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  • 1
    Online Resource
    Online Resource
    Elevated cord levels of ustekinumab following its use in the treatment of Crohn's disease in pregnancy
    SAGE Publications ; 2022
    In:  Obstetric Medicine
    Details
    In: Obstetric Medicine, SAGE Publications
    Abstract: Ustekinumab (USK) was used in the treatment of two pregnant patients with Crohn's disease. It was given in the third trimester and restarted postnatally for both women. One woman remained on USK and in remission throughout pregnancy. The second woman, took a treatment break, flared, and then had remission induced with reintroduction of USK. Both women delivered healthy term infants. The interval from last dose to birth was 11 and 8 weeks respectively. Interestingly, USK levels in cord blood was observed in higher concentrations than in the maternal serum taken in third trimester. While no adverse effect in infants has been observed, clinicians should remain aware of fetal transfer when using USK in pregnancy. An evaluation of risk and benefit may favour continuing USK in pregnancy in patients with refractory disease.
    Type of Medium: Online Resource
    ISSN: 1753-495X , 1753-4968
    URL: Article
    DOI: 10.1177/1753495X221135201
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2455873-4
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  • 2
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    Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19
    SAGE Publications ; 2022
    In:  Journal of Intensive Care Medicine Vol. 37, No. 4 ( 2022-04), p. 500-509
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications, Vol. 37, No. 4 ( 2022-04), p. 500-509
    Abstract: To determine whether surge conditions were associated with increased mortality. Design Multicenter cohort study. Setting U.S. ICUs participating in STOP-COVID. Patients Consecutive adults with COVID-19 admitted to participating ICUs between March 4 and July 1, 2020. Interventions None Measurements and Main Results The main outcome was 28-day in-hospital mortality. To assess the association between admission to an ICU during a surge period and mortality, we used two different strategies: (1) an inverse probability weighted difference-in-differences model limited to appropriately matched surge and non-surge patients and (2) a meta-regression of 50 multivariable difference-in-differences models (each based on sets of randomly matched surge- and non-surge hospitals). In the first analysis, we considered a single surge period for the cohort (March 23 – May 6). In the second, each surge hospital had its own surge period (which was compared to the same time periods in matched non-surge hospitals). Our cohort consisted of 4342 ICU patients (average age 60.8 [sd 14.8], 63.5% men) in 53 U.S. hospitals. Of these, 13 hospitals encountered surge conditions. In analysis 1, the increase in mortality seen during surge was not statistically significant (odds ratio [95% CI] : 1.30 [0.47-3.58], p = .6). In analysis 2, surge was associated with an increased odds of death (odds ratio 1.39 [95% CI, 1.34-1.43] , p  〈  .001). Conclusions Admission to an ICU with COVID-19 in a hospital that is experiencing surge conditions may be associated with an increased odds of death. Given the high incidence of COVID-19, such increases would translate into substantial excess mortality.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/08850666211067509
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2001472-7
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  • 3
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    Highlights From the Annual Meeting of the American Epilepsy Society 2022
    SAGE Publications ; 2023
    In:  Epilepsy Currents
    Details
    In: Epilepsy Currents, SAGE Publications
    Abstract: With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities. Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy. A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia.
    Type of Medium: Online Resource
    ISSN: 1535-7597 , 1535-7511
    URL: Article
    DOI: 10.1177/15357597231187227
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2135352-9
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  • 4
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    Online Resource
    Quantifying Sources of Variability in Infancy Research Using the Infant-Directed-Speech Preference
    SAGE Publications ; 2020
    In:  Advances in Methods and Practices in Psychological Science Vol. 3, No. 1 ( 2020-03), p. 24-52
    Details
    In: Advances in Methods and Practices in Psychological Science, SAGE Publications, Vol. 3, No. 1 ( 2020-03), p. 24-52
    Abstract: Psychological scientists have become increasingly concerned with issues related to methodology and replicability, and infancy researchers in particular face specific challenges related to replicability: For example, high-powered studies are difficult to conduct, testing conditions vary across labs, and different labs have access to different infant populations. Addressing these concerns, we report on a large-scale, multisite study aimed at (a) assessing the overall replicability of a single theoretically important phenomenon and (b) examining methodological, cultural, and developmental moderators. We focus on infants’ preference for infant-directed speech (IDS) over adult-directed speech (ADS). Stimuli of mothers speaking to their infants and to an adult in North American English were created using seminaturalistic laboratory-based audio recordings. Infants’ relative preference for IDS and ADS was assessed across 67 laboratories in North America, Europe, Australia, and Asia using the three common methods for measuring infants’ discrimination (head-turn preference, central fixation, and eye tracking). The overall meta-analytic effect size (Cohen’s d) was 0.35, 95% confidence interval = [0.29, 0.42], which was reliably above zero but smaller than the meta-analytic mean computed from previous literature (0.67). The IDS preference was significantly stronger in older children, in those children for whom the stimuli matched their native language and dialect, and in data from labs using the head-turn preference procedure. Together, these findings replicate the IDS preference but suggest that its magnitude is modulated by development, native-language experience, and testing procedure.
    Type of Medium: Online Resource
    ISSN: 2515-2459 , 2515-2467
    URL: Article
    DOI: 10.1177/2515245919900809
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2904847-3
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  • 5
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    Online Resource
    Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability
    SAGE Publications ; 2020
    In:  Advances in Methods and Practices in Psychological Science Vol. 3, No. 3 ( 2020-09), p. 309-331
    Details
    In: Advances in Methods and Practices in Psychological Science, SAGE Publications, Vol. 3, No. 3 ( 2020-09), p. 309-331
    Abstract: Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect ( p 〈 .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3–9; median total sample = 1,279.5, range = 276–3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (Δ r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols ( r = .05) was similar to that of the RP:P protocols ( r = .04) and the original RP:P replications ( r = .11), and smaller than that of the original studies ( r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00–.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19–.50).
    Type of Medium: Online Resource
    ISSN: 2515-2459 , 2515-2467
    URL: Article
    DOI: 10.1177/2515245920958687
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2904847-3
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  • 6
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    Ventral Hernia Synthetic Mesh Repair Infected by Mycobacterium fortuitum
    SAGE Publications ; 1999
    In:  The American Surgeon Vol. 65, No. 11 ( 1999-11), p. 1035-1037
    Details
    In: The American Surgeon, SAGE Publications, Vol. 65, No. 11 ( 1999-11), p. 1035-1037
    Abstract: We report the occurrence of a refractory infection caused by the “rapidly growing” nontuberculous mycobacterium, Mycobacterium fortuitum, after incisional hernia repair using synthetic mesh. The patient had previously undergone three herniorrhaphies incorporating polypropylene mesh. Multiple surgical debridements were required, along with complete removal of all the mesh, to eradicate the infection. Prolonged antimicrobial therapy with sulfamethoxazole, an agent active against the patient's isolate, was also used. Although this atypical mycobacterium has been reported to cause a variety of infections, including many types of periprosthetic infections, this case represents successful treatment of M. fortuitum infecting abdominal wall mesh.
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/000313489906501108
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1999
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  • 7
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    Predicting Self-Construal from Authoritarianism: A Pilot Study of Perceived Threat
    SAGE Publications ; 2007
    In:  Psychological Reports Vol. 101, No. 3 ( 2007-12), p. 896-898
    Details
    In: Psychological Reports, SAGE Publications, Vol. 101, No. 3 ( 2007-12), p. 896-898
    Abstract: This pilot study investigated the association of perceived threat and scores on a measure of Authoritarianism. Undergraduate students (29 women, 8 men; ages 18–32, M = 21, SD = 3.1), completed the Right-wing Authoritarianism scale and then the Self-construal scale after reading a nonthreatening or threatening news article. In the threatening condition, Authoritarian scores accounted for a significant amount of variance ( R 2 = .26) in Interdependent Self-construal scores, but not for Independent Self-construal scores. No significant associations were found in the nonthreatening condition.
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.2466/pr0.101.3.896-898
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
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  • 8
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    Identifying Risk Factors for the Development of Diabetic Ketoacidosis in New Onset Type 1 Diabetes Mellitus
    SAGE Publications ; 2003
    In:  Clinical Pediatrics Vol. 42, No. 7 ( 2003-09), p. 591-597
    Details
    In: Clinical Pediatrics, SAGE Publications, Vol. 42, No. 7 ( 2003-09), p. 591-597
    Abstract: To identify risk factors associated with the development of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes mellitus, a retrospective chart review of 139 new onset type 1 diabetes patients from 1995 to 1998 was conducted. Categorical data were examined with contingency table analysis. Age range was 0.5 to 18 years. Overall, 38% of the patients presented in DKA. Sixty-two percent of the patients with either Medicaid or no insurance presented in DKA compared to 34% of the patients with private insurance, odds ratio 3.17 (92% CI 1.2-8.3) p=0.03. Sixty-eight percent of patients in whom the diagnosis was missed (n=25) presented in DKA (mean age, 5.4 ± 4.4 years) compared to 32% in whom the diagnosis was not missed (mean age, 8.8 ± 4.0 years) odds ratio 4.6 (95% CI 1.9-11.7), p=0.0012; age p=0.00019. Lack of private insurance, although a risk factor for the development of DKA, did not increase the likelihood of a missed diagnosis. Lack of private insurance (a proxy for socioeconomic status) and young age are apparent risk factors for the development of ketoacidosis. Misdiagnosis by the physician at initial patient encounter is especially prevalent in the young child but not related to insurance. Both increased public awareness and greater medical alertness are necessary to reduce the high rates of DKA in new-onset type 1 diabetic children. Clin Pediatr. 2003;42:591-597
    Type of Medium: Online Resource
    ISSN: 0009-9228 , 1938-2707
    URL: Article
    DOI: 10.1177/000992280304200704
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2066146-0
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  • 9
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    The Effect of Triggered Palliative Medicine Consults on Nurse Moral Distress in the Medical Intensive Care Unit
    SAGE Publications ; 2022
    In:  American Journal of Hospice and Palliative Medicine® Vol. 39, No. 9 ( 2022-09), p. 1039-1045
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 39, No. 9 ( 2022-09), p. 1039-1045
    Abstract: Moral distress in the intensive care unit contributes to negative emotional experiences in nurses and adversely affects patient care. This prospective cohort study evaluates an intervention designed to improve nurse moral distress in the medical intensive care unit and assesses patient outcomes which may improve moral distress. Methods: Nurse moral distress was measured before and after an intervention of triggered palliative consults and scheduled family meetings in the intensive care unit during the COVID-19 pandemic. Patient outcomes in the intervention medical intensive care unit were compared to a control group. Results: Forty-eight nurses (n = 48/78, 62%) completed the pre-intervention survey and 33 (n = 33/78, 42%) completed the post-intervention survey. Nurse moral distress using the MMD-HP scale pre- and post-intervention (122.5 vs. 134.0, P = 0.1210) was not statistically different. Intervention group patients (n = 57/64, 89%) had earlier transition to do not resuscitate status (hazard ratio 2.1, 95% CI 1.1-4.0, P = 0.0294), higher rate of documented alternate decision makers (100% vs. 61%, P 〈 0.0001), and higher rate discharged to a facility (28% vs. 14%) or hospice (19% vs. 7%) (P = 0.0090). Intervention group patients with a do not resuscitate (DNR) order had lower median length of stay in the intensive care unit (4 days vs. 13 days, P = 0.0004) and hospital (10 days vs. 21 days, P = 0.0005), and lower median total hospital costs per patient ($39,067 vs. $116,476, P = 0.0029) when compared control group patients with a DNR order. Conclusion: Triggered palliative consults with scheduled family meetings were not associated with change in nurse moral distress. More research is needed to uncover methods to improve nurse moral distress in the intensive care unit.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/10499091211049398
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2236674-X
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  • 10
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    Who Goes Where? Exploring Factors Related to Placement Among Group Homes
    SAGE Publications ; 2016
    In:  Journal of Emotional and Behavioral Disorders Vol. 24, No. 1 ( 2016-03), p. 54-63
    Details
    In: Journal of Emotional and Behavioral Disorders, SAGE Publications, Vol. 24, No. 1 ( 2016-03), p. 54-63
    Abstract: Despite their widespread use as a placement option for youth with mental health problems, there is relatively little research on group homes for youth. Available data highlight concerns with practices and treatment within group homes and mixed results on youth-level outcomes. However, existing research appears to collapse a wide range of group residential settings into a single amorphous category. This article explores potential variations among group homes to examine whether different programs are systematically serving different types of youth. It examines, in particular, placement in homes using the teaching family model (TFM) versus homes that do not. Findings suggest that demographics are not significantly associated with TFM placement. However, custody status, types of mental health problems, and use of psychotropic medications are. Homes appear to be serving distinct niches within a geographic area. Implications for future research and policy/practice are discussed.
    Type of Medium: Online Resource
    ISSN: 1063-4266 , 1538-4799
    URL: Article
    DOI: 10.1177/1063426615585082
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2070071-4
    SSG: 5,2
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