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  • 1
    Online Resource
    Online Resource
    Proactive Waste Management Solutions: Implementing Reusable and Biodegradable Food Packaging at Food Festivals
    SAGE Publications ; 2020
    In:  Journal of Hospitality & Tourism Cases Vol. 8, No. 4 ( 2020-02), p. 42-49
    Details
    In: Journal of Hospitality & Tourism Cases, SAGE Publications, Vol. 8, No. 4 ( 2020-02), p. 42-49
    Type of Medium: Online Resource
    ISSN: 2164-9987 , 2164-9987
    URL: Article
    DOI: 10.1177/216499872000800408
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 2
    Online Resource
    Online Resource
    National Hockey League Scores Big with New Sustainability Program
    SAGE Publications ; 2021
    In:  Journal of Hospitality & Tourism Cases Vol. 9, No. 1 ( 2021-05), p. 27-33
    Details
    In: Journal of Hospitality & Tourism Cases, SAGE Publications, Vol. 9, No. 1 ( 2021-05), p. 27-33
    Type of Medium: Online Resource
    ISSN: 2164-9987 , 2164-9987
    URL: Article
    DOI: 10.1177/216499872100900106
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    Trends in hemorrhagic stroke incidence and mortality in a National Stroke Registry of a multi-ethnic Asian population
    SAGE Publications ; 2023
    In:  European Stroke Journal
    Details
    In: European Stroke Journal, SAGE Publications
    Abstract: High-quality epidemiological data on hemorrhagic stroke (HS) and its subtypes, intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), remains limited in Asian ethnicities. We investigated the trends in HS incidence and 30-day mortality from 2005 to 2019 in a multi-ethnic Asian population from a national registry. Patients and methods: Data on all stroke cases from the Singapore Stroke Registry from 2005 to 2019 were collected. Cases were defined using centrally adjudicated review of diagnosis codes. Death outcomes were obtained by linkage with the national death registry. Incidence (per 100,000 people) and 30-day mortality (per 100 people) were measured as crude and age-standardized rates. Trends were analyzed using linear regression. Results: We analyzed 19,017 cases of HS (83.9% ICH; 16.1% SAH). From 2005 to 2019, age-standardized incidence rates (ASIR) for HS remained stable from 34.4 to 34.5. However, age-standardized mortality rates (ASMR) decreased significantly from 29.5 to 21.4 ( p  〈  0.001). For ICH, ASIR remained stable while ASMR decreased from 30.4 to 21.3 ( p  〈  0.001); for SAH, ASIR increased from 2.7 to 6.0 ( p = 0.006) while ASMR remained stable. In subgroup analyses, HS incidence increased significantly in persons 〈 65 years (from 18.1 to 19.6) and Malays (from 39.5 to 49.7). Discussion: From 2005 to 2019, ASIR of HS remained stable while ASMR decreased. Decreasing ASMR reflects improvements in the overall management of HS, consistent with global trends. Conclusion: Population health efforts to address modifiable risk factors for HS in specific demographic subgroups may be warranted to reduce incidence and mortality of HS.
    Type of Medium: Online Resource
    ISSN: 2396-9873 , 2396-9881
    URL: Article
    DOI: 10.1177/23969873231202392
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2851287-X
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  • 4
    Online Resource
    Online Resource
    Are We Putting Our Favorite Destinations in Peril? A no Longer Lost City - Machu Picchu Case Study
    SAGE Publications ; 2022
    In:  Journal of Hospitality & Tourism Cases Vol. 10, No. 1 ( 2022-03), p. 34-39
    Details
    In: Journal of Hospitality & Tourism Cases, SAGE Publications, Vol. 10, No. 1 ( 2022-03), p. 34-39
    Type of Medium: Online Resource
    ISSN: 2164-9987 , 2164-9987
    URL: Article
    DOI: 10.1177/216499872201000104
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    The Final Straw: Delta Airlines Single-Use Plastic Onboard
    SAGE Publications ; 2021
    In:  Journal of Hospitality & Tourism Cases Vol. 9, No. 2 ( 2021-08), p. 44-49
    Details
    In: Journal of Hospitality & Tourism Cases, SAGE Publications, Vol. 9, No. 2 ( 2021-08), p. 44-49
    Type of Medium: Online Resource
    ISSN: 2164-9987 , 2164-9987
    URL: Article
    DOI: 10.1177/216499872100900210
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    The Prognostic Value of Preoperative Albumin-to-Alkaline Phosphatase Ratio on Survival Outcome for Patients With Locally Advanced Oral Squamous Cell Carcinoma
    SAGE Publications ; 2022
    In:  Technology in Cancer Research & Treatment Vol. 21 ( 2022-01), p. 153303382211412-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 21 ( 2022-01), p. 153303382211412-
    Abstract: Background: This retrospective cohort study was to assess the prognostic value of preoperative albumin-to-alkaline phosphatase ratio (AAPR) on survival outcome for patients with locally advanced oral squamous cell carcinoma (LAOSCC). Methods: A total of 250 patients with LAOSCC receiving upfront radical surgery at a single institute from January 2008 to December 2017 were enrolled. The primary endpoint was the survival predictability of preoperative AAPR on the 5-year overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). Cox proportional hazards model was used for survival analysis. The X-tile software was used to estimate the optimal cut-off value of preoperative AAPR on survival prediction. A predictive nomogram incorporating the clinicopathological factors on OS was further generated. Results: The 5-year OS, CSS, and DFS rates were 68.6%, 79.7%, and 61.7%, respectively. The optimal cut-off of preoperative AAPR to predict the 5-year OS was observed to be 0.51. For those with preoperative AAPR≧0.51, the 5-year OS, CSS, and DFS were statistically significantly superior to those with preoperative AAPR 〈 0.51 (OS: 76.1% vs 48.5%, P  〈  .001; CSS: 84.3% vs 66.4%, P = .005; DFS: 68.9% vs 42.6%, P  〈  .001). In Cox model, we observed that preoperative AAPR 〈 0.51 was a significantly negative prognosticator of OS (HR: 2.22, 95% CI: 1.466-3.361, P  〈  .001), CSS (HR: 2.037, 95% CI: 1.16-3.578, P  = .013), and DFS (HR: 1.756, 95% CI: 1.075-2.868, P  = .025). After adding the variable of preoperative AAPR, the c-index of the predictive nomogram incorporating assorted clinicopathological factors increases from 0.663 to 0.692 for OS. Conclusion: Our results suggest that preoperative AAPR serves as an independent survival predictor for patients with LAOSCC. The nomogram incorporating preoperative AAPR and various clinicopathological features may be a convenient tool to estimate the mortality risk for patients with LAOSCC.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338221141254
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 7
    Online Resource
    Online Resource
    Phenotypic Re-expression of Near Quiescent Chondrocytes: The Effects of Type II Collagen and Growth Factors
    SAGE Publications ; 2010
    In:  Journal of Biomaterials Applications Vol. 25, No. 1 ( 2010-07), p. 75-95
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 25, No. 1 ( 2010-07), p. 75-95
    Abstract: After extensively expanding in monolayer culture, the cultured chondrocytes become quiescent. The aim of this study was to establish the hypothesis that the phenotypic function of extensively expanded primary chondrocytes may be restored with extracellular matrix (ECM) compositions with or without growth factors. The restoring effects of these microenvironmental factors on the near quiescent passage 9 (P9) chondrocyte were investigated. The data showed that exogenous type I collagen and type II collagen at 1:1 ratio stimulate cell proliferation greatly while type II collagen alone was enough to revive most of cartilaginous functions of near quiescent P9 chondrocytes. Exogenous type II collagen by itself was more effective in restoring cell proliferation rate, elevating glycosaminoglycan (GAG) accumulation and promoting the re-expression of type II collagen mRNAs in the near quiescent chondrocytes. The supplement of P9 chondrocytes with type II collagen plus TGF- β1 and IGF-I appeared essential for the re-expression of aggrecan and type II collagen mRNA in monolayer culture. In 3D type II collagen construct, P9 chondrocytes appeared healthy as chondrocytes and showed clear lacuna. However, in 3D type I collagen matrix, only some P9 chondrocytes exhibited lacuna. The cartilaginous microenvironments are crucial to restoring chondrocyte-phenotypic features of the quiescent or ‘dedifferentiated’ chondrocytes, implicating the potential of expanding a scarcity of healthy chondrocytes for cartilage repair or regeneration.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328209343611
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Continuous Low-Dose Everolimus Shrinkage Tuberous Sclerosis Complex-Associated Renal Angiomyolipoma: A 48-Month Follow-up Study
    SAGE Publications ; 2019
    In:  Journal of Investigative Medicine Vol. 67, No. 3 ( 2019-03), p. 686-690
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 67, No. 3 ( 2019-03), p. 686-690
    Abstract: Tuberous sclerosis complex (TSC) is a rare disease that causes multisystem benign neoplasm, induced by dysregulation of the mammalian target of the rapamycin pathway (mTOR). This study aimed to examine the effects of continuous low-dose everolimus, a potent and selective inhibitor of mTOR, on the treatment of TSC-associated renal angiomyolipoma (AML). Between July 2013 and August 2017, 11 patients with TSC-AML were enrolled for an everolimus therapy protocol. An oral everolimus dose starting at 2.5 mg daily was gradually increased to 5.0 mg daily. All patients were evaluated using MRI or CT scanning at baseline, 12, 24, 36 and 48 months after the start of treatment for measuring changes of renal AML mass volume. Everolimus therapy resulted in significant shrinkage of TSC-AML volume after 48 months follow-up. Serum levels of everolimus were subdivided into group I ( 〈 8 ng/mL, n=6) and group II ( 〉 8 ng/mL, n=5). The volume reduction rates were 10.6%–65.2% in group I and 42.5%–70.6% in group II. To evaluate the response to treatment, three of six (50%) were responders in group I, and all the patients in group II (5/5, 100%) were responders. The differences in AML volume reduction between the groups were statistically significant at 12 months (p=0.011), 24 months (p=0006), 36 months (p=0.014) and 48 months (p=0.05). These results suggest that continuous low-dose everolimus therapy (2.5–5 mg daily) might be effective in shrinking TSC-AML volume and minimizes adverse effects and subsequent reducing medical costs.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-2018-000865
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 9
    Online Resource
    Online Resource
    Entropy-Based Quantitative Electroencephalogram Analysis for Diagnosing Attention-Deficit Hyperactivity Disorder in Girls
    SAGE Publications ; 2019
    In:  Clinical EEG and Neuroscience Vol. 50, No. 3 ( 2019-05), p. 172-179
    Details
    In: Clinical EEG and Neuroscience, SAGE Publications, Vol. 50, No. 3 ( 2019-05), p. 172-179
    Abstract: Diagnosis of attention-deficit hyperactivity disorder (ADHD) is currently based on core symptoms or checklists; however, the inevitability of practitioner subjectivity leads to over- and underdiagnosis. Although the Federal Drug Administration has approved an elevated theta/beta ratio (TBR) of the electroencephalogram (EEG) band as a tool for assisting ADHD diagnosis, several studies have reported no significant differences of the TBR between ADHD and control subjects. This study detailed the development of a method based on approximate entropy (ApEn) analysis of EEG to compare ADHD and control groups. Differences between ADHD presentation in boys and girls indicate the necessity of separate investigations. This study enrolled 30 girls with ADHD and 30 age-matched controls. The results revealed significantly higher ApEn values in most brain areas in the control group than in the ADHD group. Compared with TBR-related feature descriptors, ApEn-related feature descriptors can produce the higher average true positive rate (0.846), average true negative rate (0.814), average accuracy (0.817), and average area under the receiver operating characteristic curve value (0.862). Therefore, compared with TBR, ApEn possessed the better potential for differentiating between girls with ADHD and controls.
    Type of Medium: Online Resource
    ISSN: 1550-0594 , 2169-5202
    URL: Article
    DOI: 10.1177/1550059418814983
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2647038-X
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  • 10
    Online Resource
    Online Resource
    Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer
    SAGE Publications ; 2022
    In:  Technology in Cancer Research & Treatment Vol. 21 ( 2022-01), p. 153303382211468-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 21 ( 2022-01), p. 153303382211468-
    Abstract: The major predisposing factors of developing oral cancer include smoking, alcohol drinking, and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral mucosa by crude fibers, chemical insults by additive slaked lime, and arecoline from areca nut. These would lead to the local consequence of oral submucosal fibrosis, which is regarded clinically as a precancer lesion and a major cause of trismus. In addition, the components and additives in betel quid contain chemical toxins and carcinogens, which would further affect the oral mucosa and gradually develop a malignancy. Following literature review, aside from having a greater total tumor burden and more local diseases in the oral cavity and digestive tract, patients with betel quid-related oral cancer also have more systemic diseases from metabolic syndrome, hypertension, cardiovascular disease, type II diabetes mellitus, and obesity than those without this habit. In conclusion, those patients who have the history of smoking, alcohol drinking, and betel quid chewing would present much more unique clinical characteristics than those who only have a history of smoking and alcohol drinking. More attention should therefore be paid to pretreatment evaluation, treatment strategy, and posttreatment follow-up among betel quid chewers.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338221146870
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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