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  • 1
    Online Resource
    Online Resource
    Prevention of Positive Coronary Artery Remodeling with Statin Therapy in Patients with Coronary Artery Diseases
    SAGE Publications ; 2006
    In:  Angiology Vol. 57, No. 3 ( 2006-05), p. 259-265
    Details
    In: Angiology, SAGE Publications, Vol. 57, No. 3 ( 2006-05), p. 259-265
    Abstract: Since positive coronary artery remodeling with large plaque burden is associated with subsequent coronary events, the authors tested their hypothesis that secondary prevention of coronary events by a statin may be associated with inhibition of the process of positive coronary artery remodeling in underlying coronary atherosclerotic lesions in patients with coronary artery diseases. They evaluated the intravascular ultrasound imaging in angiographically normal coronary lesions at baseline and after 6 months of therapy in 64 patients with coronary artery diseases. External elastic membrane area was defined as the vessel area, and the difference between the vessel and lumen area was calculated as plaque area. The relative echogenicity of coronary plaque to adventitia was evaluated as acoustic characteristics of coronary plaque. Twenty-five patients were treated with a statin and 39 patients did not receive a statin. In patients treated with a statin, plaque area decreased by 12% (p=0.013) compared to an increase in plaque area of 13% (p=0.023) in those who did not receive a statin. The vessel area was not enlarged in patients treated with a statin but did show positive remodeling in patients who had plaque progression without a statin. The relative echogenicity of plaque was unchanged in patients treated with a statin but significantly decreased in patients not receiving a statin. A statin may prevent positive coronary artery remodeling via inhibition of plaque progression in underlying coronary atherosclerotic lesions in patients with coronary artery diseases.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/000331970605700301
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2065911-8
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  • 2
    Online Resource
    Online Resource
    Interferon Alpha-2a Therapy for Disseminated Intravascular Coagulation in a Patient with Blue Rubber Bleb Nevus Syndrome : A Case Report
    SAGE Publications ; 1997
    In:  Angiology Vol. 48, No. 3 ( 1997-03), p. 273-277
    Details
    In: Angiology, SAGE Publications, Vol. 48, No. 3 ( 1997-03), p. 273-277
    Abstract: The authors present a sixteen-year-old girl with blue rubber bleb nevus syndrome (BRBNS) associated with disseminated hemangiomas involving the skin, oral cavity, skeletal muscle, and cerebrum. Although she denied neurologic symptoms, magnetic resonance imaging of the brain demonstrated dilatated cerebral veins and the Chiari I malformation. Examination of hemostasis revealed disseminated intravascular coagula tion (DIC) manifesting as Kasabach-Merritt syndrome, with the potential for life-threat ening bleeding or thrombosis in the central nervous system. Since successful management of life-threatening hemangiomas with interferon alpha-2a (IFN α-2a) has been reported, the authors administered IFN α-2a with an improvement in hemostasis. These findings suggest that IFN α-2a therapy is beneficial for relieving the life-threatening consumptive coagulopathy associated with BRBNS.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/000331979704800312
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
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  • 3
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    Online Resource
    Systemic Versus Coronary Levels of Inflammation in Acute Coronary Syndromes
    SAGE Publications ; 2006
    In:  Angiology Vol. 57, No. 4 ( 2006-08), p. 459-463
    Details
    In: Angiology, SAGE Publications, Vol. 57, No. 4 ( 2006-08), p. 459-463
    Abstract: To address a possible link between systemic and coronary inflammation in the setting of acute coronary syndromes, the authors examined both levels of 3 inflammatory mediators such as high sensitive C-reactive protein (hs-CRP), interleukin (IL)-6, and matrix metalloproteinase (MMP)-9 in patients with the early phase of acute myocardial infarction (AMI). In total, 20 patients with AMI showing minimal elevation of cardiac enzymes were studied. Before angioplasty, peripheral blood and culprit coronary thrombus were sampled to compare systemic and coronary levels of hs-CRP, IL-6, and MMP-9. Relation of systemic levels of hs-CRP and IL-6 to culprit coronary morphology was also evaluated by the use of intravascular ultrasound. Systemic and coronary levels of hs-CRP were nearly equivalent (4.3 ±5.0 vs 4.7 ±5.4 mg/L, p=0.279), whereas IL-6 and MMP-9 showed higher in coronary levels than in systemic levels (169 ±154 vs 93 ±107 pg/mL, p=0.002 and 164 ±116 vs 103 ±94 ng/mL, p=0.018, respectively). Systemic levels of hs-CRP were correlated with coronary levels of IL-6 (r =0.566, p=0.009). Culprit coronary plaque area demonstrated a positive relation with systemic levels of hs-CRP (r =0.466, p=0.038) and also IL-6 (r =0.707, p 〈 0.001). The present study may provide an important insight into the link between systemic and coronary levels of inflammation, which is also associated with vulnerable coronary morphology in the setting of acute coronary syndromes.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319706290742
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2065911-8
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  • 4
    Online Resource
    Online Resource
    LXXXVI The Etiology of Papilloma of the Larynx
    SAGE Publications ; 1957
    In:  Annals of Otology, Rhinology & Laryngology Vol. 66, No. 4 ( 1957-12), p. 1119-1142
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 66, No. 4 ( 1957-12), p. 1119-1142
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348945706600419
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1957
    detail.hit.zdb_id: 2033055-8
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  • 5
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    Online Resource
    Anterior Gradient 2 is Correlated with EGFR Mutation in Lung Adenocarcinoma Tissues
    SAGE Publications ; 2015
    In:  The International Journal of Biological Markers Vol. 30, No. 2 ( 2015-04), p. 234-242
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 30, No. 2 ( 2015-04), p. 234-242
    Abstract: Epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) has demonstrated a promising therapeutic response in lung adenocarcinoma patients with EGFR gene mutations. However, the predictive factors for this therapy have not been established, except for the EGFR gene mutation status of carcinoma cells. Methods We first performed microarray analysis in EGFR-TKI–sensitive lung adenocarcinoma cell lines. The results indicated anterior gradient 2 (AGR2) as a potential surrogate marker of EGFR-TKI. Therefore, we then evaluated the correlation between the status of AGR2 immunoreactivity and clinicopathological factors including overall survival (OS), progression-free survival (PFS) and clinical response to EGFR-TKI, in 147 cases of surgically resected lung adenocarcinoma. The biological significance of AGR2 was further evaluated by transfecting small interfering RNA (siRNA) against AGR2 in these cells. Results The status of AGR2 immunoreactivity was significantly higher in lung adenocarcinoma cases with EGFR gene mutations than in those with the wild type (p 〈 0.0001), but there were no significant differences in OS, PFS and response of EGFR-TKI between the AGR2 high and low carcinoma cases. Knockdown of AGR2 gene expression following siRNA transfection resulted in a significantly lower response to EGFR-TKI in EGFR-mutated PC-3. Conclusions AGR2 could serve as an adjunctive surrogate protein marker possibly reflecting EGFR gene mutations in lung adenocarcinoma patients. Results from in vitro analysis indicated that AGR2 could be a potential clinical biomarker of EGFR-TKI therapeutic sensitivity in lung adenocarcinoma cells.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.5301/jbm.5000131
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 1475778-3
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  • 6
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    Online Resource
    Safety and feasibility of the distal transradial approach: A novel technique for diagnostic cerebral angiography
    SAGE Publications ; 2020
    In:  Interventional Neuroradiology Vol. 26, No. 6 ( 2020-12), p. 713-718
    Details
    In: Interventional Neuroradiology, SAGE Publications, Vol. 26, No. 6 ( 2020-12), p. 713-718
    Abstract: We aimed to evaluate the safety and feasibility of the distal transradial approach (DTRA) as a novel technique for cerebral angiography based on our institutional initial experience. Methods We retrospectively analyzed our institutional database of consecutive diagnostic cerebral angiographies performed with DTRA from December 2018 to August 2019. Patient demographics and clinical and procedural data were recorded. Results In total, 51 diagnostic cerebral angiographies in 51 patients (age, 15–83 years; mean age, 59.4 years, SD 13.5; 35 (69%) females) were performed or attempted with DTRA. Ultrasound evaluation showed that the mean inner distal radial artery diameter was significantly smaller than the mean inner forearm radial artery diameter (2.19 mm vs. 2.56 mm, P  〈  0.001). Cannulation via the distal radial artery was successful in 47 (92%) procedures. In the four procedures that failed, operators converted to the ipsilateral transradial approach without repositioning or redraping. Selective catheterization of the intended vessel was achieved in 64 (91%) of 70 vessels. In the remaining six, operators achieved the objective of the examination with angiography injecting from proximal and conversion to another approach was not required. One patient experienced temporary numbness around the puncture site after the procedure. No radial artery occlusion was identified in the patients who underwent ultrasound evaluation. Conclusion Our results demonstrate that DTRA could become a standard approach for diagnostic cerebral angiography owing to the low complication rate and the high cannulation success rate.
    Type of Medium: Online Resource
    ISSN: 1591-0199 , 2385-2011
    URL: Article
    DOI: 10.1177/1591019920925709
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2571161-1
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  • 7
    Online Resource
    Online Resource
    Anti-inflammatory and atheroprotective properties of glucagon
    SAGE Publications ; 2020
    In:  Diabetes and Vascular Disease Research Vol. 17, No. 5 ( 2020-09), p. 147916412096518-
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 17, No. 5 ( 2020-09), p. 147916412096518-
    Abstract: Although glucagon has been shown to exert pleiotropic actions in various types of cells and organs through the interaction with its receptor, its pathophysiological role in atherosclerotic cardiovascular disease remains unclear. Here, we examined whether and how glucagon could attenuate the progression of atherosclerotic plaques in apolipoprotein E-deficient mice (ApoE −/− ), an animal model of atherosclerosis. Glucagon (138 or 413 nmol/kg/day) or vehicle was infused to mice at 16 weeks of age. After 4-week treatment, vascular samples were collected for histological and RT-PCR analyses. Human monocytic THP-1 cells were pre-incubated with or without a glucagon receptor antagonist L-168049, and then treated with or without glucagon for 7 h. Gene and protein expressions were determined by RT-PCR and western blot analyses, respectively. High-dose glucagon infusion significantly decreased aortic plaque area and volume in ApoE −/− mice, both of which were inversely correlated with plasma glucagon levels. Glucagon infusion also reduced the ratio of pro-inflammatory interleukin-1β to anti-inflammatory interleukin-10 gene expression in aortae. Glucagon receptor was expressed in THP-1 cells, and 1 nM glucagon decreased the ratio of interleukin-1β to interleukin-10 gene expression, which was significantly prevented by L-168049. Our present findings suggest that glucagon could exert atheroprotection partly via its anti-inflammatory property.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/1479164120965183
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2250797-8
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  • 8
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    Online Resource
    PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11 C-GW2580, and 11 C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey
    SAGE Publications ; 2021
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 41, No. 9 ( 2021-09), p. 2410-2422
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 41, No. 9 ( 2021-09), p. 2410-2422
    Abstract: Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this study, we developed a novel PET radioligand for CSF1R, 11 C-GW2580, and compared it to a reported CSF1R tracer, 11 C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. Dynamic 11 C-GW2580- and 11 C-CPPC-PET images were quantified by reference tissue-based models and standardized uptake value ratio. Both tracers exhibited increased uptake in the lesioned striata of lipopolysaccharide-injected mice and in the forebrains of App NL-G-F/NL-G-F -knock-in mice, spatially in agreement with an increased 18-kDa translocator protein radioligand retention. Moreover, 11 C-GW2580 captured changes in CSF1R availability more sensitively than 11 C-CPPC, with a larger dynamic range and a smaller inter-individual variability, in these model animals. PET imaging of CSF1R in a rhesus monkey displayed moderate-to-high tracer retention in the brain at baseline. Homologous blocker (i. e. unlabeled tracer) treatment reduced the uptake of 11 C-GW2580 by ∼30% in all examined brain regions except for centrum semi-ovale white matter, but did not affect the retention of 11 C-CPPC. In summary, our results demonstrated that 11 C-GW2580-PET captured inflammatory microgliosis in the mouse brain with higher sensitivity than a reported radioligand, and displayed saturable binding in the monkey brain, potentially providing an imaging-based quantitative biomarker for reactive microgliosis.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X211004146
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2039456-1
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  • 9
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    Online Resource
    Submicrosecond Preliminary Process of Electric-Field-Induced Reorientation of a Ferroelectric Liquid Crystal, 5-(2-Fluoroalkoxy)-2-(4- n -Alkylphenyl)-Pyrimidine, Studied by Time-Resolved Infrared Spectroscopy
    SAGE Publications ; 1995
    In:  Applied Spectroscopy Vol. 49, No. 7 ( 1995-07), p. 977-980
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 49, No. 7 ( 1995-07), p. 977-980
    Abstract: Pulsed electric-field-induced reorientation of a ferroelectric liquid crystal (FLC), 5-(2-fluorooctyloxy)-2-(4-hexylphenyl)-pyrimidine, has been investigated by using a dispersive submicrosecond time-resolved infrared spectroscopic technique. The observed absorbance decay for a band at 1440 cm −1 due to a ring-stretching mode of the phenylpyrimidine group indicates that the FLC molecule reorients from a stationary state with a slight delay (less than 1 μs) just after the upswing of the electric field, while counter-reorientation occurs with a delay time of a microsecond after the reverse of the electric field. The delay time for the counter-reorientation changes with temperature, indicating that the viscosity has a strong influence on the delay time. It is also indicated in the present study that the whole FLC molecule reorients simultaneously as a rigid rod in both the preliminary and the counter-reorientation process.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1366/0003702953964697
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1995
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 10
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    Involvement of TRPA1 Activation in Acute Pain Induced by Cadmium in Mice
    SAGE Publications ; 2013
    In:  Molecular Pain Vol. 9 ( 2013-01-01), p. 1744-8069-9-7-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 9 ( 2013-01-01), p. 1744-8069-9-7-
    Abstract: Cadmium (Cd) is an environmental pollutant and acute exposure to it causes symptoms related to pain and inflammation in the airway and gastrointestinal tract, but the underlying mechanisms are still unclear. TRPA1 is a nonselective cation channel expressed in sensory neurons and acts as a nociceptive receptor. Some metal ions such as Ca, Mg, Ba and Zn are reported to modulate TRPA1 channel activity. In the present study, we investigated the effect of Cd on cultured mouse dorsal root ganglion neurons and a heterologous expression system to analyze the effect of Cd at the molecular level. In addition, we examined whether Cd caused acute pain in vivo. Results In wild-type mouse sensory neurons, Cd evoked an elevation of the intracellular Ca concentration ([Ca 2+ ] i ) that was inhibited by external Ca removal and TRPA1 blockers. Most of the Cd-sensitive neurons were also sensitive to cinnamaldehyde (a TRPA1 agonist) and [Ca 2+ ] i responses to Cd were absent in TRPA1(−/−) mouse neurons. Heterologous expression of TRPA1 mutant channels that were less sensitive to Zn showed attenuation of Cd sensitivity. Intracellular Cd imaging revealed that Cd entered sensory neurons through TRPA1. The stimulatory effects of Cd were confirmed in TRPA1-expressing rat pancreatic cancer cells (RIN-14B). Intraplantar injection of Cd induced pain-related behaviors that were largely attenuated in TRPA1(−/−) mice. Conclusions Cd excites sensory neurons via activation of TRPA1 and causes acute pain, the mechanism of which may be similar to that of Zn. The present results indicate that TRPA1 is involved in the nociceptive or inflammatory effects of Cd.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1186/1744-8069-9-7
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2174252-2
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