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  • SAGE Publications  (68)
  • 1
    Online Resource
    Online Resource
    Safety and Immunogenicity from a Phase I Trial of Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine
    SAGE Publications ; 2007
    In:  Antiviral Therapy Vol. 12, No. 7 ( 2007-10), p. 1107-1114
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 12, No. 7 ( 2007-10), p. 1107-1114
    Abstract: Emergence of severe acute respiratory syndrome (SARS) from the winter of 2002 to the spring of 2003 has caused a serious threat to public health. Methods To evaluate the safety and immunogenicity of the inactivated SARS coronavirus (SARS-CoV) vaccine, 36 subjects received two doses of 16 SARS-CoV units (SU) or 32 SU inactivated SARS-CoV vaccine, or placebo control. Results On day 42, the seroconversion reached 100% for both vaccine groups. On day 56, 100% of participants in the group receiving 16 SU and 91.1% in the group receiving 32 SU had seroconverted. The geometric mean titre of neutralizing antibody peaked 2 weeks after the second vaccination, but decreased 4 weeks later. Conclusion The inactivated vaccine was safe and well tolerated and can elicit SARS-CoV-specific neutralizing antibodies.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350701200702
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Paleoprecipitation record from coral Sr/Ca and δ18O during the mid Holocene in the northern South China Sea
    SAGE Publications ; 2009
    In:  The Holocene Vol. 19, No. 6 ( 2009-09), p. 811-821
    Details
    In: The Holocene, SAGE Publications, Vol. 19, No. 6 ( 2009-09), p. 811-821
    Abstract: Coupled high-resolution Sr/Ca and δ 18 O records of a modern and a mid-Holocene coral from Sanya in the southern Hainan Island, northern South China Sea (SCS), were reported and the residual δ 18 O (Δδ 18 O) were calculated to indicate precipitation change in this region. Unlike other paleoclimate studies, this study focused on changes of precipitation time rather than precipitation amount. As negative Δδ 18 O peaks in coral generally correspond to peak precipitations or rainy seasons in the surrounding region, the time offsets between negative Δδ 18 O peaks and other seasonal indicators, such as sea surface temperature (SST), can well indicate the time of rainy seasons, and the precise time offsets can be estimated by the method of cross spectral analysis. The results of the modern coral indicate that the variation of the coral Δδ 18 O lags that of the instrumental measured precipitation by about 2 months, and about 3 months to the SST derived from coral Sr/Ca ratios. This agrees well with the modern observation that the salinity change in the southern coastal regions generally lags that of the precipitation in Hianan Island by about 2 months, and the precipitation change lags about 1 month behind the SST in this region. Thus, coral Δδ 18 O records can be a reliable proxy for the change of rainy seasons in this region. The results of the mid-Holocene coral show about 2.5 months’ leading of the Δδ 18 O variation ahead of the SST. By compensating the approximate 3 months’ lag of the Δδ 18 O variation behind the SST in modern time, the occurrence of rainy seasons during the mid Holocene may have advanced about 5—6 months. In detail, it may start around December and end around April to May with maximum occurring around February. Therefore, rainy seasons mainly occur in winter through early spring during the mid Holocene, compared with that from May through October in modern times. Such precipitation patterns appear to agree with the mid-Holocene pollen records in this region. Variations of large-scale circulation may possibly result in such a different precipitation pattern. Further studies, in particular climate model studies collaborated with meteorologists, are required for a better understanding of the mechanism.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683609337355
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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  • 3
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    Online Resource
    Experimental and three-dimensional numerical investigations on H 2 /air continuous rotating detonation wave
    SAGE Publications ; 2013
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 227, No. 2 ( 2013-02), p. 326-341
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 227, No. 2 ( 2013-02), p. 326-341
    Abstract: Results of both experimental and three-dimensional numerical studies on H 2 /air continuous rotating detonation are presented. Tangentially injected H 2 /O 2 hotshot jet was used to ignite the engine successfully. Under the condition of air and hydrogen mass flow rates of 265 and 7.7 g/s and the ambient pressure of 11 kPa, H 2 /air continuous rotating detonation has been realized for about 300 ms. Time–frequency characteristics of the measured results were analyzed by different methods, and the results agreed well with each other. The detonation wave propagated stably during the test, with the propagation frequency variation of 5.35–5.85 kHz. The mean propagation velocity was 1674.3 m/s, which was about 85.0% of the theoretical value. Corresponding three-dimensional numerical simulation was carried out. Flow field structure of the rotating detonation wave was analyzed, and the curvature effect was also considered. Propagation processes of both the experiment and simulation results were compared. The variation of detonation wave propagation frequency of the simulation case was 6.262–6.27 kHz, with the mean propagation velocity of 1870.1 m/s, which was larger than the experiment result. Distribution of the mean combustor pressure along the axis direction was analyzed. Within the heat release zone, the mean pressure decreased greatly, and it changed gently beyond this zone. The changing tendency of both the experimental and numerical results agreed with each other, but there were differences between the pressure values.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410011433542
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2032759-6
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  • 4
    Online Resource
    Online Resource
    Layer-specific strain for assessing the effect of naringin on systolic myocardial dysfunction induced by sepsis and its underlying mechanisms
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 1 ( 2021-01), p. 030006052098636-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 1 ( 2021-01), p. 030006052098636-
    Abstract: This study aimed to investigate the protective effects of naringin on myocardial deformation and oxidative responses in rats with sepsis-induced myocardial dysfunction (SIMD). Methods Global and segmental layer-specific longitudinal strain (LS) was assessed by speckle tracking echocardiography. Serum levels of creatine kinase, lactate dehydrogenase, superoxide dismutase, and malondialdehyde were measured. The activity of cleaved caspase-3 was determined by immunohistochemistry. Protein expression levels of Kelch-like ECH-related protein 1 (Keap1), nuclear erythroid factor 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) were measured by western blotting. Results Naringin inhibited the lipopolysaccharide-induced decrease in global and layer-specific LS of the left ventricle. Naringin also increased superoxide dismutase expression and decreased malondialdehyde, creatine kinase, lactate dehydrogenase, and cleaved caspase-3 expression in rats with SIMD. Furthermore, naringin increased Nrf2 and HO-1 protein expression levels, and decreased Keap1 protein expression levels in rats with SIMD. Conclusion Layer-specific LS analysis of myocardial function by speckle tracking echocardiography can reflect early changes in myocardial systolic function. Naringin may possess a protective effect through moderating lipopolysaccharide-induced myocardial oxidative stress via the Keap1/Nrf2/HO-1 pathway in rats with SIMD.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520986369
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 5
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    Online Resource
    Numerical investigation in chaos characteristics of macro-mixing efficiency of two-dimensional supersonic mixing layer
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 229, No. 7 ( 2015-06), p. 1226-1235
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 229, No. 7 ( 2015-06), p. 1226-1235
    Abstract: Coherent structures of two-dimensional supersonic turbulent mixing layers with the engineering background have been investigated numerically with large eddy simulation method. The chaos characteristics of transverse sections of mixing layer flowfield have been obtained through the analyses of two chaos characteristic parameters, Lyapunov exponent and correlation dimension. The results show that under the conditions of the present numerical simulations and physical models, the distribution of correlation dimension is roughly consistent with that of streamwise turbulent intensity at transverse sections of mixing layers through analysis of nonlinear time series, as may be used to measure the macro-mixing efficiency of mixing layers quantitatively. The distribution of maximal Lyapunov exponent could be used to validate the quantitative results. Therefore, a potential experimental method measuring the thickness of mixing layers with low costs on the basis of chaos characteristic parameters has been proposed firstly.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410014548461
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2032759-6
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  • 6
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    The transient response of high-speed wheel/rail rolling contact on “roaring rails” corrugation
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit Vol. 233, No. 10 ( 2019-11), p. 1068-1080
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit, SAGE Publications, Vol. 233, No. 10 ( 2019-11), p. 1068-1080
    Abstract: A high-speed wheel/rail finite element model is developed to focus on the non-steady-state rolling contact. The wheel/rail contact is solved based on the surface-to-surface contact algorithm, and the explicit finite element method is used to simulate the dynamic high-speed wheel/rail rolling contact. Considering the track–vehicle coupling system dynamics and the wheel/rail geometric nonlinearities, the wheel/rail contact on the short wave rail corrugation under the high-frequency vibration and the influence of train passing frequency on the track–vehicle system dynamics are studied. The explicit finite element method can be used to simulate the non-steady-state rolling contact process of the high-speed wheel/rail. After the initial load condition, the wheel/rail contact state tends to be stable in a short period of time. The short wave corrugation causes the high-frequency vibration of the track–vehicle system; the slightly advanced phase of the wheel/rail contact force promotes the development of rail corrugation in the rolling direction. When the train passing frequency is close to the rail pinned–pinned frequency, the pinned–pinned resonance occurs. The overall vibration near the fastening is relatively large and accelerates the damage of components. The longitudinal force is clearly affected by the traction torque with a periodic wheel/rail stick-slip vibration. The pinned–pinned resonance will promote the sliding wear at the wave trough near the fastening and it will become severe with the increase of the traction.
    Type of Medium: Online Resource
    ISSN: 0954-4097 , 2041-3017
    URL: Article
    DOI: 10.1177/0954409719825682
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024901-9
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  • 7
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    Water and Oil Repellent and Durable Press Finishes for Cotton Based on a Perfluoroalkyl-Containing Multi-Epoxy Compound and Citric Acid
    SAGE Publications ; 2004
    In:  Textile Research Journal Vol. 74, No. 10 ( 2004-10), p. 851-855
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 74, No. 10 ( 2004-10), p. 851-855
    Abstract: A novel perfluoroalkyl-containing multi-epoxy compound (PFME), designed and syn thesized in our laboratory, is applied to cotton fabrics by the pad-dry-cure process to give durable water and oil repellency by developing permanent covalent bonds to the textile substrate. The specimens pretreated by citric acid are further treated with PFME. The dual finished cotton shows both durable water and oil repellent appearances and durable press properties. The optimum treatment conditions for the dual finishing are discussed.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/004051750407401002
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2209596-2
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  • 8
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    Prognostic Value of Combined Lactate Dehydrogenase, C-Reactive Protein, Cancer Antigen 153 and Cancer Antigen 125 in Metastatic Breast Cancer
    SAGE Publications ; 2022
    In:  Cancer Control Vol. 29 ( 2022-01), p. 107327482110531-
    Details
    In: Cancer Control, SAGE Publications, Vol. 29 ( 2022-01), p. 107327482110531-
    Abstract: Breast cancer (BC), especially metastatic BC, is one of the most lethal diseases in women. CA 125 and CA 15-3 are commonly used indicators for diagnosis and prognosis of BC. Some serological indicators, such as lactate dehydrogenase (LDH) and C-reactive protein (CRP), can also be used to assess the prognosis and progression in BC. Methods Univariate Cox regression analysis and LASSO regression analysis were performed to identify prognostic factors and build prognostic models. We distributed the patients into 2 groups based on the median risk score, analyzed prognosis by Kaplan–Meier curve, and screened independent prognostic factors by multivariate Cox regression analysis. Result We identified 4 indicators-LDH, CRP, CA 15-3, and CA 125—related to the prognosis in BC and established a prognostic model. The high LDH group showed worse overall survival (OS) than low LDH group ( P = .017; hazard ratio (HR), 1.528; 95% confidence interval (CI), 1.055-2.215). The high CRP group showed worse OS than low CRP group ( P = .004; HR, 1.666; 95% CI, 1.143-2.429). The high CA153 group showed worse OS than low CA 15-3 group (P=.011; HR, 1.563; 95% CI, 1.075-2.274). The high CA 125 group showed worse OS than low CA 125 group ( P = .021; HR, 1.499; 95% CI, 1.031-2.181). The area under the curve for risk score was .824, Ki-67 was .628, age was .511, and grade was .545. Risk score was found to be an independent prognostic factor using multivariate Cox regression analysis. Conclusion We successfully established an optimization model by combining 4 prognosis-related indicators to assess the prognosis in patients with metastatic BC.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    URL: Article
    DOI: 10.1177/10732748211053150
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2004182-2
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  • 9
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    Impact of Platelet-to-Lymphocyte Ratio on Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction
    SAGE Publications ; 2017
    In:  Angiology Vol. 68, No. 4 ( 2017-04), p. 346-353
    Details
    In: Angiology, SAGE Publications, Vol. 68, No. 4 ( 2017-04), p. 346-353
    Abstract: We investigated the association between platelet-to-lymphocyte ratio (PLR) and clinical outcomes (including all-cause mortality, recurrent myocardial infarction, heart failure, serious cardiac arrhythmias and ischemic stroke) in patients with ST-segment elevation myocardial infarction (STEMI). Based on PLR quartiles, 5886 patients with STEMI were categorized into 4 groups: 〈 98.8 (n = 1470), 98.8 to 125.9 (n = 1474), 126.0 to 163.3 (n = 1478), 〉 163.3 (n = 1464), respectively. We used Cox proportional hazards models to examine the relation between PLR and clinical outcomes. Mean duration of follow-up was 81.6 months, and 948 patients (16.1%) died during follow-up. The lowest mortality occurred in the lowest PLR quartile group ( P = 0.006), with an adjusted hazard ratio of 1.18 (95% confidence interval [CI], 1.04-1.55), 1.31 (95% CI, 1.18-1.64), and 1.59 (95% CI, 1.33-1.94) in patients with PLR of 98.8 to 125.9, 126.0 to 163.3, 〉 163.3, respectively. Higher levels of PLR were also associated with recurrent myocardial infarction ( P trend = .023), heart failure ( P trend = .018), and ischemic stroke ( P trend = .043). In conclusion, a higher PLR was associated with recurrent myocardial infarction, heart failure, ischemic stroke, and all-cause mortality in patients with STEMI.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319716657258
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2065911-8
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  • 10
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    Response to the Letter to the Editor “N-Acetylcysteine and Contrast-Induced Nephropathy”
    SAGE Publications ; 2018
    In:  Angiology Vol. 69, No. 1 ( 2018-01), p. 86-86
    Details
    In: Angiology, SAGE Publications, Vol. 69, No. 1 ( 2018-01), p. 86-86
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319717733181
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2065911-8
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