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  • 1
    Online Resource
    Online Resource
    Toxicity of Gases Produced From Pyrolysis of Polychloroprene Flexible Foams
    SAGE Publications ; 1979
    In:  Journal of Elastomers & Plastics Vol. 11, No. 3 ( 1979-07), p. 201-207
    Details
    In: Journal of Elastomers & Plastics, SAGE Publications, Vol. 11, No. 3 ( 1979-07), p. 201-207
    Abstract: Three samples of polychloroprene flexible foams were evalu ated for toxicity of pyrolysis gases, using the toxicity screening test method developed at the University of San Francisco. On the basis of time to death, ALS, LS, and LS200 foams ranked among the least toxic of the over 300 materials evaluated using the particular test conditions of USF Procedure B.
    Type of Medium: Online Resource
    ISSN: 0095-2443 , 1530-8006
    URL: Article
    DOI: 10.1177/009524437901100302
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1979
    detail.hit.zdb_id: 2098535-6
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  • 2
    Online Resource
    Online Resource
    Bursting Strength Evaluation in an Experimental Model of Incisional Hernia
    SAGE Publications ; 2007
    In:  The American Surgeon Vol. 73, No. 7 ( 2007-07), p. 722-724
    Details
    In: The American Surgeon, SAGE Publications, Vol. 73, No. 7 ( 2007-07), p. 722-724
    Abstract: Incisional hernias occur in up to 11 per cent of patients undergoing abdominal surgery. Up to 50 per cent of these patients with hernias will require repeat operative procedures. Management of these hernias have focused primarily on tensile strength of the mesh material, have not addressed currently used materials, and have not compared the strength of these repairs with each other. Forty-nine adult Sprague–Dawley rats had an incisional hernia created by removing a portion of their abdominal wall that was then repaired primarily, using either a composite mesh, Dual mesh (Gore-Tex), or polypropylene mesh. Six weeks after the repair, the rats were euthanized. Hydrostatic distension of the abdominal cavity was performed to compare bursting strength of each repair. Wound tensile strength was assessed and compared. Tissue samples were also taken to compare repair types for incorporation of prosthetic materials. The gross weight of the animals subjected to hydrostatic distention was equivalent between groups, as was the volume required prior to failure of the repair. There was a trend toward improved tensile strength of the Prolene mesh repair, which had a lower average inflammatory and fibrosis score on histology. Overall, the type of mesh used for repair does not seem to impact significantly the strength of the repair when assessed 6 weeks postoperatively. Choice of prosthetic material to repair the hernia should be made based on economics and handling characteristics alone. Prolene mesh has satisfactory strength with the least amount of inflammation and fibrosis.
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/000313480707300718
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
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  • 3
    Online Resource
    Online Resource
    More Security for Old Age, A Report and a Program.
    SAGE Publications ; 1939
    In:  American Sociological Review Vol. 4, No. 2 ( 1939-04), p. 295-
    Details
    In: American Sociological Review, SAGE Publications, Vol. 4, No. 2 ( 1939-04), p. 295-
    Type of Medium: Online Resource
    ISSN: 0003-1224
    URL: Article
    DOI: 10.2307/2084233
    RVK:
    MN 1000
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 1939
    detail.hit.zdb_id: 203405-0
    detail.hit.zdb_id: 2010058-9
    SSG: 2,1
    SSG: 3,4
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  • 4
    Online Resource
    Online Resource
    Associations of site-specific CD4 + -T-cell hypomethylation within CD40-ligand promotor and enhancer regions with disease activity of women with systemic lupus erythematosus
    SAGE Publications ; 2021
    In:  Lupus Vol. 30, No. 1 ( 2021-01), p. 45-51
    Details
    In: Lupus, SAGE Publications, Vol. 30, No. 1 ( 2021-01), p. 45-51
    Abstract: To comprehensively assess associations of site-specific CD4 + -T-cell hypomethylation of the CD40-Ligand gene ( CD40L) with disease activity of women with systemic lupus erythematosus (SLE). Methods CpG-sites within the DNA of the promotor and two enhancer regions (n = 22) of CD40L were identified and numbered consecutively. The rate of methylated DNA in isolated CD4 + -T-cells of women with SLE were quantified for each methylation site by MALDI-TOF. Disease activity was assessed by SLE Disease Activity Index (SLEDAI). Associations of site-specific methylation rates with the SLEDAI scores were assessed by linear regression modelling. P values were adjusted according to Bonferroni-Holm as indicated. Results 60 female SLE patients participated in the study (age 45.7 ± 11.1 years, disease duration 17.0 ± 8.3 years). Significant associations to the SLEDAI were noted for CpG22 hypomethylation of the promotor (β = −40.1, p = 0.017, adjusted p = 0.027), trends were noted for CpG17 hypomethylation of the promotor (β = −30.5, p = 0.032, adjusted p = 0.6), and for CpG11 hypermethylation of the second enhancer (β = 15.0, p = 0.046, adjusted p = 0.8). Conclusion Site-specific hypomethylation of the CD40L promotor in CD4 + -T-cells show associations with disease activity in female SLE patients.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203320965690
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2008035-9
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  • 5
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    Online Resource
    Beneficial effects associated to a healthy lifestyle in systemic lupus erythematosus: A cross-sectional study
    SAGE Publications ; 2023
    In:  Lupus Vol. 32, No. 7 ( 2023-06), p. 855-863
    Details
    In: Lupus, SAGE Publications, Vol. 32, No. 7 ( 2023-06), p. 855-863
    Abstract: To assess whether a healthy lifestyle is associated to beneficial effects on various systemic lupus erythematosus (SLE) health domains. Methods In a cross-sectional study, Mediterranean Diet Adherence Score (MEDAS), physical activity energy expenditure (PAEE), and smoking status were assessed by questionnaires, along with clinical parameters and various health domains including Systemic Lupus Disease Activity Score (SLEDAI), Depression Scale (CES-D), Fatigue Severity (FSS), functional status (FFbH), physical and mental quality of life (PCS, MCS). Lifestyle choices were assessed with respect to health domains by linear regression modeling. Additionally, SLE patients with a healthy lifestyle (MEDAS ≥ 4, ≥ 1 h sport per week, no smoking) were compared to those without by Wilcoxon’s signed-rank test. Results 49 of 145 SLE patients (44.3 ± 31.7 years, 87.6% female) followed a healthy lifestyle and showed a higher physical quality of life (β = 4.5 (95%-CI 1.5–7.9) p = 0.01), lower depression (β = −5.0 (−8.2 to −0.2) p = 0.02) and lower fatigue (β = −0.8 (−1.5 to −0.2) p = 0.01) independently of SLE disease activity. Furthermore, dsDNA-antibodies were lower (146 ± 540 vs 266 ± 146 U/mL, p = 0.049). In a more detailed analysis, physical activity had the highest impact on the various health domains when compared to smoking or diet adherence, which was consistent even after adjusting for multiple potential confounders. Each 1,000 kcal of weekly PAEE was associated to a 1.8 (0.9–2.6) point increase in the PCS ( p = 0.0001), a 0.2 (0.03–0.4) point decrease in the CES-D ( p = 0.01) and a 2.8 (1.2–4.4) point increase in the FFbH ( p = 0.0006). Conclusion A healthy lifestyle, especially physical activity is associated with beneficial effects including quality of life, depression and fatigue in SLE.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/09612033231175289
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2008035-9
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  • 6
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    Online Resource
    Centennial-scale variations in diatom productivity off Peru over the last 3000 years
    SAGE Publications ; 2016
    In:  The Holocene Vol. 26, No. 4 ( 2016-04), p. 520-531
    Details
    In: The Holocene, SAGE Publications, Vol. 26, No. 4 ( 2016-04), p. 520-531
    Abstract: The Peruvian coastal upwelling is one of the most productive systems in the global ocean, with important impacts on the carbon cycle. Primary productivity there displays strong variations at the interannual to decadal timescales. However, down-core investigations rarely reach sufficient temporal resolution to assess the response of productivity to climatic variations at these timescales beyond the instrumental and historical periods. We here analyzed diatom assemblages, sea-surface temperatures (SSTs), and nitrogen and organic carbon contents on a laminated sediment core from the Peruvian continental shelf to trace variations in regional productivity over the last 3000 years. Our record provides evidence for different climatic and oceanic conditions with more humid and less productive conditions older than 2500 cal. yr BP and drier and more productive conditions younger than 2500 cal. yr BP. The last 2500 years also present much stronger centennial-scale variability with the occurrence of six intervals with higher total diatom abundances and stronger percentages in upwelling-related diatom species, representative of intensified productivity, congruent to lower percentages in benthic diatoms, indicative of reduced rainfall. These six periods were synchronous to intervals of enhanced Walker circulation, suggesting a strong imprint of the Pacific zonal circulation on productivity variations off Peru. Our record also demonstrates that SSTs did not vary in phase with productivity, arguing against the idea of regional SSTs controlled by the upwelling intensity, but were rather in agreement to SST records off southern Chile, suggesting that Peruvian SST variations were largely controlled by oceanic currents at southern high latitudes.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683615612589
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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  • 7
    Online Resource
    Online Resource
    Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients – Analysis of the German LuLa study
    SAGE Publications ; 2021
    In:  Lupus Vol. 30, No. 12 ( 2021-10), p. 1931-1937
    Details
    In: Lupus, SAGE Publications, Vol. 30, No. 12 ( 2021-10), p. 1931-1937
    Abstract: The aim of this study was to identify factors associated with impaired work productivity and impaired daily activities in patients with systemic lupus erythematosus (SLE). Methods The LuLa study is a longitudinal patient-reported study. Beyond sociodemographic data, work productivity, daily activities and fatigue, several other clinical outcome parameters (e.g. mental health–related quality of life and physical functioning, disease activity, damage and pain) were surveyed with validated questionnaires. The effects of confounders on work productivity (WPAI 2) and daily activity domains (WPAI 4) were studied by multivariate regression analysis. Results A total of 585 patients completed the questionnaire of whom 259 were employed and analysed. The median impairment in work productivity (WPAI 2) was 20% (Q1–3 0–40), and the median impairment in daily activities (WPAI 4) was 30% (Q1–3 10–50%). Multivariate regression analysis revealed that fatigue, pain, disease activity and health-related quality of life affected WPAI 2 and 4. Furthermore, we observed distinct synergistic effects of fatigue, disease activity and pain on both work productivity and daily activities: a higher impact of fatigue was associated with the reported extent of pain or disease activity. Conclusion In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/09612033211045063
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2008035-9
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  • 8
    Online Resource
    Online Resource
    Late-Holocene climate variability in the Adriatic Sea (Central Mediterranean)
    SAGE Publications ; 2008
    In:  The Holocene Vol. 18, No. 1 ( 2008-01), p. 153-167
    Details
    In: The Holocene, SAGE Publications, Vol. 18, No. 1 ( 2008-01), p. 153-167
    Abstract: Planktic and benthic foraminifera assemblages from a set of sediment cores, collected on the Adriatic shelf and the Southern Adriatic deep basin, provide compelling evidence of submillennial-scale environmental changes during the last 6000 years. Repeated peaks in Globigerinoides sacculifer represent warm-dry intervals, including the `Mediaeval Warm Period', the `Roman Age', the late `Bronze Age' and the `Copper Age'. The Last Occurrence (LO) of G. sacculifer (550 years BP) approximates the base of the `Little Ice Age' (LIA). Significant turnovers in the structure of the water column reflect changes in the rate of formation and depth of flow of the North Adriatic Dense Water (NAdDW) and the Levantine Intermediate Water (LIW). About 7500 years BP the benthic oxygen isotope records mark the timing when the NAdDW formation intensified on the slope and shifted to its modern route. About 5500 years BP, when sea level reached its modern high stand, oxygen isotope records of intermediate planktic dwellers indicate a northward intrusion of the LIW on the slope. The oscillating isotope trends during the last five millennia document a discontinuous invasion of LIW into the Central Adriatic, possibly reflecting short-term climate changes with weakened LIW production during colder and wetter intervals.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683607085606
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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  • 9
    Online Resource
    Online Resource
    Compensatory Intracranial Arterial Dilatation in Extracranial Carotid Atherosclerosis: The Northern Manhattan Study
    SAGE Publications ; 2015
    In:  International Journal of Stroke Vol. 10, No. 6 ( 2015-08), p. 843-848
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 10, No. 6 ( 2015-08), p. 843-848
    Abstract: There is a scarcity of data supporting the association between atherosclerosis and dolichoectasia in unbiased samples. Aims To test the hypothesis that the association between dolichoectasia and extracranial carotid atherosclerosis depends on the degree of collateral circulation. Methods The Northern Manhattan Study magnetic resonance imaging substudy consists of 1290 participants who remained stroke-free at the time of magnetic resonance imaging. Arterial diameters were collected in all participants with available magnetic resonance angiography. Dolichoectasia was defined as a head-size adjusted diameter 〉 2 standard deviation for each artery. Carotid Doppler was used to evaluate for carotid atherosclerosis (carotid plaque, maximum plaque thickness and carotid intima media thickness). Results We included 994 participants with available Doppler and magnetic resonance angiography data (mean age 63 years, 60% female). Any dolichoectasia was reported in 16% of participants, 54% had at least one carotid plaque and the mean carotid intima media thickness was 0·92 ± 0·09 mm. After adjusting for demographic and clinical characteristics, there was no association between markers of carotid atherosclerosis and dolichoectasia. However, stratifying by collaterals, it was observed that dolichoectasia was more likely in the anterior and posterior circulations when collaterals were available among participants with carotid atherosclerosis. These associations were confirmed by noting an increment in arterial diameters in the corresponding arteries ipsilateral and contralateral to each carotid as well as in the posterior circulation. Conclusions We did not find an association of extracranial carotid atherosclerosis with dolichoectasia. However, we found that dolichoectasia is more frequent when intracranial collaterals are available suggesting a compensatory process that needs further investigation.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1111/ijs.12464
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2211666-7
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  • 10
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    Online Resource
    Holocene water mass changes in the Labrador Current
    SAGE Publications ; 2019
    In:  The Holocene Vol. 29, No. 4 ( 2019-04), p. 676-690
    Details
    In: The Holocene, SAGE Publications, Vol. 29, No. 4 ( 2019-04), p. 676-690
    Abstract: The Labrador Current is part of the anticlockwise subpolar gyre and plays a major role in the formation of North Atlantic Deep Water. It is influenced by the West Greenland and Baffin currents supplying warmer Atlantic and cold polar waters, respectively. During the early Holocene, at the final stage of the last deglaciation, meltwater and iceberg discharge caused highly variable conditions in the Labrador Current. In order to assess its sensitivity to such freshening, this study provides a well-resolved Holocene paleoclimatic record from the Labrador Shelf. Based on benthic foraminiferal faunal and alkenone biomarker analyses, we differentiated four distinct climatic periods in the western Labrador Sea. From 8.9 to 8.6 ka BP, the Labrador Shelf was dominated by polar water outflow from Baffin Bay and covered by perennial sea ice. Between 8.6 and 7.4 ka BP, a strong subsurface inflow of warmer Atlantic water masses is ascribed to an intensification and redirection of the West Greenland Current. At 7.4 ka BP, the decreased influence of Atlantic water masses on the Labrador Shelf marks the establishment of winter convection leading to the formation of Labrador Sea Water in the central basin. Concurrently, an intensified polar water outflow through the Canadian Gateways strengthened the inner Labrador Current, and higher primary productivity suggests longer spring blooms because of a shorter sea-ice season during the Holocene Thermal Maximum. In the late Holocene after 3 ka BP, periodic fluctuations of primary productivity may tentatively be correlated with stronger and weaker northwesterly winds.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683618824752
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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