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  • 1
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    Online Resource
    MRI Tracking of iPS Cells-Induced Neural Stem Cells in Traumatic Brain Injury Rats
    SAGE Publications ; 2019
    In:  Cell Transplantation Vol. 28, No. 6 ( 2019-06), p. 747-755
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 28, No. 6 ( 2019-06), p. 747-755
    Abstract: Induced pluripotent stem cells (iPS cells) are promising cell source for stem cell replacement strategy applied to brain injury caused by traumatic brain injury (TBI) or stroke. Neural stem cell (NSCs) derived from iPS cells could aid the reconstruction of brain tissue and the restoration of brain function. However, tracing the fate of iPS cells in the host brain is still a challenge. In our study, iPS cells were derived from skin fibroblasts using the four classic factors Oct4, Sox2, Myc, and Klf4. These iPS cells were then induced to differentiate into NSCs, which were incubated with superparamagnetic iron oxides (SPIOs) in vitro. Next, 30 TBI rat models were prepared and divided into three groups ( n = 10). One week after brain injury, group A & B rats received implantation of NSCs (labeled with SPIOs), while group C rats received implantation of non-labeled NSCs. After cell implantation, all rats underwent T2*-weighted magnetic resonance imaging (MRI) scan at day 1, and 1 week to 4 weeks, to track the distribution of NSCs in rats’ brains. One month after cell implantation, manganese-enhanced MRI (ME-MRI) scan was performed for all rats. In group B, diltiazem was infused during the ME-MRI scan period. We found that (1) iPS cells were successfully derived from skin fibroblasts using the four classic factors Oct4, Sox2, Myc, and Klf4, expressing typical antigens including SSEA4, Oct4, Sox2, and Nanog; (2) iPS cells were induced to differentiate into NSCs, which could express Nestin and differentiate into neural cells and glial cells; (3) NSCs were incubated with SPIOs overnight, and Prussian blue staining showed intracellular particles; (4) after cell implantation, T2*-weighted MRI scan showed these implanted NSCs could migrate to the injury area in chronological order; (5) the subsequent ME-MRI scan detected NSCs function, which could be blocked by diltiazem. In conclusion, using an in vivo MRI tracking technique to trace the fate of iPS cells-induced NSCs in host brain is feasible.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689718819994
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2020466-8
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  • 2
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    Control of uncertain piecewise discrete-time linear systems via state and output feedback
    SAGE Publications ; 2012
    In:  Transactions of the Institute of Measurement and Control Vol. 34, No. 5 ( 2012-07), p. 509-519
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 34, No. 5 ( 2012-07), p. 509-519
    Abstract: Based on piecewise quadratic Lyapunov function techniques, this paper first provides a stability condition for the uncertain piecewise discrete-time linear system, which is a feasibility problem of linear matrix inequalities. Then the control methods for uncertain piecewise discrete-time linear systems via state feedback and output feedback controllers are proposed. It is shown that both the state feedback and output feedback controllers can be obtained by solving a set of bilinear matrix inequalities. A numerical example is given to illustrate the effectiveness of the developed methods
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331211403539
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2025882-3
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  • 3
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    Testing of diagnosis criteria of tension-type headache: A multicenter clinical study
    SAGE Publications ; 2018
    In:  Cephalalgia Vol. 38, No. 12 ( 2018-10), p. 1833-1840
    Details
    In: Cephalalgia, SAGE Publications, Vol. 38, No. 12 ( 2018-10), p. 1833-1840
    Abstract: Tension-type headache is *These authors contributed equally to this work. usually manifested as head pain without associated symptoms, and the validation of diagnostic criteria presented are lacking and highly required in the International Classification of Headache Disorders. The aim of the present study was to explore the diagnosis criteria of tension-type headache in a multicenter-based sample from Chongqing, China. Methods Clinical characteristics and demographics were systematically and prospectively collected between March 2014 and December 2015 from 15 participating hospitals in Chongqing, using a semi-structured face-to-face interview. All patients were asked to complete a headache diary for at least 4 weeks. Results Out of 1832 patients with headache, 150 patients (97 female/53 male, 44.56 ± 11.9 years old) were diagnosed with tension-type headache based on the standard International Classification of Headache Disorders, 3rd edition beta version, and interestingly, 114 (76%) patients were diagnosed with tension-type headache based on the alternative criteria. One patient was excluded because only two of the four characteristics were fulfilled. Thirty-five (23.3%) patients did not meet the alternative criteria because of associated symptoms, including mild nausea (n = 6), photophobia (n = 1), and phonophobia (n = 28). All patients with TTH had mild or moderate headaches, 98.0% of patients suffered from non-pulsating headaches, 99.3% of patients said their headaches were not aggravated by routine physical activity, and 77.3% of patients had bilateral headache. Conclusions Non-pulsating headaches and headaches that are not aggravated by routine physical activity may represent core criteria for screening patients with tension-type headache. Nausea might not be an exclusion feature for diagnosis of TTH, but an important criterion for screening. Further studies are needed.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/0333102418759784
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2019999-5
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  • 4
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    A novel fusion approach of deep convolution neural network with auto-encoder and its application in planetary gearbox fault diagnosis
    SAGE Publications ; 2021
    In:  Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability Vol. 235, No. 1 ( 2021-02), p. 3-16
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability, SAGE Publications, Vol. 235, No. 1 ( 2021-02), p. 3-16
    Abstract: The fault features of gearbox are often influenced and interwoven with each other under the non-stationary condition. The traditional shallow intelligent diagnosis models are difficult to detect and identify gearbox faults with selected features according to prior knowledge. To solve this problem, a novel deep convolutional auto-encoding neural network is designed based on the fusion of the convolutional neural network with the automatic encoder in this research. The vibration signals of gearbox are transformed into Hilbert envelope spectrum by using Hilbert transform and Fourier transform, and the different characteristics of spectral spatial data are automatically learned by convolutional auto-encoding neural network with multiple convolution kernels. The parameters of the convolutional neural network are fine-tuned through a fully connected neural network with a small number of labeled samples. Through the analysis for gearbox fault experiments, the effectiveness and practicability of the proposed method in equipment fault diagnosis are verified. The deep convolutional neural network embedded in the auto-encoder has stronger learning ability, and the diagnosis performance is more stable and reliable in practical engineering application.
    Type of Medium: Online Resource
    ISSN: 1748-006X , 1748-0078
    URL: Article
    DOI: 10.1177/1748006X20964614
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2246471-2
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  • 5
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    An actor-critic-based portfolio investment method inspired by benefit-risk optimization
    SAGE Publications ; 2018
    In:  Journal of Algorithms & Computational Technology Vol. 12, No. 4 ( 2018-12), p. 351-360
    Details
    In: Journal of Algorithms & Computational Technology, SAGE Publications, Vol. 12, No. 4 ( 2018-12), p. 351-360
    Abstract: How to get maximal benefit within a range of risk in securities market is a very interesting and widely concerned issue. Meanwhile, as there are many complex factors that affect securities’ activity, such as the risk and uncertainty of the benefit, it is very difficult to establish an appropriate model for investment. Aiming at solving the curse of dimension and model disaster caused by the problem, we use the approximate dynamic programming to set up a Markov decision model for the multi-time segment portfolio with transaction cost. A model-based actor-critic algorithm under uncertain environment is proposed, where the optimal value function is obtained by iteration on the basis of the constrained risk range and a limited number of funds, and the optimal investment of each period is solved by using the dynamic planning of limited number of fund ratio. The experiment indicated that the algorithm could get a stable investment, and the income could grow steadily.
    Type of Medium: Online Resource
    ISSN: 1748-3026 , 1748-3026
    URL: Article
    DOI: 10.1177/1748301818779059
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2478205-1
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  • 6
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    Global fast terminal sliding mode control based on radial basis function neural network for course keeping of unmanned surface vehicle
    SAGE Publications ; 2019
    In:  International Journal of Advanced Robotic Systems Vol. 16, No. 2 ( 2019-03-01), p. 172988141982996-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 16, No. 2 ( 2019-03-01), p. 172988141982996-
    Abstract: A scheme to solve the course keeping problem of the unmanned surface vehicle with nonlinear and uncertain characteristics and unknown external disturbances is investigated in this article. The chattering existing in global fast terminal sliding mode controller in solving the course keeping problem of the unmanned surface vehicle with external disturbance is analyzed. To reduce the chattering and eliminate the influence of the unknown disturbance, an adaptive global fast terminal sliding mode controller based on radial basis function neural network is developed. The equivalent control that usually requires a precise model information of the system is computed using the radial basis function neural network. The weights of the neural network are online adjusted according to the adaptive law that is derived using Lyapunov method to ensure the stability of the closed-loop system. Using the online learning of the neural network, the nonlinear uncertainty of the system and the unknown disturbance of external environment are compensated, and the system chattering is reduced effectively as well. The simulation results demonstrate that the proposed controller can achieve a good performance regarding the fast response and smooth control.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.1177/1729881419829961
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2202393-8
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  • 7
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    Comprehensive Bioinformatics Analysis of Key Methyltransferases and Demethylases for Histone Lysines in Hepatocellular Carcinoma
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303382098328-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303382098328-
    Abstract: Methylation of lysines on histones, controlled by various methyltransferases and demethylases, is an important component of epigenetic modifications, and abnormal regulation of such enzymes serves as common events in hepatocellular carcinoma. We determined to identify important methyltransferases and demethylases that might regulate the development of hepatocellular carcinoma by bioinformatics. Methods: The Oncomine and UALCAN databases were used to retrieve mRNA expression levels of histone lysine methyltransferases and demethylases in hepatocellular carcinoma. Data analyses of genetic alterations, mainly mutations and copy number alterations, were performed on the cBioportal platform. Protein-protein interactions were established in the STRING database. Results: mRNA expression of 8 genes correlated with clinical staging and grading, whereas 4 genes indicated a role in the prognosis, all co-expressed with SEDB1 and WHSC1. Genetically, 12 genes showing an alteration rate higher than 5% were identified, and only 3 were indicative of prognosis. Copy number gains in ASH1L, SETDB1, and KDM5B might partially contribute to the upregulation of their mRNA expression. The close relationship of mutations in MLL2/MLL3 with driver gene mutations in hepatocellular carcinoma provided a rationale for further investigation. Conclusions: We identified 11 methyltransferases and demethylases for major histone lysines that might be promising research targets in the pathogenesis, development, and prediction of prognosis in hepatocellular carcinoma using bioinformatics.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033820983284
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 8
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    Application of five frozen human-pooled serum samples assigned by the International Federation of Clinical Chemistry and Laboratory Medicine reference procedure in a traceability investigation of γ-glutamyltransferase catalytic concentration measurements in China
    SAGE Publications ; 2010
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 47, No. 3 ( 2010-05), p. 189-194
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 47, No. 3 ( 2010-05), p. 189-194
    Abstract: The in vitro directive of the European Union requires traceability to the international recommended reference procedures. The application of the reference procedures is necessary in order to evaluate the accuracy of γ-glutamyltransferase (GGT) assays of routine measurement systems in China. Methods Five frozen patient-pooled serum samples were assigned values by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) reference procedure in order to evaluate the traceability of the results of GGT catalytic activity from six homogeneous systems. One of the serum samples was used to calibrate seven non-homogeneous systems. Results All of the homogeneous systems, except the Dade system (Dade Bering Inc, IL, USA), achieved traceability within the measurement range. The Roche and Hitachi systems were better than the other systems. After calibration, the variance of the non-homogeneous systems decreased dramatically from between 14.50% and 25.23% to between 1.25% and 3.09% and the bias decreased from between −11.4% and −4.1% to between 0.5% and 3.5%. Conclusion Manufacturers in China should ensure that their calibration systems correspond to the IFCC reference procedures. Fresh frozen pooled patient serum assigned by reference laboratories can be used to calibrate non-homogeneous systems in order to achieve traceability.
    Type of Medium: Online Resource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1258/acb.2009.009210
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2041298-8
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  • 9
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    Multinational prospective cohort study of incidence and risk factors for central line-associated bloodstream infections over 18 years in 281 ICUs of 9 Asian countries
    SAGE Publications ; 2023
    In:  The Journal of Vascular Access
    Details
    In: The Journal of Vascular Access, SAGE Publications
    Abstract: Our objective was to identify central line (CL)-associated bloodstream infections (CLABSI) rates and risk factors (RF) in Asia. Methods: From 03/27/2004 to 02/11/2022, we conducted a multinational multicenter prospective cohort study in 281 ICUs of 95 hospitals in 44 cities in 9 Asian countries (China, India, Malaysia, Mongolia, Nepal, Pakistan, Philippines, Sri Lanka, Thailand, and Vietnam). For estimation of CLABSI rate we used CL-days as denominator and number of CLABSI as numerator. To estimate CLABSI RF for we analyzed the data using multiple logistic regression, and outcomes are shown as adjusted odds ratios (aOR). Results: A total of 150,142 patients, hospitalized 853,604 days, acquired 1514 CLABSIs. Pooled CLABSI rate per 1000 CL-days was 5.08; per type of catheter were: femoral: 6.23; temporary hemodialysis: 4.08; jugular: 4.01; arterial: 3.14; PICC: 2.47; subclavian: 2.02. The highest rates were femoral, temporary for hemodialysis, and jugular, and the lowest PICC and subclavian. We analyzed following variables: Gender, age, length of stay (LOS) before CLABSI acquisition, CL-days before CLABSI acquisition, CL-device utilization ratio, CL-type, tracheostomy use, hospitalization type, ICU type, facility ownership and World Bank classifications by income level. Following were independently associated with CLABSI: LOS before CLABSI acquisition, rising risk 4% daily (aOR = 1.04; 95% CI = 1.03–1.04; p  〈  0.0001); number of CL-days before CLABSI acquisition, rising risk 5% per CL-day (aOR = 1.05; 95% CI 1.05–1.06; p  〈  0.0001); medical hospitalization (aOR = 1.21; 95% CI 1.04–1.39; p = 0.01); tracheostomy use (aOR = 2.02;95% CI 1.43–2.86; p  〈  0.0001); publicly-owned facility (aOR = 3.63; 95% CI 2.54–5.18; p  〈  0.0001); lower-middle-income country (aOR = 1.87; 95% CI 1.41–2.47; p  〈  0.0001). ICU with highest risk was pediatric (aOR = 2.86; 95% CI 1.71–4.82; p  〈  0.0001), followed by medical-surgical (aOR = 2.46; 95% CI 1.62–3.75; p  〈  0.0001). CL with the highest risk were internal-jugular (aOR = 3.32; 95% CI 2.84–3.88; p  〈  0.0001), and femoral (aOR = 3.13; 95% CI 2.48–3.95; p  〈  0.0001), and subclavian (aOR = 1.78; 95% CI 1.47–2.15; p  〈  0.0001) showed the lowest risk. Conclusions: The following CLABSI RFs are unlikely to change: country income level, facility-ownership, hospitalization type, and ICU type. Based on these findings it is suggested to focus on reducing LOS, CL-days, and tracheostomy; using subclavian or PICC instead of internal-jugular or femoral; and implementing evidence-based CLABSI prevention recommendations.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    URL: Article
    DOI: 10.1177/11297298231169542
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2079292-X
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  • 10
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    Research on vehicle speed identification method based on time interpolation method and feature point recognition
    SAGE Publications ; 2023
    In:  International Journal of Advanced Robotic Systems Vol. 20, No. 1 ( 2023-01-01), p. 172988062311537-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 20, No. 1 ( 2023-01-01), p. 172988062311537-
    Abstract: Based on camera calibration in detection area, an improved method of time interpolation for vehicle speed identification is proposed. Firstly, calibration of camera parameters during photogrammetry is carried out through preset rectangular detection area. Secondly, the key frames are extracted from the video images and the target vehicle feature points and their image coordinates are identified by the image morphological processing. Then the actual coordinates of the characteristic points are determined through the coordinate conversion. Finally, the improved time interpolation method considering the acceleration between frames is used to identify the vehicle speed, so as to improve the accuracy of the vehicle speed measurement. The results proved that the vehicle speed calculated by improved time interpolation method is more reliable, and the error is reduced by 0.7%.
    Type of Medium: Online Resource
    ISSN: 1729-8806 , 1729-8814
    URL: Article
    DOI: 10.1177/17298806231153726
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2202393-8
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