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  • SAGE Publications  (42)
  • 1
    Online Resource
    Online Resource
    Preliminary application of a 3D-printed track-guided precise drug delivery device for the sinuses after endoscopic sinus surgery
    SAGE Publications ; 2023
    In:  Journal of Biomaterials Applications Vol. 37, No. 6 ( 2023-01), p. 961-968
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 37, No. 6 ( 2023-01), p. 961-968
    Abstract: Conventional treatment for eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is usually limited; consequently, relapses occur frequently, accurate local drug delivery is currently a research area of major interest. Methods Based on postoperative nasal sinus computed tomography (CT) images, the 3D printing technique was used to design and fabricate a precise track-guided sinus drug delivery device. The control group was treated with glucocorticoids by nasal spray for 1 year according to the conventional method, while the experimental group received topical nasal glucocorticoids using the 3D-printed track-guided precise sinus drug delivery device for 1 year. Scores on the Sino-Nasal Outcome Test (SNOT-22) scale and the Lund-Kennedy nasal endoscopic scale during reexamination at 1 month, 3 months, 6 months, and 1 year after the operation were used as the basis for evaluation. Results The follow-up duration was 12 months or more following endoscopic sinus surgery (ESS) with neosinus cavity formation. The two groups showed significant differences in SNOT-22 scores and nasal polyp Lund-Kennedy subscores at 3 months, 6 months, and 1 year (p 〈 0.001) and no differences in plasma cortisol at 6 months and 1 year (p 〉 0.05). Conclusion Local drug administration using our 3D-printed precise sinus drug delivery device is superior to conventional nasal cavity administration in controlling eCRS recurrence.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/08853282221132982
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2072559-0
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  • 2
    Online Resource
    Online Resource
    Cerebral blood flow regulates iron overload in the cerebral nuclei of hemodialysis patients with anemia
    SAGE Publications ; 2023
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 43, No. 5 ( 2023-05), p. 749-762
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 43, No. 5 ( 2023-05), p. 749-762
    Abstract: Hemodialysis patients exhibit anemia-related cerebral hyperperfusion and iron deposition (ID). However, the mechanisms underlying the pathology of cerebral ID are not clear. We investigated the role of cerebral blood flow (CBF) in the pathophysiology of cerebral ID in hemodialysis patients with anemia. This study recruited 33 hemodialysis patients with anemia and thirty-three healthy controls (HCs). All the subjects underwent quantitative susceptibility mapping (QSM) and arterial spin labeling (ASL) to measure ID and CBF in the cerebral nuclei. Furthermore, we evaluated lacunar infarction (LI), cerebral microbleeds, and total white matter hyperintensity volume (TWMHV). Hemodialysis patients with anemia showed significantly higher ID and CBF in some nuclei compared to the HCs after adjusting for age, sex, and total intracranial volume (TIV) [ P  〈  0.05, false discovery rate (FDR) corrected]. CBF showed a positive correlation with ID in both patients and HCs after adjustments for age, gender, and TIV ( P  〈  0.05, FDR corrected). Serum phosphorus, calcium, TWMHV, hypertension, and dialysis duration were independently associated with ID ( P  〈  0.05). Hemoglobin, serum phosphorus, and LI were independently associated with CBF ( P  〈  0.05). Mediation analysis demonstrated that CBF mediated the effects between hemoglobin and ID. Our study demonstrated that CBF mediated aberrant cerebral ID in hemodialysis patients with anemia.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X221147363
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2039456-1
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  • 3
    Online Resource
    Online Resource
    Effect of pulsed ultrasonic on arc acoustic binding in pulsed ultrasonic wave-assisted pulsed gas tungsten arc welding
    SAGE Publications ; 2017
    In:  Science and Technology of Welding and Joining Vol. 22, No. 6 ( 2017-08), p. 465-471
    Details
    In: Science and Technology of Welding and Joining, SAGE Publications, Vol. 22, No. 6 ( 2017-08), p. 465-471
    Abstract: This paper investigated the effect of pulsed ultrasonic on the microstructure and mechanical properties of weld joints using novel pulsed ultrasonic wave-assisted pulsed gas tungsten arc welding. The principle of proposed method was to apply pulsed ultrasonic to the welding process during background current. The results indicated that arc contraction degree, weld pool oscillation, and weld penetration were remarkably enhanced by applying pulsed ultrasonic. The microstructure refined by pulsed ultrasonic was much finer than those refined by continuous ultrasonic due to the more stable ultrasonic field in arc zone and consequent stronger fluid flow in weld pool. Furthermore, tensile strength of the joints with pulsed ultrasonic was significantly improved compared with that of the joints with no and continuous ultrasonic.
    Type of Medium: Online Resource
    ISSN: 1362-1718 , 1743-2936
    URL: Article
    DOI: 10.1080/13621718.2016.1258812
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2053754-2
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  • 4
    Online Resource
    Online Resource
    Study on Optimizing Operation of Preheating Commissioning for Waxy Crude Oil Pipelines
    SAGE Publications ; 2014
    In:  Advances in Mechanical Engineering Vol. 6 ( 2014-01-01), p. 894256-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 6 ( 2014-01-01), p. 894256-
    Abstract: A mathematical model is established for the preheating commissioning process of waxy crude oil pipelines. The governing equations are solved by the finite volume method and the finite difference method. Accordingly, numerical computations are made for the Niger crude oil pipeline and the Daqing-Tieling 3rd pipeline. The computational results agree well with the field test data. On this basis, fluid temperature in the process of the preheating commissioning is studied for single station-to-station pipeline. By comparing different preheating modes, it is found that the effect of forward preheating is the best. Under different preheating commissioning conditions, the optimal combination of outlet temperature and flow rate is given.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1155/2014/894256
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2501620-9
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  • 5
    Online Resource
    Online Resource
    Posterior Displacement of L1 May be a Risk Factor for Proximal Junctional Kyphosis After Adult Spinal Deformity Correction
    SAGE Publications ; 2023
    In:  Global Spine Journal Vol. 13, No. 4 ( 2023-05), p. 1042-1048
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 13, No. 4 ( 2023-05), p. 1042-1048
    Abstract: Retrospective cohort study. Objective: Overcorrection in adult spinal deformity (ASD) surgery may lead to proximal junctional kyphosis (PJK) because of posterior spinal displacement. The aim of this paper is to determine if the L1 position relative to the gravity line (GL) is associated with PJK. Methods: ASD patients fused from the lower thoracic spine to sacrum by 4 spine surgeons at our hospital were retrospectively studied. Lumbar-only and upper thoracic spine fusions were excluded. Spinopelvic parameters, the L1 plumb line (L1PL), L1 distance to the GL (L1-GL), and Roussouly type were measured. Results: One hundred fourteen patients met inclusion criteria (63 patients with PJK, 51 without). Mean age and follow up was 65.51 and 3.39 years, respectively. There was no difference between the PJK and the non-PJK groups in baseline demographics, pre-operative and immediate post-operative pelvic incidence-lumbar lordosis mismatch, sagittal vertical axis, or coronal Cobb. The immediate postoperative L1-GL was -7.24 cm in PJK and -3.45 cm in non-PJK ( P 〈 0.001), L1PL was 1.71 cm in PJK and 3.07 cm in non-PJK ( P = 0.004), and PT (23.76° vs 18.90°, P = 0.026) and TK (40.56° vs 31.39°, P 〈 0.001) were larger in PJK than in non-PJK. After univariate and multivariate analyses, immediate postoperative TK and immediate postoperative L1-GL were independent risk factors for PJK without collinearity. Conclusions: A dorsally displaced L1 relative to the GL was associated with an increased risk of PJK after ASD surgery. The postoperative L1-GL distance may be a factor to consider during ASD surgery.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682211015651
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 6
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    Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief
    SAGE Publications ; 2022
    In:  Molecular Pain Vol. 18 ( 2022-04), p. 174480692211450-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 18 ( 2022-04), p. 174480692211450-
    Abstract: Pain involves both sensory and affective dimensions. The amygdala is a key player in linking nociceptive stimuli to negative emotional behaviors or affective states. Relief of pain is rewarding and activates brain reward circuits. Whether the reward circuit from the ventral tegmental area (VTA) to the central amygdala (CeA) is involved in pain relief remains unexplored. Using a model of experimental postsurgical pain, we found that pain relief elicited conditioned place preference (CPP), activated CeA-projecting dopaminergic cells in the VTA, and decreased dopaminergic D2 receptor expression in the CeA. Activation of the VTA–CeA neural pathway using optogenetic approaches relieved incisional pain. Administration of a D2 receptor agonist reversed the pain relief elicited by light-induced activation of the VTA-CeA pathway. These findings indicate that the VTA-CeA circuit is involved in pain relief in mice via dopamine receptor D2 in the CeA.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1177/17448069221145096
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2174252-2
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  • 7
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    Online Resource
    The Use of an Autoregressive Integrated Moving Average Model for Prediction of the Incidence of Dysentery in Jiangsu, China
    SAGE Publications ; 2016
    In:  Asia Pacific Journal of Public Health Vol. 28, No. 4 ( 2016-05), p. 336-346
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 28, No. 4 ( 2016-05), p. 336-346
    Abstract: The aim of this study is to forecast the incidence of bacillary dysentery with a prediction model. We collected the annual and monthly laboratory data of confirmed cases from January 2004 to December 2014. In this study, we applied an autoregressive integrated moving average (ARIMA) model to forecast bacillary dysentery incidence in Jiangsu, China. The ARIMA (1, 1, 1) × (1, 1, 2) 12 model fitted exactly with the number of cases during January 2004 to December 2014. The fitted model was then used to predict bacillary dysentery incidence during the period January to August 2015, and the number of cases fell within the model’s CI for the predicted number of cases during January-August 2015. This study shows that the ARIMA model fits the fluctuations in bacillary dysentery frequency, and it can be used for future forecasting when applied to bacillary dysentery prevention and control.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539516645153
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2394975-2
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  • 8
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    Current situation of asthma–COPD overlap in Chinese patients older than 40 years with airflow limitation: a multicenter, cross-sectional, non-interventional study
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Respiratory Disease Vol. 14 ( 2020-01), p. 175346662096169-
    Details
    In: Therapeutic Advances in Respiratory Disease, SAGE Publications, Vol. 14 ( 2020-01), p. 175346662096169-
    Abstract: Asthma–chronic obstructive pulmonary disease (COPD) overlap (ACO) is poorly recognized in China. Our study determined the distribution of ACO and its clinical characteristics among patients (aged ⩾40 years) with airflow limitation at Chinese tertiary hospitals. Methods: This cross-sectional, non-interventional study (NCT02600221), conducted between December 2015 and October 2016 in 20 Tier-3 Chinese hospitals, included patients aged ⩾40 years with post-bronchodilator (BD) FEV 1 /FVC 〈 0.7. The primary variable was distribution of ACO in adults with post-BD forced expiratory volume /forced vital capacity (FEV 1 /FVC) 〈 0.7 based on Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2015 and 2017 reports. Other variables included determination of characteristics of ACO and its clinical recognition rate. Results: In 2003 patients (mean age 62.30 ± 9.86 years), distribution of ACO, COPD and asthma were 37.40%, 48.50% and 14.10%, respectively. Proportions of patients with A, B, C and D grouping were 11.70%, 31.00%, 6.90% and 50.30% as per GOLD 2017, whereas they were 15.10%, 51.10%, 3.60% and 30.20% as per GOLD 2015. Similar clinical symptoms were reported in all three groups. A higher percentage of ACO patients presented with dyspnea, wheezing and chest tightness. Compared with the COPD group, a greater proportion of ACO patients reported wheezing (74.6% and 65.40%), while a lower proportion in the ACO group reported cough (79.40% versus 82.70%) and expectoration (76.50% versus 81.60%). Blood eosinophil count ⩾0.3 × 10 9 /L was observed in 34.6% of ACO patients. The clinical recognition rate of ACO was 31.4%. Conclusion: Despite ACO affecting two-fifths of the study population, the initial diagnosis rate was low at 6% in China, thus warranting concerted efforts to improve ACO diagnosis. ClinicalTrials.gov: [ClinicalTrials.gov identifier: NCT02600221] registered 22 Oct ober 2015, https://clinicaltrials.gov/ct2/show/NCT02600221 The reviews of this paper are available via the supplemental material section.
    Type of Medium: Online Resource
    ISSN: 1753-4666 , 1753-4666
    URL: Article
    DOI: 10.1177/1753466620961699
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2387506-9
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  • 9
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    The reduced soluble fibrinogen-like protein 2 and regulatory T cells in acute coronary syndrome
    SAGE Publications ; 2016
    In:  Experimental Biology and Medicine Vol. 241, No. 4 ( 2016-02), p. 421-425
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 241, No. 4 ( 2016-02), p. 421-425
    Abstract: Soluble fibrinogen-like protein 2, sfgl2, is the new effector of CD4 + CD25 + FOXP3 + regulatory T cell (Treg) and exerts immunosuppressive activity. We design this study to investigate the possible role of sfgl2 in atherosclerosis. A total of 58 acute coronary syndrome (ACS) patients, together with 22 stable angina (SA) patients and 31 normal coronary artery (NCA) people were enrolled in our study. Serum level of sfgl2 and plasma level of Treg were respectively measured. In line with the change of Treg, serum level of sfgl2 in ACS (8.70 ng/mL) was significantly decreased ( P = 0.003), compared with that in SA (11.86 ng/mL) and NCA (17.55 ng/mL). Both sfgl2 and Treg level were obviously decreased in ACS; Sfgl2 may play a protective role in atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370215612138
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2020856-X
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  • 10
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    The application of a modified technique of SCP under DHCA during total aortic arch replacement combined with stented elephant trunk implantation
    SAGE Publications ; 2006
    In:  Perfusion Vol. 21, No. 5 ( 2006-09), p. 255-258
    Details
    In: Perfusion, SAGE Publications, Vol. 21, No. 5 ( 2006-09), p. 255-258
    Abstract: We reviewed the perfusion experiences of 60 cases with a modified technique of selected cerebral perfusion (SCP) under deep hypothermic circulatory arrest (DHCA) during ascending aorta and total aortic arch replacement combined with transaortic stented graft implantation into the descending aorta for acute and chronic type A aortic dissection. Right auxiliary artery cannulation was routinely used for cardiopulmonary bypass (CPB) and SCP in this procedure. Generally, this technique requires two main pumps for two arterial lines before we applied the modified technique; one for CPB and the other for SCP. In order to simplify the circuit of the extracorporeal circuit (ECC) to operate easily, the arterial line was separated into two branches with a Y–connector on the operating table, one for axillary artery perfusion and the other for graft perfusion connected to the ECC set–up. This method is easy for the perfusionist to install and convenient for the surgeon. This is a safe and simple to use modified technique for SCP under DHCA during ascending aorta and total aortic arch replacement combined with transaortic stented graft implantation into the descending aorta.
    Type of Medium: Online Resource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/0267659106074766
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2029611-3
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