In:
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 23, No. 2_suppl ( 2003-12), p. 34-36
Abstract:
Although early reports demonstrated that serum β 2 -microglobulin (s-β 2 m) concentrations in patients on peritoneal dialysis (PD) were lower than those in patients on hemodialysis (HD), more recent studies demonstrated lower s-β 2 m concentrations in HD patients treated mainly with high-flux synthetic membranes. We therefore compared s-β 2 m concentrations between patients on PD and on HD, and also analyzed the relationship between s-β 2 m concentrations and other parameters in patients on PD. Patients and Methods We investigated 24 patients who had been undergoing PD [11 on continuous ambulatory peritoneal dialysis, 13 on continuous cycling peritoneal dialysis] for 4.3 ± 2.7 years, and 24 patients who had been undergoing HD with high-flux synthetic membranes for 6.1 ± 3.2 years. Concentrations of s-β 2 m in the PD patients were compared to concentrations in the HD patients. In patients on PD, we also analyzed the relationship between s-β 2 m concentration and other parameters, including residual renal function, total weekly Kt/V urea, total weekly creatinine clearance (CCr), and dialysis schedules. Results We found no significant difference in s-β 2 m concentrations between the PD and HD patients (33.6 ± 10.4 mg/L vs 30.3 ± 10.5 mg/L respectively). Concentrations of s-β 2 m in PD patients rose with PD duration and were significantly inversely correlated with residual renal function ( r = –0.71, p 〈 0.0001). Unexpectedly, concentrations of s-β 2 m in anuric PD patients rose as peritoneal CCr increased. And most of the patients with high s-β 2 m levels fell into the high or high-average transport categories according to a peritoneal equilibration test. Conclusions Concentrations of s-β 2 m in patients on PD did not differ significantly from concentrations in HD patients who were using high-flux synthetic membranes. The contribution of residual renal function to removal of β 2 m was more important than the contribution of peritoneal clearance. High peritoneal clearance of small molecules did not result in low s-β 2 m concentrations, especially in anuric patients with accelerated peritoneal permeability.
Type of Medium:
Online Resource
ISSN:
0896-8608
,
1718-4304
DOI:
10.1177/089686080302302s07
Language:
English
Publisher:
SAGE Publications
Publication Date:
2003
detail.hit.zdb_id:
2075957-5
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