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  • 1
    Online Resource
    Online Resource
    Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity : Comparison of Agarose and Self-Assembling Peptide Scaffolds
    SAGE Publications ; 2013
    In:  CARTILAGE Vol. 4, No. 1 ( 2013-01), p. 63-74
    Details
    In: CARTILAGE, SAGE Publications, Vol. 4, No. 1 ( 2013-01), p. 63-74
    Abstract: Dexamethasone (Dex) is a synthetic glucocorticoid that has pro-anabolic and anticatabolic effects in cartilage tissue engineering systems, though the mechanisms by which these effects are mediated are not well understood. We tested the hypothesis that the addition of Dex to chondrogenic medium would affect matrix production and aggrecanase activity of human and bovine bone marrow stromal cells (BMSCs) cultured in self-assembling peptide and agarose hydrogels. Design: We cultured young bovine and adult human BMSCs in (RADA) 4 self-assembling peptide and agarose hydrogels in medium containing TGF-β1±Dex and analyzed extracellular matrix composition, aggrecan cleavage products, and the effects of the glucocorticoid receptor antagonist RU-486 on proteoglycan content, synthesis, and catabolic processing. Results: Dex improved proteoglycan synthesis and retention in agarose hydrogels seeded with young bovine cells but decreased proteoglycan accumulation in peptide scaffolds. These effects were mediated by the glucocorticoid receptor. Adult human BMSCs showed minimal matrix accumulation in agarose, but accumulated ~50% as much proteoglycan and collagen as young bovine BMSCs in peptide hydrogels. Dex reduced aggrecanase activity in (RADA) 4 and agarose hydrogels, as measured by anti-NITEGE Western blotting, for both bovine and human BMSC-seeded gels. Conclusions: The effects of Dex on matrix production are dependent on cell source and hydrogel identity. This is the first report of Dex reducing aggrecanase activity in a tissue engineering culture system.
    Type of Medium: Online Resource
    ISSN: 1947-6035 , 1947-6043
    URL: Article
    DOI: 10.1177/1947603512455196
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
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  • 2
    Online Resource
    Online Resource
    The Importance of Interagency Collaboration for Crossover Youth : A Research Note
    SAGE Publications ; 2017
    In:  Youth Violence and Juvenile Justice Vol. 15, No. 4 ( 2017-10), p. 481-491
    Details
    In: Youth Violence and Juvenile Justice, SAGE Publications, Vol. 15, No. 4 ( 2017-10), p. 481-491
    Abstract: Crossover or dually involved youth are youth enmeshed in the child welfare system (CWS) and juvenile justice system (JJS). Given their dual status and high needs, attention has recently focused on how to best respond to them in an integrated, interagency fashion. The Crossover Youth Practice Model (CYPM) is designed to facilitate interagency collaboration between the CWS and JJS in order to enhance services and diversion to these youths. This study reports on the benefits and challenges that the JJS and CWS, as well as the personnel working within them, experience by participating in a CYPM effort in a Midwestern county, and provides recommendations for continued improvements in interagency collaborations for crossover youth.
    Type of Medium: Online Resource
    ISSN: 1541-2040 , 1556-9330
    URL: Article
    DOI: 10.1177/1541204016686663
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 3
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    Online Resource
    Responding to Crossover Youth: A Look Beyond Recidivism Outcomes
    SAGE Publications ; 2020
    In:  Youth Violence and Juvenile Justice Vol. 18, No. 4 ( 2020-10), p. 381-394
    Details
    In: Youth Violence and Juvenile Justice, SAGE Publications, Vol. 18, No. 4 ( 2020-10), p. 381-394
    Abstract: Crossover youth are involved in both child welfare and juvenile justice systems. The Crossover Youth Practice Model (CYPM) promotes collaboration between these systems to inform decision making between the two agencies and better serve these youth. Yet, few outcome evaluations of the CYPM exist, especially those that assess outcomes beyond recidivism, such as case dispositions, case closure, or placement or living situations. This study examined whether the CYPM ( n = 210) decreased recidivism and increased system/case responses and positive outcomes among youth within 9–18 months after the youth’s initial arrest relative to a comparison group of crossover youth ( n = 425) who were arrested 1 year before the CYPM was implemented. Overall, the findings suggest that the CYPM in the jurisdiction under study dismisses or diverts crossover youth more often, closes delinquency cases more often, and leads to more home placements than was previously done in the jurisdiction, but it does not significantly reduce recidivism.
    Type of Medium: Online Resource
    ISSN: 1541-2040 , 1556-9330
    URL: Article
    DOI: 10.1177/1541204020922887
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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    detail.hit.zdb_id: 2124662-2
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  • 4
    Online Resource
    Online Resource
    Rape and Mental Health Outcomes Among Women: Examining the Moderating Effects of “Healthy” Fear Levels
    SAGE Publications ; 2017
    In:  Violence Against Women Vol. 23, No. 9 ( 2017-08), p. 1055-1075
    Details
    In: Violence Against Women, SAGE Publications, Vol. 23, No. 9 ( 2017-08), p. 1055-1075
    Abstract: This study examined the mediating and moderating impact of fear of victimization on the relationships between forcible and vicarious rape on depression and post-traumatic stress disorder (PTSD) among college women. Forcible and vicarious rape positively affected PTSD and depression symptomology, but fear did not mediate these relationships. Fear moderated the impact of forcible rape on PTSD, but was not a moderator for depression. Findings suggest that there may be “healthy” levels of fear in the aftermath of victimization where having too little fear may leave women unnecessarily vulnerable to victimization, while having too much fear may lead to social isolation and withdrawal.
    Type of Medium: Online Resource
    ISSN: 1077-8012 , 1552-8448
    URL: Article
    DOI: 10.1177/1077801216655625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 5
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    Online Resource
    Type of Victimization Exposure, Perpetrator Type, and Timing of Victimization: The Impact on Behavioral Health Outcomes
    SAGE Publications ; 2024
    In:  Journal of Interpersonal Violence Vol. 39, No. 5-6 ( 2024-03), p. 1132-1160
    Details
    In: Journal of Interpersonal Violence, SAGE Publications, Vol. 39, No. 5-6 ( 2024-03), p. 1132-1160
    Abstract: The effect of abuse victimization in correctional samples has been researched previously, particularly with an eye toward these experiences on justice-involved youth and prison samples’ offending and recidivism behavior. The role of this type of victimization, including physical abuse, sexual abuse, and polyvictimization, is less studied in jail populations. The effect of abuse victimization is also less researched among other outcomes, including behavioral health disorders (BHDs) and substance use disorder (SUD). While the effect of abuse, generally, has been examined, less is known about how abuse perpetrator type and timing of abuse impact justice-involved individuals’ outcomes. Using logistic regressions, we examined the influence of abuse perpetrator type (non-stranger or stranger) and timing (before childhood, after childhood, or before and after childhood) in a population of jailed adults from one state ( n = 4,713). Outcomes studied included internalizing BHDs, externalizing BHDs, and severe SUD. Results indicated that abuse perpetrated by a non-stranger yielded a greater impact on mental illness compared to abuse perpetrated by a stranger. In contrast to abuse experienced as an adult, childhood abuse was more consistently associated with internalizing and externalizing disorders but was not related to severe SUD, with an exception of physical abuse. Further, BHDs and SUD were strongly associated with each other. Overall, polyvictimization had the strongest effect on the outcomes compared to either physical abuse or sexual abuse alone. Our findings suggest that screening for abuse experiences as a potential destabilizing factor in justice-involved populations could improve case management and interventions for people incarcerated in jails. Results also highlight the importance of distinguishing between the perpetrator type of abuse and timing of abuse.
    Type of Medium: Online Resource
    ISSN: 0886-2605 , 1552-6518
    URL: Article
    DOI: 10.1177/08862605231203609
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
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  • 6
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    Online Resource
    Functional status in postural tachycardia syndrome
    SAGE Publications ; 2022
    In:  British Journal of Occupational Therapy Vol. 85, No. 6 ( 2022-06), p. 418-426
    Details
    In: British Journal of Occupational Therapy, SAGE Publications, Vol. 85, No. 6 ( 2022-06), p. 418-426
    Abstract: Postural tachycardia syndrome is a form of orthostatic intolerance that often leads to functional impairment. Methods This survey explored functional status and impact of symptoms in adults ( n = 958) ages 18 to 60 (M = 32.63 ± 10.52 years, 96.7% female) with postural tachycardia syndrome. Results Individuals reported an average of 11 daily life activities impacted by postural tachycardia syndrome with high levels of self-perceived disability. Additionally, 93.4% reported some degree of cognitive impairment and falls occurred in 55.3% of participants annually. Despite frequent falls and functional impairment, participants infrequently (26.9%) utilized therapy services. Conclusion Individuals with postural tachycardia syndrome are at an increased risk of experiencing disability and often require assistance with daily activities. Further research is necessary to understand the potential role of therapy in improving function and quality of life.
    Type of Medium: Online Resource
    ISSN: 0308-0226 , 1477-6006
    URL: Article
    DOI: 10.1177/03080226211031807
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 390834-3
    detail.hit.zdb_id: 2099814-4
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  • 7
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    Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19
    SAGE Publications ; 2022
    In:  Journal of Intensive Care Medicine Vol. 37, No. 4 ( 2022-04), p. 500-509
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications, Vol. 37, No. 4 ( 2022-04), p. 500-509
    Abstract: To determine whether surge conditions were associated with increased mortality. Design Multicenter cohort study. Setting U.S. ICUs participating in STOP-COVID. Patients Consecutive adults with COVID-19 admitted to participating ICUs between March 4 and July 1, 2020. Interventions None Measurements and Main Results The main outcome was 28-day in-hospital mortality. To assess the association between admission to an ICU during a surge period and mortality, we used two different strategies: (1) an inverse probability weighted difference-in-differences model limited to appropriately matched surge and non-surge patients and (2) a meta-regression of 50 multivariable difference-in-differences models (each based on sets of randomly matched surge- and non-surge hospitals). In the first analysis, we considered a single surge period for the cohort (March 23 – May 6). In the second, each surge hospital had its own surge period (which was compared to the same time periods in matched non-surge hospitals). Our cohort consisted of 4342 ICU patients (average age 60.8 [sd 14.8], 63.5% men) in 53 U.S. hospitals. Of these, 13 hospitals encountered surge conditions. In analysis 1, the increase in mortality seen during surge was not statistically significant (odds ratio [95% CI] : 1.30 [0.47-3.58], p = .6). In analysis 2, surge was associated with an increased odds of death (odds ratio 1.39 [95% CI, 1.34-1.43] , p  〈  .001). Conclusions Admission to an ICU with COVID-19 in a hospital that is experiencing surge conditions may be associated with an increased odds of death. Given the high incidence of COVID-19, such increases would translate into substantial excess mortality.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/08850666211067509
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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    detail.hit.zdb_id: 2001472-7
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  • 8
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    Augmented Reality Design Heuristics: Designing for Dynamic Interactions
    SAGE Publications ; 2017
    In:  Proceedings of the Human Factors and Ergonomics Society Annual Meeting Vol. 61, No. 1 ( 2017-09), p. 2100-2104
    Details
    In: Proceedings of the Human Factors and Ergonomics Society Annual Meeting, SAGE Publications, Vol. 61, No. 1 ( 2017-09), p. 2100-2104
    Abstract: Augmented Reality (AR) has emerged as a rapidly developing technology, capable of a wide scope of applications across a variety of domains. AR technologies allow for a virtual experience to be overlaid on top of a physical environment, creating a hybrid experience in which virtual objects become a part of the user’s perceptual and physical environment. Rapid progression of the AR field requires that effective and validated methods of design evaluation be developed. Failure to consider the usability of AR applications during the design process will result in an increase in user errors and accidents, limiting user trust of the technology and undermining user perceptions of the technology, for both AR and Virtual Reality (VR) technologies (Nordrum, 2016). Through a robust and iterative process, a set of Design Heuristics for AR were developed for multidimensional augmented environments with the aim of advancing AR design methods for human factors, ergonomics, and user experience practitioners within the expanding AR community.
    Type of Medium: Online Resource
    ISSN: 2169-5067 , 1071-1813
    URL: Article
    DOI: 10.1177/1541931213602007
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 9
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    Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability
    SAGE Publications ; 2020
    In:  Advances in Methods and Practices in Psychological Science Vol. 3, No. 3 ( 2020-09), p. 309-331
    Details
    In: Advances in Methods and Practices in Psychological Science, SAGE Publications, Vol. 3, No. 3 ( 2020-09), p. 309-331
    Abstract: Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect ( p 〈 .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3–9; median total sample = 1,279.5, range = 276–3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (Δ r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols ( r = .05) was similar to that of the RP:P protocols ( r = .04) and the original RP:P replications ( r = .11), and smaller than that of the original studies ( r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00–.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19–.50).
    Type of Medium: Online Resource
    ISSN: 2515-2459 , 2515-2467
    URL: Article
    DOI: 10.1177/2515245920958687
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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    detail.hit.zdb_id: 2904847-3
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  • 10
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    Cost-effectiveness of Different Diabetic Retinopathy Screening Modalities
    SAGE Publications ; 2016
    In:  Journal of Diabetes Science and Technology Vol. 10, No. 2 ( 2016-03), p. 301-307
    Details
    In: Journal of Diabetes Science and Technology, SAGE Publications, Vol. 10, No. 2 ( 2016-03), p. 301-307
    Type of Medium: Online Resource
    ISSN: 1932-2968 , 1932-2968
    URL: Article
    DOI: 10.1177/1932296815624109
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2467312-2
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