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  • 1
    Online Resource
    Online Resource
    Using the Gene Expression Signature of Scutebarbalactone VN Isolated from Scutellaria barbata to Elucidate its Anticancer Activities
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 2 ( 2015-02), p. 1934578X1501000-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 2 ( 2015-02), p. 1934578X1501000-
    Abstract: Bioassay-guided fractionation led to the discovery of a novel neo-clerodane diterpenoid, scutebarbalactone VN (BalA: 8,13-epoxy-3-en-7-hydroxy-6,11- O-dibenzoyl-15,16-clerodanolide), from the methanol extract of the whole-plant of Vietnamese Scutellaria barbata D. Don. A microarray technique combined with bioinformatic analyses showed that BalA could inhibit cell cycle pathways by downregulating genes such as CDC25A and AURKA. BalA also showed the potential to reactivate downregulated genes in hepatocellular carcinoma cells and genes in antioxidant pathways such as HMOX1 and HSPA1A. Querying Connectivity map 2.0 resulted in a match of the BalA-modulated gene signature with that of 10 known compounds, most of which are currently marketed chemotherapy drugs. The highest matching scores belonged to lomustine, semustine, and withaferin A. Lomustine and semustine were found to alkylate DNA and RNA, while withaferin A inhibits nuclear factor kappa B (NF-κB) activity. A luciferase reporter assay was also conducted on 293/NF-κB human embryonic kidney cells that had been transfected with the NF-κB-luciferase plasmid to verify the anticancer activity of BalA. The assay showed that Ba1A effectively blocked NF-κB with an IC 50 of 38.6 ± 0.05 μM.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501000237
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
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  • 2
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    Online Resource
    Design and Synthesis of New 2-Aminobenzamide Derivatives Containing Benzothiazole and Phenylamine Moiety and Their Cytotoxicity
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 7 ( 2022-07), p. 1934578X2211161-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 7 ( 2022-07), p. 1934578X2211161-
    Abstract: Twelve new compounds including 2-aminobenzamide derivatives bearing benzothiazole and phenylamine moiety were designed and synthesized. The synthesized compounds were tested their cytotoxic activity against A549 and SW480 tumor cell lines. Compounds 3a and 3c exhibited cytotoxicity toward A549 cell line with IC 50 values of 24.59 and 29.59 µM, respectively.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221116188
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 3
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    Online Resource
    Nanoliposomal Cercodemasoide A and Its Improved Activities Against NTERA-2 Cancer Stem Cells
    SAGE Publications ; 2020
    In:  Natural Product Communications Vol. 15, No. 12 ( 2020-12), p. 1934578X2098210-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 15, No. 12 ( 2020-12), p. 1934578X2098210-
    Abstract: Recently, saponins derived from marine sources have received much attention because of their promising bioactivities, such as anticancer, anti-angiogenesis, and anti-inflammation. In particular, a triterpene saponin from the sea cucumber Cercodemas anceps Selenka, cercodemasoide A (CAN1), showed potent cytotoxicity against various cancer cell lines. Recent evidence has indicated that cancer stem cells (CSCs) could be a novel target for efficient cancer therapies. In order to improve the biopharmaceutical properties of CAN1, the compound was loaded into nanoliposomes as an ideal drug carrier. CAN1 was successfully incorporated into nanoliposomes as small unilamellar liposome vesicles with an average size of 73.39 ± 1.57 nm, zeta potential of −0.299 ± 0.046 mV, polydispersity index of 0.336 ± 0.038, and with an encapsulation efficiency of up to 62.9%. For the first time, CAN1 and its nanoliposomal forms have been shown to have a promising cytotoxic activity against NTERA-2 CSCs, with half-maximal inhibitory concentration (IC 50 ) =1.03 ± 0.04 and 0.41 ± 0.03 µM, respectively. The CAN1 nanoliposomes also presented significantly improved activities in suppressing the growth of NTERA-2 3-dimensional tumorspheres (IC 50 = 1.71 ± 0.06 µM) in comparison with the free form ( P 〈 .05). The anti-CSC effects of CAN1 nanoliposomes on NTERA-2 cells were due to their apoptotic induction through enhancing caspase-3 activity (more than 2-fold) and arresting the cell cycle at the S phase ( P 〈 .05). The obtained CAN1-encapsulated nanoliposomes suggest valuable applications in CSC-targeting treatment for more efficient clinical therapy.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X20982108
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 4
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    Online Resource
    Design, Synthesis and Cytotoxic Evaluation of 4-Anilinoquinazoline– triazole–AZT Hybrids as Anticancer Agents
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 12 ( 2018-12), p. 1934578X1801301-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 12 ( 2018-12), p. 1934578X1801301-
    Abstract: A series of 4-anilinoquinazoline–triazole–AZT hybrids were designed and synthesized as anticancer agents. Their cytotoxic potential has been evaluated by means of a micro-dilution assay against three human cancer cell lines (KB, epidermoid carcinoma; HepG2, hepatoma carcinoma; SK-Lu-1, non-small lung cancer). The biological results revealed that compounds 4b and 6d showed good anticancer activities against KB, HepG2, and Lu cell lines (IC 50 values ranging from 9 μM to 100 μM). Especially, compounds 4b and 6d exhibited up to 3-fold more potent than reference drugs erlotinib hydrochloride and AZT in term of anti-lung cancer activity.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801301215
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 5
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    Online Resource
    A New Liposomal Formulation of Hydrogenated Anacardic Acid to Improve Activities Against Cancer Stem Cells
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 6 ( 2022-06), p. 1934578X2211056-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 6 ( 2022-06), p. 1934578X2211056-
    Abstract: Anacardic acid (AA) is a natural active ingredient that accounts for 65% of the liquid extract from the shell of the cashew nut. Due to the stronger cytotoxic activity of hydrogenated AA (HAA) against NTERA-2 cancer stem cells (CSCs) than AA itself, HAA was co-conjugated with CD133 monoclonal antibody (mAb^CD133) into nanoliposomal particles (AMC). This nanoliposomal complex is expected to improved HAA activities against CSCs based on the targeting capacity of mAb^CD133 toward CD133, a typical CSCs’ surface marker. AMC was manufactured with a mean size of 100.9 nm, a zeta potential of −40.7 mV, and a PDI of 0.283. We report a 100% encapsulation efficiency of HAA into liposomes and a 90.7% conjugation efficiency with mAb^CD133. The penetration of AMC into NTERA-2 CSCs after 2 h was 83.7%. The AMC complex inhibited NTERA-2 growth with an IC 50 (inhibition concentration at 50%) value of 75.83  ±  6.70 µM, showing the targeting ability and lower toxicity (IC 50   〉  100 µM) on healthy cells. The AMC nanoparticles also demonstrated significant potential apoptotic induction by activating caspase 3 activity by up to 2.57 and 2.06 folds compared to that of the negative control at 20 and 4 µM, respectively. This induction was significant improvement in comparison with that of unconjugated HAA ( P  〈  .05). AMC presented a clear effect on the solid structure of NTERA-2 spheroids and significantly suppressed the proliferation of CSCs in the 3D tumorspheres with an IC 50  = 64.25  ±  3.15 µM, compared to the free form with an IC 50   =  82.22  ±  0.65 µM ( P  〈  .05). Therefore, this nanoliposomal complex exhibits promising capacities as an effective material against NTERA-2 CSCs.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221105696
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 6
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    Online Resource
    Capacity of Commune Health Stations in Chi Linh District, Hai Duong Province, for Prevention and Control of Noncommunicable Diseases
    SAGE Publications ; 2017
    In:  Asia Pacific Journal of Public Health Vol. 29, No. 5_suppl ( 2017-07), p. 94S-101S
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 29, No. 5_suppl ( 2017-07), p. 94S-101S
    Abstract: The primary health care system in Vietnam has been playing an important role in prevention and control of diseases. This study aimed to describe the capacity of commune health stations in Chi Linh district, Hai Duong province for prevention and control of noncommunicable diseases (NCDs). A mixed-methods (quantitative and qualitative approaches) approach was applied to collect data in 20 commune health stations. The participants, including health workers, stakeholders, and patients with NCDs, were selected for the study. The findings reported that the main activities of prevention and control of NCDs at commune health stations (CHSs) still focused on information-education-community (IECs), unqualified for providing screening, diagnosis, and treatments of NCDs. The capacity for prevention and control of NCDs in CHSs was inadequate to provide health care services related to prevention and control of NCDs and unmet with the community’s demands. In order to ensure the role and implementation of primary care level, there is an urgent need to improve the capacity of CHSs for prevention and control of NCDs, particularly a national budget for NCDs prevention and control, the essential equipment and medicines recommended by the World Health Organization should be provided and available at the CHSs.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539517717020
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2394975-2
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  • 7
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    Online Resource
    Toxicity and Anti-inflammatory Activities of an Extract of the Eleutherine bulbosa Rhizome on Collagen Antibody-induced Arthritis in a Mouse Model
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 7 ( 2018-07), p. 1934578X1801300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 7 ( 2018-07), p. 1934578X1801300-
    Abstract: As a continuation of our interest in the anti-inflammatory activities of Vietnamese plants, we searched for novel anti-inflammatory agents in Eleutherine bulbosa and evaluated the anti-inflammatory effects of an ethanol extract of the rhizome of E. bulbosa (EBE) on lipopolysaccharide-stimulated RAW 264.7 macrophages in vitro and in a collagen antibody-induced arthritic (CAIA) mouse model in vivo. Treatment of the CAIA mice with EBE decreased the incidence of arthritis, especially at a dose of 1000 mg/kg body weight. A significant ( P 〈 0.05) decrease in the arthritis score was seen after high-dose EBE treatment between days 10 and 14 in comparison with the negative control. The serum levels of the inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-10 in the mice were measured using commercial ELISA kits. The results suggest that an ethanol extract of the E. bulbosa rhizome has beneficial effects on inflammatory cytokine regulation in an experimental CAIA model.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801300725
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 8
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    Online Resource
    The Improved Anticancer Activities of Piperine Nanoliposome Conjugated CD133 Monoclonal Antibody Against NTERA-2 Cancer Stem Cells
    SAGE Publications ; 2021
    In:  Natural Product Communications Vol. 16, No. 2 ( 2021-02), p. 1934578X2199818-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 16, No. 2 ( 2021-02), p. 1934578X2199818-
    Abstract: Black pepper ( Piper nigrum L.) is widely grown in the Chu-se district of Gia Lai province in Vietnam. The pepper, used as a spice, also serves as a traditional medicine in many countries. Black pepper contains many different substances; the most active of these is piperine, which exerts anti-oxidant, anti-inflammatory, and anti-cancer effects. However, piperine is a poorly absorbed alkaloid, and high concentrations may be toxic. Therefore, its medicinal uses remain limited. Here, we extracted piperine from black peppers collected at Chu Se, created piperine and anti-CD133 monoclonal antibodies (mAb^CD133) containing nanoliposomal complexes (PMCs), and evaluated their inhibitory effects on cancer stem cells (CSCs) in vitro. The physical properties of PMCs showed an approximated diamater of 170 nm, a PDI of 0.23, zeta potential of −9.38 mV, and an encapsulated efficiency of 73.33 ± 9.09%. The PMCs significantly inhibited NTERA-2 cell growth (IC 50 = 435.3 ± 4.3 µM), but were not toxic to healthy cells (IC 50 〉 500 µM). The PMCs remarkably affected the CSC surface marker expressed level of which the CD44 + /CD133 + population was only 2.12% compared with 21.72% for blank nanoliposomes. The NTERA-2 antiproliferative activities of PMCs might be associated with their G2 cell cycle phase arresting and caspase-3 inducible activities (up to 1.51 times) ( P 〈 0.05). The nanoliposomal complex also significantly inhibited the proliferation of NTERA-2 cells in three dimensional tumorspheroids with an IC 50 = 245.82 ± 11.44 µM and reduced the size by up to 41.50 ± 4.31% ( P 〈 0.05). Thus, the PMCs proved their enhanced potential biomedical and pharmacological applications in targeted cancer therapies.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X21998184
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 9
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    Potential Anticancer Activities of a Combination of Curcumin, Ginger Oleoresin, and Rutin Solid Lipid Nanoparticles (Vietlife-Antican) in LLC Tumor-Bearing Mice
    SAGE Publications ; 2019
    In:  Natural Product Communications Vol. 14, No. 6 ( 2019-06), p. 1934578X1985846-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 14, No. 6 ( 2019-06), p. 1934578X1985846-
    Abstract: Natural products play an important role in medicine and human healthcare and, as a result, drugs that are derived from natural resources are increasingly being used for the treatment of various diseases, including cancer. Vietlife-Antican (VLA) is a novel combination of curcumin solid lipid nanoparticles, ginger oleoresin solid lipid nanoparticles, and rutin solid lipid nanoparticles, which all possess low toxicity and enhanced bioavailabilities. To clarify the antitumor effects of this product, cytotoxic tests of VLA were conducted in various cancer cell lines in vitro and in an in vivo tumorized mouse model induced by Lewis lung carcinoma (LLC) cells. VLA expressed some cytotoxicity against breast cancer cells (MCF7), hepatocarcinoma cells (HepG2), lung cancer cells (SK-LU-1), colorectal adenocarcinoma cells (SW480), and human leukemia cells (HL-60). Additionally, LLC tumor-bearing mice treated with VLA (600 mg/kg body weight [bw]) exhibited significant reductions in tumor growth ( P 〈 0.05), a longer mean survival time (34.05 days), and improved liver function. Furthermore, a combination of VLA (200 mg/kg bw) and cisplatin strongly suppressed tumor development and increased mean survival time ( P 〈 0.05). Interestingly, cotreatment with VLA and cisplatin also induced the serum production of interleukin (IL)-2 and IL-10, which are important antitumor and anti-inflammatory cytokines, respectively, in tumorized mice. Taken together, the present results suggest that VLA may be a very promising and efficient phytochemical product that can support cancer treatment or therapy.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X19858461
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 10
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    Changes in the Correlates for Intimate Partner Violence Against Women in Vietnam: Evidence From the 2010 and 2019 National Prevalence Surveys
    SAGE Publications ; 2023
    In:  Violence Against Women Vol. 29, No. 14 ( 2023-11), p. 2699-2729
    Details
    In: Violence Against Women, SAGE Publications, Vol. 29, No. 14 ( 2023-11), p. 2699-2729
    Abstract: This study sought to understand whether the risk and protective factors associated with current partner violence changed in Vietnam using findings from two comparable surveys conducted in 2010 and 2019. Fifteen (2010) and 17 (2019) factors were significantly associated with violence, and the level of consistency was high—nonpartner sexual violence, respondent and partner prior abuse, men's expressions of masculinity, and indicators of low economic status continue to put women at risk. Gender-transformative approaches that address power inequalities, foster positive parenting, and promote the political and social influence of women are required and should be adapted to the Vietnam context.
    Type of Medium: Online Resource
    ISSN: 1077-8012 , 1552-8448
    URL: Article
    DOI: 10.1177/10778012231197566
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2031375-5
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