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  • 1
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    Biglycan expression correlates with aggressiveness and poor prognosis of gastric cancer
    SAGE Publications ; 2011
    In:  Experimental Biology and Medicine Vol. 236, No. 11 ( 2011-11), p. 1247-1253
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 236, No. 11 ( 2011-11), p. 1247-1253
    Abstract: Biglycan, a member of the small leucine-rich proteoglycan family, has been implicated in the development and progression of human cancers. However, the clinical significance of biglycan expression in gastric cancer has not been determined. In the present study, biglycan mRNA and protein concentrations were analyzed using quantitative realtime reverse transcription polymerase chain reaction and Western blot in 69 gastric cancer and adjacent non-tumorous tissues, respectively. Biglycan expression was further assessed using immunohistochemistry in tissue microarrays that contained 264 cases of gastric cancer, and others containing normal or metastasized lymph node tumor tissues. Biglycan was upregulated at the transcriptional and translational levels and there was a correlation between the expression of biglycan mRNA and protein ( P = 0.000, κ = 0.769). Over-expression of biglycan was strongly associated with lymph node metastasis, tumor (T) classification, metastasis (M) classification, vascular invasion and Union for International Cancer Control (UICC) stage. Patients with biglycan-positive tumors had a significantly higher disease recurrence rate and poorer survival than patients with biglycan-negative tumors after the radical surgery. Multivariate analysis revealed that biglycan expression is an independent prognostic indicator for survival of patients with gastric cancer. The data from the current study demonstrate that elevated expression of biglycan may play an important role in the development and progression of gastric cancer, and could be further evaluated as a biomarker for predication of a poor clinical outcome.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2011.011124
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
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  • 2
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    Analysis of IL-6 and IL-1β release in cryopreserved pooled human whole blood stimulated with endotoxin
    SAGE Publications ; 2018
    In:  Innate Immunity Vol. 24, No. 5 ( 2018-07), p. 316-322
    Details
    In: Innate Immunity, SAGE Publications, Vol. 24, No. 5 ( 2018-07), p. 316-322
    Abstract: To overcome the lack of availability of fresh human whole blood for pyrogen detection, we explored the feasibility of utilizing cryopreserved pooled human blood to detect the responses of the pro-inflammatory cytokines IL-6 and IL-1β to LPS. Whole blood was obtained from five donors and incubated with LPS. The quantities of pro-inflammatory cytokines were measured using ELISA, and the results were compared among the samples. After the blood was cryopreserved with Dimethyl sulfoxide (DMSO) (10% v/v) and stored for 4 mo at –196℃, the detection limits of the IL-6/IL-1β responses to LPS were 0.2/0.4 endotoxin units (EU)/ml, respectively, and IL-6/IL-1β release increased in response to LPS in a dose-dependent manner. When these experiments were performed in three separate laboratories, the within-laboratory reproducibility of the IL-6/IL-1β responses was 100%/86.7%, 93.3%/100%, and 86.7%/80%, and the inter-laboratory reproducibility was 92.9%/85.7%, 64.3%/63.6%, and 57.1%/66.7%, respectively. The sensitivity (the probability of correctly classifying positive samples) and specificity (the probability of correctly classifying negative samples) of the IL-6/IL-1β tests were 81.7%/82.5% and 100%/100%, respectively. The results of this study suggest that cryopreserved pooled blood is a convenient and viable alternative for evaluating in vitro pyrogenicity. Additionally, maintaining cryopreserved pooled blood promotes safety for the user because it is released only after pretesting for infection parameters and has lower variation than fresh donations from a variety of donors.
    Type of Medium: Online Resource
    ISSN: 1753-4259 , 1753-4267
    URL: Article
    DOI: 10.1177/1753425918777596
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2381250-3
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  • 3
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    Translocation of High Mobility Group Box 1 From the Nucleus to the Cytoplasm in Depressed Patients With Epilepsy
    SAGE Publications ; 2022
    In:  ASN Neuro Vol. 14 ( 2022-01), p. 175909142211366-
    Details
    In: ASN Neuro, SAGE Publications, Vol. 14 ( 2022-01), p. 175909142211366-
    Abstract: Depression is a common psychiatric comorbidity in patients with epilepsy, especially those with temporal lobe epilepsy (TLE). The aim of this study was to assess changes in high mobility group box protein 1 (HMGB1) expression in epileptic patients with and without comorbid depression. Sixty patients with drug-resistant TLE who underwent anterior temporal lobectomy were enrolled. Anterior hippocampal samples were collected after surgery and analyzed by immunofluorescence ( n = 7/group). We also evaluated the expression of HMGB1 in TLE patients with hippocampal sclerosis and measured the level of plasma HMGB1 by enzyme-linked immunosorbent assay. The results showed that 28.3% of the patients (17/60) had comorbid depression. HMGB1 was ubiquitously expressed in all subregions of the anterior hippocampus. The ratio of HMGB1-immunoreactive neurons and astrocytes was significantly increased in both TLE patients with hippocampal sclerosis and TLE patients with comorbid depression compared to patients with TLE only. The ratio of cytoplasmic to nuclear HMGB1-positive neurons in the hippocampus was higher in depressed patients with TLE than in nondepressed patients, which suggested that more HMGB1 translocated from the nucleus to the cytoplasm in the depressed group. There was no significant difference in the plasma level of HMGB1 among patients with TLE alone, TLE with hippocampal sclerosis, and TLE with comorbid depression. The results of the study revealed that the translocation of HMGB1 from the nucleus to the cytoplasm in hippocampal neurons may play a previously unrecognized role in the initiation and amplification of epilepsy and comorbid depression. The direct targeting of neural HMGB1 is a promising approach for anti-inflammatory therapy.
    Type of Medium: Online Resource
    ISSN: 1759-0914 , 1759-0914
    URL: Article
    DOI: 10.1177/17590914221136662
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2485467-0
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  • 4
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    Growth of infants and young children born small for gestational age: growth restriction accompanied by overweight
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 9 ( 2018-09), p. 3765-3777
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 9 ( 2018-09), p. 3765-3777
    Abstract: To compare growth profiles of children born small for gestational age (SGA) with those born the appropriate size for gestational age (AGA), and examine expected growth patterns for SGA in early childhood. Methods A survey on 23,871 SGA children was conducted in Shanghai. Data were collected at 1, 2, 4, 6, 8, 10, 12, 18, 24, 36, 48, and 60 months of age (+30 days). A check-up included assessments of weight, height, and head circumference. Results At 5 years old, weight, height, and head circumference were lower in SGA children compared with AGA children. The proportions of overweight and obesity of SGA children at 4 to 18 months after birth were significantly higher than those in AGA children, with higher proportions in boys than in girls. There was no correlation between overweight at 5 years old and overweight before 2 years old in SGA children. Conclusions Children born SGA remain shorter and lighter, with a smaller head circumference at 5 years old compared with AGA children. At 4 to 18 months after birth, there is a high incidence of overweight and obesity in SGA children. Overweight and obesity in SGA boys are more serious than those in SGA girls.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518779305
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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  • 5
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    Moisture insensitive analysis of polyester/viscose waste textiles using Near-Infrared spectroscopy and Orthogonalization of external parameters algorithm
    SAGE Publications ; 2023
    In:  Journal of Industrial Textiles Vol. 53 ( 2023-01)
    Details
    In: Journal of Industrial Textiles, SAGE Publications, Vol. 53 ( 2023-01)
    Abstract: Near-Infrared (NIR) spectroscopic analyses can be applied in waste textile recycling as a rapid and non-invasive method to provide both qualitative and quantitative results. However, it has been a challenge to enhance the accuracy rate of NIR-based waste textile sorting due to the major influences from water contexts in the samples. Orthogonalization of External Parameters (EPO) has been introduced to reduce the interference from water absorption in NIR spectral signals for better accuracy and reliability in modeling. Here we explore the feasibility of applying EPO strategy with varieties of algorithms, including partial least squares regression (PLS), artificial neural network (ANN), decision tree (DT), random forest (RF), gradient boosting decision tree (GBDT), extreme random tree (Extra-tree), decision tree model based on AdaBoost algorithm (AdaBoost-tree), support Vector machine (SVM), one-dimensional convolutional neural network (1D-CNN), and one-dimensional convolutional neural network with improved Inception structure (1D-Inception-CNN). 216 waste textiles samples from Xinjiang, China, were studied with different moisture levels. Among them, 80 samples were used to develop the EPO algorithm, 112 were used to establish the prediction models, and 24 were used as test datasets. Then, the samples were scanned using a near-infrared spectrometer at different moisture regain rates. Our results showed that the moisture content of waste textiles had strong absorption peaks near 1150 and 1450 nm, leading to a decrease in the near-infrared reflectance of waste textiles. To verify the effectiveness of the EPO algorithm, the decision coefficients (R 2 score) and other indicators of the model without the EPO process and the model with EPO process are systematically compared. Our results show that the EPO algorithm preprocessing improves the accuracy of the NIR model (The average decision coefficient (R 2 score) of the models was increased by 0.83), especially when the moisture interference level is significant. Therefore, the EPO integrated modeling method is a reliable approach for better accuracy in NIR-based waste textile sorting.
    Type of Medium: Online Resource
    ISSN: 1528-0837 , 1530-8057
    URL: Article
    DOI: 10.1177/15280837231187671
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2095351-3
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  • 6
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    Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Medical Oncology Vol. 14 ( 2022-01), p. 175883592211124-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 14 ( 2022-01), p. 175883592211124-
    Abstract: Studies of local therapy (LT) to metastatic foci from nasopharyngeal carcinoma (NPC) are inconsistent and controversial. Here, we aimed to explore the survival benefit of LT directed at metastatic foci from NPC. Methods: A retrospective analysis was conducted in NPC patients with liver, lung, and/or bone metastases. The postmetastatic overall survival (OS) rate was analyzed using the Kaplan–Meier method and compared by the log-rank test. Multivariate analysis was performed using the Cox hazard model. Subgroup analyses evaluating the effect of LT were performed for prespecified covariates. Propensity score matching was applied to homogenize the compared arms. Results: Overall, 2041 of 2962 patients were eligible for analysis. At a median follow-up of 43.4 months, the 5-year OS improved by an absolute difference of 14.6%, from 46.2% in the LT group versus 31.6% in the non-LT group, which led to a hazard ratio of 0.634 for death ( p  〈  0.001). Matched-pair analyses confirmed that LT was associated with improved OS ( p = 0.003), and the survival benefits of LT remained consistent in the subcohorts of liver and lung metastasis ( p = 0.009 and p = 0.007, respectively) but not of bone metastasis (BoM; p = 0.614). Radiotherapy was predominantly used for BoM and biological effective dose (BED) 〉 60 Gy was found to yield more survival benefit than that of BED ⩽ 60 Gy. Conclusions: The addition of LT directed at metastasis has demonstrated an improvement to OS compared with non-LT group in the present matched-pair study, especially for patients with liver and/or lung metastases.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359221112486
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 7
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    A time difference of arrival/angle of arrival fusion algorithm with steepest descent algorithm for indoor non-line-of-sight locationing
    SAGE Publications ; 2019
    In:  International Journal of Distributed Sensor Networks Vol. 15, No. 9 ( 2019-09), p. 155014771986035-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 15, No. 9 ( 2019-09), p. 155014771986035-
    Abstract: In complex indoor propagation environment, the non-line-of-sight error caused by various obstacles brings great error to node positioning. Choosing the appropriate signal transmission methods is important to improve node indoor positioning accuracy. In this research, ultra-wideband technology, as baseband with high theoretical positioning accuracy and real-time performance, is implemented to transmit indoor signals. The proposed fusion algorithm with ultra-wideband baseband takes advantages from both time difference of arrival and angle of arrival algorithms, combined through the steepest descent algorithm. The non-line-of-sight signal estimation error is iteratively eliminated to achieve effective positioning accuracy. The experimental results indicate that the novel time difference of arrival/angle of arrival fusion algorithm with steepest descent algorithm can largely improve node positioning accuracy and stability.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147719860354
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2192922-1
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  • 8
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    A multi-objective optimization approach for simultaneously lightweighting and maximizing functional performance of vehicle body structure
    SAGE Publications ; 2020
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 234, No. 7 ( 2020-06), p. 2086-2102
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 234, No. 7 ( 2020-06), p. 2086-2102
    Abstract: This study presents a hybrid approach to integrate the comprehensive sensitivity analysis method, support vector machine technology, modified non-dominated sorting genetic algorithm-II method and the technique for order preference by similarity to ideal solution, which have been applied to multi-objective lightweight optimization of the B-pillar structure of an automobile. First, numerical models of the static–dynamic stiffness and the crashworthiness performance of automobile are established and validated by experimental testing. Then, the comprehensive sensitivity analysis method is used to define the final optimization variables. Experimental design and support vector machine based surrogate model techniques are introduced to establish the approximate model; subsequently, the modified non-dominated sorting genetic algorithm-II algorithm is applied to the multi-objective lightweight optimization design of the B-pillar structure, and the non-dominated solution set is determined. The principal component analysis method is applied to determine the weight of each objective. Finally, the technique for order preference by similarity to ideal solution method is used to rank Pareto front from best to worst to obtain the optimal solution; furthermore, a comparison between the original model and optimized design denotes that the mass of the B-pillar being reduced by 22.55% under the other impacting indicators is well guaranteed. Therefore, the proposed hybrid approach provided promising prospects in the lightweight and crashworthiness optimization application of the B-pillar.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/0954407019868140
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 9
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    Design of active disturbance rejection controller for compass-like biped walking
    SAGE Publications ; 2018
    In:  International Journal of Advanced Robotic Systems Vol. 15, No. 3 ( 2018-05-01), p. 172988141877684-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 15, No. 3 ( 2018-05-01), p. 172988141877684-
    Abstract: This article proposes an active disturbance rejection controller design scheme to stabilize the unstable limit cycle of a compass-like biped robot. The idea of transverse coordinate transformation is applied to form the control system based on angular momentum. With the linearization approximation, the limit cycle stabilization problem is simplified into the stabilization of an linear time-invariant system, which is known as transverse coordinate control. In order to solve the problem of poor adaptability caused by linearization approximation, we design an active disturbance rejection controller in the form of a serial system. With the active disturbance rejection controller, the system error can be estimated by extended state observer and compensated by nonlinear state error feedback, and the unstable limit cycle can be stabilized. The numerical simulations show that the control law enhances the performance of transverse coordinate control.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.1177/1729881418776845
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2202393-8
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  • 10
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    Methylene Blue–Based Near-Infrared Fluorescence Imaging for Breast Cancer Visualization in Resected Human Tissues
    SAGE Publications ; 2019
    In:  Technology in Cancer Research & Treatment Vol. 18 ( 2019-01-01), p. 153303381989433-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 18 ( 2019-01-01), p. 153303381989433-
    Abstract: Breast-conserving surgery is facing the challenge of objective tumor margin identification intraoperatively. Near-infrared fluorescence imaging would be an ideal approach to visualize tumor margins during surgeries. In this preliminary study, the feasibility of methylene blue–based near-infrared fluorescence imaging technique for breast cancer detection was assessed in resected human breast specimens after breast cancer surgeries. Thirty patients with breast cancer scheduled for surgical treatment were enrolled, including 10 patients with preoperative chemotherapy and 20 patients without. Each of them received an injection of 1 mg/kg methylene blue intravenously 3 hours before the surgery. Then, a home-developed methylene blue–specific near-infrared fluorescence imaging system was employed to image the resected breast tissues and identify the tumor by the fluorescence contrast. Specimens were taken for pathological examinations as the reference. There were no severe adverse events attributable to methylene blue. Of 20 patients, who did not receive preoperative chemotherapy, 16 exhibited fluorescent contrast on their resected tissues (signal-to-background ratio: 1.94 ± 0.71). In contrast, tumors were identified in 3 of 10 specimens from patients who underwent preoperative chemotherapy (signal-to-background ratio: 1.63 ± 0.38). A total of 35 tissues were sampled from 30 specimens. Besides 30 tumor samples, 5 more suspicious samples with fluorescence signal were confirmed to be benign hemorrhagic tissues. Therefore, a sensitivity of 0.63 and a positive predictive value of 0.79 were achieved by the methylene blue fluorescence imaging strategy. Here, we demonstrate the feasibility of using methylene blue fluorescence imaging to identify breast cancer. Preoperative chemotherapy had an impact on imaging effect, which may reduce the detection rate. After all, methylene blue fluorescence imaging has great potential to be used into breast-conserving surgery for tumor-positive margins detection, but further clinical trial study is needed ( http://www.chictr.org.cn/ Clinical Trial Registry ID: ChiCTR1800015400, Near-infrared fluorescence imaging applied in breast cancer identification with methylene blue).
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033819894331
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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