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  • SAGE Publications  (81)
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  • 1
    Online-Ressource
    Online-Ressource
    Total and regional ASPECT score for non-contrast CT, CT angiography, and CT perfusion: inter-rater agreement and its association with the final infarction in acute ischemic stroke patients
    SAGE Publications ; 2022
    In:  Acta Radiologica Vol. 63, No. 8 ( 2022-08), p. 1093-1101
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 63, No. 8 ( 2022-08), p. 1093-1101
    Kurzfassung: Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a grading system to assess the extent and distribution of early ischemic changes. Purpose To assess inter-rater agreement for total and regional ASPECTS on non-contrast computed tomography (NCCT) images, CT angiography source images (CTA-SI), and CT-perfusion cerebral blood volume (CTP-CBV) maps, and their association with final infarction in patients with acute ischemic stroke (AIS). Material and Methods A total of 96 consecutive patients with AIS who underwent pre-treatment NCCT and CTP were retrospectively enrolled. CTA-SI was reconstructed using the raw data of CTP. Total and regional ASPECTS were assessed on baseline NCCT, CTA-SI, and CTP-CBV, and on follow-up NCCT or diffusion-weighted imaging. Follow-up ASPECTS served as the reference standard for final infarction. Results CTP-CBV demonstrated higher concordance for total ASPECTS (interclass correlation coefficient, 0.895 vs. 0.771 vs. 0.777) and regional ASPECTS in internal capsule, lentiform, caudate nuclei, M5 and M6, compared with NCCT and CTA-SI. CTP-CBV showed a trend of stronger correlation with final ASPECTS than NCCT and CTA-SI (0.717 vs. 0.711 vs. 0.565; P  〉  0.05). ASPECTS in the internal capsule (ρ, 0.756 vs. 0.556; P = 0.016) and caudate nucleus (ρ, 0.717 vs. 0.476; P = 0.010) on CTP-CBV were more strongly correlated with follow-up ASPECTS than NCCT. CTP-CBV showed higher accuracy for predicting final infarction in the internal capsule (92.5% vs. 90.3% and 87.1%; P  〉  1.000, P = 0.125, respectively) and caudate nucleus (87.1% vs. 79.6% and 77.4%; P = 0.453, P = 0.039, respectively) than CTA-SI and NCCT. Conclusion CTP-CBV ASPECTS might be more reliable for delineating early ischemic changes and predicting final infarction.
    Materialart: Online-Ressource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/02841851211029080
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2024579-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Use of ABC/2 method for rapidly estimating the target mismatch on computed tomography perfusion imaging in patients with acute ischemic stroke
    SAGE Publications ; 2023
    In:  Acta Radiologica Vol. 64, No. 1 ( 2023-01), p. 320-327
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 64, No. 1 ( 2023-01), p. 320-327
    Kurzfassung: Target mismatch (ischemic core, mismatch volume and mismatch ratio) in patients with acute ischemic stroke (AIS) highly relies on the automated perfusion analysis software. Purpose To evaluate the feasibility and accuracy of using the ABC/2 method to rapidly estimate the target mismatch on computed tomography perfusion (CTP) imaging in patients with AIS, using RAPID results as a reference. Material and Methods In total, 243 patients with anterior circulation AIS who underwent CTP imaging were retrospectively reviewed. Target mismatch associated perfusion parameters were derived from RAPID results and calculated using the ABC/2 method. Paired t-test was used to assess the difference of volumetric parameters between the two methods. The ability of using the ABC/2 method to predict the important cutoff volumetric metrics was also evaluated. Result There was no significant difference in the volumes of ischemic core ( P = 0.068), ischemic area ( P = 0.209), and mismatch volume ( P = 0.518) between ABC/2 and RAPID. Using RAPID results as reference, the ABC/2 method showed high accuracy for predicting perfusion parameters (70 mL and 90 mL: sensitivity=98.5% and 98.5%, specificity=100% and 100%, positive predictive value [PPV]=100% and 100%, negative predictive value [NPV] =93.8% and 92.9%; 10 mL and 15mL: sensitivity=99.6% and 99.5%, specificity=55.6% and 50.0%, PPV=96.6% and 94.8%, NPV=90.9% and 92.3%; 1.2 and 1.8: sensitivity=99.6% and 94.8%, specificity=75.0% and 96.9%, PPV=98.7% and 99.5%, NPV=90.0% and 73.8%). Conclusion The ABC/2 method may be a feasible alternative to RAPID for estimation of target mismatch parameters on CTP in patients with AIS.
    Materialart: Online-Ressource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/02841851211069778
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2023
    ZDB Id: 2024579-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Acute myeloid leukemia with T lymphoblastic lymphoma: a case report and literature review
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 5 ( 2021-05), p. 030006052110161-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 5 ( 2021-05), p. 030006052110161-
    Kurzfassung: Acute myeloid leukemia (AML) with T lymphoblastic lymphoma (T-LBL) is a hematologic tumor of two origins, myeloid and lymphoblastic, and is relatively rare in the same patient. We report a rare case of AML with T-LBL. After the patient was diagnosed, he received standard chemotherapy, which decreased the primitive bone marrow cell percentage from 84% to 5%; however, the enlarged superficial lymph nodes showed no obvious change in size. Immunohistochemistry revealed the following: cluster of differentiation (CD)3 (+), CD5 (+), CD7 (+), transmission disequilibrium test (TDT) (+), myeloperoxidase (MPO) (−), and lysozyme (Lys) (−). The lymph node morphology and immunohistochemical results indicated T-LBL. Therefore, the final diagnosis was AML with T-LBL, with both diseases occurring independently and concurrently.
    Materialart: Online-Ressource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211016138
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2021
    ZDB Id: 2082422-1
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Use of dry needling therapy to improve lower limb dysfunction in a patient with 10-year cerebral hemorrhage sequelae: a case report
    SAGE Publications ; 2022
    In:  Acupuncture in Medicine Vol. 40, No. 3 ( 2022-06), p. 270-271
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 40, No. 3 ( 2022-06), p. 270-271
    Materialart: Online-Ressource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1177/09645284221076505
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2126127-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Synthesis and Biological Evaluation of Heat-Shock Protein 90 Inhibitors: Geldanamycin Derivatives with Broad Antiviral Activities
    SAGE Publications ; 2010
    In:  Antiviral Chemistry and Chemotherapy Vol. 20, No. 6 ( 2010-08), p. 259-268
    Details
    In: Antiviral Chemistry and Chemotherapy, SAGE Publications, Vol. 20, No. 6 ( 2010-08), p. 259-268
    Kurzfassung: Previous studies have suggested that geldanamycin (GA) inhibits the replication of several viruses in vitro. Here, we aimed to synthesize and evaluate the antiviral activity of 17-amino-17-demethoxygeldanamycin derivatives. Methods: A series of 17-substituted and 17-,19-disubstituted GA derivatives were screened for antiviral activities against eight different viral strains, including herpesvirus, hepatitis virus, retrovirus and picornavirus. Results: Most of the tested compounds showed inhibitory activity against the viruses and showed reduced cytotoxicity in vitro as compared with the parent compound GA. In vivo efficacy evaluation results showed that compound 6 noticeably inhibited duckling hepatitis B virus DNA replication in duckling serum after oral administration. Viral rebound did not occur after termination of the treatment. The modified GA derivatives also showed median lethal dose values that were higher than that of the parent GA in mice intraperitoneally treated with the study compounds. Conclusions: Targeting heat-shock protein 90 could be a new antiviral approach that is not prone to the development of drug resistance. The 17-amino-17-demethoxygeldanamycin derivatives could be novel agents with potential antiviral activity.
    Materialart: Online-Ressource
    ISSN: 2040-2066 , 2040-2066
    URL: Article
    DOI: 10.3851/IMP1631
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2010
    ZDB Id: 2130088-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    MALDI-TOF mass spectrometry provides high accuracy in identification of Salmonella at species level but is limited to type or subtype Salmonella serovars
    SAGE Publications ; 2017
    In:  European Journal of Mass Spectrometry Vol. 23, No. 2 ( 2017-04), p. 70-82
    Details
    In: European Journal of Mass Spectrometry, SAGE Publications, Vol. 23, No. 2 ( 2017-04), p. 70-82
    Kurzfassung: Salmonella can cause global foodborne illnesses in humans and many animals. The current diagnostic gold standard used for detecting Salmonella infection is microbiological culture followed by serological confirmation tests. However, these methods are complicated and time-consuming. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis offers some advantages in rapid identification, for example, simple and fast sample preparation, fast and automated measurement, and robust and reliable identification up to genus and species levels, possibly even to the strain level. In this study, we established a reference database for species identification using whole-cell MALDI-TOF MS; the database consisted of 12 obtained main spectra of the Salmonella culture collection strains belonged to seven serotypes. Eighty-two clinical isolates of Salmonella were identified using established database, and partial 16S rDNA gene sequencing and serological method were used as comparison. We found that MALDI-TOF mass spectrometry provided high accuracy in identification of Salmonella at species level but was limited to type or subtype Salmonella serovars. We also tried to find serovar-specific biomarkers and failed. Our study demonstrated that (a) MALDI-TOF MS was suitable for identification of Salmonella at species level with high accuracy and (b) that MALDI-TOF MS method presented in this study was not useful for serovar assignment of Salmonella currently, because of its low matching with serological method and (c) MALDI-TOF MS method presented in this study was not suitable to subtype S. typhimurium because of its low discriminatory ability.
    Materialart: Online-Ressource
    ISSN: 1469-0667 , 1751-6838
    URL: Article
    DOI: 10.1177/1469066717699216
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2021540-X
    ZDB Id: 2021340-2
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Using coprophilous fungi to reconstruct the history of pastoralism in the Qinghai Lake Basin, Northeastern Qinghai-Tibetan Plateau
    SAGE Publications ; 2020
    In:  Progress in Physical Geography: Earth and Environment Vol. 44, No. 1 ( 2020-02), p. 70-93
    Details
    In: Progress in Physical Geography: Earth and Environment, SAGE Publications, Vol. 44, No. 1 ( 2020-02), p. 70-93
    Kurzfassung: The history of permanent human settlement in the high-altitude regions ( 〉 3000 m above sea level [masl]) of the Qinghai-Tibetan Plateau (QTP) is important in understanding human adaptation to this cold “Third Pole” region. The Qinghai Lake Basin was an important corridor used by prehistoric humans migrating to the inner QTP. Pastoralism is currently the most important means of sustaining permanent human settlement in the high-altitude regions of the QTP. However, the lack of reliable proxy measures reflecting prehistoric pastoral activities impedes our understanding of how pastoralism developed. The identification of coprophilous fungi in prehistoric cultural deposits may help refine the history of pastoralism. We collected 21 modern domesticated herbivore dung samples and 66 surface soil samples from the Qinghai Lake Basin for fungal spore analyses. We then evaluated how useful such analyses are for identifying grazing activities. Fifty-three samples were also collected from the JXG2 stratigraphic profile (∼10.0–0 ka; 3312 masl) for fungal spore analysis. Results indicate that low and stable values of the total concentration of coprophilous fungi were present from ∼10.0 to ∼5.5 ka. Concentrations gradually increased from ∼5.5 to ∼4.2 ka, significantly increased from ∼4.2 to ∼2.6 ka, and then increased dramatically after ∼2.6 ka. By combining these results with charcoal concentrations ( 〉 50 µm), lithic artifacts, bones and potsherds recovered from the JXG2 site, we infer that early pastoralism in Qinghai Lake Basin appeared between ∼6.0 to ∼5.5 ka and gradually intensified throughout the remainder of the Holocene as herding and farming gradually replaced hunting–gathering as the primary subsistence strategies. These results are supported by pollen records, archeological remains and historical records in the northeastern QTP.
    Materialart: Online-Ressource
    ISSN: 0309-1333 , 1477-0296
    URL: Article
    DOI: 10.1177/0309133319869596
    RVK:
    RA 1000
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2006623-5
    SSG: 14
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Is preoperative anaemia really a predictor of adverse outcomes after cardiac surgery?
    SAGE Publications ; 2016
    In:  Perfusion Vol. 31, No. 4 ( 2016-05), p. 353-354
    Details
    In: Perfusion, SAGE Publications, Vol. 31, No. 4 ( 2016-05), p. 353-354
    Materialart: Online-Ressource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/0267659115604713
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2016
    ZDB Id: 2029611-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    The effect of bend positions on premixed methane–air explosion overpressures in ducts
    SAGE Publications ; 2016
    In:  International Journal of Spray and Combustion Dynamics Vol. 8, No. 4 ( 2016-12), p. 254-261
    Details
    In: International Journal of Spray and Combustion Dynamics, SAGE Publications, Vol. 8, No. 4 ( 2016-12), p. 254-261
    Kurzfassung: Bend structures in process industries can enhance gas explosions. Many researchers have studied their effects on flame propagations or overpressure evolutions with experiments or numerical simulations. In this work, three bends with different angles ranging from obtuse to acute were examined, and the effect of bend positions on gas explosions was also studied in the experiments. It was found that the peak overpressure evolutions under three different angles experienced three different stages, i.e. a slight downtrend before the bend, a sudden uptrend in and after the bend, and a following downtrend. The explosion violence was enhanced due to a reflection wave and flame tip wrinkle. The peak overpressure increased when the bend angles decreased because of stronger reflection and turbulence under a smaller bend angle. Additionally, the bend shortened the distance at which the peak overpressure reached its maximum values. However, the bend positions had little effect on the maximum overpressure in the ducts.
    Materialart: Online-Ressource
    ISSN: 1756-8277 , 1756-8285
    URL: Article
    DOI: 10.1177/1756827716645115
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2016
    ZDB Id: 2504645-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Detection and Clinical Significance of Lymph Node Micrometastasis in Gastric Cardia Adenocarcinoma
    SAGE Publications ; 2012
    In:  Journal of International Medical Research Vol. 40, No. 1 ( 2012-02), p. 293-299
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 40, No. 1 ( 2012-02), p. 293-299
    Kurzfassung: OBJECTIVES: Lymph node micro metastasis was investigated in gastric cardia adenocarcinoma (GCA) patients without lymph node metastasis on routine pathological examination. The relationship between micrometastasis and clinicopathological features was also evaluated. METHODS: A total of 349 lymph nodes were obtained from 45 patients with GCA. Micrometastases were detected by immunohistochemical staining for the markers cytokeratin 19 (CK19) and CD44 variant 6 (CD44v6). RESULTS: A total of 33 lymph nodes (9.5%) from 15 patients (33.3%) were positive for CK19. Of these, 27 lymph nodes (7.7%) from 12 patients (26.7%) were also positive for CD44v6. Micrometastasis was significantly related to depth of tumour invasion and Lauren classification (intestinal or diffuse). The recurrence rate was significantly higher and 2-year survival rate significantly lower in patients with than in those without lymph node micrometastasis, showing the necessity of detecting micrometastasis in GCA patients who test negative for lymph node metastasis on routine examination. CONCLUSION: CK19 and CD44v6 were shown to be good markers for micrometastasis detection.
    Materialart: Online-Ressource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323001204000129
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2012
    ZDB Id: 2082422-1
    Standort Signatur Einschränkungen Verfügbarkeit
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