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  • 1
    Online Resource
    Online Resource
    Static Testing and Analysis of Composite Wing of a Two-Seater Aircraft Powered by Li-Ion Battery Electric Propulsion
    SAGE Publications ; 2016
    In:  Advanced Composites Letters Vol. 25, No. 6 ( 2016-11), p. 096369351602500-
    Details
    In: Advanced Composites Letters, SAGE Publications, Vol. 25, No. 6 ( 2016-11), p. 096369351602500-
    Abstract: The present paper studied the strength and deformation characteristics of a composite wing of a two-seater aircraft powered by Li-ion battery electric propulsion. In order to get the airworthiness certificate, the static testing is indispensable. The primary wing structure component includes upper and lower skins, leading edge, trailing edge, a root rib and main spar. The main purpose of static testing is to examine the bending strength of the wing. The testing results are in good agreement with the FE analysis results and the bending strength of wing is strong enough to support the limit loads (the maximum loads to the expected in service) without detrimental and permanent deformation, and without failure for at least 3s under the ultimate loads (limit loads multiplied by prescribed factors of safety), which meets ASTM F2245-11(Standard Specification for Design and Performance of a Light Sport Airplane) enough.
    Type of Medium: Online Resource
    ISSN: 2633-366X , 2633-366X
    URL: Article
    DOI: 10.1177/096369351602500601
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 3053419-7
    detail.hit.zdb_id: 2144398-1
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  • 2
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    Differences in the prognostic value of tumor extent of resection among the molecular subgroups of medulloblastoma:A single centre study of 113 cases
    SAGE Publications ; 2017
    In:  Translational Neuroscience and Clinics Vol. 3, No. 2 ( 2017), p. 66-73
    Details
    In: Translational Neuroscience and Clinics, SAGE Publications, Vol. 3, No. 2 ( 2017), p. 66-73
    Type of Medium: Online Resource
    ISSN: 2096-0441
    URL: Article
    DOI: 10.18679/CN11-6030/R.2017.015
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 3
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    Chinese guideline on the application of anti-seizure medications in the perioperative period of supratentorial craniocerebral surgery
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Neurological Disorders Vol. 15 ( 2022-01), p. 175628642211143-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 15 ( 2022-01), p. 175628642211143-
    Abstract: Seizures are a common symptom of craniocerebral diseases, and epilepsy is one of the comorbidities of craniocerebral diseases. However, how to rationally use anti-seizure medications (ASMs) in the perioperative period of craniocerebral surgery to control or avoid seizures and reduce their associated harm is a problem. The China Association Against Epilepsy (CAAE) united with the Trauma Group of the Chinese Neurosurgery Society, Glioma Professional Committee of the Chinese Anti-Cancer Association, Neuro-Oncology Branch of the Chinese Neuroscience Society, and Neurotraumatic Group of Chinese Trauma Society, and selected experts for consultancy regarding outcomes from evidence-based medicine in domestic and foreign literature. These experts referred to the existing research evidence, drug characteristics, Chinese FDA-approved indications, and expert experience, and finished the current guideline on the application of ASMs during the perioperative period of craniocerebral surgery, aiming to guide relevant clinical practice. This guideline consists of six sections: application scope of guideline, concepts of craniocerebral surgery-related seizures and epilepsy, postoperative application of ASMs in patients without seizures before surgery, application of ASMs in patients with seizures associated with lesions before surgery, emergency treatment of postoperative seizures, and 16 recommendations.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/17562864221114357
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2442245-9
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  • 4
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    Long-term outcomes in a retrospective cohort of patients with rectal cancer with complete response after total neoadjuvant therapy: a propensity-score weighted analysis
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Medical Oncology Vol. 15 ( 2023-01)
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 15 ( 2023-01)
    Abstract: The watch-and-wait (W & W) strategy is a novel treatment option for patients with rectal cancer who have a strong desire for organ preservation. The study aimed to explore the long-term outcomes of the W & W strategy in a large cohort of rectal cancer patients who achieved a clinical complete response (cCR) after consolidation total neoadjuvant therapy (TNT), and to compare with patients who achieved a pathological complete response (pCR) after radical surgery. Methods: The W & W group comprised patients who were assessed as having a cCR after consolidation TNT and adopted the W & W strategy. Patients who underwent standard resection and achieved a pCR were compared as a reference. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan–Meier analysis with log-rank test was used to compare survival outcomes. Results: We included 89 and 171 patients in the W & W and pCR groups, respectively. The median follow-up period was 45 and 58 months for the W & W and pCR groups, respectively. After IPTW adjustment, the 2-year local regrowth/recurrence rate for the W & W and pCR groups were 9.9% and 2.0%, respectively ( p 〈 0.001). The W & W and pCR groups had similar 5-year outcomes, including overall survival, disease-free survival, and distant metastasis-free survival (all p 〉 0.05). No significant difference was observed in the rates of distant metastasis between patients in the W & W group with local regrowth and those without local regrowth (25% versus 6.2%, p = 0.119). Conclusion: Patients who were managed with a W & W strategy after consolidation TNT had favorable survival outcomes, which were similar to those of patients with a pCR. The rate of local regrowth in W & W patients was lower in our study than in other studies as a result of the implementation of consolidation TNT.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359231197955
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2503443-1
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  • 5
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    A deep-learning-based prognostic nomogram integrating microscopic digital pathology and macroscopic magnetic resonance images in nasopharyngeal carcinoma: a multi-cohort study
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592097141-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592097141-
    Abstract: To explore the prognostic value of radiomics-based and digital pathology-based imaging biomarkers from macroscopic magnetic resonance imaging (MRI) and microscopic whole-slide images for patients with nasopharyngeal carcinoma (NPC). Methods: We recruited 220 NPC patients and divided them into training ( n = 132), internal test ( n = 44), and external test ( n = 44) cohorts. The primary endpoint was failure-free survival (FFS). Radiomic features were extracted from pretreatment MRI and selected and integrated into a radiomic signature. The histopathological signature was extracted from whole-slide images of biopsy specimens using an end-to-end deep-learning method. Incorporating two signatures and independent clinical factors, a multi-scale nomogram was constructed. We also tested the correlation between the key imaging features and genetic alternations in an independent cohort of 16 patients (biological test cohort). Results: Both radiomic and histopathologic signatures presented significant associations with treatment failure in the three cohorts (C-index: 0.689–0.779, all p  〈  0.050). The multi-scale nomogram showed a consistent significant improvement for predicting treatment failure compared with the clinical model in the training (C-index: 0.817 versus 0.730, p  〈  0.050), internal test (C-index: 0.828 versus 0.602, p  〈  0.050) and external test (C-index: 0.834 versus 0.679, p  〈  0.050) cohorts. Furthermore, patients were stratified successfully into two groups with distinguishable prognosis (log-rank p  〈  0.0010) using our nomogram. We also found that two texture features were related to the genetic alternations of chromatin remodeling pathways in another independent cohort. Conclusion: The multi-scale imaging features showed a complementary value in prognostic prediction and may improve individualized treatment in NPC.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920971416
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 6
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    Electroacupuncture stimulation at BL20, BL23 and SP6 prevents hind limb unloading–induced osteoporosis in rats
    SAGE Publications ; 2021
    In:  Acupuncture in Medicine Vol. 39, No. 6 ( 2021-12), p. 656-662
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 39, No. 6 ( 2021-12), p. 656-662
    Abstract: Bone loss induced by microgravity is a serious problem in space flight. However, the effects of acupuncture stimulation on osteoporosis induced by microgravity have not been studied. With the goal of developing an effective countermeasure, our aim was to evaluate the effects of electroacupuncture (EA) stimulation at BL20, BL23, and SP6 on osteoporosis induced by simulated microgravity in rats. Methods: Thirty male Wistar rats (aged 10 weeks) were randomly divided into three groups: healthy control group (CON, n = 10), hind limb unloading by tail-suspension group (T-S, n = 10), and EA treatment group (TRE, n = 10). Rats in the T-S and TRE groups were subjected to tail-suspension at −30° for 30 days, while the CON group experienced freedom of activity. In this period, the TRE group received EA treatment at BL20, BL23, and SP6 for 30 min every other day, which continued for 30 days. The microarchitecture of the proximal tibia and the biomechanical features of the femur in the rats were analyzed. In addition, the levels of serum biomarkers bone alkaline phosphatase (BALP) and osteocalcin (BGP) were measured. Results: Compared with the CON group, the value of bone volume/total volume (BV/TV) and trabecular number (Tb.N) of the tibias in the TRE group remarkably decreased ( p  〈  0.01). However, these changes were markedly less than those of the T-S group after 4 weeks of EA treatment ( p  〈  0.05). Moreover, the serum concentration of BGP in the TRE group was also significantly higher than that of the T-S group ( p  〈  0.05). Conclusions: These findings indicate that EA stimulation at BL20, BL23, and SP6 retards osteoporosis induced by hind limb unloading in rats.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1177/0964528421995494
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2126127-1
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  • 7
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    The Peritoneal Dialysis Telemedicine-assisted Platform Cohort (PDTAP) Study: Design and methods
    SAGE Publications ; 2022
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 42, No. 1 ( 2022-01), p. 75-82
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 42, No. 1 ( 2022-01), p. 75-82
    Abstract: The primary objective of the Peritoneal Dialysis Telemedicine-assisted Platform Cohort (PDTAP) Study is to explore potential predictors and their effects on patient survival, technique survival, and the occurrence of infectious and noninfectious complications. Design: The PDTAP study is a national-level cohort study in China. A newly developed PD telemedicine application provided a unique and convenient way to collect multicenter, structured data across units. Setting: The PDTAP study was underway in 27 hospitals from 14 provinces located at 7 geographical regions (northwest, northeast, north, central, southwest, southeast, and south) in China. Participants: Our study aims to enroll at least 7000 adult patients with end-stage renal disease receiving PD. Methods: Approval has been obtained through the ethics committees of all hospitals. All participants signed the informed consent form after the center had received ethics board approval in accordance with the Declaration of Helsinki. Main outcome measures: Patient survival, technique survival, hospitalization, and the occurrence of infectious and noninfectious complications. Conclusions: The PDTAP study aims to explore potential predictors and their effects on patient survival, technique survival, and infectious and noninfectious complications using a newly developed PD telemedicine system to collect multicenter, structured data in real-world practice. Substantial and transformable findings in relation to PD practices were expected. This study also developed a national-level infrastructure for further collaboration and ancillary investigation.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.1177/0896860820962901
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2075957-5
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  • 8
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    An Investigation of Two Kinds of Magnetic Chitosan Composite Microspheres
    SAGE Publications ; 2007
    In:  Journal of Bioactive and Compatible Polymers Vol. 22, No. 4 ( 2007-07), p. 429-441
    Details
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 22, No. 4 ( 2007-07), p. 429-441
    Abstract: In this study, two composite magnetic microspheres made of tamarind gum with chitosan and artemisia seed gum with chitosan were prepared by suspension cross-linking for magnetic carrier applications. The magnetic material used in the preparation of the microspheres was prepared by precipitating FeCl3 and FeSO4 solutions in a basic medium. The morphological, thermal stability, and magnetic properties of the two composite magnetic microspheres were characterized by scanning electron microscope, magnetometry, and differential scanning calorimeter (DSC). The swelling kinetics and pH responsive behavior of the two microspheres were also studied.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    URL: Article
    DOI: 10.1177/0883911507079967
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2073790-7
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  • 9
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    Surgical Revascularization of Symptomatic Kinking of the Internal Carotid Artery
    SAGE Publications ; 2016
    In:  Vascular and Endovascular Surgery Vol. 50, No. 7 ( 2016-10), p. 470-474
    Details
    In: Vascular and Endovascular Surgery, SAGE Publications, Vol. 50, No. 7 ( 2016-10), p. 470-474
    Abstract: To evaluate the safety and outcomes of surgical revascularization for patients with symptomatic kinking of the internal carotid artery (ICA). Methods: Twenty-five consecutive patients presented with symptomatic kinking of the ICA and a history of transient ischemic attack (TIA) or stroke were prospectively enrolled in this study. All patients were treated with ICA transection and end-to-side reimplantation at the level of the carotid bulb. Patients were followed up for a median of 32 months. Results: There were no deaths or strokes within the 30 days of the treatment. No postprocedural thrombosis or narrowing of the ipsilateral ICA was observed. One (4%) patient had temporary recurrent nerve palsy, which was completely recovered at 4-week follow-up. One (4%) patient had a myocardial ischemic event. At the end of the 32-month follow-up, 1 (4%) patient developed ipsilateral minor stroke. No recurrent stenosis was detected by Doppler ultrasound. Conclusion: Surgical treatment for isolated, symptomatic kinking of the ICA and a history of TIA or stroke is safe, and the outcomes are acceptable.
    Type of Medium: Online Resource
    ISSN: 1538-5744 , 1938-9116
    URL: Article
    DOI: 10.1177/1538574416671246
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2095223-5
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  • 10
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    The effects of carbon disulfide on male sexual function and semen quality
    SAGE Publications ; 2010
    In:  Toxicology and Industrial Health Vol. 26, No. 6 ( 2010-07), p. 375-382
    Details
    In: Toxicology and Industrial Health, SAGE Publications, Vol. 26, No. 6 ( 2010-07), p. 375-382
    Abstract: A cross-sectional study was initiated to clarify whether the current level of exposure to carbon disulphide (CS 2 ) is low enough to prevent occurrence of subclinical health impairments. This paper describes the effects of exposure to CS 2 on male sexual function and semen quality in a baseline observation. The effects of CS 2 on male sexual function were evaluated, including number of sexual encounters and length of sexual encounters related to solvents in 80 male workers exposed to CS 2 and 49 reference workers from the filature and cotton pulp departments of a fabric factory in China. And the semen samples were obtained from 43 of the exposed and 35 of the control. Adjustment was made for potential confounding factors such as age or alcohol drinking. Exposure to CS 2 was dichotomized by job type. The rate of sexual dysfunction was higher, number of sexual encounters was lower, and length of sexual encounters was shorter compared with the control (p 〈 0.001). It was indicated that exposed workers had fewer semen quantity, longer liquefaction time, lower acrosomal membrane integrity rate, vitality and density, and more deformity of semen than the control (p 〈 0.01). The age and type of work played the most important roles in sexual dysfunction by the multinomial logistic regression analysis (p 〈 0.01).The duration of exposure had the effect on sexual function and semen quality but no statistical significance (p 〉 0.05). Clinical effects on the male sexual function and semen quality were found in the workers exposed to CS 2 .
    Type of Medium: Online Resource
    ISSN: 0748-2337 , 1477-0393
    URL: Article
    DOI: 10.1177/0748233710369127
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2010891-6
    SSG: 12
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