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  • 1
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    Online Resource
    The prevalence, course and clinical correlates of migraine in Parkinson’s disease: A multicentre case-controlled study
    SAGE Publications ; 2018
    In:  Cephalalgia Vol. 38, No. 9 ( 2018-08), p. 1535-1544
    Details
    In: Cephalalgia, SAGE Publications, Vol. 38, No. 9 ( 2018-08), p. 1535-1544
    Abstract: Previous studies have reported a lower migraine prevalence in Parkinson’s disease (PD) patients and improvements in migraine headaches after PD onset, but the clinical association of migraines with PD is unclear. Methods We analysed headache and migraine prevalence and clinical correlates in 436 PD patients (mean age, 69.3 ± 7.8 years) and 401 age- and sex-matched controls (mean age, 69.2 ± 8.6 years) in a case-controlled, multicentre study. Migraines were diagnosed by a questionnaire developed according to the International Classification of Headache Disorders, second edition. We evaluated changes in headache intensity, frequency and severity over several years around the onset of PD among PD patients with headaches or migraines, and over the past several years among control subjects with headaches or migraines. Results PD patients had lower lifetime (9.6% vs. 18.0%) and 1-year (6.7% vs. 11.0%) migraine prevalences than controls. However, lifetime (38.5% vs. 38.9%) and 1-year (26.1% vs. 26.2%) headache prevalence did not differ between PD patients and controls. After adjusting for gender, timing of the evaluation of headache changes, and recall period, PD patients with headaches or migraines exhibited a pronounced reduction in the intensity, frequency and overall severity of their headaches and migraines after the onset of PD compared with controls with headaches or migraines. PD patients with migraines exhibited a higher rate of depression and higher Pittsburgh Sleep Quality Index and PD sleep scale-2 scores than those without headaches. Conclusion While overall headache and migraine severity reduced after PD onset, the presence of migraines was associated with sleep disturbances and depression in PD patients.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/0333102417739302
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2019999-5
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  • 2
    Online Resource
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    Dream-enacting behaviour is associated with impaired sleep and severe headache-related disability in migraine patients
    SAGE Publications ; 2013
    In:  Cephalalgia Vol. 33, No. 10 ( 2013-07), p. 868-878
    Details
    In: Cephalalgia, SAGE Publications, Vol. 33, No. 10 ( 2013-07), p. 868-878
    Abstract: Sleep disorders, nightmares and visual hallucinations have been reported in migraine patients, which may suggest the involvement of rapid eye movement (REM) sleep regulation in migraine. However, the relationship between migraine and REM sleep behaviour disorder (RBD) remains unclear. Methods To investigate the clinical correlates of dream-enacting behaviours (DEB) in migraine patients, we assessed episodic migraine patients ( n = 161, mean age 33.1 years) and headache-free control subjects ( n = 140, mean age 33.1 years) under 50 years of age in a cross-sectional, case-control study. The Japanese version of the RBD screening questionnaire was used, and subjects scoring 5 or higher were defined as having DEB. Results A significantly increased frequency of DEB was observed in migraine patients compared to controls (24.2% vs. 14.3%). Migraine patients with DEB presented higher scores on the Migraine Disability Assessment and Pittsburgh Sleep Quality Index and an increased rate of smoking compared to those without DEB. Duration of migraine and headache frequency and intensity were not different between migraine patients with or without DEB. Conclusion DEB was associated with impaired sleep and severe headache-related disability in migraine patients and may reflect brainstem dysfunction and increased brain excitability in migraine patients.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/0333102413477742
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2019999-5
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  • 3
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    Effectiveness of three calcitonin gene-related peptide monoclonal antibodies for migraine: A 12-month, single-center, observational real-world study in Japan
    SAGE Publications ; 2023
    In:  Cephalalgia Vol. 43, No. 5 ( 2023-05), p. 033310242311776-
    Details
    In: Cephalalgia, SAGE Publications, Vol. 43, No. 5 ( 2023-05), p. 033310242311776-
    Abstract: Real-world data on the effectiveness of calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) in migraine patients are needed. Methods We performed a single-center, real-world study with an observation period of up to 12 months (mean 7.5 ± 3.4 months) after CGRP mAb administration. A total of 228 Japanese patients with episodic or chronic migraine (age, 45.9 ± 13.2 years; 184F; 45 erenumab; 60 galcanezumab; 123 fremanezumab) who were treated with CGRP mAbs for at least three months were ultimately included in this study. Results In the total cohort, after CGRP mAb treatment, mean monthly migraine days decreased by 7.2 ± 4.8, 8.3 ± 4.7, and 9.5 ± 5.0 at three, six and 12 months, respectively. The ≥50% monthly migraine day reduction rates at three, six and 12 months were 48.2%, 61.0% and 73.7%, respectively. In the logistic regression analysis, the presence of osmophobia and fewer baseline monthly migraine days contributed to ≥50% responders at three, six and 12 months. The ≥50% responders at three or six months were useful in predicting ≥50% responders at 12 months. In subgroups of patients with difficult-to-treat migraine (those with medication overuse headache or psychiatric comorbidities) and previous CGRP mAb users, monthly migraine days were substantially reduced over 12 months. There was no difference in monthly migraine day reduction over 12 months among three different CGRP mAbs. Adverse reactions were observed in 28 (12.3%) patients, with injection site reactions being the most common (n = 22) though generally mild in severity. Conclusion This real-world study confirmed the efficacy and safety of three different CGRP mAbs for prophylactic treatment of patients with migraine.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/03331024231177649
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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  • 4
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    Impact of the COVID-19 pandemic on patients with mental health problems and the differences among diagnostic categories
    SAGE Publications ; 2022
    In:  International Journal of Social Psychiatry Vol. 68, No. 5 ( 2022-08), p. 969-980
    Details
    In: International Journal of Social Psychiatry, SAGE Publications, Vol. 68, No. 5 ( 2022-08), p. 969-980
    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has resulted in a total upending of our daily lives. While anxiety and depression were frequently reported among the general population, the pandemic’s impact on patients with mental health problems remains unknown. Methods: A cross-sectional questionnaire survey involving 1,166 patients was conducted at one psychiatric hospital and one mental health clinic. Results: Symptom deterioration was reported in 23% to 34% of the patients and 9% to 20% reported increase in drug dosage. No significant differences were reported in these items among diagnostic categories. Patients with F3 (mood disorders) reported more psychological stress during the pandemic’s beginning and during the emergency. Patients with F2 (schizophrenia, schizotypal, and delusional disorders) did online shopping and meetings less frequently, and reported poorer adherence of 3C’s, while mask management was stricter in patients with F4 (neurotic, stress-related, and somatoform disorders). Symptom deterioration was significantly associated with increase in drug dosage, new physical symptoms, anxiety unrelated to COVID-19, stress at the beginning of pandemic, stress during the ‘state of emergency’, poor adaptability to environmental change, daily life changes, decrease in sleeping time, and decrease in time spent outside. Conclusion: One third of patients reported symptom deterioration during the pandemic, which was associated with stress and daily life changes. Patients with good adaptability to environmental changes might resilient against symptom deterioration. Providing continuous support to help patients manage their daily life in this COVID-19 era may minimize the risk of symptom deterioration.
    Type of Medium: Online Resource
    ISSN: 0020-7640 , 1741-2854
    URL: Article
    DOI: 10.1177/00207640221097509
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2066492-8
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  • 5
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    Intentional Binding Without Intentional Action
    SAGE Publications ; 2019
    In:  Psychological Science Vol. 30, No. 6 ( 2019-06), p. 842-853
    Details
    In: Psychological Science, SAGE Publications, Vol. 30, No. 6 ( 2019-06), p. 842-853
    Abstract: The experience of authorship over one’s actions and their consequences—sense of agency—is a fundamental aspect of conscious experience. In recent years, it has become common to use intentional binding as an implicit measure of the sense of agency. However, it remains contentious whether reported intentional-binding effects indicate the role of intention-related information in perception or merely represent a strong case of multisensory causal binding. Here, we used a novel virtual-reality setup to demonstrate identical magnitude-binding effects in both the presence and complete absence of intentional action, when perceptual stimuli were matched for temporal and spatial information. Our results demonstrate that intentional-binding-like effects are most simply accounted for by multisensory causal binding without necessarily being related to intention or agency. Future studies that relate binding effects to agency must provide evidence for effects beyond that expected for multisensory causal binding by itself.
    Type of Medium: Online Resource
    ISSN: 0956-7976 , 1467-9280
    URL: Article
    DOI: 10.1177/0956797619842191
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2022256-7
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  • 6
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    Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population
    SAGE Publications ; 2018
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 55, No. 4 ( 2018-07), p. 437-445
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 55, No. 4 ( 2018-07), p. 437-445
    Abstract: It has been demonstrated that circulating microRNA profiles are affected by physiological conditions. Several studies have demonstrated that microRNAs play important roles in the regulation of adiposity. However, few have investigated the relationship between circulating microRNAs and obesity, which has become a major public health problem worldwide. This study investigated the association between circulating microRNAs and obesity in a Japanese population. Methods Obesity parameters, such as subcutaneous and visceral fat adipose tissue, body fat percentage, and body mass index were assessed in a cross-sectional sample of 526 participants who attended health examinations in Yakumo, Japan. In addition, five circulating microRNAs (miR-20a, -21, -27a, -103a, and -320), which are involved in adipocyte proliferation and differentiation, were quantified using real-time polymerase chain reaction amplification. Results We compared the circulating microRNA concentrations in a percentile greater than 75th (high) with below the value (low) of subcutaneous adipose tissue, visceral fat adipose tissue, body mass index, and per cent body fat. For visceral fat adipose tissue, significant decrease in miR-320 expression was observed in high group. Also, for body mass index, significant change of miR-20a, -27a, 103a, and 320 expression level was observed in high group. Multiple linear regression analysis demonstrated that circulating levels of some microRNA such as miR-27a were significantly associated with subcutaneous adipose tissue, visceral fat adipose tissue, and body mass index. Conclusions Our findings support the need for further studies to determine whether such changes are consistent across different populations and whether the identified microRNAs may represent novel biomarkers to predict the susceptibility and progression of obesity-related disorders.
    Type of Medium: Online Resource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1177/0004563217735124
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2041298-8
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  • 7
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    Clinical characteristics of patients with Rutherford category IV, compared with V and VI
    SAGE Publications ; 2015
    In:  SAGE Open Medicine Vol. 3 ( 2015-10-27), p. 205031211559708-
    Details
    In: SAGE Open Medicine, SAGE Publications, Vol. 3 ( 2015-10-27), p. 205031211559708-
    Type of Medium: Online Resource
    ISSN: 2050-3121 , 2050-3121
    URL: Article
    DOI: 10.1177/2050312115597087
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2735399-0
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  • 8
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    Evaluation of Postoperative Radiocapitellar Joint Alignment in Congenital Radioulnar Synostosis Patients
    SAGE Publications ; 2016
    In:  HAND Vol. 11, No. 1_suppl ( 2016-09), p. 29S-29S
    Details
    In: HAND, SAGE Publications, Vol. 11, No. 1_suppl ( 2016-09), p. 29S-29S
    Abstract: Hypothesis: No study has evaluated radiocapitellar joint alignment or proximal radioulnar joint alignment postoperatively in congenital radioulnar synostosis patients. The aim of this study was to clarify the postoperative clinical results and radiocapitellar joint alignment. Methods: Eight forearms in 7 patients (6 males and 1 female with a mean age of 8.8 years) with congenital radioulnar synostosis, who underwent surgery with a minimum of a year and a mean of 2.1 years of follow-up, were evaluated. The surgery consisted of division of the synostosis and interposition with a pedicled vascularized adipofascial flap between the radius and the ulna. A corrective radial osteotomy was performed in 3 patients at the radial neck, which had a great angular deformity, and in 1 patient at the mid-diaphysis, which had a great bowing deformity. Radiocapitellar joint alignment was evaluated in a lateral view radiograph and classified into 3 types as anterior, intermediate, or posterior, defined by whether the radial neck and head axis were above, within, or below the capitellum. This alignment was evaluated preoperatively and at final follow-up. The active range of prono-supination was also evaluated as a clinical outcome. There was no patient who had recurrence of bony union at the divided synostosis. Results: Preoperatively, there were 5 forearms of the anterior type, 1 intermediate type, and 2 of the posterior type. At final follow-up, there were 2 forearms of the anterior type and 6 of the posterior type. Four forearms were changed into a posterior type. At the final follow-up, the active range was 37.5 ± 8° in pronation and 20 ± 10° in supination in the anterior type, and was 41 ± 23° in pronation and 26 ± l8° in supination in the posterior type. There was no significant difference in pronation or supination between types. It was more difficult to improve supination than pronation in each type. Summary points: In this case series, it was difficult to reconstruct the proper radiocapitellar alignment. To better improve the range, especially of supination, reconstruction of the radiocapitellar joint or the proximal radioulnar joint with a more accurate corrective radial osteotomy or sigmoid notch plasty should be considered.
    Type of Medium: Online Resource
    ISSN: 1558-9447 , 1558-9455
    URL: Article
    DOI: 10.1177/1558944716660555aj
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 9
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    Evaluating recanalization of relevant lenticulostriate arteries in acute ischemic stroke using high-resolution MRA at 7T
    SAGE Publications ; 2021
    In:  International Journal of Stroke Vol. 16, No. 9 ( 2021-12), p. 1039-1046
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 16, No. 9 ( 2021-12), p. 1039-1046
    Abstract: Occluded major intracranial arteries can spontaneously recanalize in patients with acute ischemic stroke mainly due to embolic mechanisms. However, it remains unknown whether recanalization can occur in perforating arteries, such as lenticulostriate arteries. Therefore, in the present study, we assessed changes suggesting recanalization of the lenticulostriate arteries in patients with acute ischemic stroke of the lenticulostriate artery territory using high-resolution magnetic resonance angiography (HR-MRA) at 7T. Methods We prospectively examined 39 consecutive patients with acute infarcts confined within the lenticulostriate artery territory. Using a 7T scanner during the acute period and one month thereafter, we evaluated imaging findings indicating the recanalization of the relevant lenticulostriate arteries, following which we examined differences in other imaging findings and clinical characteristics between patients with/without recanalization. Results HR-MRA findings suggestive of recanalization (i.e. patent lenticulostriate arteries within acute infarct lesions with/without hemorrhagic changes) were observed in 8 (25%) of 32 patients who were eligible for analyses. These findings were detected in three and five patients on the baseline and follow-up images, respectively. The lengths of relevant lenticulostriate arteries on the follow-up MRA were significantly larger in patients with recanalization than in those without ( P = 0.01). However, there were no significant differences in the infarct volume or clinical outcomes between the recanalization and non-recanalization groups. Conclusion HR-MRA at 7T revealed that recanalization of the relevant lenticulostriate arteries can occur in patients with acute ischemic stroke confined to the lenticulostriate artery territory.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493019897868
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2211666-7
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  • 10
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    Usefulness of magnetic resonance angiography for the evaluation of varices at hepaticojejunostomy after liver transplantation
    SAGE Publications ; 2015
    In:  Acta Radiologica Open Vol. 4, No. 5 ( 2015-05-01), p. 205846011557860-
    Details
    In: Acta Radiologica Open, SAGE Publications, Vol. 4, No. 5 ( 2015-05-01), p. 205846011557860-
    Abstract: A 7-year-old Japanese girl who had undergone living-donor liver transplantation (LT) at the age of 10 months for decompensated liver cirrhosis caused by biliary atresia presented with recurrent episodes of obscure gastrointestinal bleeding (GIB) with anemia. Over the following 6 years, she experienced five episodes of GIB requiring hospitalization. Subsequent evaluations including repeat esophagogastroduodenoscopy (EGD), colonoscopy (CS), contrast-enhanced computed tomography (CT), and Meckel’s scan all failed to reveal a bleeding source. However, varices at the site of hepaticojejunostomy were detected on abdominal ultrasonography and magnetic resonance angiography (MRA) at the age of 7 years. MRA might be more helpful than contrast-enhanced CT for identifying such bleeding.
    Type of Medium: Online Resource
    ISSN: 2058-4601 , 2058-4601
    URL: Article
    DOI: 10.1177/2058460115578600
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2818429-4
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