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  • SAGE Publications  (64)
  • 1
    Online Resource
    Online Resource
    Exploring the Structure of Haplotype Blocks and Genetic Diversity in Chinese Indigenous Pig Populations for Conservation Purpose
    SAGE Publications ; 2019
    In:  Evolutionary Bioinformatics Vol. 15 ( 2019-01), p. 117693431882508-
    Details
    In: Evolutionary Bioinformatics, SAGE Publications, Vol. 15 ( 2019-01), p. 117693431882508-
    Abstract: Chinese indigenous pigs in the Taihu Lake region are well known for their high fecundity and other excellent characteristics. To better understand the characteristics of these breeds in this area as well as to provide the government and breeders the molecular basis for formulating a reasonable conservation policy, we explored the structure of haplotype blocks and genetic diversity of the 7 populations which is relevant for the management and conservation of these important genetic resources using next-generation sequencing data. In this study, a total of 131 300 single-nucleotide polymorphisms with minor allele frequencies ⩾0.05 were obtained for further analysis. In general, there are similar within-breed genetic diversities (He, Ho, P n , A r ) among these 7 pig populations in the Taihu Lake region. Average values for the inbreeding coefficients estimates in the 7 populations are 0.110 (F1), 0.056 (F2), and 0.078 (F3). All the breeds have seen a continuous decline in Ne estimates over time with FJ and SW populations having a very similar curve. Moreover, the Ne of SMS pig breeds were smaller than other Chinese pig breeds, indicating that SMS pig breeds underwent stronger selection pressure than other Chinese pig breeds. The average genetic distances among the 7 populations in the Taihu Lake region were 0.235 (MMS), 0.240 (SMS), 0.269 (EH), 0.248 (MI), 0.221 (FJ), 0.254 (JX), and 0.212 (SW). A summary of the number of haplotype blocks and haplotype diversity was also presented. This study provide a deep understanding of the current situation of conservation in this region, thereby uncovering the pertinent insight to better formulate more reasonable preservation policies for the government departments and breeding planners to follow-up.
    Type of Medium: Online Resource
    ISSN: 1176-9343 , 1176-9343
    URL: Article
    DOI: 10.1177/1176934318825082
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2227610-5
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  • 2
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    Tissue perfusion of the kurtosis/diffusion mismatch differs from the central core and peripheral regions in acute cerebral infarction patients
    SAGE Publications ; 2023
    In:  Acta Radiologica Vol. 64, No. 3 ( 2023-03), p. 1155-1165
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 64, No. 3 ( 2023-03), p. 1155-1165
    Abstract: Despite its wide adoption in stroke imaging, the diffusion-weighted imaging (DWI) lesion is heterogeneous. The emerging diffusion kurtosis imaging (DKI) has been postulated to resolve the graded DWI lesion. Purpose To determine the perfusion characteristics of the central infarction core, kurtosis/diffusion mismatch, and peripheral regions. Material and Methods Patients with acute ischemic stroke underwent DWI, DKI, and perfusion-weighted imaging (PWI) scans. The patients were divided into mean kurtosis (MK)/mean diffusivity (MD) match and mismatch groups. Perfusion parameters were measured in the MK/MD lesion and peripheral areas in the MK/MD match group. We also analyzed perfusion status in the MK/MD lesion mismatch area for the mismatch group. Results A total of 40 eligible patients (24 MK/MD match and 16 MK/MD mismatch) were enrolled in the final data analysis. The MTT and TTP progressively decreased, while the cerebral blood flow (CBF) and cerebral blood volume (CBV) increased from the central to peripheral areas. In addition, CBF in the MK/MD mismatch region was significantly higher than that in the central region ( P  〈  0.05), but similar to the peripheral region. Furthermore, CBV in the MK/MD mismatch region did not differ significantly from that of the central region, but both were significantly lower than that of the peripheral area ( P  〈  0.05). Conclusion The MK/MD mismatch region had blood flow similar to the peripheral region but with a reduced blood volume, indicating that it was less ischemic from the infarction core, albeit insufficient collateral circulation.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/02841851221109678
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024579-8
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  • 3
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    Design Thinking and Cloud Manufacturing: A Study of Cloud Model Sharing Platform Based on Separated Data Log
    SAGE Publications ; 2013
    In:  Advances in Mechanical Engineering Vol. 5 ( 2013-01), p. 247695-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 5 ( 2013-01), p. 247695-
    Abstract: To solve the product data consistency problem which is caused by the portable system that cannot conduct real-time update of product data in mobile environment under the mass customization production mode, a new product data optimistic replication method based on log is presented. This paper focuses on the design thinking provider, probing into a manufacturing resource design thinking cloud platform based on manufacturing resource-locating technologies, and also discuss several application scenarios of cloud locating technologies in the manufacturing environment. The actual demand of manufacturing creates a new mode which is service-oriented and has high efficiency and low consumption. Finally, they are different from the crowd-sourcing application model of Local-Motors. The sharing platform operator is responsible for a master plan for the platform, proposing a open interface standard and establishing a service operation mode.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1155/2013/247695
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2501620-9
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  • 4
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    Prognostic Factors in Older Patients with Advanced Non-small Cell Lung Cancer in China
    SAGE Publications ; 2014
    In:  Tumori Journal Vol. 100, No. 1 ( 2014-01), p. 69-74
    Details
    In: Tumori Journal, SAGE Publications, Vol. 100, No. 1 ( 2014-01), p. 69-74
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/1430.15818
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 5
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    Detection of the Ischemic Penumbra Using pH-Weighted MRI
    SAGE Publications ; 2007
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 27, No. 6 ( 2007-06), p. 1129-1136
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 27, No. 6 ( 2007-06), p. 1129-1136
    Abstract: The classic definition of the ischemic penumbra is a hypoperfused region in which metabolism is impaired, but still sufficient to maintain cellular polarization. Perfusion- and diffusion-weighted MRI (PWI, DWI) can identify regions of reduced perfusion and cellular depolarization, respectively, but it often remains unclear whether a PWI—DWI mismatch corresponds to benign oligemia or a true penumbra. We hypothesized that pH-weighted MRI (pHWI) can subdivide the PWI—DWI mismatch into these regions. Twenty-one rats underwent permanent middle cerebral artery occlusion and ischemic evolution over the first 3.5 h post-occlusion was studied using multiparametric MRI. End point was the stroke area defined by T 2 -hyperintensity at 24 h. In the acute phase, areas of reduced pH were always larger than or equal to DWI deficits and smaller than or equal to PWI deficits. Group analysis showed that pHWI deficits during this phase coincided with the resulting infarct area at endpoint. Final infarcts were smaller than PWI deficits (range 65% to 90%, depending on the severity of the occlusion) and much larger than acute DWI deficits. These data suggest that the outer boundary of the hypoperfused area showing a decrease in pH without DWI abnormality may correspond to the outer boundary of the ischemic penumbra, while the hypoperfused region at normal pH may correspond to benign oligemia. These first results show that pHWI can provide information complementary to PWI and DWI in the delineation of ischemic tissue.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/sj.jcbfm.9600424
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2039456-1
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  • 6
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    MicroRNA-363-3p downregulation in papillary thyroid cancer inhibits tumor progression by targeting NOB1
    SAGE Publications ; 2021
    In:  Journal of Investigative Medicine Vol. 69, No. 1 ( 2021-01), p. 66-74
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 69, No. 1 ( 2021-01), p. 66-74
    Abstract: MicroRNA-363-3 p (miR-363–3 p) has been reported to play a crucial role in tumor development and progression, and function as a tumor suppressor in many types of cancer. In our previous studies, we found that miRNA-363–3 p inhibited papillary thyroid carcinoma (PTC) progression by targeting PIK3CA. Meanwhile, we found that NIN1/RPN12 binding protein 1 (NOB1) was significantly upregulated in thyroid carcinoma tissue and downregulation of NOB1 expression significantly inhibited cell proliferation, migration and invasion in PTC. However, the correlation of NOB1 and miR-363–3 p has not been investigated. Here, we performed bioinformatic analysis to explore miRNA targeting NOB1. We found that NOB1 was a target of miR-363–3 p and miR-363–3 p regulated NOB1 expression at the translational and transcriptional levels by targeting its 3’ untranslated region (3′-UTR). Further, we showed that miR-363–3 p inhibited tumor progression by targeting NOB1 in vitro and in vivo. We found that overexpression miR-363–3 p or silencing NOB1 significantly increased G0/G1-phase and decreased S-phase in the human papillary thyroid cells, which led to a significant delay in cell proliferation, indicating miR-363–3 p and NOB1 are crucial for human papillary thyroid cancer tumorigenesis. Collectively, our data unveil that miR-363–3 p negatively regulates NOB1 activity by reducing its stability. This study provides a new therapeutic target for regulation of NOB1 stability to modulate human papillary thyroid cancer progression.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-2020-001562
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 7
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    Responses of sedimentary proxy indicators to lake-level fluctuations on the central Tibetan Plateau since the last deglaciation
    SAGE Publications ; 2022
    In:  Progress in Physical Geography: Earth and Environment Vol. 46, No. 6 ( 2022-12), p. 922-948
    Details
    In: Progress in Physical Geography: Earth and Environment, SAGE Publications, Vol. 46, No. 6 ( 2022-12), p. 922-948
    Abstract: Lake sediments are valuable archives to investigate past changes in climate and environment on various timescales. Closed-basin lakes can be regarded as precipitation gauges, which are ideal for studying past climate changes. However, the climatic implications of various sedimentary proxy indicators from closed-basin lakes are often confounded by lake-level fluctuations, which are affected by lake watershed processes, besides climate change. Here, we present records of multi-proxy indicators since the last deglaciation at Lake Cuoe, on the central Tibetan Plateau, which was once connected with Selin Co and became separated during the middle Holocene, as evidenced by a series of paleo-shorelines. The sedimentary proxies are categorized into three groups based on their origins, with differences in their environmental significance. The proxy indicators derived from within-lake processes effectively revealed past lake-level fluctuations, including the Ca/(Al, Ti, Fe) ratio, Fe/Mn ratio, carbonate minerals, stable carbon and oxygen isotopes of authigenic carbonate, and the percentage of aquatic inputs (Paq) derived from n-alkanoic acids. These proxy indicators showed obvious changes at ∼7–6 ka, when Lake Cuoe became hydrologically separated from Selin Co. The stable oxygen isotope record of Lake Cuoe, apparently modulated by lake-level changes, differs significantly from that from Selin Co. The proxy indicators reflecting watershed processes, including terrigenous elements, Rb/Sr ratio, grain size, and the chain length proxy based on n-alkanoic acids, directly reflected changes in the regional climate and environment. The proxy indicators derived from both allochthonous and authigenic sources, including total organic carbon (TOC) and total nitrogen (TN), reflected the effects of climate change as well as lake-level fluctuations. Overall, our results suggest that great caution should be applied in interpreting proxy records of climatic and environmental changes from closed-basin lakes on the Tibetan Plateau. They also highlight the potential of using sedimentary proxies to reconstruct continuous records of lake-level fluctuations.
    Type of Medium: Online Resource
    ISSN: 0309-1333 , 1477-0296
    URL: Article
    DOI: 10.1177/03091333221138685
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2006623-5
    SSG: 14
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  • 8
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    Dental pulp tissue engineering with bFGF-incorporated silk fibroin scaffolds
    SAGE Publications ; 2015
    In:  Journal of Biomaterials Applications Vol. 30, No. 2 ( 2015-08), p. 221-229
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 30, No. 2 ( 2015-08), p. 221-229
    Abstract: The clinical translation of regenerative endodontics demands further development of suitable scaffolds. Here, we assessed the possibility of using silk fibroin scaffold for pulp regeneration with dental pulp stem cells (DPSCs) and basic fibroblast growth factor (bFGF) in ectopic root canal transplantation model. Porous silk fibroin scaffolds were fabricated using freeze-drying technique (with or without bFGF incorporation), and characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy. DPSCs were isolated, characterized, seeded onto scaffolds, and inserted into the tooth root fragments. Cell viability and morphology were tested in the 3D model in vitro using CCK8 assay and SEM. Furthermore, the ectopic transplantation model was used to verify the generation of pulp-like tissue in DPSCs seeded silk fibroin scaffold with bFGF, as examined by histological analysis. DPSCs seeded in silk fibroin scaffold survived, exhibited cytoplasmic elongation in scaffolds at least 4 weeks in culture. bFGF promoted DPSCs viability in tooth fragments/scaffolds (TSS) between 7 and 28 days. Pulp-like tissue was generated in the bFGF-incorporated TSS with DPSCs. Histologically, the generated tissue was shown to be with well vascularity, have new matrix deposition and dentin-like tissue formation, and consist of both the transplanted and host-derived cells. Collectively, these data support the use of bFGF-incorporated silk fibroin scaffold as a highly promising scaffold candidate for future treatment concepts in regenerative endodontics to save teeth.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328215577296
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 9
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    Heart Leiomyosarcoma Mimicking Pulmonary Thromboembolism
    SAGE Publications ; 2001
    In:  Asian Cardiovascular and Thoracic Annals Vol. 9, No. 1 ( 2001-03), p. 68-70
    Details
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 9, No. 1 ( 2001-03), p. 68-70
    Abstract: A 34-year-old man was admitted with a putative diagnosis of pulmonary artery trunk thromboembolism. Magnetic resonance imaging and angiography showed a solid mass extending from the pulmonary trunk to the right pulmonary artery. During surgery, a tumor was found arising from the pulmonary valve annulus. The tumor was completely removed and pulmonary valvuloplasty was performed. The result was satisfactory. Histopathology showed the tumor to be a leiomyosarcoma.
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    URL: Article
    DOI: 10.1177/021849230100900120
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2044527-1
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  • 10
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    The modeling and controlling of electrohydraulic actuator for quadruped robot based on fuzzy Proportion Integration Differentiation controller
    SAGE Publications ; 2014
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 228, No. 14 ( 2014-10), p. 2557-2568
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 228, No. 14 ( 2014-10), p. 2557-2568
    Abstract: Hydraulic actuators are widely used in various kinds of industrial applications. High-power density is key parameters for engineering applications especially for quadruped robots applied in the outdoor environment. Therefore, an increasing number of advanced robots are equipped with hydraulic actuators. In this paper, to compensate the inherent nonlinearities and enhance the performance of the quadruped robot, a hybrid fuzzy controller composed of fuzzy logic controller and Proportion Integration Differentiation controller is evaluated both in simulations and experiments. The control strategy is developed based on the accurate mathematical model. The Matlab Simulink and Fuzzy Logic Toolbox are implemented to accomplish the simulations under flexible loads. Single hydraulic actuator and single leg experiments are accomplished on the specific platforms. Both the simulations and the experimental results indicate that the fuzzy Proportion Integration Differentiation control strategy is capable of fulfilling the specific position tracking under diverse loads. Compared with the conventional Proportion Integration Differentiation controller, the fuzzy Proportion Integration Differentiation controller provided a desirable performance under heavy load with comparatively little response and settling time. Results show that the fuzzy Proportion Integration Differentiation control strategy can effectively achieve the objective of enhancing position tracking robustness under flexible loads and improve the performance of quadruped robot.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406213519613
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2024890-8
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