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  • 1
    Online Resource
    Online Resource
    Clinical Features and Outcomes of Pediatric Monophasic and Recurrent Idiopathic Optic Neuritis
    SAGE Publications ; 2020
    In:  Journal of Child Neurology Vol. 35, No. 1 ( 2020-01), p. 77-83
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 35, No. 1 ( 2020-01), p. 77-83
    Abstract: Limited data exist on isolated optic neuritis in children. We report the clinical features and treatment of pediatric subjects with monophasic and recurrent idiopathic optic neuritis. This retrospective cohort study of patients with isolated optic neuritis identified 10 monophasic and 7 recurrent optic neuritis cases. Monophasic optic neuritis patients were older (mean 13.3 ± 4.22) than those with recurrent idiopathic optic neuritis (9.86 ± 3.63). Females represented 50% of monophasic and 85.7% of recurrent idiopathic optic neuritis cases. Patients with monophasic optic neuritis were less likely to have a bilateral onset than recurrent idiopathic optic neuritis (40% vs 57.1%). Only 1 case had oligoclonal bands in the cerebrospinal fluid CSF. Most recurrent idiopathic optic neuritis cases had evidence of anti–myelin oligodendrocyte glycoprotein (MOG) antibodies (5/7). Treatment of recurrent idiopathic optic neuritis cases included intravenous pulse glucocorticosteroids and immunotherapy. We observed differences between recurrent and monophasic idiopathic optic neuritis. Immunosuppression appeared to prevent further relapses in recurrent idiopathic optic neuritis patients. Weaning immunotherapies after several years of quiescence in recurrent idiopathic optic neuritis may be possible, but larger studies are needed.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073819877334
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2068710-2
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  • 2
    Online Resource
    Online Resource
    Caries Inhibition by and Safety of Lactobacillus paracasei DSMZ16671
    SAGE Publications ; 2010
    In:  Journal of Dental Research Vol. 89, No. 9 ( 2010-09), p. 921-926
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 89, No. 9 ( 2010-09), p. 921-926
    Abstract: Lactobacillus paracasei DSMZ16671, even if heat-killed, sensitively co-aggregates mutans streptococci specifically. Mutans streptococci are strongly implicated in caries induction in humans and rodents. We hypothesized: (1) that S. mutans recoveries from rats’ teeth in vivo will decrease, with an associated decrease in caries, if these lactobacilli are fed to rats in an established caries model; and (2) that toxicological assays of these lactobacilli will show them to be benign. Four groups of specific-pathogen-free rats were formed: S. mutans 10449S-inoculated/16671-supplemented diet; un-inoculated/16671-supplemented diet; S. mutans 10449S-inoculated/placebo diet; and un-inoculated/placebo diet. Standard tests of toxicity and mutagenicity of heat-killed DSMZ16671 were performed. S. mutans recoveries were significantly reduced both in mid-experiment and at termination, as were caries lesion scores for the rats inoculated by S. mutans and fed the DSMZ16671 supplement, by comparison with controls. Neither toxicity nor mutagenicity of DSMZ16671 was detected. Use of heat-killed DSMZ16671 is efficacious in rats and appears safe.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/0022034510369460
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2057074-0
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  • 3
    Online Resource
    Online Resource
    Die Wirkung von Work-Life Balance Initiativen auf das Mitarbeitercommitment: Eine empirische Untersuchung in der Unternehmensberatungsbranche
    SAGE Publications ; 2010
    In:  German Journal of Human Resource Management: Zeitschrift für Personalforschung Vol. 24, No. 3 ( 2010-08), p. 231-265
    Details
    In: German Journal of Human Resource Management: Zeitschrift für Personalforschung, SAGE Publications, Vol. 24, No. 3 ( 2010-08), p. 231-265
    Abstract: Der vorliegende Beitrag untersucht die Wirkung von unternehmerischen Work-Life Balance Initiativen für die emotionale Bindung der Mitarbeiter zum Unternehmen, d. h. das organisationale Commitment von Mitarbeitern im Kontext der Unternehmensberatung. Dazu wurde eine Untersuchung mit insgesamt 275 Unternehmensberaterinnen und -beratern durchgeführt. Die Datenanalyse erfolgte anhand eines PLS-Strukturgleichungsmodells (Partial-Least-Squares-Ansatz). Die Ergebnisse weisen darauf hin, dass auch in Beratungsorganisationen ein Zusammenhang zwischen der Nutzung von Work-Life Balance Initiativen und dem affektiven Commitment von Mitarbeitern besteht und zwar sowohl direkt als auch über den Einfluss der Initiativennutzung auf einen so reduzierten Work-Life Conflict. Darüber hinaus konnte ein positiver Einfluss der Unterstützung durch den Vorgesetzten für die Inanspruchnahme von Work-Life Balance Initiativen gezeigt werden.
    Type of Medium: Online Resource
    ISSN: 2397-0022 , 2397-0030
    URL: Article
    DOI: 10.1177/239700221002400309
    Language: German
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2842165-6
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  • 4
    Online Resource
    Online Resource
    Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS
    SAGE Publications ; 2007
    In:  Multiple Sclerosis Journal Vol. 13, No. 9 ( 2007-11), p. 1086-1094
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 13, No. 9 ( 2007-11), p. 1086-1094
    Abstract: The aim of this study was to test the contribution of anti-myelin antibodies in predicting conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) when considering either Poser's or McDonald's diagnostic criteria. Fifty-one patients with CIS and abnormal brain MRI were imaged monthly for six months and then at 12, 18, 24, 36 months. At baseline serum samples testing antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) and myelin basic protein (anti-MBP) were collected. During the 36-month follow-up, 26 (51%) patients developed a relapse thus becoming clinically definite MS (CDMS) according to Poser's criteria; 46 (90.2%) patients converted to MS according to McDonald's criteria. Out of 51 patients, 28 (54.9%) had either double or single positivity for anti-myelin antibodies. Antibody status significantly predicted MS according to Poser's criteria ( P = 0.004), but did not according to the McDonald's criteria. When compared to antibody negative patients, the risk of developing a relapse was 8.9 (95% CI: 2.7—29.8; P 〈 0.001) for anti-MBP positive (anti-MBP+) patients and 1.5 (95% CI: 0.4—5.4; P = 0.564) for those anti-MOG positive (anti-MOG+); double positive patients (ie, anti-MBP+/anti-MOG+) had a risk of relapse's occurrence equal to 3.4 (95% CI: 1.1—10.2; P = 0.031). Also, the antibody status predicted the median time span from CIS to CDMS, that was of 36 months in the anti-MOG-/anti-MBP- group, 33 months in the anti-MOG+/anti-MBP- group, 24 months in the anti-MOG+/anti-MBP+ group and 12 months in the anti-MOG-/anti-MBP+ patients ( P = 0.003 by ANOVA). Our data support the prognostic value of anti-myelin antibodies in CIS patients at risk of CDMS, with positive patients showing shorter time interval to relapse occurrence than negative patients. Multiple Sclerosis 2007; 13: 1086—1094. http://msj.sagepub.com
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458507077622
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2008225-3
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