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  • 1
    Online Resource
    Online Resource
    Diffusion MRI: A New Strategy for Assessment of Cancer Therapeutic Efficacy
    SAGE Publications ; 2002
    In:  Molecular Imaging Vol. 1, No. 4 ( 2002-10-1), p. 336-343
    Details
    In: Molecular Imaging, SAGE Publications, Vol. 1, No. 4 ( 2002-10-1), p. 336-343
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1535-3508
    URL: Article
    DOI: 10.1162/153535002321093945
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2069848-3
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  • 2
    Online Resource
    Online Resource
    Diffusion MRI: A New Strategy for Assessment of Cancer Therapeutic Efficacy
    SAGE Publications ; 2002
    In:  Molecular Imaging Vol. 1, No. 4 ( 2002-10-01), p. 153535002002214-
    Details
    In: Molecular Imaging, SAGE Publications, Vol. 1, No. 4 ( 2002-10-01), p. 153535002002214-
    Abstract: The use of anatomical imaging in clinical oncology practice traditionally relies on comparison of patient scans acquired before and following completion of therapeutic intervention. Therapeutic success is typically determined from inspection of gross anatomical images to assess changes in tumor size. Imaging could provide significant additional insight into therapeutic impact if a specific parameter or combination of parameters could be identified which reflect tissue changes at the cellular or physiologic level. This would provide an early indicator of treatment response/outcome in an individual patient before completion of therapy. Moreover, response of a tumor to therapeutic intervention may be heterogeneous. The use of imaging could assist in delineating therapeutic-induced spatial heterogeneity within a tumor mass by providing information related to specific regions that are resistant or responsive to treatment. Largely untapped potential resides in exploratory methods such as diffusion MRI, which is a non-volumetric intravoxel measure of tumor response based upon water molecular mobility. Alterations in water mobility reflect changes in tissue structure at the cellular level. While the clinical utility of diffusion MRI for oncologic practice is still under active investigation, this overview on the use of diffusion MRI for the evaluation of brain tumors will serve to introduce how this approach may be applied in the future for the management of patients with solid tumors.
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1536-0121
    URL: Article
    DOI: 10.1162/15353500200221482
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2069848-3
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  • 3
    Online Resource
    Online Resource
    Consumption Behavior across Ethnic Categories
    SAGE Publications ; 1971
    In:  California Management Review Vol. 14, No. 1 ( 1971-10), p. 65-70
    Details
    In: California Management Review, SAGE Publications, Vol. 14, No. 1 ( 1971-10), p. 65-70
    Type of Medium: Online Resource
    ISSN: 0008-1256 , 2162-8564
    URL: Article
    DOI: 10.2307/41164367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1971
    detail.hit.zdb_id: 222930-4
    detail.hit.zdb_id: 2066069-8
    SSG: 3,2
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  • 4
    Online Resource
    Online Resource
    Barriers to Optimal Care for Patients with Coexisting Substance Use and Mental Health Disorders
    SAGE Publications ; 2002
    In:  Australian & New Zealand Journal of Psychiatry Vol. 36, No. 6 ( 2002-12), p. 792-799
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 36, No. 6 ( 2002-12), p. 792-799
    Abstract: Objective: This paper describes qualitative research that was carried out as part of a project aimed at drawing up a series of guidelines for the assessment and management for people with coexisting substance use and mental health disorders, or dual diagnosis [ 1 ]. Method: A core consultation team of 14 experts with experience in the areas of both substance use and mental health in New Zealand was established to advise on the development of eight clinical scenarios. The clinical scenarios were selected to highlight a range of real life issues in the treatment of people with coexisting substance use and mental health disorders and were presented at 12 focus groups around New Zealand. The 261 participants of the focus groups were asked to comment on what was optimal management for each of the scenarios and to identify barriers to optimal care in their region. Written notes were analysed for recurring and strongly stated themes and these comprise the results of the study. Results: While there was marked regional variation in treatment approaches and service structures, many of the barriers to optimal care that were identified were common to all regions. The results are considered under the headings of systems issues, clinical issues and attitudes. Conclusions: A wide variety of barriers that impede the delivery of optimal care have been identified. These range from the attitudes of individual clinicians to the structure of the systems within which they work. A system of key principles and processes for organizing treatment in a way which helps overcome these barriers is proposed.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.1046/j.1440-1614.2002.01049.x
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2003849-5
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  • 5
    Online Resource
    Online Resource
    Efficacy of Chlorhexidine Varnish for the Prevention of Adult Caries : A Randomized Trial
    SAGE Publications ; 2012
    In:  Journal of Dental Research Vol. 91, No. 2 ( 2012-02), p. 150-155
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 91, No. 2 ( 2012-02), p. 150-155
    Abstract: The Prevention of Adult Caries Study, an NIDCR-funded multicenter, double-blind, randomized clinical trial, enrolled 983 adults (aged 18-80 yrs) at high risk for developing caries (20 or more intact teeth and 2 or more lesions at screening) to test the efficacy of a chlorhexidine diacetate 10% weight per volume (w/v) dental coating (CHX). We excluded participants for whom the study treatment was contraindicated or whose health might affect outcomes or ability to complete the study. Participants were randomly assigned to receive either the CHX coating (n = 490) or a placebo control (n = 493). Coatings were applied weekly for 4 weeks and a fifth time 6 months later. The primary outcome (total net D 1-2 FS increment) was the sum of weighted counts of changes in tooth surface status over 13 months. We observed no significant difference between the two treatment arms in either the intention-to-treat or per-protocol analyses. Analysis of 3 protocol-specified secondary outcomes produced similar findings. This trial failed to find that 10% (w/v) chlorhexidine diacetate coating was superior to placebo coating for the prevention of new caries ( Clinicaltrials.gov registration number NCT00357877).
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/0022034511424154
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2057074-0
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  • 6
    Online Resource
    Online Resource
    Social Phobia in an Outpatient Alcohol and Drug Treatment Sample
    SAGE Publications ; 2008
    In:  Australian & New Zealand Journal of Psychiatry Vol. 42, No. 2 ( 2008-02), p. 134-140
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 42, No. 2 ( 2008-02), p. 134-140
    Abstract: Objective: To examine characteristics of patients with social phobia (SP) in alcohol and drug treatment settings and to identify features distinguishing this group from patients with and without other psychiatric conditions. Method: A random sample of 105 patients completing an initial assessment at two outpatient alcohol and drug treatment services were assessed and agreed to a 9 month follow-up interview, completed by n=102 (97%). At baseline the Composite International Diagnostic Interview (CIDI) was administered. Current diagnoses at baseline were used to separate the sample into those with SP (n=33), other current psychiatric disorders (OPD, n=40), and those with no current psychiatric diagnosis other than a substance use disorder (NPD, n=29). The novel methodology used in this study compared the SP group first to the NPD group to see if SP was associated with a different presentation, and then compared the SP group to the OPD group to see if any identified differences were associated with SP per se or psychopathology generally. The three groups were compared on demographic, current clinical, and past treatment utilization variables at baseline, while follow-up data were used to compare the groups on treatment outcome and treatment utilization. Results: The SP group did not differ from either group in a systematic way. What differences did emerge tended to show a difference between OPD and NPD, with SP intermediate between the two, or that SP and OPD together were different from NPD. Conclusions: Despite the relatively small sample size, these findings suggest that in substance use disorder treatment settings, patients with coexisting SP do not represent a distinctly high-needs or at-risk group in the broader context of patient populations, for which coexisting psychiatric diagnoses are the norm rather than the exception.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.1080/00048670701787511
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2003849-5
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  • 7
    Online Resource
    Online Resource
    Glenoid Version Assessment When the CT Field of View Does Not Permit the Friedman Method: The Robertson Method
    SAGE Publications ; 2022
    In:  Orthopaedic Journal of Sports Medicine Vol. 10, No. 5 ( 2022-05-01), p. 232596712210835-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 10, No. 5 ( 2022-05-01), p. 232596712210835-
    Abstract: To improve spatial resolution, current clinical shoulder cross-sectional imaging studies reduce the field of view of the shoulder, excluding the medial scapula border and preventing glenoid version measurement according to the Friedman method. Purpose: To evaluate a method to accurately and reliably measure glenoid version on cross-sectional shoulder images when the medial scapula border is not included in the field of view, and to establish measurements equivalent to the Friedman method. Study Design: Controlled laboratory study. Methods: Sixty-five scapulae underwent computed tomography (CT) scanning with an optimal shoulder CT-positioning protocol. Glenoid version was measured on CT images of the full scapula using the Friedman method. We developed a measurement method (named the Robertson method) based on the glenoid vault version from partial scapula images, with a correction angle subtracted from the articular-surface-glenoid vault measurement. Comparison with the Friedman method defined the accuracy of the Robertson method. Three observers tested inter- and intraobserver reliability of the Robertson method. Accuracy was statistically evaluated with t tests and reliability with the intraclass correlation coefficient (ICC). Results: The statistical distribution of glenoid version was similar to published data,–0.5° ± 3° [mean ± SD]. The initial measurement using the Robertson method resulted in a more retroverted angle compared with the Friedman method, and a correction angle of 7° was then applied. After this adjustment, the difference between the 2 methods was nonsignificant (0.1° ± 4°; P 〉 .65). Reliability of the Robertson method was excellent, as the interrater ICC was 0.77, the standard error of measurement (SEM) was 1.1° with P 〈 .001. The intrarater ICC ranged between 0.84 and 0.92, the SEM ranged between 0.9° and 1.2° with P 〈 .01. Conclusion: A validated glenoid version measurement method is now available for current clinical shoulder CT protocols that reliably create Friedman-equivalent values. Clinical Relevance: Friedman-equivalent values may be made from common clinical CTs of the shoulder and compared with prior and future Friedman measurements of the scapula.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/23259671221083589
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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