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  • 1
    Online Resource
    Online Resource
    A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group
    SAGE Publications ; 2021
    In:  Lupus Vol. 30, No. 4 ( 2021-04), p. 630-640
    Details
    In: Lupus, SAGE Publications, Vol. 30, No. 4 ( 2021-04), p. 630-640
    Abstract: Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203320988586
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2008035-9
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  • 2
    Online Resource
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    Convergent validation of a questionnaire to assess the mode and frequency of commuting to and from school
    SAGE Publications ; 2017
    In:  Scandinavian Journal of Public Health Vol. 45, No. 6 ( 2017-08), p. 612-620
    Details
    In: Scandinavian Journal of Public Health, SAGE Publications, Vol. 45, No. 6 ( 2017-08), p. 612-620
    Abstract: Aims: The purposes of this research were to study the convergent validity of the Mode and Frequency of Commuting To and From School Questionnaire using objectively assessed steps and time spent in different physical activity intensities and to compare the self-reported versus objective journey time in Spanish youths. Methods: Three hundred and eighty-nine Spanish youth aged 7–19 years were asked to complete the questionnaire and wore an accelerometer for five days. The objective commuting distance and time from home to school were estimated using Google Maps TM . Results: There were significant differences between passive and walking participants on step numbers, sedentary time and physical activity levels (except for vigorous physical activity in children). For children, a mean difference of −4.03 minutes between objective measured and self-reported journey time was found (95% limits of agreement were 13.55 and −21.60 minutes). For adolescents, the mean difference was −1.39 minutes (95% limits of agreement were 15.23 and −18.02 minutes). Conclusions: The findings indicated that the Mode of Commuting To and From School Questionnaire showed a convergent validity to assess this behaviour in Spanish youths. Self-reported journey time for walking is comparable to Google Maps TM in adolescents but not in children.
    Type of Medium: Online Resource
    ISSN: 1403-4948 , 1651-1905
    URL: Article
    DOI: 10.1177/1403494817718905
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2027122-0
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  • 3
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    The performance of researchers in multidisciplinary research groups: does social capital matter?
    SAGE Publications ; 2022
    In:  International Review of Administrative Sciences Vol. 88, No. 2 ( 2022-06), p. 337-354
    Details
    In: International Review of Administrative Sciences, SAGE Publications, Vol. 88, No. 2 ( 2022-06), p. 337-354
    Abstract: Points for practitioners • Research and development managers at supranational, national and university levels should consider promoting the formation of multidisciplinary research groups. Our results provide evidence that multidisciplinary research groups support higher research performance, at least to some extent. • The research performance of multidisciplinary groups is assisted by the social capital of the research groups. Therefore, leaders of research groups should promote initiatives that allow collaboration and the exchange of ideas, knowledge and information among researchers, thus creating trust and increasing the internal social capital of the groups.
    Type of Medium: Online Resource
    ISSN: 0020-8523 , 1461-7226
    URL: Article
    DOI: 10.1177/0020852320919487
    RVK:
    PM 7370
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2023655-4
    SSG: 2
    SSG: 3,6
    SSG: 3,7
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  • 4
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    Clinical and immunological study of Tofacitinib and Baricitinib in refractory Blau syndrome: case report and literature review
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Musculoskeletal Disease Vol. 14 ( 2022-01), p. 1759720X2210932-
    Details
    In: Therapeutic Advances in Musculoskeletal Disease, SAGE Publications, Vol. 14 ( 2022-01), p. 1759720X2210932-
    Abstract: Blau syndrome (BS) is an autoinflammatory disorder characterized by non-caseating granulomatous dermatitis, arthritis, and uveitis. We present a case of refractory and severe BS that was treated with the Janus kinase inhibitors (JAKINIBS), Tofacitinib (TOFA) and then Baricitinib (BARI). Our aim was to describe the clinical and immunological outcomes after treatment with JAKINIBS. Blood tests and serum samples were obtained during follow-up with TOFA and BARI. We assessed their effects on clinical outcomes, acute phase reactants, absolute lymphocyte counts (ALCs), lymphocyte subset counts, immunoglobulins, and cytokine levels. A review of the literature on the use of JAKINIBS for the treatment of uveitis and sarcoidosis was also conducted. TOFA led to a rapid and maintained disease control and a steroid-sparing effect. A decrease from baseline was observed in ALC, CD3+, CD4+, CD8+, and natural killer (NK) cell counts. B-cells were stable. Serum levels of interleukin (IL)-4 and tumor necrosis factor alpha (TNF-α) increased, whereas IL-2, IL-6, IL-10, and IL-17 maintained stable. TOFA was discontinued after 19 months due to significant lymphopenia. The initiation of BARI allowed maintaining adequate control of disease activity with an adequate safety profile. The literature review showed seven patients with uveitis and five with sarcoidosis treated with JAKINIBS. No cases of BS treated with JAKINIBS were found. We report the successful use of JAKINIBS in a patient with refractory and severe BS.
    Type of Medium: Online Resource
    ISSN: 1759-720X , 1759-7218
    URL: Article
    DOI: 10.1177/1759720X221093211
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2516075-8
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  • 5
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    When Staff Create the Organisational Culture : A Case Study in the Spanish Emergency Health Care System
    SAGE Publications ; 2008
    In:  Journal of Health Management Vol. 10, No. 2 ( 2008-08), p. 163-189
    Details
    In: Journal of Health Management, SAGE Publications, Vol. 10, No. 2 ( 2008-08), p. 163-189
    Abstract: Emergency units suffer from continuous overload because all types of users demand the service. The literature shows that in general, the percentage of non-urgent users varies from 20 per cent to 80 per cent, depending on the type of centre analysed, the research approach or the methodology. While some studies have analysed this phenomenon focusing on the users, the current research adopts a different perspective. In this article, we try to explain how the break-down in the emergency services affects the work that the staff do. Drawing on evidence obtained from a six-month ethnographic study in two Spanish public hospitals, we conclude that in this overloaded context, official definitions of emergencies and formal classification protocols are completely useless. Exploring the staff's perceptions about the users and the service itself we try to re-create the process by which the diverse health care workers informally re-define symbols, concepts and behaviour patterns, creating a specific internal culture that helps them cope with the complexity of the service and the excessive demand.
    Type of Medium: Online Resource
    ISSN: 0972-0634 , 0973-0729
    URL: Article
    DOI: 10.1177/097206340801000201
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2180461-8
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  • 6
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    A New Approach for Catheter Placement and Care in CAPD
    SAGE Publications ; 1985
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 5, No. 4 ( 1985-10), p. 223-225
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 5, No. 4 ( 1985-10), p. 223-225
    Abstract: Between April 1981 and December 1984, 54 double-cuff straight Tenckhoff catheters were inserted in 50 patients. This paper describes our experience with a new approach for catheter placement and care. It is based on a) ambulatory insertion by nephrologists; b) no flushing, heparinization or cycling; c) “break-in” delayed for two weeks and performed with regular two-liter bags; dialysis and d) ambulatory training carried out over 7–10 days. The actuarial survival rates of the catheters were 98% at 12 months and 80% at 24 and 36 months. Catheter failure was seen in six patients, three were due to peritonitis, two to tunnel infection and one to outflow obstruction caused by peritoneal adhesions. We conclude that this approach is feasible, safe, cheap and affordable and probably will produce less complications than other methods. Our nephrology section started a CAPD program in early 1981 but limited financial resources led us to devise a simplified and affordable protocol for catheter placement and care and for patient training and follow-up. Thus, we provide ambulatory catheter placement followed by two weeks without any type of peritoneal dialysis or catheter flushing. After this period, patients are trained as outpatients for seven to 10 days. This paper reports our experience with this approach.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.1177/089686088500500405
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1985
    detail.hit.zdb_id: 2075957-5
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  • 7
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    Death and everyday life : The Argaric societies from Southeast Iberia
    SAGE Publications ; 2009
    In:  Journal of Social Archaeology Vol. 9, No. 2 ( 2009-06), p. 139-162
    Details
    In: Journal of Social Archaeology, SAGE Publications, Vol. 9, No. 2 ( 2009-06), p. 139-162
    Abstract: This essay highlights the relationships between the realm of the symbolic world expressed in the funerary sphere and the realm of the maintenance activities of quotidian life, focusing on the Argaric culture of Southeast Iberia (c. 2250—1450 cal BC). The article begins by summarizing engendered mortuary archaeology in relation to maintenance activities and by briefly reviewing the funerary record of the Argaric societies. We then expand on the Argar culture, presenting in more depth two different types of archaeological evidence: grave goods deposited in tombs and paleoanthropological analyses conducted on Argaric skeletons. In the first case, we evaluate the relationship of grave goods to material culture integrated in practices related to the management of everyday domestic life, discussing the socio-symbolical significance that the exclusive association between awls and women may have had. In the second case, we report on those skeletal studies that allow us to infer information about sex differentiated tasks. To conclude, we bring these two different bodies of evidence into a focused dialogue in order to reach a better understanding about the relationship between the social perception and construction of Argaric women's identity and the practices that they may have carried out on a quotidian basis.
    Type of Medium: Online Resource
    ISSN: 1469-6053 , 1741-2951
    URL: Article
    DOI: 10.1177/1469605309104134
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2051499-2
    SSG: 6,14
    SSG: 6,11
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  • 8
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    Chronic Obstructive Sialadenitis due to an Abnormal Wharton’s Duct Draining to the Tonsillar Fossa
    SAGE Publications ; 2023
    In:  Annals of Otology, Rhinology & Laryngology Vol. 132, No. 2 ( 2023-02), p. 217-220
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 132, No. 2 ( 2023-02), p. 217-220
    Abstract: Chronic obstructive sialadenitis (COS) is an entity that causes a marked loss in patient quality of life, including changes in eating habits and a progressive loss of gland function. It is characterized by repeated episodes of painful glandular swelling often requiring emergency care. There are multiple causes of COS, including lithiasis, strictures, anatomical variants, and others. The development of specific imaging tests such as magnetic resonance (MR) sialography or sialendoscopy have increased knowledge of these obstructions and how to specifically treat them. Case Summary: We present an unusual case of a woman with a years-long history of chronic obstructive sialadenitis in which an abnormal path of Wharton’s duct was in evidence. This duct, which was atrophic and smaller in diameter, opened in the tonsillar fossa rather than lateral to the lingual frenulum. This case, the first in vivo description of its kind, was confirmed by MR sialography and sialendoscopy. Discussion: Congenital anomalies of the submandibular duct are a rare finding, but may cause COS. Therefore, COS requires a detailed diagnostic study, usually by ultrasound, MR sialography and sialendoscopy, to rule out complex anatomical variants.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/00034894221081607
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2033055-8
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  • 9
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    Improving Mortality Predictions in Trauma Patients Undergoing Damage Control Strategies
    SAGE Publications ; 2011
    In:  The American Surgeon Vol. 77, No. 6 ( 2011-06), p. 778-782
    Details
    In: The American Surgeon, SAGE Publications, Vol. 77, No. 6 ( 2011-06), p. 778-782
    Abstract: The increased use of damage control surgery in complex trauma patients requires accurate prognostic indicators. We compared the discriminatory capacity of commonly used trauma and intensive care unit (ICU) scores, including revised trauma score, injury severity scores, trauma score-injury severity scores, acute physiology and chronic health evaluations II, and clinical and laboratory parameters, on 83 consecutive trauma patients admitted to the ICU, undergoing damage control. Logistic regressions were built for mortality prediction within 30 days. Performances of the models were assessed in terms of discrimination and calibration. Areas under the receiver operating characteristic curve from the models were compared. Overall mortality was 38.5 per cent. A “clinical” model was constructed including ICU admission pH and hypothermia (≤ 35 C °) and the number of packed red blood cells during the first 24 hours. This model was adjusted for age and demonstrated better discrimination for mortality prediction (areas under the receiver operating characteristic curve = 0.8054) than injury severity score ( P value = 0.049), abdominal trauma index ( P value = 0.049), and acute physiology and chronic health evaluations II ( P value = 0.001). There was no statistically significant difference in discrimination for mortality prediction between the “clinical” model and revised trauma score ( P value = 0.4) and trauma score-injury severity score ( P value = 0.4). We concluded that the combination of ICU admission pH and hypothermia and blood transfusions during 24 hours provided an excellent discriminatory capacity for mortality prediction in this complex patient population.
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/000313481107700637
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
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  • 10
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    Medial Temporal Lobe Correlates of Memory Screening Measures in Normal Aging, MCI, and AD
    SAGE Publications ; 2010
    In:  Journal of Geriatric Psychiatry and Neurology Vol. 23, No. 2 ( 2010-06), p. 100-108
    Details
    In: Journal of Geriatric Psychiatry and Neurology, SAGE Publications, Vol. 23, No. 2 ( 2010-06), p. 100-108
    Abstract: This article aimed to study the correlations for both the Memory Impairment Screen (MIS) and the Free and Cued Selective Reminding Test (FCSRT) with regard to the volumetric measures of hippocampal formation and entorhinal cortex and to explore the effect size of these measures. Methods: A total of 34 healthy controls, 24 participants with mild cognitive impairment (MCI), and 20 mild-to-moderate-staged Alzheimer disease (AD) participants underwent neuropsychological testing and magnetic resonance imaging (MRI). Global volumetric measures were obtained and hippocampal and entorhinal volumes were calculated. Spearman correlations were calculated between memory scores and brain volumes and an effect size analysis was performed. Results: No significant correlations with global brain volumes were found. There were dissimilar correlations among groups regarding memory and hippocampal and entorhinal volumes. No significant relationships were observed in healthy controls. The MCI group reached the higher correlation indexes, up to r = .55. In AD, only one significant correlation was observed between the delayed score of the FCSRT and the left hippocampus. Effect size values were higher for memory tests than for MRI measures, reaching d = 4.3 for the delayed score of the FCSRT. Conclusions: Although the MIS did not reach the strong results of the FCSRT, it demonstrated a similar pattern to the FCSRT in correlational analysis. These results support the validity and usefulness of the MIS despite its brevity of application. Memory testing showed better discrimination among healthy controls, MCI, and AD participants than MRI measures by means of effect size analysis.
    Type of Medium: Online Resource
    ISSN: 0891-9887 , 1552-5708
    URL: Article
    DOI: 10.1177/0891988709355271
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2094096-8
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