813-818
    Abstract: Evidence suggests that the human histamine H3 receptor ( HRH3) may be involved in the pharmacodynamics of risperidone and influence clinical efficacy. More information on the pharmacogenetics of this receptor may therefore be useful in developing individualized therapy. However, to our knowledge, no study has been reported in this area. The aim of this investigation was to clarify whether H3 receptor polymorphism could affect risperidone efficacy. We genotyped tag single nucleotide polymorphisms (SNPs) of the HRH3 gene (rs3787429 and rs3787430) and analyzed their association with the reduction of Brief Psychiatric Rating Scale (BPRS) score in Chinese Han schizophrenia patients ( N = 129), following an eight-week period of risperidone monotherapy. The confounding effects of non-genetic factors were estimated, and then the significant one was included as the covariate for adjustment in statistical analysis. Baseline symptom score was the only significant confounding effect and thus the covariate. After adjustment, significant association of HRH3 with antipsychotic efficacy was detected (for rs3787429, p = 0.013, 0.087 after 4 weeks and 8 weeks of treatment, respectively; for rs3787430, p = 0.024, 0.010 after 4 weeks and 8 weeks of treatment, respectively) and stood up to conservative Bonferroni correction. Our results demonstrate that polymorphism of the HRH3 gene may be a potential genetic marker for predicting the therapeutic effect of risperidone, and suggest novel pharmacological links between HRH3 and risperidone. Further studies with larger samples and different ethnic populations are warranted to confirm our results.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881111405358
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2028926-1
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  • 3
    Online Resource
    Online Resource
    Circulating tumour DNA biomarkers in savolitinib-treated patients with non-small cell lung cancer harbouring MET exon 14 skipping alterations: a post hoc analysis of a pivotal phase 2 study
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Medical Oncology Vol. 14 ( 2022-01), p. 175883592211335-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 14 ( 2022-01), p. 175883592211335-
    Abstract: Savolitinib, a selective MET inhibitor, showed efficacy in patients with non-small cell lung cancer (NSCLC), including pulmonary sarcomatoid carcinoma (PSC), harbouring MET exon 14 skipping alteration ( METex14). Objective: To analyse post hoc, the association between circulating tumour DNA (ctDNA) biomarkers and clinical outcomes, including resistance, with savolitinib. Design: A multicentre, single-arm, open-label phase 2 study. Methods: All enrolled patients with baseline plasma samples were included. Outcomes were objective response rate (ORR), progression-free survival (PFS) and overall survival (OS) by baseline METex14 and post-treatment clearance, coexisting gene alterations at baseline and disease progression. Results: Among 66 patients with baseline ctDNA sequencing, 46 (70%) had detectable METex14. Frequent coexisting baseline gene alterations included TP53 and POT1 mutations. Patients with detectable baseline METex14 exhibited worse PFS [hazard ratio (HR), 1.77; 95% confidence interval (CI), 0.88–3.57; p = 0.108] and OS (HR, 3.26; 95% CI, 1.35–7.89; p = 0.006) than those without, despite showing a numerically higher ORR. Among 24 patients with baseline detectable METex14 and evaluable postbaseline samples, 13 achieved METex14 clearance post-treatment. Median time to first clearance was 1.3 months (range, 0.7–1.5). METex14 post-treatment clearance was associated with better ORR (92.3%; 95% CI, 64.0–99.8 versus 36.4%; 95% CI, 10.9–69.2; p = 0.0078), PFS (HR, 0.44; 95% CI, 0.2–1.3; p = 0.1225) and OS (HR, 0.31; 95% CI, 0.1–1.0; p = 0.0397) versus non-clearance. Among 22 patients with disease progression, 10 acquired pathway alterations (e.g. in RAS/RAF and PI3K/PTEN) alone or with secondary MET mutations (D1228H/N and Y1230C/H/S). Conclusion: ctDNA biomarkers may allow for longitudinal monitoring of clinical outcomes with savolitinib in patients with METex14-positive PSC and other NSCLC subtypes. Specifically, undetectable baseline METex14 or post-treatment clearance may predict favourable clinical outcomes, while secondary MET mutations and other acquired gene alterations may explain resistance to savolitinib. Registration: The trial was registered with ClinicalTrials.gov (NCT02897479) on 13 September 2016.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359221133546
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2503443-1
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  • 4
    Online Resource
    Online Resource
    Synthesis and Characterisation of New N -alkyl- N,N -dimethyl[ N -(pyridin-2-yl) Carbamoyl]Methylammonium Chlorides
    SAGE Publications ; 2013
    In:  Journal of Chemical Research Vol. 37, No. 12 ( 2013-12), p. 733-735
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 37, No. 12 ( 2013-12), p. 733-735
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751913X13842783432845
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 3010810-X
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  • 5
    Online Resource
    Online Resource
    Expression and clinical significance of connective tissue growth factor in thyroid carcinomas
    SAGE Publications ; 2013
    In:  Journal of International Medical Research Vol. 41, No. 4 ( 2013-08), p. 1214-1220
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 41, No. 4 ( 2013-08), p. 1214-1220
    Abstract: To examine expression of the connective tissue growth factor ( CTGF) gene in human thyroid cancer and establish whether a correlation exists between the presence of CTGF protein and clinicopathological parameters of the disease. Methods CTGF protein expression was investigated retrospectively by immunohistochemical analysis of CTGF protein levels in thyroid tumour tissue. Associations between immunohistochemical score and several clinicopathological parameters were examined. Results In total, 131 thyroid tissue specimens were included. High levels of CTGF protein were observed in papillary thyroid carcinoma tissue; benign thyroid tumour tissue scored negatively for CTGF protein. In papillary thyroid carcinoma, there was a significant relationship between high CTGF protein levels and Union for International Cancer Control disease stage III–IV, and presence of lymph node metastasis. In papillary thyroid carcinomas, CTGF protein levels were not significantly associated with sex or age. Conclusions These findings suggest that the CTGF protein level is increased in papillary thyroid carcinoma cells compared with benign thyroid tumours. CTGF expression might play a role in the development of malignant tumours in the thyroid.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060513476595
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2082422-1
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  • 6
    Online Resource
    Online Resource
    Biological effects and mechanisms of action of mesenchymal stem cell therapy in chronic obstructive pulmonary disease
    SAGE Publications ; 2015
    In:  Journal of International Medical Research Vol. 43, No. 3 ( 2015-06), p. 303-310
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 43, No. 3 ( 2015-06), p. 303-310
    Abstract: Chronic obstructive pulmonary disease (COPD) is the most frequent chronic respiratory disease and a leading cause of morbidity and mortality, worldwide. Given that the foremost risk factor leading to the development of COPD is cigarette smoke, the initial treatment for COPD is smoking cessation. Even after smoking cessation, inflammation, apoptosis and oxidative stress can persist and continue to contribute to COPD. Although current therapies for COPD (which are primarily based on anti-inflammatory drugs such as corticosteroids, theophylline and bronchodilators) reduce airway obstruction, limit COPD exacerbation and improve the patient’s health-related quality-of-life, none can prevent disease progression or reduce mortality. Recent advances in stem cell research have provided novel insight into the potential of bone marrow mesenchymal stem cells (MSCs) in the treatment of several pulmonary diseases. This review article discusses the biological effects and mechanisms of action of MSC transplantation in COPD, and highlights the foundation that MSCs provide for novel therapeutic approaches in COPD.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060514568733
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2082422-1
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  • 7
    Online Resource
    Online Resource
    Effect of silver/polydopamine graphene oxide as lubricating oil additive on temperature rise and vibration of motorized spindle
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications
    Abstract: In this study, polydopamine and silver-modified graphene oxide (Ag/PGO) were prepared using a one-step method, and the effects of Ag/PGO as a lubricating oil additive on the viscosity, thermal conductivity, and lubricating performance of lubricating oil were studied. The influence of additive lubricating oil on the temperature increase and vibration of a high-speed motorized spindle was studied through a motorized spindle experiment. The results showed that the addition of Ag/PGO nanocomposites could improve the thermophysical properties and lubricating properties of the lubricating oil. The Ag/PGO nanoparticles deposited on the friction surface formed a friction protective film, which prevented direct contact between the friction pairs and effectively reduced the heat generated through friction and micro-peak collision during bearing operation. The lubricating oil containing Ag/PGO had high thermal conductivity and a good heat dissipation effect in convection heat transfer in the bearing cavity. The deposition and repair of nanoparticles could improve the micro-morphology of the friction surface and reduce the high-frequency amplitude of the motorized spindle.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/09544062231187731
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024890-8
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  • 8
    Online Resource
    Online Resource
    Molecular dynamics simulation and experimental study on the lubrication of graphene additive films
    SAGE Publications ; 2020
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 234, No. 12 ( 2020-12), p. 1957-1972
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 234, No. 12 ( 2020-12), p. 1957-1972
    Abstract: Friction between silicon nitride (Si 3 N 4 ) and bearing steel (GCr15) affects the hybrid bearing performance. The effects of graphene as an additive in n-hexadecane (C 16 H 34 ) lubricating oil on the lubricating properties of a Si 3 N 4 -GCr15 friction pair were studied. The effects of pressure and shear velocity on the coefficient of friction and friction force were probed experimentally, while the changes in the van der Waals energy, shear stress, and thickness of the solid film in the lubrication area were simulated by molecular dynamics methods. Graphene additives increased the van der Waals energy and thickness of the solid film in the lubrication region, while reducing the shear stress of the Si 3 N 4 -GCr15 friction pair, coefficient of friction, and friction force. Furthermore, the lower the overall shearing velocity, the lower was the van der Waals energy and shear stress, and the thicker was the solid film. Finally, as the pressure and shear velocity increased, graphene exerted a greater influence on the lubricating properties of the Si 3 N 4 -GCr15 friction pair.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/1350650119899213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2032767-5
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  • 9
    Online Resource
    Online Resource
    Endoscopic resection techniques for squamous premalignant lesions and early carcinoma of the esophagus: ER-Cap, MBM, and ESD, how do we choose? A multicenter experience
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Gastroenterology Vol. 13 ( 2020-01), p. 175628482090917-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 13 ( 2020-01), p. 175628482090917-
    Abstract: Endoscopic resection cap technique (ER-Cap), multiband mucosectomy (MBM), and endoscopic submucosal dissection (ESD) have been widely applied in the treatment of esophageal squamous neoplasia and cancer. However, little is known with regards to the comparison of these methods. This study aimed to compare the feasibility, safety, effectiveness, and costs of these three techniques. Methods: A retrospective analysis of patients with squamous premalignant or early malignant lesions of the esophagus undergoing ER-Cap, MBM, or ESD from January 2009 to December 2015 in one of the centers in China was performed. The procedural data and follow-up data for all patients were recorded. Results: A total of 672 patients with 733 lesions were included; 148 lesions (133 patients) were treated with ER-Cap, 427 lesions (388 patients) with MBM, and 158 lesions (151 patients) with ESD. The mean age was 61.59 years and the male-to-female ratio was 2.78:1. The operation time was significantly shorter for ER-Cap (29.26 ± 16.73 mins, p  〈  0.001) group, and the hospitalization costs were significantly lower in the MBM group (20,942.03 ± 8435.56￥, p = 0.003). The resection sample size of ESD was significantly larger (4.40 ± 1.20 cm, p  〈  0.001) and the en bloc resection rate of ESD was significantly higher ( p  〈  0.001) than that of the other two groups. The frequencies of perforation, bleeding, and cicatricial stenosis were significantly lower in the MBM group ( p  〈  0.001, p = 0.011, p = 0.009). Three local recurrences were observed in the ER-Cap group, while no recurrence was observed in MBM and ESD groups. There were three and two metastatic patients observed in the MBM and ESD groups, respectively. Conclusions: ER-Cap, MBM, and ESD are all minimally invasive, safe, and effective methods for treating early esophageal squamous cell carcinoma. MBM could be considered as a good alternative when performed by a less-experienced endoscopist in high-incidence areas with limited resources.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/1756284820909172
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2440710-0
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  • 10
    Online Resource
    Online Resource
    House Dust Mite Allergen Levels in Households and Correlation with Allergic Rhinitis Symptoms
    SAGE Publications ; 2014
    In:  American Journal of Rhinology & Allergy Vol. 28, No. 5 ( 2014-09), p. e193-e196
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 28, No. 5 ( 2014-09), p. e193-e196
    Abstract: House dust mite (HDM) allergen is a risk factor for the development of allergic rhinitis (AR). Objectives To determine the levels of indoor allergens in the households of patients with AR in Wuhan city, identify the environmental risk factors for high allergen exposure, and investigate the correlations between allergen exposure and specific immunoglobulin E levels and symptoms. Methods The study examined 50 patients with AR. Two dust samples were collected from the bedding of each patient, one in summer and one in winter. Major allergens Der p 1 and Der f 1, from Dermatophagoides pteronyssinus and Dermatophagoides farinae, were measured with an enzyme-linked immunosorbent assay. Participants completed a standardized questionnaire about their living environments, and their rhinitis symptom scores were calculated. Specific immunoglobulin E levels against Der p and Der f were measured. Results The percentage of bedding samples with high HDM allergen (Der f 1 + Der p 1) levels ( 〉 10 μg/g) was 44% in summer and 46% in winter. There was no significant difference between the level of mite allergens in summer and winter; however, the level of Der f 1 was higher than that of Der p 1 (p 〈 0.05). The age of the mattress and pillow was significantly correlated with allergen concentration. Indoor HDM allergen level affected the severity of nasal itching. Conclusions HDMs are important indoor allergens in Wuhan. Mattresses and pillows that have been used for a long time contain high levels of allergens. High levels of exposure to HDM allergens correlates with the severity of nasal itching.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.2500/ajra.2014.28.4095
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2554548-6
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