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  • SAGE Publications  (7)
  • 1
    In: Therapeutic Advances in Musculoskeletal Disease, SAGE Publications, Vol. 5, No. 1 ( 2013-02), p. 13-31
    Abstract: The Wnt signaling pathway plays an important role not only in embryonic development but also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt signaling has been shown as an important regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. Induction of the Wnt signaling pathway promotes bone formation while inactivation of the pathway leads to osteopenic states. Our current understanding of Wnt signaling in osteogenesis elucidates the molecular mechanisms of classic osteogenic pathologies. Activating and inactivating aberrations of the canonical Wnt signaling pathway in osteogenesis results in sclerosteosis and osteoporosis respectively. Recent studies have sought to target the Wnt signaling pathway to treat osteogenic disorders. Potential therapeutic approaches attempt to stimulate the Wnt signaling pathway by upregulating the intracellular mediators of the Wnt signaling cascade and inhibiting the endogenous antagonists of the pathway. Antibodies against endogenous antagonists, such as sclerostin and dickkopf-1, have demonstrated promising results in promoting bone formation and fracture healing. Lithium, an inhibitor of glycogen synthase kinase 3β, has also been reported to stimulate osteogenesis by stabilizing β catenin. Although manipulating the Wnt signaling pathway has abundant therapeutic potential, it requires cautious approach due to risks of tumorigenesis. The present review discusses the role of the Wnt signaling pathway in osteogenesis and examines its targeted therapeutic potential.
    Type of Medium: Online Resource
    ISSN: 1759-720X , 1759-7218
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2516075-8
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Journal of International Medical Research Vol. 45, No. 1 ( 2017-02), p. 220-230
    In: Journal of International Medical Research, SAGE Publications, Vol. 45, No. 1 ( 2017-02), p. 220-230
    Abstract: To investigate the synergistic effects of cryptotanshinone (CPT) and doxorubicin (DOXO) on induction of apoptosis in human gastric cancer cells and the mechanisms. Methods Cell proliferation and apoptosis were detected using the CCK8 assay and AnnexinV/PI staining, respectively. Western blotting was used to determine the levels and phosphorylation of proteins encoded by STAT3-regulated genes and the cleaved forms of caspases and PARP. Results CPT significantly potentiated the antiproliferative effect of DOXO in gastric cancer cell lines. CPT combined with DOXO induced apoptosis and cleavage of caspases-3,-7,-9 as well as PARP. CPT or a STAT3 siRNA significantly suppressed constitutive and IL-6-induced phosphorylation of STAT3 Tyr705, decreasing the levels of proteins encoded by STAT3-target genes (Bcl-xL, Mcl-1, survivin, and XIAP). Conclusions CPT enhanced the anticancer activity of DOXO in gastric cancer cells via STAT3 inactivation and suppression STAT3-regulated antiapoptotic gene expression, indicating that DOXO combined with CPT may serve as effective therapy for gastric cancer.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2082422-1
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications
    Abstract: The adhesion of wear-resistant diamond coating deposited on titanium was weakened by the porous titanium carbide interlayer, which was formed before film growth. In order to enhance substrate-coating adherence, a new pretreatment method was presented: Ti substrates were carbonized by hot filament chemical vapor deposition system, and then the carbonized substrates were ultrasonically vibrated using diamond micro-powder suspension. Diamond coatings were deposited by hot filament chemical vapor deposition as well. The effect of carbonization time on adhesion was investigated. The carbonized substrates and the interface between diamond coatings and substrates were characterized. The results showed that as the carbonization time increases, porous structures and cracks appear and increase on the surface of the substrate. The carbonized substrates possess high surface energy and thus the nucleation is promoted. After deposition, a dense and thin titanium carbide was observed. Ultrasonic after carbonization pretreatment can significantly enhance the adhesion of Ti-based diamond coatings by promoting nucleation and suppressing the formation of porous titanium carbide.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032745-6
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit Vol. 233, No. 4 ( 2019-04), p. 448-465
    In: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit, SAGE Publications, Vol. 233, No. 4 ( 2019-04), p. 448-465
    Abstract: In wind tunnel experiments, the inter-car gaps are designed in such a way as to separate the force measurements for each car and prevent the interference between cars during tests. Moreover, the inter-car gap has a significant effect on the aerodynamic drag of a train. In order to guide the design of the inter-car gaps between cars in wind tunnel experiments, the impact of the inter-car gap length on the aerodynamic characteristics of a 1/8th scale high-speed train is investigated using computational fluid dynamics. The shear stress transport k-ω model is used to simulate the flow around a high-speed train. The aerodynamic characteristics of the train with 10 different inter-car gap lengths are numerically simulated and compared. The 10 different inter-car gap lengths are 5, 8, 10, 15, 20, 30, 40, 50, 60, and 80 mm. Results indicate that the aerodynamic drag coefficients obtained using computational fluid dynamics fit the experimental data well. Rapid pressure variations appear in the upper and lower parts of the inter-car gaps. With the increase of the inter-car gap length, the drag force coefficient of the head car gradually increases. The total drag force coefficients of the trains with the inter-car gap length less than 10 mm are practically equal to those of the trains without inter-car gaps. Therefore, it can be concluded from the present study that 10 mm is recommended as the inter-car gap length for the 1/8th scale high-speed train models in wind tunnel experiments.
    Type of Medium: Online Resource
    ISSN: 0954-4097 , 2041-3017
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024901-9
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Human & Experimental Toxicology Vol. 41 ( 2022-01), p. 096032712210846-
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 41 ( 2022-01), p. 096032712210846-
    Abstract: Liver fibrosis is a wound-healing response and the activation of the hepatic stellate cell (HSC) is the core of hepatic fibrosis. MicroRNAs (miRNAs) participate in the development of fibrosis. It is reported that histone deacetylases (HDAC2) tyrosine phosphorylation by cellular-Abelsongene (c-Abl) induces malignant growth of cells. Here, we investigated the effect of miR-122-5p on the proliferation and apoptosis of HSCs. Normal human HSC line LX-2 and LX-2 cells stimulated by transforming growth factor (TGF)-β1 for 24 h were cultured and assigned into the blank group and the TGF-β1 group. The miR-122-5p inhibitor and its negative control were transfected into LX-2 cells and miR-122-5p mimic and its negative control were transfected into LX-2 cells stimulated by TGF-β1. The result showed that miR-122-5p expression was decreased in TGF-β1-stimulated LX-2 cells. miR-122-5p overexpression reduced the mRNA and protein levels of collagen I and α-smooth muscle actin, inhibited cell proliferation, and accelerated cell apoptosis. miR-122-5p targeted c-Abl. Meanwhile, miR-122-5p overexpression inhibited HSC activation by suppressing the c-Abl/HDAC2 pathway. In summary, miR-122-5p overexpression exerted anti-fibrosis effect and inhibited HSC activation by suppressing the c-Abl/HDAC2 pathway.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1483723-7
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Advances in Structural Engineering Vol. 25, No. 12 ( 2022-09), p. 2496-2507
    In: Advances in Structural Engineering, SAGE Publications, Vol. 25, No. 12 ( 2022-09), p. 2496-2507
    Abstract: In this study, the flexural behaviour of lattice-web reinforced composite sandwich beams was investigated. The innovative composite sandwich beams consisted of glass fibre reinforced composite materials as the surface layer and web, Paulownia wood and South Pine as the core material. While keeping the external size unchanged, 1, 2, 3, 4 and 5 wood cores were formed by the vacuum infusion process at one time, to develop a different number of lattice-webs. In addition, the wood beam was used as a control. A four-point bending test was carried out on all specimen beams. The equivalent bending stiffness, equivalent shear stiffness, mid-span deflection of the specimens and bearing capacity were analysed. There is a larger plateau stage in the latter part of the load-midspan deflection curve of the beams strengthened by the lattice-web, which means the beams had ductile failure characteristics. Furthermore, the type of wood core greatly influenced the flexural behaviour of the composite sandwich beam, and the optimum lattice-web number of the Paulownia specimen is 2, and that of the South Pine specimen is 3.
    Type of Medium: Online Resource
    ISSN: 1369-4332 , 2048-4011
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2026561-X
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  Environment and Planning B: Planning and Design Vol. 43, No. 2 ( 2016-03), p. 276-296
    In: Environment and Planning B: Planning and Design, SAGE Publications, Vol. 43, No. 2 ( 2016-03), p. 276-296
    Abstract: Hierarchy is an important property of a street network, which suggests that only a small number of streets are prominent. A previous empirical study of a European city has identified four levels of scale in a street network, namely the top 1%, top 20%, bottom 80%, and bottom 20%. This paper investigates such street hierarchies in a large Asian city, Wuhan, with a complicated network of streets. Based on network analysis, we find that street hierarchies in this case study are slightly different so that the fourth scale is adjusted from the initial 20 to 25%. The detected street hierarchies are further compared to the intensity of large-scale traffic flows at different time scales. We find that distributions of both daily and hourly traffic conform well to the street hierarchies. More specifically, the 20% of top streets accommodate about 98% of traffic flow, and the 1% of top streets account for more than 60% of traffic flow. Moreover, this finding indicates that the current street network of Wuhan needs to be improved because the top 20% of streets are rather overburdened leading to traffic congestion. Our study not only provides new quantitative evidence as to the emergence of street hierarchies but also highlights the possible traffic congestion.
    Type of Medium: Online Resource
    ISSN: 0265-8135 , 1472-3417
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2039719-7
    detail.hit.zdb_id: 199345-8
    detail.hit.zdb_id: 2879402-3
    SSG: 3,4
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