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  • 1
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    Uterine peristalsis and junctional zone: correlation with age and postmenopausal status
    SAGE Publications ; 2017
    In:  Acta Radiologica Vol. 58, No. 2 ( 2017-02), p. 224-231
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 58, No. 2 ( 2017-02), p. 224-231
    Abstract: Although age-related change of junctional zone (JZ) of the uterus has been known, there has been no previous systematic study of age-related changes of uterine peristalsis that is observed as the wave conduction of the thickest or darkest area within the JZ. Purpose To examine the age-related changes of uterine peristalsis in pre and postmenopausal women using cine magnetic resonance imaging (MRI), and to determine the correlation between peristalsis and JZ on T2-weighted (T2W) imaging. Material and Methods Cine MRI analysis was performed in 64 premenopausal volunteers and in 43 postmenopausal women. The peristaltic frequency, JZ detectability, and JZ thickness were evaluated and compared between the two groups. In the premenopausal group, the correlations between age and each item was examined. In the postmenopausal group, the number of years after menopause was used instead of age. The correlation between peristaltic frequency and JZ detectability or thickness was also analyzed. Results Peristaltic frequency and JZ detectability significantly differed between the two groups, while JZ thickness did not. Peristaltic frequency did not vary significantly with age before menopause and no peristalsis was observed after menopause. JZ detectability did not change significantly with age or number of years after menopause, while JZ thickness significantly increased with age before menopause, but did not vary after menopause. A significant moderate correlation was observed between JZ detectability and peristaltic frequency, but not between JZ thickness and peristaltic frequency. Conclusion Uterine peristalsis frequency did not change significantly according to age, but observed peristalsis on MRI significantly decreased after menopause.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185116639768
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 2
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    Utility of real-time image fusion technology in ultrasonography-guided fiducial marker implantation for stereotactic body radiation therapy for liver tumors
    SAGE Publications ; 2021
    In:  Acta Radiologica Vol. 62, No. 5 ( 2021-05), p. 567-573
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 62, No. 5 ( 2021-05), p. 567-573
    Abstract: Ultrasonography (US) is useful when implanting fiducial markers in the liver. However, the implant position is sometimes lost. Recently, real-time image fusion technology (Volume Navigation [V-navi]; GE Healthcare, Milwaukee, WI, USA) has been introduced as a technique for using images from different modalities, and its utility for fiducial marker implantation has been hypothesized. Purpose To evaluate the utility of US-guided fiducial marker implantation in the liver using V-navi compared to conventional US. Material and Methods We retrospectively reviewed 35 patients who underwent fiducial marker implantation for stereotactic body radiation therapy of liver tumors in 2013–2018. To avoid artifacts obscuring the tumor, the target point of implantation was set 10 mm cranial or caudal to the tumor. Marker implantation was then performed using US alone (US group, n = 24) or V-navi with computed tomography (CT) or magnetic resonance imaging (V-navi group, n = 11). Postprocedural CT was evaluated to determine technical success, distances between marker and either tumor surface or target point, and whether marker-induced artifacts obscured the tumor. Complications were also evaluated. Results were compared between groups. Results Technical success was obtained in 33 patients. Distance between the tumor and marker showed no significant difference between groups. Distance between target point and marker was shorter in the V-navi group ( P = 0.0093). Tumor-obscuring artifacts were seen in 12 patients (V-navi group, n = 1; US group, n = 11; P = 0.055). The only complication was minor bleeding in the US group (n = 1). Conclusion V-navi appears useful for US-guided fiducial marker implantation in the liver compared with conventional US.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185120934479
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 3
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    Diffusion tensor MRI of the kidney at 3.0 and 1.5 Tesla
    SAGE Publications ; 2010
    In:  Acta Radiologica Vol. 51, No. 9 ( 2010-11), p. 1059-1063
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 51, No. 9 ( 2010-11), p. 1059-1063
    Abstract: Background: Diffusion tensor imaging (DTI) at 3 T provides information on the microstructure and pathophysiology of tissues that is not available from conventional imaging with an advantage of high signal to noise ratio (SNR). Purpose: To evaluate the feasibility of DTI of the normal kidney at 3.0 T compared to results obtained at 1.5 T. Material and Methods: DTI of the normal kidney of 15 healthy volunteers obtained with 3.0 and 1.5 T scanners using respiration-triggered acquisition was examined. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of both the renal cortex and the medulla and SNRs were measured (b-values 0 and 400 s/mm 2 , diffusion direction of 6). The image quality of FA and ADC maps was also compared subjectively. Results: The FA values of the renal cortex were 0.15 ± 0.03 at 3.0 T and 0.14± 0.03 at 1.5 T on average. This difference was not significant. The FA values of the renal medulla were 0.49 ±0.04 at 3.0 T and 0.42 ± 0.05 at 1.5 T. ADC values of the renal cortex were 2.46 × 10 −3 ± 0.09 mm 2 /s at 3.0 T and 2.20 ×10 −3 ±0.11 mm 2 /s at 1.5 T. The ADC values of the renal medulla were 2.08 × 10 −3 ± 0.08 mm 2 /s at 3.0 T and 1.90 × 10 −3 ± 0.11 mm 2 /s at 1.5 T. These FA and ADC values were consistent with previous publications. The difference was significant for the FA value of the medulla ( P 〈 0.01) and ADC values in both cortex and medulla ( P 〈 0.01). The subjective image quality of the FA map with the 3.0 T scanner was significantly superior to that with the 1.5 T scanner ( P 〈 0.01), but not significant for the ADC map ( P = 0.18). There was a significant difference in SNR between 3.0 T (48.8 ± 6.6) and 1.5 T images (32.8 ± 5.0). Conclusion: The feasibility of renal DTI with a 3.0 T magnet resulting in improved SNR was demonstrated.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.3109/02841851.2010.504741
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
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  • 4
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    Intra- and inter-observer agreement in the visual interpretation of interim 18F-FDG PET/CT in malignant lymphoma: influence of clinical information
    SAGE Publications ; 2018
    In:  Acta Radiologica Vol. 59, No. 10 ( 2018-10), p. 1218-1224
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 59, No. 10 ( 2018-10), p. 1218-1224
    Abstract: Interim PET/CT is widely performed in lymphoma patients in clinical practice and clinical trials. Visual assessment using a 5-point scale is proposed for PET/CT interpretation, but intra- and inter-observer variation is not fully investigated. Purpose To investigate intra- and inter-observer variations in the reporting of interim positron emission tomography/computed tomography (PET/CT) in lymphoma patients, and the influence of clinical information on the interpretation. Material and Methods Three expert readers from different institutions interpreted interim PET/CT images of 42 consecutive patients with malignant lymphoma twice, with and without clinical information. The intra- and inter-observer agreements were calculated using the kappa statistic on a patient and a region basis. Results On a patient basis, intra-observer agreement, inter-observer agreement without information, and inter-observer agreement with information were within the ranges 0.48–0.62, 0.51–0.62, and 0.42–0.76, respectively. In the evaluation of lymph nodes, intra-observer agreement, inter-observer agreement without information, and inter-observer agreement with information were within the ranges 0.78–0.92, 0.80–0.82, and 0.77–0.83, respectively. Observer agreements were in almost perfect to substantial agreement categories for most lymphatic organs, but were generally low for the other organs. Conclusion The intra- and inter-observer agreements in evaluating interim PET/CT were relatively low for extranodal lesions, but they were substantial to almost perfect when interpreting nodal regions in malignant lymphoma, irrespective of the provision of clinical information, although memory at the first interpretation might have affected the intra-observer results.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185117751279
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 5
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    Non-contrast-enhanced MR portography and hepatic venography with time-spatial labeling inversion pulses: comparison at 1.5 Tesla and 3 Tesla
    SAGE Publications ; 2015
    In:  Acta Radiologica Open Vol. 4, No. 5 ( 2015-05-01), p. 205846011558411-
    Details
    In: Acta Radiologica Open, SAGE Publications, Vol. 4, No. 5 ( 2015-05-01), p. 205846011558411-
    Abstract: A 3 Tesla (3 T) magnetic resonance (MR) scanner is a promising tool for upper abdominal MR angiography. However, there is no report focused on the image quality of non-contrast-enhanced MR portography and hepatic venography at 3 T. Purpose To compare and evaluate images of non-contrast-enhanced MR portography and hepatic venography with time-spatial labeling inversion pulses (Time-SLIP) at 1.5 Tesla (1.5 T) and 3 T. Material and Methods Twenty-five healthy volunteers were examined using respiratory-triggered three-dimensional balanced steady-state free-precession (bSSFP) with Time-SLIP. For portography, we used one tagging pulse (selective inversion recovery) and one non-selective inversion recovery pulse; for venography, two tagging pulses were used. The relative signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were quantified, and the quality of visualization was evaluated. Results The CNRs of the main portal vein, right portal vein, and left portal vein at 3 T were better than at 1.5 T. The image quality scores for the portal branches of segment 4, 5, and 8 were significantly higher at 3 T than at 1.5 T. The CNR of the right hepatic vein (RHV) at 3 T was significantly lower than at 1.5 T. The image quality scores of RHV and the middle hepatic vein were higher at 1.5 T than at 3 T. For RHV visualization, the difference was statistically significant. Conclusion Non-contrast-enhanced MR portography with Time-SLIP at 3 T significantly improved visualization of the peripheral branch in healthy volunteers compared with1.5 T. Non-contrast-enhanced MR hepatic venography at 1.5 T was better than at 3 T.
    Type of Medium: Online Resource
    ISSN: 2058-4601 , 2058-4601
    URL: Article
    DOI: 10.1177/2058460115584110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
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  • 6
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    Electrophysiological and neurochemical characterization of the effect of repeated treatment with milnacipran on the rat serotonergic and noradrenergic systems
    SAGE Publications ; 2006
    In:  Journal of Psychopharmacology Vol. 20, No. 4 ( 2006-07), p. 562-569
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 20, No. 4 ( 2006-07), p. 562-569
    Abstract: The present study was undertaken to elucidate the effects of repeated treatment with milnacipran, a serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor (SNRI), on the synaptic plasticity in the hippocampal CA1 field, focusing on the interaction between the serotonergic and noradrenergic system. Repeated treatment with milnacipran (30mg/kg, i.p. after 30mg/kg, p.o. 14 days) completely restored the suppression of the long-term potentiation (LTP) induced by single milnacipran treatment (30mg/kg, i.p.). Single and repeated milnacipran increased to a similar extent extracellular NA in the hippocampus. Single milnacipran increased extracellular 5-HT and this effect tended to be enhanced by repeated treatment. The restoration of LTP and facilitation of the 5-HT level were not shown after repeated treatment with a selective 5-HT reuptake inhibitor (SSRI) fluvoxamine (30mg/kg, p.o. 14 days). These results suggest that milnacipran-induced restoration of LTP suppression is responsible for the enhancement of 5-HT neurotransmission, which appears to be associated with noradrenergic neuronal activity. In addition, the 5-HT 1A receptor agonist tandospirone-induced suppression of LTP was completely blocked by repeated treatment with milnacipran, indicating the possibility that this reversal effect is due to the functional changes in postsynaptic 5-HT 1A receptors. Taken together, the present data suggest that the interaction between the serotonergic and noradrenergic mechanism play an important role in the modulation of synaptic plasticity caused by repeated treatment with milnacipran, which may be implicated in the therapeutic effects of SNRI on psychiatric disorders.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881106059694
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2028926-1
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  • 7
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    Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models
    SAGE Publications ; 2018
    In:  Acta Radiologica Open Vol. 7, No. 1 ( 2018-01), p. 205846011775156-
    Details
    In: Acta Radiologica Open, SAGE Publications, Vol. 7, No. 1 ( 2018-01), p. 205846011775156-
    Abstract: Perfusion-related intravoxel incoherent motion (IVIM) and non-Gaussian diffusion magnetic resonance (MR) parameters are becoming important biomarkers for differentiating malignant from benign tumors without contrast agents. However, diffusion-time dependence has rarely been investigated in tumors. Purpose To investigate the relationship between diffusion time and diffusion parameters in breast cancer and hepatocellular carcinoma xenograft mouse models. Material and Methods Diffusion-weighted MR images (DWI) were obtained on a 7-T magnetic resonance imaging (MRI) scanner at two different diffusion times (9.6 ms and 27.6 ms) in human breast cancer (MDA-MB-231) and hepatocellular carcinoma (HepG2 and PLC/PRF/5) xenograft mouse models. Perfusion-related IVIM (fIVIM and D*) and non-Gaussian diffusion (ADC 0 and K) parameters were estimated. Parametric maps of diffusion changes with the diffusion times were generated using a synthetic apparent diffusion coefficient (sADC) obtained from b = 438 and 2584 s/mm 2 . Results ADC 0 values significantly decreased when diffusion times were changed from 9.6 ms to 27.6 ms in MDA-MB-231, HepG2, and PLC/PRF/5 groups ( P = 0.0163, 0.0351, and 0.0170, respectively). K values significantly increased in MDA-MB-231 and HepG2 groups ( P  〈  0.0003 and = 0.0007, respectively); however, no significant difference was detected in the PLC/PRF/5 group. fIVIM values increased, although not significantly ( P = 0.164–0.748). The maps of sADC changes showed that diffusion changes with the diffusion time were not homogeneous across tumor tissues. Conclusion Diffusion MR parameters in both breast cancer and HCC xenograft models were found to be diffusion time-dependent. Our results show that diffusion time is an important parameter to consider when interpreting DWI data.
    Type of Medium: Online Resource
    ISSN: 2058-4601 , 2058-4601
    URL: Article
    DOI: 10.1177/2058460117751565
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 8
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    What is the most suitable MR signal index for quantitative evaluation of placental function using Half-Fourier acquisition single-shot turbo spin-echo compared with T2-relaxation time?
    SAGE Publications ; 2018
    In:  Acta Radiologica Vol. 59, No. 6 ( 2018-06), p. 748-754
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 59, No. 6 ( 2018-06), p. 748-754
    Abstract: Half-Fourier acquisition single-shot turbo spin-echo (HASTE) imaging is now widely used for placental and fetal imaging because of its rapidity and low sensitivity to fetal movement. If placental dysfunction is also predicted by quantitative value obtained from HASTE image, then it might be beneficial for evaluating placental wellbeing. Purpose To ascertain the most suitable magnetic resonance (MR) signal indexes reflecting placental function using HASTE imaging. Material and Methods This retrospective study included 37 consequent patients who had given informed consent to MR imaging (MRI) examinations. All had undergone MRI examinations between February 2014 and June 2015. First, the correlation between T2-relaxation time of normal placenta and gestational age (GA) was examined. Second, correlation between signal intensity ratios (SIRs) using HASTE imaging and placental T2-relaxation time were assessed. The SIRs were calculated using placental signal intensity (SI) relative to the SI of the amniotic fluid, fetal ocular globes, gastric fluid, bladder, maternal psoas major muscles, and abdominal subcutaneous adipose tissue. Results Among the 37 patients, the correlation between T2-relaxation time of the 25 normal placentas and GA showed a moderately strong correlation (Spearman rho = –0.447, P = 0.0250). The most significant correlation with placental T2-relaxation time was observed with the placental SIR relative to the maternal psoas major muscles (SIR pl./psoas muscle ) (Spearman rho = −0.531, P = 0.0007). Conclusion This study revealed that SIR pl./psoas muscle showed the best correlation to placental T2-relaxation time. Results show that SIR pl./psoas muscle might be optimal as a clinically available quantitative index of placental function.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185117727786
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 9
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    Diagnostic accuracy of 3D breath-hold MR cholangiography using compressed sensing acceleration in visualizing non-dilated biliary system in living donor liver transplantation donors
    SAGE Publications ; 2019
    In:  Acta Radiologica Vol. 60, No. 10 ( 2019-10), p. 1209-1215
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 60, No. 10 ( 2019-10), p. 1209-1215
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185118822631
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 10
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    MR appearance of normal uterine endometrium considering menstrual cycle: differentiation with benign and malignant endometrial lesions
    SAGE Publications ; 2016
    In:  Acta Radiologica Vol. 57, No. 12 ( 2016-12), p. 1540-1548
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 57, No. 12 ( 2016-12), p. 1540-1548
    Abstract: The thickness and signal intensity (SI) of normal uterine endometrium on T2-weighted (T2W) imaging changes depend on the menstrual cycle phase. Cases of normal endometrium that appear similar to endometrial lesions sometimes occur, and may result in misdiagnosis. Purpose To investigate normal endometrial appearance in luteal phase (LP) compared to that in follicular phase (FP), and to differentiate these appearances with those of endometrial lesions. Material and Methods Thirty-two normal volunteers prospectively underwent magnetic resonance (MR) examinations during LP and FP. Patients with pathologically confirmed endometrial polyps ( n = 9), hyperplasia ( n = 7), and cancer ( n = 15), who underwent MR examinations, were evaluated for comparison. Endometrial appearance was categorized into the following five types on sagittal T2W imaging and compared between LP, FP, and endometrial lesions: type 1, homogeneous higher SI; type 2, homogeneous iso SI; type 3, a bright midline and a peripheral iso SI layer; type 4, a lower/iso SI central line; and type 5, heterogeneous lower/iso SI. Endometrial thickness and SI were measured and also compared. Results Endometrial lesions were more frequently categorized as type 5 than normal endometrium ( P  〈  0.05). Endometrial thickness in LP (mean, 1.0 cm) was significantly greater than that in FP (0.6 cm), but not significantly different from polyps (1.1 cm), hyperplasia (1.0 cm), and cancer (0.9 cm). SI in FP was significantly higher than that in LP and that of all endometrial lesions. Conclusion Differentiation between normal endometrium in LP and endometrial lesions may be difficult based on thickness alone. Heterogeneous low SI may help to differentiate normal endometrium from endometrial lesions. Performing MR imaging during FP may also help due to higher SI of normal endometrium.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185115626478
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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