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  • SAGE Publications  (38)
  • 1
    Online Resource
    Online Resource
    Nitric Oxide Signaling Contributes to Ectopic Orofacial Neuropathic Pain
    SAGE Publications ; 2013
    In:  Journal of Dental Research Vol. 92, No. 12 ( 2013-12), p. 1113-1117
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 92, No. 12 ( 2013-12), p. 1113-1117
    Abstract: Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechanical sensitivity of the whisker pad skin following IANX, neuronal nitric oxide synthase (nNOS) expression in the trigeminal ganglion (TG), and the functional significance of NO in relation to the mechanical allodynia following intra-TG administration of a chemical precursor to NO and selective nNOS inhibitors. IANX induced mechanical allodynia, which was diminished by intra-TG administration of selective nNOS inhibitors. NO metabolites and nNOS immunoreactive neurons innervating the lower lip were also increased in the TG. Intra-TG administration of nNOS substrate induced the mechanical allodynia. The present findings suggest that NO released from TG neurons regulates the excitability of TG neurons innervating the whisker pad skin, and the enhancement of TG neuronal excitability may underlie ectopic mechanical allodynia.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/0022034513509280
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2057074-0
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  • 2
    Online Resource
    Online Resource
    Possible Link between Glycolysis and Apoptosis Induced by Sodium Fluoride
    SAGE Publications ; 2005
    In:  Journal of Dental Research Vol. 84, No. 10 ( 2005-10), p. 919-923
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 84, No. 10 ( 2005-10), p. 919-923
    Abstract: Fluoride has been used to prevent caries in the dentition, but the possible underlying mechanisms of cytotoxicity induction by this compound are still unclear. Since fluoride is known as an inhibitor of glycolytic enzymes, we investigated the possible connection between NaF-induced apoptosis and glycolysis in human promyelocytic leukemia HL-60 cells. NaF-induced apoptotic cell death is characterized by caspase activation, internucleosomal DNA fragmentation, loss of mitochondrial membrane potential, and production of apoptotic bodies. Higher activation of caspases-3 and -9, as compared with that of caspase-8, suggested the involvement of an extrinsic pathway. Utilization of glucose was nearly halted by NaF, whereas that of glutamine was rather enhanced. NaF enhanced the expression of Bad protein, but not that of Bcl-2 and Bax proteins, and reduced HIF-1α mRNA expression. Analysis of these data suggests a possible link between glycolysis and apoptosis.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/154405910508401009
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2057074-0
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  • 3
    Online Resource
    Online Resource
    The efficacy of add-on tacrolimus for minor flare in patients with systemic lupus erythematosus: a retrospective study
    SAGE Publications ; 2016
    In:  Lupus Vol. 25, No. 1 ( 2016-01), p. 54-60
    Details
    In: Lupus, SAGE Publications, Vol. 25, No. 1 ( 2016-01), p. 54-60
    Abstract: We have assessed the effectiveness of tacrolimus for minor flares in systemic lupus erythematosus (SLE) patients. Methods The medical records of 313 patients were retrospectively reviewed over a period of seven years, from 2006 to 2013. We enrolled patients with minor flare treated with add-on tacrolimus, without glucocorticoid (GC) intensification (tacrolimus group). Minor flare was defined as a ≥1-point increase in a total score between 3 and 11 in the SLE Disease Activity Index (SLEDAI). We enrolled as controls patients who were administered increased doses of GC for minor flare (GC group). All patients were followed for one year. The primary outcome measure was the proportion of responders. Results There were 14 eligible patients in the tacrolimus group and 20 eligible patients in the GC group. The mean SLEDAI at flare tended to be higher in the tacrolimus group than in the GC group (7.5 vs. 6.2, p = 0.085). A mean dose of 1.6 mg tacrolimus/day was administered for flare, while the mean GC dose was 13.7 mg/day in the GC group. The proportion of responders was 86% (12/14) in the tacrolimus group and 75% (15/20) in the GC group ( p = 0.67). The mean dose of GC at 12 months was higher in the GC group than in the tacrolimus group (9.7 mg/day vs. 7.1 mg/day, p  〈  0.05). Only one patient discontinued tacrolimus because of fatigue after three months. Conclusion Adding tacrolimus without increasing the GC dose may provide an effective treatment option for minor flares in patients with SLE.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203315600538
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2008035-9
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  • 4
    Online Resource
    Online Resource
    Localization of copper to afferent terminals in rat locus ceruleus, in contrast to mitochondrial copper in cerebellum.
    SAGE Publications ; 1994
    In:  Journal of Histochemistry & Cytochemistry Vol. 42, No. 12 ( 1994-12), p. 1585-1591
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 42, No. 12 ( 1994-12), p. 1585-1591
    Abstract: We examined copper localization in the locus ceruleus and cerebellum of rat brain by Timm's sulfide-silver staining, as modified by Danscher. Dense silver particles revealing copper localization were observed in sections of the locus ceruleus and cerebellum after pre-treatment with trichloroacetic acid. In the locus ceruleus, copper appeared to be distributed to neuropil rather than glial or neuronal cell bodies, and at the ultrastructural level copper was mainly localized on synaptic membranes of afferent terminals in contact with somatic spines or dendrites of locus ceruleus neurons, whereas copper was distributed to mitochondria in the granular layers of cerebellum and fine, sparse silver particles were observed throughout ependymal cells and epithelial cells of blood vessels. The specific localization of copper to afferent terminals in the locus ceruleus was confirmed by X-ray microanalysis, which showed a significant level of copper, but not zinc, in synaptic membranes. These results suggest a distinct role of copper depending on its regional distribution. Copper or copper protein may be involved in neurotransmission in the locus ceruleus but in mitochondrial activity in the cerebellum.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1177/42.12.7983358
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Subtype-specific expression patterns of inositol 1,4,5-trisphosphate receptors in rat airway epithelial cells.
    SAGE Publications ; 1996
    In:  Journal of Histochemistry & Cytochemistry Vol. 44, No. 11 ( 1996-11), p. 1237-1242
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 44, No. 11 ( 1996-11), p. 1237-1242
    Abstract: We investigated the immunohistochemical localization of inositol 1,4,5-trisphosphate receptor (IP3R) Types 1, 2, and 3 in rat airway epithelium using the monoclonal antibodies KM1112, KM1083, and KM1082 specific for each type of IP3R. The epithelium from trachea to distal intrapulmonary airways (bronchioles) showed positive immunoreactivity for all types of IP3R. However, cell type as well as subcellular site immunoreactivity for each type of IP3R varied. IP3R Type 1 was found only in the apical thin cytoplasmic area of ciliated cells throughout all airway levels. IP3R Type 2 was exclusively localized to the entire cytoplasm of ciliated cells from the trachea to bronchioles. IP3R Type 3 was expressed mainly in the supranuclear cytoplasm not only of ciliated cells at all airway levels but also in Clara cells of the bronchiolar epithelium. Double fluorescent staining using combinations of KM1083 and Wisteria floribunda lectin or anti-rat 10-KD Clara cell-specific protein antibody confirmed that the IP3R Type 2-positive cells were neither seromucous cells nor Clara cells. These results indicate that the expression of three types of IP3Rs in different cell types and subcellular sites may reflect diverse physiological functions of IP3Rs within airway epithelial cells. The double staining studies suggested that the anti-IP3R Type 2 monoclonal antibody KM1083 would be a specific cell marker for ciliated cells of the airway epithelium.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1177/44.11.8918898
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1996
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Distance education for health centre staff in rural Japan
    SAGE Publications ; 2000
    In:  Journal of Telemedicine and Telecare Vol. 6, No. 2_suppl ( 2000-08), p. 67-69
    Details
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 6, No. 2_suppl ( 2000-08), p. 67-69
    Abstract: We have evaluated a course delivered by videoconferencing to rural health centre staff in Hokkaido. The course focused on the planning and evaluation of community health interventions. It included four 90 min sessions and two follow-up sessions. Fourteen professional staff members (public health nurses, nutritionists and dental assistants) attended each class. Knowledge of community health-care planning and evaluation was higher at post-education testing than pre-education testing. Ratings for ‘using a computer’, ‘using some computer software’, ‘using the Internet’ and ‘interest in telehealth’ increased significantly in post-education testing compared with pre-education testing. The course had an additional benefit in increasing the collaboration between community health workers and university staff.
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    URL: Article
    DOI: 10.1258/1357633001935635
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2007700-2
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  • 7
    Online Resource
    Online Resource
    Upgrading rural Japanese nurses’ respiratory rehabilitation skills through videoconferencing
    SAGE Publications ; 2000
    In:  Journal of Telemedicine and Telecare Vol. 6, No. 2_suppl ( 2000-08), p. 69-71
    Details
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 6, No. 2_suppl ( 2000-08), p. 69-71
    Abstract: We examined the effect of distance learning on nurses’ clinical skills in a rural Japanese hospital. The subject matter was respiratory rehabilitation. After one face-to-face session, two 30min sessions were delivered by videoconferencing to staff nurses working in a 100–bed rural hospital 250 miles (400 km) from Sapporo Medical University. A self-rating questionnaire was distributed before and after the sessions. Responses were collected from 15 out of 32 nurses participating in the face-to-face session (47%). Before the first videoconferencing session, ‘always use’ and ‘sometime use’ the new skills were rated by 67% of nurses, but after the second videoconferencing session ‘always use’ and ‘sometimes use’ were rated by 73% and ‘never use’ at 0%. This implies that there was increased use of new skills after the second session, although the difference was not significant. The nurses’ opinions about the effectiveness for patients increased from 8% to 27% after the second session, which was significant. The pilot project indicated the usefulness of distance learning for upgrading nurses’ clinical practice in one rural Japanese hospital and suggested ways in which videoconferencing can be used in future.
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    URL: Article
    DOI: 10.1258/1357633001935653
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2007700-2
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  • 8
    Online Resource
    Online Resource
    Transplantation of New Autologous Biomaterials into Jaw Cleft
    SAGE Publications ; 2001
    In:  Journal of International Medical Research Vol. 29, No. 4 ( 2001-08), p. 287-291
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 29, No. 4 ( 2001-08), p. 287-291
    Abstract: This study compared bone-marrow grafting using chondroid or fibula bone grafts transplanted into simulated alveolar bone defects in mice. The osteogenic procedure was also investigated. As an experimental model of the maxillary alveolar bone cleft, suitable for testing bone-inductive materials, a surgical trephine with a low-speed dental engine was used to form critical-sized defects in the pre-maxillary bones of male mice. Distraction osteogenesis was performed using an external fixation device. The osteotomy site was surrounded by an external callus, consisting of hyaline cartilage, that contained a large quantity of chondroid bone. Transplanted bone within chondroid bone was characterized by bone formation and remodelling 30 days post-transplantation, and bone adhesion following chondroid bone grafting was better than adhesion following fibula grafting. The present findings are the first to demonstrate the potential of chondroid bone transplantation as a new therapeutic system of bone grafting, suitable for bone substitution in craniofacial bone defects.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323000102900404
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2082422-1
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  • 9
    Online Resource
    Online Resource
    A case of progressive systemic sclerosis complicated by massive pleural effusion with elevated CA125
    SAGE Publications ; 2000
    In:  Lupus Vol. 9, No. 5 ( 2000-06), p. 382-385
    Details
    In: Lupus, SAGE Publications, Vol. 9, No. 5 ( 2000-06), p. 382-385
    Abstract: A tumor marker, CA125, is known to increase in the serum or other body fluids in various malignancies such as ovarian cancer. Here we present a case of progressive systemic sclerosis (PSS) with massive pleural effusion, in which CA125 in the serum and pleural fluid were elevated. The serum level of CA125 decreased in accordance with the change of the pleural effusion. CA125 level may be an indicator for the activity of serositis in some cases with collagen vascular diseases.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1191/096120300678828334
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2008035-9
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  • 10
    Online Resource
    Online Resource
    Basis of Type A and F Toxicities of Clostridium botulinum Strain 84
    SAGE Publications ; 1972
    In:  Experimental Biology and Medicine Vol. 141, No. 3 ( 1972-12-01), p. 1063-1067
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 141, No. 3 ( 1972-12-01), p. 1063-1067
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/00379727-141-36933
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1972
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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