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  • 1
    Online Resource
    Online Resource
    Prison Homicide.
    SAGE Publications ; 1979
    In:  Contemporary Sociology Vol. 8, No. 1 ( 1979-01), p. 76-
    Details
    In: Contemporary Sociology, SAGE Publications, Vol. 8, No. 1 ( 1979-01), p. 76-
    Type of Medium: Online Resource
    ISSN: 0094-3061
    URL: Article
    DOI: 10.2307/2064910
    RVK:
    MN 1000
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 1979
    detail.hit.zdb_id: 121249-7
    detail.hit.zdb_id: 2010085-1
    SSG: 3,4
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  • 2
    Online Resource
    Online Resource
    Influences of Mental Illness, Current Psychological State, and Concussion History on Baseline Concussion Assessment Performance
    SAGE Publications ; 2018
    In:  The American Journal of Sports Medicine Vol. 46, No. 7 ( 2018-06), p. 1742-1751
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 46, No. 7 ( 2018-06), p. 1742-1751
    Abstract: A student-athlete’s mental state, including history of trait anxiety and depression, or current psychological state may affect baseline concussion assessment performance. Purpose: (1) To determine if mental illness (anxiety, depression, anxiety with depression) influences baseline scores, (2) to determine if psychological state correlates with baseline performance, and (3) to determine if history of concussion affects Brief Symptom Inventory–18 (BSI-18) subscores of state anxiety, depression, and somatization. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A sample of 8652 collegiate student-athletes (54.5% males, 45.5% females) participated in the Concussion Assessment, Research and Education (CARE) Consortium. Baseline assessments included a demographic form, a symptom evaluation, Standardized Assessment of Concussion, Balance Error Scoring System, a psychological state assessment (BSI-18), and Immediate Post-concussion Assessment and Cognitive Test. Baseline scores were compared between individuals with a history of anxiety (n = 59), depression (n = 283), and anxiety with depression (n = 68) and individuals without a history of those conditions (n = 8242). Spearman’s rho correlations were conducted to assess the relationship between baseline and psychological state subscores (anxiety, depression, somatization) (α = .05). Psychological state subscores were compared between individuals with a self-reported history of concussions (0, 1, 2, 3, 4+) using Kruskal-Wallis tests (α = .05). Results: Student-athletes with anxiety, depression, and anxiety with depression demonstrated higher scores in number of symptoms reported (anxiety, 4.3 ± 4.2; depression, 5.2 ± 4.8; anxiety with depression, 5.4 ± 3.9; no anxiety/depression, 2.5 ± 3.4), symptom severity (anxiety, 8.1 ± 9.8; depression, 10.4 ± 12.4; anxiety with depression, 12.4 ± 10.7; no anxiety/depression, 4.1 ± 6.9), and psychological distress in state anxiety (anxiety, 3.7 ± 4.7; depression, 2.5 ± 3.6; anxiety with depression, 3.8 ± 4.2; no anxiety/depression, 0.8 ± 1.8), depression (anxiety, 2.4 ± 4.0; depression, 3.2 ± 4.5; anxiety with depression, 3.8 ± 4.8; no anxiety/depression, 0.8 ± 1.8), and somatization (anxiety, 2.3 ± 2.9; depression, 1.8 ± 2.8; anxiety with depression, 2.2 ± 2.4; no anxiety/depression, 0.9 ± 1.7). A moderate positive relationship existed between all BSI-18 subscores and total symptom number (n = 8377; anxiety: r s = 0.43, P 〈 .001; depression: r s = 0.42, P 〈 .001; somatization: r s = 0.45, P 〈 .001), as well as total symptom severity (anxiety: r s = 0.43, P 〈 .001; depression: r s = 0.41, P 〈 .001; somatization: r s = 0.45, P 〈 .001). Anxiety, depression, and somatization subscores were greater among student-athletes that self-reported more concussions. Conclusion: Clinicians should be cognizant that student-athletes with a history of trait anxiety, depression, and anxiety with depression may report higher symptom score and severity at baseline. Individuals with extensive concussion history may experience greater state anxiety, depression, and somatization.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546518765145
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 3
    Online Resource
    Online Resource
    Vancomycin Pharmacokinetics in Neonates and Infants: A Retrospective Evaluation
    SAGE Publications ; 1993
    In:  Annals of Pharmacotherapy Vol. 27, No. 4 ( 1993-04), p. 490-496
    Details
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 27, No. 4 ( 1993-04), p. 490-496
    Abstract: To evaluate the frequency with which current loading and maintenance vancomycin dosages achieve target serum concentrations based on pharmacokinetic parameters obtained after the initial dose. Also, to identify the daily vancomycin dosage necessary to achieve target serum concentrations at steady-state and to determine if any relationships exist between vancomycin pharmacokinetic parameters and various patient characteristics. SETTING: Neonatal intensive care unit (NICU) at Georgia Baptist Medical Center. PATIENTS/METHODS: Twenty-three infants with suspected or documented gram-positive infection who received intravenous vancomycin between July 1990 and November 1991 were included in this retrospective analysis. Gestational age ranged from 23 to 41 weeks and postconceptional age (PCA) at the time of the study ranged from 26 to 46 weeks. Vancomycin therapy was initiated with a loading dose of 15 mg/kg, followed by a maintenance dosage of 20–30 mg/kg/d, which was usually given as 10 mg/kg q8–12h. All vancomycin doses were administered using a syringe pump. Peak and trough serum concentrations were obtained following the first dose. Vancomycin pharmacokinetic parameters were determined using a one-compartment model. Infants receiving indomethacin within two weeks prior to study were analyzed separately (group 2, n=4). All other infants were included in group 1 (n=19). RESULTS: For group 1, vancomycin clearance (CI), volume of distribution (V d ), and half-life were (mean ± 1 SD) 0.072 ± 0.032 L/kg/h, 0.52 ± 0.08 L/kg, and 5.6 ± 1.6 hours, respectively. For both groups, loading doses provided 1-hour postinfusion peak concentrations of 25–35 mg/L in one of every two infants studied, whereas only three percent of initial maintenance doses were projected to provide desired peak and trough concentrations at steady-state. For group 1, the mean daily dosage necessary to provide target peak (25–35 mg/L) and trough (5–10 mg/L) concentrations at steady-state was larger than that initially prescribed (29.6 ± 13.1 vs. 22.2 ± 4.7 mg/kg/d). For group 2, the mean daily dosage required to achieve target peak and trough concentrations at steady-state was smaller than that initially prescribed (14.8 ± 4.3 vs. 20.0 ±0.1 mg/kg/d) and was exactly half of that required for group 1. Excellent correlations were observed between PCA and vancomycin Cl (L/h) (r=0.92; p 〈 0.0001), body weight and V d (L) (r=0.94; p 〈 0.0001), body weight and vancomycin Cl (L/h) (r=0.85; p 〈 0.0001), PCA and V d (L) (r=0.89; p 〈 0.0001), and body surface area and V d (L) (r=0.93; p 〈 0.0001) for group 1. Moderate correlations were also noted between PCA and Cl relative to body weight (L/kg/h), postnatal age and Cl (L/kg/h), and PCA and vancomycin dosage requirements (mg/kg/d). No linear correlation was observed between any patient characteristic and V d standardized for body weight. CONCLUSIONS: Our data demonstrate the need for a more accurate method of estimating initial vancomycin dosage requirements in this NICU population. Although some of the relationships revealed in this study could be used to determine vancomycin dosage for infants in the range of approximately 30–36 weeks PCA, we hesitate to suggest this approach presently because of the potential limitations of our study design. Further prospective study is needed to confirm these observations. In addition, further study is necessary to describe the time course of the interaction between vancomycin and indomethacin in infants with successful and unsuccessful closure of their patent ductus arteriosus.
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    URL: Article
    DOI: 10.1177/106002809302700417
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1993
    detail.hit.zdb_id: 2053518-1
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Image Analysis Algorithms for Immunohistochemical Assessment of Cell Death Events and Fibrosis in Tissue Sections
    SAGE Publications ; 2009
    In:  Journal of Histochemistry & Cytochemistry Vol. 57, No. 7 ( 2009-07), p. 649-663
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 57, No. 7 ( 2009-07), p. 649-663
    Abstract: Cell death is of broad physiological and pathological importance, making quantification of biochemical events associated with cell demise a high priority for experimental pathology. Fibrosis is a common consequence of tissue injury involving necrotic cell death. Using tissue specimens from experimental mouse models of traumatic brain injury, cardiac fibrosis, and cancer, as well as human tumor specimens assembled in tissue microarray (TMA) format, we undertook computer-assisted quantification of specific immunohistochemical and histological parameters that characterize processes associated with cell death. In this study, we demonstrated the utility of image analysis algorithms for color deconvolution, colocalization, and nuclear morphometry to characterize cell death events in tissue specimens: (a) subjected to immunostaining for detecting cleaved caspase-3, cleaved poly(ADP-ribose)-polymerase, cleaved lamin-A, phosphorylated histone H2AX, and Bcl-2; (b) analyzed by terminal deoxyribonucleotidyl transferase–mediated dUTP nick end labeling assay to detect DNA fragmentation; and (c) evaluated with Masson's trichrome staining. We developed novel algorithm-based scoring methods and validated them using TMAs as a high-throughput format. The proposed computer-assisted scoring methods for digital images by brightfield microscopy permit linear quantification of immunohistochemical and histochemical stainings. Examples are provided of digital image analysis performed in automated or semiautomated fashion for successful quantification of molecular events associated with cell death in tissue sections. (J Histochem Cytochem 57:649–663, 2009)
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/jhc.2009.952812
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    The Enduring Effects of Education.
    SAGE Publications ; 1977
    In:  Contemporary Sociology Vol. 6, No. 2 ( 1977-03), p. 182-
    Details
    In: Contemporary Sociology, SAGE Publications, Vol. 6, No. 2 ( 1977-03), p. 182-
    Type of Medium: Online Resource
    ISSN: 0094-3061
    URL: Article
    DOI: 10.2307/2065787
    RVK:
    MN 1000
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 1977
    detail.hit.zdb_id: 121249-7
    detail.hit.zdb_id: 2010085-1
    SSG: 3,4
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  • 6
    Online Resource
    Online Resource
    Congenital Cytoplasmic Body Myopathy: Case Report
    SAGE Publications ; 1997
    In:  Journal of Child Neurology Vol. 12, No. 2 ( 1997-02), p. 149-152
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 12, No. 2 ( 1997-02), p. 149-152
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/088307389701200215
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
    detail.hit.zdb_id: 2068710-2
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  • 7
    Online Resource
    Online Resource
    Anthropometric Dimensions of Individuals With High Body Mass Index
    SAGE Publications ; 2019
    In:  Human Factors: The Journal of the Human Factors and Ergonomics Society Vol. 61, No. 8 ( 2019-12), p. 1277-1296
    Details
    In: Human Factors: The Journal of the Human Factors and Ergonomics Society, SAGE Publications, Vol. 61, No. 8 ( 2019-12), p. 1277-1296
    Abstract: This study presents anthropometric data for individuals with high body mass index (BMI). Modified anthropometric dimensions were also developed to address the challenges of obtaining accurate and repeatable data for this population segment. Background: The prevalence of obesity affects approximately 40% of the U.S. adult population. Anthropometric data are needed to guide product design and safety, but few individuals with high BMI have been measured in available datasets. Method: Anthropometric data for a convenience sample of 288 adults with high BMI (≥30 kg/m 2 ) were collected. To increase participation and minimize participant discomfort, measurements were collected at three bariatric weight loss clinics and one academic research institution. Results: The current obese cohort are heavier than the U.S. general population, with a difference in mean body weight of 47 kg for women and 56 kg for men. The obese cohort are also heavier and have a higher BMI compared with the NIOSH (National Institute for Occupational Safety and Health) truck driver population. Waist circumferential measures of the current obese cohort were larger than women or men in either population compared, a result indicative of meaningful body shape differences. Conclusion: To our knowledge, this study is the first to collect anthropometric data for the obese population segment and conduct comparisons to the U.S. general population and available occupational databases. The obese cohort differed substantially with respect to the distributions of anthropometric variables. Application: These data provide insights about the obese population segment that are relevant to product design, and establish a foundation for future data collection efforts.
    Type of Medium: Online Resource
    ISSN: 0018-7208 , 1547-8181
    URL: Article
    DOI: 10.1177/0018720819839809
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2066426-6
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  • 8
    Online Resource
    Online Resource
    Toxicity of Hydroxyurea in Rats and Dogs
    SAGE Publications ; 2015
    In:  Toxicologic Pathology Vol. 43, No. 4 ( 2015-06), p. 498-512
    Details
    In: Toxicologic Pathology, SAGE Publications, Vol. 43, No. 4 ( 2015-06), p. 498-512
    Abstract: The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascular, and gastrointestinal toxicity with steep dose response curves. In rats dosed for 10 days, 50 mg/kg/day was tolerated; 500 mg/kg/day produced decreased body weight gain; decreased circulating leukocytes, erythrocytes, and platelets; decreased cellularity of thymus, lymph nodes, and bone marrow; and epithelial degeneration and/or dysplasia of the stomach and small intestine; 1,500 mg/kg/day resulted in deaths on day 5. In dogs, a single dose at ≥250 mg/kg caused prostration leading to unscheduled euthanasia. Dogs administered 50 mg/kg/day for 1 month had decreased circulating leukocytes, erythrocytes, and platelets; increased bone marrow cellularity with decreased maturing granulocytes; increased creatinine kinase activity; and increased iron pigment in bone marrow and hepatic sinusoidal cells. In telemetered dogs, doses ≥15 mg/kg decreased systolic blood pressure (BP); 50 mg/kg increased diastolic BP, heart rate, and change in blood pressure over time (+d P/d t), and decreased QT and PR intervals and maximum left ventricular systolic and end diastolic pressures with measures returning to control levels within 24 hr.
    Type of Medium: Online Resource
    ISSN: 0192-6233 , 1533-1601
    URL: Article
    DOI: 10.1177/0192623314559103
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2056753-4
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  • 9
    Online Resource
    Online Resource
    The Enduring Effects of Education
    SAGE Publications ; 1976
    In:  American Educational Research Journal Vol. 13, No. 3 ( 1976-22), p. 225-
    Details
    In: American Educational Research Journal, SAGE Publications, Vol. 13, No. 3 ( 1976-22), p. 225-
    Type of Medium: Online Resource
    ISSN: 0002-8312
    URL: Article
    DOI: 10.2307/1162434
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 1976
    detail.hit.zdb_id: 280032-9
    detail.hit.zdb_id: 2143269-7
    SSG: 5,2
    SSG: 5,3
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  • 10
    Online Resource
    Online Resource
    Intravenous Ribavirin for Hantavirus Pulmonary Syndrome: Safety and Tolerance during 1 Year of Open-Label Experience
    SAGE Publications ; 1999
    In:  Antiviral Therapy Vol. 4, No. 4 ( 1999-05), p. 211-219
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 4, No. 4 ( 1999-05), p. 211-219
    Abstract: Intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (HPS) in the United States between 4 June 1993 and 1 September 1994. Therapy was initiated prior to laboratory confirmation of hantavirus infection because most deaths from HPS occur within 48 h of hospitalization. Thirty patients with confirmed HPS, 105 patients without HPS and 5 patients without adequate diagnostic testing for HPS were enrolled. This observational study arguably provides the most complete information available on ribavirin-associated adverse effects. Although ribavirin was generally well tolerated, 71% of recipients became anaemic and 19% underwent transfusion. An apparent excess of hyperamylasaemia/pancreatitis was either therapy-associated or due to enrolment bias. The 30 enrolled HPS patients had a case–fatality rate of 47% (14/30). It is not possible to assess efficacy with this study design. However, comparison of survival curves for the 30 enrolled HPS patients and 34 patients who developed HPS during the same time period but were not enrolled did not suggest an appreciable drug effect. A randomized, placebo-controlled trial that enrols patients during the prodrome phase would be necessary to assess the efficacy and further define the safety of intravenous ribavirin for HPS.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965359900400404
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1999
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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