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  • SAGE Publications  (20)
  • 1
    Online Resource
    Online Resource
    Practice guidance for the use of terlipressin for liver cirrhosis–related complications
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Gastroenterology Vol. 15 ( 2022-01), p. 175628482210982-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 15 ( 2022-01), p. 175628482210982-
    Abstract: Liver cirrhosis is a major global health burden worldwide due to its high risk of morbidity and mortality. Role of terlipressin for the management of liver cirrhosis–related complications has been recognized during recent years. This article aims to develop evidence-based clinical practice guidance on the use of terlipressin for liver cirrhosis–related complications. Methods: Hepatobiliary Study Group of the Chinese Society of Gastroenterology of the Chinese Medical Association and Hepatology Committee of the Chinese Research Hospital Association have invited gastroenterologists, hepatologists, infectious disease specialists, surgeons, and clinical pharmacists to formulate the clinical practice guidance based on comprehensive literature review and experts’ clinical experiences. Results: Overall, 10 major guidance statements regarding efficacy and safety of terlipressin in liver cirrhosis were proposed. Terlipressin can be beneficial for the management of cirrhotic patients with acute variceal bleeding and hepatorenal syndrome (HRS). However, the evidence regarding the use of terlipressin in cirrhotic patients with ascites, post-paracentesis circulatory dysfunction, and bacterial infections and in those undergoing hepatic resection and liver transplantation remains insufficient. Terlipressin-related adverse events, mainly including gastrointestinal symptoms, electrolyte disturbance, and cardiovascular and respiratory adverse events, should be closely monitored. Conclusion: The current clinical practice guidance supports the use of terlipressin for gastroesophageal variceal bleeding and HRS in liver cirrhosis. High-quality studies are needed to further clarify its potential effects in other liver cirrhosis–related complications.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/17562848221098253
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2440710-0
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  • 2
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    The Combination of Astragalus membranaceus and Ligustrazine Protects Against Thrombolysis-Induced Hemorrhagic Transformation Through PKCδ/Marcks Pathway in Cerebral Ischemia Rats
    SAGE Publications ; 2020
    In:  Cell Transplantation Vol. 29 ( 2020-01-01), p. 096368972094602-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 29 ( 2020-01-01), p. 096368972094602-
    Abstract: Astragalus membranaceus (Ast) and ligustrazine (Lig) have a protective effect on lower hemorrhagic transformation induced by pharmaceutical thrombolysis. The cerebral ischemia rat model was induced with autologous blood clot injections. A combination of Ast and Lig, or a protein kinase C delta (PKCδ) inhibitor—rottlerin, or a combination of Ast, Lig, and rottlerin was administered immediately after recombinant tissue plasminogen activator injection. The cerebral infarct area, neurological deficits, cerebral hemorrhage status, neuronal damage and tight junctions’ changes in cerebral vessels, and the messenger RNA and protein levels of PKCδ, myristoylated alanine-rich C kinase substrate (Marcks), and matrix metallopeptidase 9 (MMP9) were determined after 3 h and 24 h of thrombolysis. The ultrastructure of the neuronal damage and tight junctions was examined under a transmission electron microscope. The expression levels of PKCδ, Marcks, and MMP9 were assessed by immunohistochemistry, western blot, and quantitative real-time polymerase chain reaction . Administration of Ast and Lig not only significantly decreased neurological deficit scores, infarct volumes, and cerebral hemorrhage but also inhibited the disruption due to neuronal dysfunction and the tight junction integrity in the cerebral vessel. Treatment with a combination of Ast and Lig effectively protected ischemia-induced microhemorrhage transformation through PKCδ/Marcks pathway suppression.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689720946020
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2020466-8
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  • 3
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    Comparison of Suture Button and Syndesmotic Screw for Ankle Syndesmotic Injuries: A Meta-analysis of Randomized Controlled Trials
    SAGE Publications ; 2023
    In:  Orthopaedic Journal of Sports Medicine Vol. 11, No. 1 ( 2023-01-01), p. 232596712211276-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 11, No. 1 ( 2023-01-01), p. 232596712211276-
    Abstract: The syndesmotic screw (SS) and suture button (SB) fixation methods are both widely used for the reduction of ankle syndesmotic injury, with varying outcomes. Purpose: To review recently published randomized controlled trials (RCTs) to assess the outcomes between SS and SB fixation for ankle syndesmotic injury. Study Design: Systematic review; Level of evidence, 1. Methods: The PubMed, Embase, ClinicalTrials.gov , and Cochrane databases were searched for relevant RCTs published between 1966 and 2021 according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Eligible studies were RCTs comparing SS and SB fixation for ankle syndesmotic injury. The risk of bias was evaluated using the Cochrane Risk of Bias tool. Primary outcomes included complications, malreduction, and unplanned reoperation, and secondary outcomes were the American Orthopaedic Foot & Ankle Society (AOFAS) score, Olerud-Molander ankle score (OMAS), and EuroQol-5 Domain (EQ-5D) score. The mean difference (MD) and risk ratio (RR) were calculated for continuous and dichotomous outcomes, respectively. Random- or fixed-effects model was applied according to heterogeneity. Results: Of 389 studies, 8 RCTs involving 512 patients were included. Overall, 257 patients received SS fixation and 255 patients received SB fixation. The 2 groups did not differ significantly in malreduction (RR, –0.06; 95% CI, –0.18 to 0.07) or EQ-5D (MD, 0.01; 95% CI, –0.01 to 0.03). However, the SB group showed significant advantages over the SS group in complications (RR, 0.42; 95% CI, 0.26 to 0.66), unplanned reoperation (RR, 0.62; 95% CI, 0.43 to 0.89), AOFAS score (MD, 3.04; 95% CI, 1.77 to 4.31), and OMAS (MD, 4.51; 95% CI, 1.54 to 7.48). The risk of bias of the included studies was acceptable. Conclusion: The results showed that there were no significant differences between the SS and SB groups in malreduction and EQ-5D scores. However, the SB group had significantly better local irritation rates, unplanned reoperation rates, AOFAS scores, and OMASs.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/23259671221127665
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2706251-X
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  • 4
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    A hybrid optimization approach for unequal-sized dynamic facility layout problems under fuzzy random demands
    SAGE Publications ; 2020
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture Vol. 234, No. 3 ( 2020-02), p. 382-399
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications, Vol. 234, No. 3 ( 2020-02), p. 382-399
    Abstract: Dynamic facility layout problems involve devising the optimal layout for each different production period. This article studies unequal-area dynamic facility layout problems under fuzzy random environment to minimize the sum of the material handling costs and rearrangement costs. For a more general situation, a novel model of unequal-area dynamic facility layout problems is proposed on the basis of fuzzy random theory, in which uncertain demands are characterized by fuzzy random variables. Unequal-area dynamic facility layout problems are one of the non-deterministic polynomial-time hard problems. Therefore, a hybrid particle swarm optimization and simulated annealing algorithm is innovated to solve the proposed unequal-area dynamic facility layout problems model under fuzzy random environment, in which the shapes and areas of facilities are changed dynamically. Two facility-swapping methods and two local search methods help hybrid algorithm escape from local optima, allowing a more reliable solution. Moreover, a new shifting method is developed to prevent the spatial overlapping between adjacent facilities and save material handling costs. The performance of the hybrid algorithm is confirmed by some test problems available. Finally, the proposed method is extended to a facility layout planning of a new aircraft assembly shop floor. Computational results show that the efficiency and effectiveness of the proposed method, in sharp comparison with other approaches.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/0954405419883046
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2032745-6
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  • 5
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    Acupuncture at LR3 and KI3 shows a control effect on essential hypertension and targeted action on cerebral regions related to blood pressure regulation: a resting state functional magnetic resonance imaging study
    SAGE Publications ; 2021
    In:  Acupuncture in Medicine Vol. 39, No. 1 ( 2021-02), p. 53-63
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 39, No. 1 ( 2021-02), p. 53-63
    Abstract: The aim of this study was to investigate the effects of acupuncture at LR3 and KI3 on hypertension at different time points and on related cerebral regions using resting-state functional magnetic resonance imaging (rs-fMRI). Methods We randomly divided 29 subjects into two groups: Group A (receiving acupuncture at LR3 + KI3; 15 subjects) and group B (receiving acupuncture at LR3 and a sham location not corresponding to any traditional acupuncture point; 14 subjects). Acupuncture was performed. Blood pressure (BP) changes were recorded and analyzed using SPSS 20.0 statistical software. We used a 3.0T MRI scanner and standard GE 8 channel head coil to collect whole brain fMRI data in both groups. Data analysis and processing was based on the R2009a MATLAB platform. REST 1.8 software was used to analyze the whole brain amplitude of low-frequency fluctuation (ALFF). Results After acupuncture, a statistically significant reduction in BP at different time points was observed in group A. In group B, a statistically significant reduction was found only in diastolic blood pressure (DBP) and was not sustained. Acupuncture at LR3 + KI3 specifically affected brain areas involved in BP regulation, as well as those involved in auditory sense, speech, vision, movement and sensation. Conclusion Acupuncture at LR3 + KI3 showed positive immediate and long-term effects on BP, particularly systolic blood pressure (SBP). After ALFF analysis, we concluded that LR3 + KI3 activates brain areas related to BP regulation. In addition, after acupuncture at LR3 + KI3, a highly targeted effect was observed in brain areas associated with BP. In addition, extracerebral areas involving vision, motion control, cognition and hearing were activated, which could potentially contribute to the mitigation of hypertensive complications in patients in an advanced stage of the disease.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1177/0964528420920282
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2126127-1
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  • 6
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    Synthesis, crystal structure, fluorescence and antioxidant properties of a binuclear Ag(I) complex based on the SPPh 3 ligand
    SAGE Publications ; 2019
    In:  Journal of Chemical Research Vol. 43, No. 5-6 ( 2019-05), p. 184-188
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 43, No. 5-6 ( 2019-05), p. 184-188
    Abstract: The binuclear silver(I) complex [Ag 2 (η 2 -SPPh 3 ) 2 (SPPh 3 ) 2 ](BF 4 ) 2 has been synthesized. Crystal analysis shows the coordination sphere around Ag(I) can be described as a three-coordinated slightly distorted planar triangular configuration with both monodentate and monoatomic bidentate bridging coordination modes for the SPPh 3 ligand. The fluorescence properties of free SPPh 3 and the Ag(I) complex have been studied in the solid state. The Ag(I) complex shows quasi-reversible Ag + /Ag pairs in its electrochemistry and has significant antioxidant activity against hydroxyl radicals.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.1177/1747519819857503
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 3010810-X
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  • 7
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    Weight Loss During Neoadjuvant Therapy Is Associated With Poor Response Among the Patients With Gastrointestinal Cancer: A Propensity Score Matching Analysis
    SAGE Publications ; 2023
    In:  Cancer Control Vol. 30 ( 2023-04)
    Details
    In: Cancer Control, SAGE Publications, Vol. 30 ( 2023-04)
    Abstract: The aim of the current study was to identify the relationship between body composition changes during neoadjuvant therapy (NAT) and the treatment efficiency of NAT in gastrointestinal cancer (GC) patients. Methods From January 2015 to July 2020, 277 GC patients treated with NAT had included for retrospective analysis. The body mass index (BMI) and computed tomography (CT) imaging before and after NAT were recorded. The BMI change optimal cut-off value were calculated by ROC curve. Balancing essential characteristic variables using propensity score matching (PSM) method. Exploring the association between BMI changes and tumor response to NAT using logistic regression analysis. The survival outcome of matched patients between different BMI change groups was compared. Results A cutoff point of BMI change 〉 2% during NAT was defined as BMI loss. Among the 277 patients, 110 (39.7%) patients showed BMI change with a loss after NAT. In total, 71 pairs of patients were selected for further analysis. The median follow-up time was 22 months (range 3 to 63 months). Univariate and multivariate logistic regression analyses in matched cohort showed that BMI change was a prognostic factor for tumor response after NAT in GC patients (odds ratio (OR), .471; 95% confidence interval (CI), .233-.953; P = .036). In addition, patients who experienced BMI loss after NAT showed worse overall survival than those who had BMI gain or stable. Conclusion BMI loss during NAT probably may has negative effects on NAT efficiency and survival for gastrointestinal cancer patients. It is necessary to monitor and maintain weight for patients during treatment.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1526-2359
    URL: Article
    DOI: 10.1177/10732748231164016
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2004182-2
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  • 8
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    Tool reliability of sintered diamond drill bit for processing silicon carbide ceramics based on Bayesian theory
    SAGE Publications ; 2020
    In:  Advanced Composites Letters Vol. 29 ( 2020-01-01), p. 2633366X2092367-
    Details
    In: Advanced Composites Letters, SAGE Publications, Vol. 29 ( 2020-01-01), p. 2633366X2092367-
    Abstract: Silicon carbide (SiC) ceramics, as a superhard nonmetallic material, would induce severe tool wear during drilling. To ensure the quality of processing, the drill bits must be replaced in advance before failure, which leads to serious waste without effective usage. Aiming at the tool reliability problem determined by the tool wear during drilling of the high hardness nonmetallic materials, this article proposed a reliability analysis method of sintered diamond drill bit for machining SiC ceramics based on the distribution of tool degradation increment and the modeling of gamma process, and a tool reliability model of degradation increment was established based on the Bayesian theory. The drilling experiment of sintered SiC ceramics was carried out by sintering diamond drill bit to obtain the degradation increment data. The accuracy of the model was tested by the reliability model deviation rate, which indicated that the reliability model with considering individual differences was more accurate. This research can provide a theoretical model and analytical method for improving the reliability of the nonmetallic brittle material processing tools.
    Type of Medium: Online Resource
    ISSN: 2633-366X , 2633-366X
    URL: Article
    DOI: 10.1177/2633366X20923672
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 3053419-7
    detail.hit.zdb_id: 2144398-1
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  • 9
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    Efficient Heterogeneous Catalyst for Biodiesel Production from Soybean Oil over Modified CaO
    SAGE Publications ; 2014
    In:  Progress in Reaction Kinetics and Mechanism Vol. 39, No. 3 ( 2014-09), p. 273-280
    Details
    In: Progress in Reaction Kinetics and Mechanism, SAGE Publications, Vol. 39, No. 3 ( 2014-09), p. 273-280
    Abstract: Biodiesel production by transesterification of soybean oil with methanol was carried out efficiently over modified CaO by using octadecyltrichlorosilane as surface modifier. It was found that the fatty acid methyl esters (FAME) yield was significantly enhanced from 35.4% to 93.5% over modified CaO with a methanol/oil ratio of 15: 1 at 65 °C after 3 h. Furthermore, good catalytic activity, i.e. 82.8% yield of FAME, remains even with a 2% water-content condition over modified CaO. The higher catalytic activity and good stability of modified CaO should be mainly attributed to the organic layer formed by the modifier over the CaO surface, which promotes the absorption of grease to CaO surface and protects CaO from water at the same time.
    Type of Medium: Online Resource
    ISSN: 1471-406X , 1471-406X
    URL: Article
    DOI: 10.3184/146867814X14043731662828
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2018085-8
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  • 10
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    A Chinese family with familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2
    SAGE Publications ; 2019
    In:  Cephalalgia Vol. 39, No. 11 ( 2019-10), p. 1382-1395
    Details
    In: Cephalalgia, SAGE Publications, Vol. 39, No. 11 ( 2019-10), p. 1382-1395
    Abstract: ATP1A2 has been identified as the genetic cause of familial hemiplegic migraine type 2. Over 80 ATP1A2 mutations have been reported, but no data from Chinese family studies has been included. Here, we report the first familial hemiplegic migraine type 2 Chinese family with a novel missense mutation. Methods Clinical manifestations in the family were recorded. Blood samples from patients and the unaffected members were collected for whole-exome sequencing to identify the pathogenic mutation. Seven online softwares (SIFT, PolyPhen-2, PROVEAN, PANTHER, MutationTaster2, MutationAssessor and PMut) were used for predicting the pathogenic potential of the mutation. PredictProtein, Jpred 4 and PyMOL were used to analyze structural changes of the protein. The mutation function was further tested by Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. Results All patients in the family had typical hemiplegic migraine attacks. Co-segregation of the mutation with the migraine phenotype in four generations, with 10 patients, was completed. The identified novel mutation, G762S in ATP1A2, exhibited the disease-causing feature by all the predictive softwares. The mutation impaired the local structure of the protein and decreased cell viability. Conclusion G762S in ATP1A2 is a novel pathogenic mutation identified in a Chinese family with familial hemiplegic migraine, which causes loss of function by changing the protein structure of the Na + /K + -ATPase α2 subunit.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/0333102419847738
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2019999-5
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