In:
Clinical Medicine Insights: Endocrinology and Diabetes, SAGE Publications, Vol. 15 ( 2022-01), p. 117955142210984-
Abstract:
In pregnant women with gestational diabetes mellitus (GDM), insulin resistance (IR) increases the risk of developing manifest type 2 diabetes mellitus and is associated with complications in both mother and fetus. Objectives: This research aimed to evaluate the associations between IR evaluated by 3 indices (namely updated homeostasis model assessment model (HOMA2), QUICKI, and McAuley’s index) and the diabetes risk factors and the fetal growth indices in Vietnamese women with GDM. Methods: A cross-sectional descriptive study was conducted on 370 women with GDM and 40 healthy pregnant women from January 2015 to May 2019. IR was calculated by HOMA2 (HOMA2-IR), QUICKI, and McAuley’s index. Fetal anthropometric measurements were assessed via ultrasound which was performed and interpreted by ultrasound experts. Results: In the simple regression analysis, McAuley’s index illustrated had statistically significant correlations to the highest number of risk factors of diabetes mellitus compared with HOMA2-IR and QUICKI indices. Moreover, McAuley’s index correlated statistically significantly to the highest number of fetal ultrasound measurements factors such as including biparietal diameter (BPD) ( r = −0.271, P 〈 .001), head circumference (HC) ( r = −0.225, P 〈 .001), abdominal circumference (AC) ( r = −0.214, P 〈 .001), femur length (FL) ( r = −0.231, P 〈 .001), estimated fetal weight (EFW) ( r = −0.239, P 〈 .001) and fetal estimated age ( r = −0.299, P 〈 .001). In the multivariable analysis, the McAuley’s index contributed the greatest to AC (Standardized B of −0.656, P 〈 .001). Conclusion: The McAuley’s index was significantly associated with a higher number of more risk factors for diabetes mellitus as well as fetal ultrasound sonography findings measurements than compared with HOMA2-IR and QUICKI indices.
Type of Medium:
Online Resource
ISSN:
1179-5514
,
1179-5514
DOI:
10.1177/11795514221098403
Language:
English
Publisher:
SAGE Publications
Publication Date:
2022
detail.hit.zdb_id:
2628990-8
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